Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Paul  Kutyabami
ID: UNCST-2020-R015029
 An Evaluation of Perceptions and Effectiveness of the Ethical Review Process at Makerere University: A pilot Evaluation at the School of Health Sciences Research and Ethics Committee
REFNo: HS5322ES

1. Assess the perceptions of researchers (from the departments of pharmacy, nursing, dentistry, staff at Makerere University and researchers outside the institution) regarding MaKSHSREC’s ethical review process.
2. To assess the level of satisfaction among researchers on the existing MaKSHSREC ethical review processes.
3. Assess the efficiency and effectiveness of MaKSHSREC ethical review processes.
4. Explore the challenges and areas for improvement in the current MaKSHSREC ethical review processes.

Uganda 2024-12-23 11:38:43 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
PAULA KWOREKWA
ID: UNCST-2024-R005035
 Assessing the Impact of COVID-19 on the Knowledge, Attitude, and Practice of Medical Waste Management among Waste Handlers at Luweero General Hospital
REFNo: HS5350ES

Main Objective:
To investigate the impact of COVID-19 on the Knowledge, attitude, and practice of medical waste management among waste handlers at Luweero General Hospital.
Specific Objectives:
1. To determine the knowledge of medical waste handlers in recommended waste management practices following the COVID-19 pandemic.
2. To investigate the attitude of medical waste handlers towards practicing the recommendations for proper Medical Waste Management in the post COVID-19 pandemic era.
3. To compare the practices for medical waste management before and after the COVID-19 pandemic.


Uganda 2024-12-23 11:37:27 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David Aziku
ID: UNCST-2023-R007595
 Baseline Study for Safe and Inclusive Cities Project -Uganda.
REFNo: SS3476ES

To evaluate the achievement of the programme’s intended outcomes, integrating qualitative insights and quantitative data on change in outcome indicators over time (from endline to end-line).

Identify and validate good practices, learnings, and examples of innovation on gender transformative programming.

To generate practical recommendations related to the programme outcomes and the approaches to inform future programming.
 Uganda 2024-12-23 11:36:17 2027-12-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rebecca Nansubuga Kaaya
ID: UNCST-2024-R002104
 Piloting a frugally innovated surgical fracture table in Uganda: Assessing its functionality, usability, and acceptability.
REFNo: SIR454ES

To pilot a frugally innovated surgical fracture table in Uganda and assess its functionality, usability, and acceptability in resource-limited healthcare settings through:
1. To evaluate the functionality of the frugally innovated surgical fracture table selected healthcare professionals by assessing its ability to: securely position patients, allow for stable positioning and smooth adjustment of the tentative limb position.
2. To assess the usability of the surgical fracture table selected healthcare professionals by measuring: the time required for set-up, the perceived ease of use of the table, the perceived comfort levels during manipulation.
3. To determine the acceptability of the surgical fracture table among selected healthcare professionals by assessing: their overall satisfaction with the table's design, functionality, and usability, willingness to recommend or use the table in their clinical practice and their perceptions of the table's potential impact on patient outcomes and safety

 Uganda 2024-12-23 11:35:30 2027-12-23 Engineering and Technology Non-Clinical Trial Non-degree Award
Afiz Kibuuka Kibuuka
ID: UNCST-2021-R012755
 A phase III, Multicenter, Randomized, Placebo Controlled, Double blind Study to Assess Efficacy and Safety of Crizanlizumab (5 mg/kg) versus placebo, with or without Hydroxyurea/Hydroxycarbamide Therapy, in Adolescent and Adult Sickle Cell Disease Patients with Frequent Vaso-Occlusive Crises
REFNo: HS5365ES

To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without hydroxyurea/hydroxycarbamide, on the annualized rate of VOCs* that are healthcare professional (HCP)-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in 12 months prior to the screening visit).
To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without hydroxyurea/hydroxycarbamide, on the annualized rate of all VOCs including VOCs that are HCP-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) and VOCs that are self-managed without recommendations from HCP during the event over the planned 52 week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in the 12 months prior to the Screeening visit
To evaluate the annualized rate of VOCs by type of management between treatment arms over the planned 52-week treatment period: • VOCs that are HCP-managed at a health care facility • VOCs that are HCP-managed via remote consultation • VOCs that are self-managed without recommendations from HCP during the event • VOCs that are HCP-managed via remote consultation or self-managed without recommendations from HCP during the event
To evaluate the time to first VOC that is HCP managed (including VOCs leading to management at a health care facility or those managed via remote consultation) between treatment arms over the planned 52-week treatment period.
To evaluate the proportion of participants free from VOCs that are HCP-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) between treatment arms over the planned 52-week treatment period.
 Uganda 2024-12-23 11:34:49 2027-12-23 Medical and Health Sciences Clinical Trial Non-degree Award
Wakib Bunnya
ID: UNCST-2024-R016233
 An analysis of youth participation in elections
REFNo: SS3488ES

Three key objectives guide the research: first, to examine the role of voter education in shaping youth participation; second, to analyze the inclusion of young women and youth with disabilities in elections; and third, to explore the role of youth in peacebuilding and election-related violence.
Uganda 2024-12-23 11:32:13 2027-12-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Spencer  Birungi
ID: UNCST-2024-R003017
 TRANSBOUNDARY MIGRATION SURVEILLANCE CONTROLS AND THE INFECTIOUS DISEASES MONITORING MECHANISMS: THE CASE OF WEST NILE UGANDA-DEMOCRATIC REPUBLIC OF THE CONGO
REFNo: SS3504ES

1. To describe the transboundary migration patterns along the West Nile Uganda – DRC borderline
2. To explore the transboundary migration infectious disease monitoring in practice along the West Nile Uganda –DRC borderline
3. To establish the association between the transboundary migration surveillance controls and the practices in monitoring of infectious diseases at border points; of entry
4. To describe the adherence to protocols for infectious disease monitoring before, during and after the outbreaks at border points of entry


 Uganda 2024-12-23 11:29:01 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
MARGARET NAKATO
ID: UNCST-2024-R002167
 LIBRARY SERVICE QUALITY AND USER SATISFACTION AMONG GRADUATE STUDENTS IN THE FACULTIES OF SCIENCE AND ENGINEERING AT KYAMBOGO UNIVERSITY, UGANDA
REFNo: SS3545ES

The objectives of the study are to:
1. Establish the effect of tangibility on graduate students' satisfaction with library services at Kyambogo University.
2. Determine the effect of reliability on graduate students' satisfaction with library services at Kyambogo University.
3. Examine the effect of empathy on graduate students' user satisfaction with library services at Kyambogo University.
4. Establish the effect of responsiveness on graduate students' user satisfaction with library services at Kyambogo University.
5. Determine the effect of assurance on graduate students' user satisfaction with library services at Kyambogo University.
6. Develop a framework for measuring library service quality at Kyambogo university
 Uganda 2024-12-23 11:27:18 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
Lily Bastian R
ID: UNCST-2024-R002139
 A Mixed Methods Study on Psychosocial and Health Practices Among Young People Living with HIV (YPLHIV) in Kampala, Uganda
REFNo: HS5354ES

The objective of this study is to assess the impact of resilience on sexual practices, behaviors, and health-related outcomes among young people living with HIV (YPLHIV) in Kampala, Uganda.
 USA 2024-12-23 11:24:59 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Andrew Seguya Ggunga
ID: UNCST-2024-R002054
 Assessing the World Economic Forum’s Travel and Tourism Development Index as A Framework for Uganda's Tourism Growth
REFNo: SS3501ES

To create a prioritised ranking of factors that accurately predict tourism and travel growth in Uganda, using data-driven methods and expert analysis to measure the impact of each factor on key growth indicators such as tourist arrivals, revenue, and employment.,To investigate, over the same period, whether there are factors not included in the WEF Travel and Tourism Development Index framework that effectively predict T&T growth in Uganda.,This study will investigate, using data from the Tourism Master Plan 2014-2024, whether the factors included in the WEF Travel and Tourism Development Index framework (such as infrastructure, environmental sustainability, and government policies) effectively predict T&T growth in Uganda, measured through indicators of tourist arrivals, revenue, and employment.,
 Uganda 2024-12-23 11:23:37 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
John Francis Mafuko Francis
ID: UNCST-2024-R002186
 Management of medicinal indigenous knowledge on snakebites in selected districts of Eastern Uganda.
REFNo: SS3517ES

i.To examine the sharing of the medicinal indigenous knowledge by the snakebites herbalists’ in Pallisa and Kamuli districts of Eastern Uganda.
ii. To establish the essential kind of information to be documented by the medicinal indigenous herbalists on snakebites management in Pallisa and Kamuli districts of Eastern Uganda for future use.
iii. To establish whether there is incorporation of the explicit medicinal indigenous herbalists’ knowledge on snakebites by the medical practitioners in Pallisa and Kamuli districts of Eastern Uganda.
iv. To evaluate the likelihood of the community in using the two-eyed seeing framework to integrate western knowledge and indigenous knowledge to deal with the snakebites in Pallisa and Kamuli districts of Eastern Uganda.
v. To propose a medicinal indigenous snakebites herbalists’ knowledge management framework in Pallisa and Kamuli districts of Eastern Uganda.

Uganda 2024-12-23 11:21:49 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
Ernest Mwebaze
ID: UNCST-2024-R015880
 EmpowerHerAI: Advancing Gender Equality and Responsible AI in Sub-Saharan Africa through Gender and Responsible AI Network (GRAIN)
REFNo: SIR456ES

General Objective
The general objective of the research study is to develop and evaluate low-resource multilingual AI language models by addressing issues of gender fairness, bias, and trustworthiness, and promoting inclusive and culturally contextualized AI tools for African languages.

Specific Objectives
1. Conduct a comprehensive review of existing datasets and training processes to identify potential gender gaps in relation to fairness, bias, and trustworthiness issues in low-resource multilingual language models.
2. Curate and collect parallel datasets for selected African languages to improve the development of low-resource multilingual language technologies.
3. Develop a robust and generalizable framework for creating AI language tools that address gender fairness, safety, and trustworthiness in non-English, low-resource multilingual models.
4. Develop a framework for incorporating human feedback and preferences into evaluating multilingual machine translation, speech recognition, and synthesis models, addressing the unique gender challenges presented by low-resource settings.

 Uganda 2024-12-23 11:15:21 2027-12-23 Engineering and Technology Non-Clinical Trial Non-degree Award
KADAI LAWAN ALHAJI
ID: UNCST-2024-R015583
 Analysis of Antimicrobial Metabolites of Aspergillus fumigatus, Isolated from Kitagata Hot Spring Utilizing Metabolomic and Molecular Docking Techniques
REFNo: NS891ES

Objectives
1 To ascertain physicochemical characteristics of Kitagata hot springs.
2 To isolate and identify thermophilic Aspergillus fumigatus from water sample of Kitagata hot spring.
3 To produce, extract and fractionate metabolites of thermophilic Aspergillus fumigatus to be isolated.
4 To determine the efficacy of antimicrobial value of extracted metabolites from the study organisms.
5 To simulate and predict the interaction between two structures of the metabolites

 Nigeria 2024-12-23 11:14:18 2027-12-23 Natural Sciences Non-Clinical Trial Degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Improving business continuity for health services following extreme weather events (RESilience in HeAlth Post-Extreme weather events-RESHAPE Study)
REFNo: HS5370ES

Overall Objective

The primary objective of the proposed study is to develop and deploy the tools that will help healthcare services to better prepare for EWEs, cope better when affected by such events, and recover more effectively afterwards.


Specific Aims
Aim 1: Describe the healthcare systems in the Kasese District, and its served communities and how both have been affected by and responded to EWEs to provide a foundation for locally relevant insights into processes and adaptations, and their influence on health outcomes

Aim 2: Develop, with local partners, through business continuity planning, resilience engineering and participatory research methods, protocols for EWE preparedness, response and recovery, and guidance on good practices, knowledge exchange, and interventions development as a process for enhancing resilient healthcare delivery

Uganda 2024-12-23 11:10:15 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bamidele Olaiya Charles
ID: UNCST-2024-R003262
 OPTIMIZATION OF MECHANICAL AND THERMAL PROPERTIES OF SANDCRETE-BRICKS INCORPORATING SAWDUST AND BANANA-LEAF ASH USING GENETIC ALGORITHM AND ARTIFICIAL-NEURAL-NETWORK
REFNo: SIR366ES

i. To characterize the Sawdust Ash (SDA) and Banana Leaf Ash (BLA)
ii. To examine the effects of varying percentages of sawdust and banana-leaf ashes on the mechanical (compressive strength, flexural strength) and thermal properties of sandcrete bricks.
iii. To develop an optimization approach using a combination of Genetic Algorithm (GA) and Artificial Neural Network (ANN) to determine the optimal mix proportions for sandcrete bricks with improved mechanical and thermal properties.
iv. To evaluate the mineralogical and microstructural properties of the sandcrete bricks made with the SDA and BLA.
v. To provide insights into the sustainable and energy-efficient production of sandcrete bricks incorporating sawdust and banana-leaf ash

 Nigeria 2024-12-23 11:08:48 2027-12-23 Engineering and Technology Non-Clinical Trial Degree Award
Gertrude Nakigozi
ID: UNCST-2023-R007979
 CLIMATE SHOCK PILOT STUDY
REFNo: NS890ES

Validate the climate shock survey for Lake Victoria basin/ South western Uganda and examine determinants of climate variability impact, and conduct a comparison on the effects of Climate variability by community and occupation Climate variability
 Uganda 2024-12-23 11:07:21 2027-12-23 Natural Sciences Non-Clinical Trial Non-degree Award
Julia Harrison
ID: UNCST-2024-R004345
 Neonatal and Pediatric HIV and Sepsis on a Pediatric Surgery Ward in Uganda: A Prospective Study Standardizing HIV Testing and Sepsis Resuscitation and Treatment Algorithm to Guide Clinical Care
REFNo: HS5416ES

Main Objective 1. The general objective of this project is to determine the prevalence of sepsis, the underlying etiologies leading to sepsis, and the prevalence of HIV among patients with sepsis on the pediatric surgery ward at Mulago hospital. Additionally, our objective is to implement the 2020 surviving sepsis campaign guidelines on the pediatric surgery ward at Mulago Hospital. Specific Objectives 1. We will identify the etiologies leading to sepsis on the pediatric surgery ward at Mulago Hospital by examining the underlying pathologies in patients diagnosed with sepsis over a period of 7 months 2. We will determine the prevalence of HIV among patients with sepsis on the pediatric surgery ward at Mulago Hospital by testing patients with sepsis for HIV over a period of 7 months 3. We will implement the 2020 Surviving Sepsis Campaign Guidelines on the pediatric surgery ward at Mulago Hospital over a period of 1 month 4. We will determine the prevalence of sepsis on the pediatric surgery ward at Mulago Hospital by tracking patients diagnosed with sepsis over a period of 7 months
 USA 2024-12-23 11:05:56 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SIYA AGGREY
ID: UNCST-2019-R001737
 WATER HYACINTH’S EXTENT ON FRESHWATER SITES WITHIN QUEEN ELIZABETH NATIONAL PARK, UGANDA; IMPLICATIONS ON WATER QUALITY AND WILDLIFE HEALTH
REFNo: NS894ES

i) To assess the spatial extent and distribution of Water hyacinth (Pontederia crassipes) in Lake Edward, Lake George and the Kazinga Channel
ii) To examine the determinants of Water hyacinth (Pontederia crassipes) distribution within Lake Edward, Lake George and the Kazinga Channel
iii) To assess impact of Water hyacinth (Pontederia crassipes) on water quality within Lake Edward, Lake George and the Kazinga Channel
iv) To analyze policies that would support management of Water hyacinth (Pontederia crassipes) invasion within Lake Edward, Lake George and the Kazinga Channel.

 Uganda 2024-12-23 11:03:12 2027-12-23 Natural Sciences Non-Clinical Trial Non-degree Award
Solomon Kibudde
ID: UNCST-2021-R013747
 PHASE II RANDOMIZED NON-INFERIORITY TRIAL OF HYPOFRACTIONATED RADIOTHERAPY FOR LOCALLY ADVANCED CERVICAL CANCER IN UGANDA.
REFNo: HS5348ES

1) To compare the incidence of grade 3+ gastrointestinal and genitourinary toxicity at 1 year post-treatment with hypofractionated radiotherapy (40 Gy in 16 fractions) and conventional fractionated radiotherapy (45 Gy in 25 fractions) in women with cervical cancer in Uganda.
2) To evaluate and compare local control and cervical cancer-specific survival rates at 1 year after hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional radiotherapy (45 Gy in 25 fractions).
3) To determine the association between stage-adjusted mean squamous cell carcinoma antigen (SCC-Ag) at 1-month post-treatment with the Progression-free survival at 1- year post-treatment with hypofractionated radiotherapy (40 Gy in 16 fractions) or conventionally fractionated radiotherapy (45 Gy in 25 fractions).
4) To compare the costs of healthcare to patients with cervical cancer treated with hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional fractionated radiotherapy (45 Gy in 25 fractions).
5) To evaluate patient-reported outcomes and quality of life in patients with cervical cancer treated with hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional fractionated radiotherapy (45 Gy in 25 fractions).

 Uganda 2024-12-23 11:01:22 2027-12-23 Medical and Health Sciences Clinical Trial Degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Investigation of mpox transmission, disease sequel, and molecular epidemiology in Uganda (Mpoxep)
REFNo: HS5387ES

Primary Objectives
1. To characterize the socio-demographic, clinical, immunological, and virologic epidemiology of Mpox cases in Uganda.
2. To describe the natural history and asymptomatic transmission dynamics of Mpox among contacts.
3. To assess risk factors for clinical hospitalization, ICU admission, and fatal Mpox outcomes.
4. To investigate long-term sequelae among Mpox survivors.

Secondary Objectives
1. To determine the incidence and prevalence of Mpox among high-risk populations (long-distance truck drivers, commercial sex workers, refugees, and PLHA).
2. To assess infection risk and asymptomatic transmission using serology among contacts.
3. To identify risk factors for infection among ‘de novo’ cases with no documented epidemiological link.
4. To explore socio-anthropological factors influencing Mpox transmission, prevention, and care-seeking behavior.
5. To identify potential animal reservoirs of MPXV in Uganda.
6. To describe histopathologic features of Mpox skin lesions and localization of MPXV in different body organs and tissues.

 Uganda 2024-12-23 10:56:56 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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