Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Robert MPIIRA
ID: UNCST-2022-R005391
 Dual Generation Interventions and Poverty Alleviation in Refugee Settlements in Uganda
REFNo: SS4265ES

The primary research objective for the proposed study is to determine if households participating in both the ultra-poor graduation program (UPG) and Humanitarian Play Lab (HPL) will have better outcomes for households, caregivers and children than households participating in the humanitarian play lab alone.
Specifically, the study seeks to:
(i) Examine if households which participate in both the Ultra-poor graduation and Humanitarian Play Lab programs have more income and are more food secure than households which only participate in the Humanitarian Play Lab program
(ii) Ascertain if Caregivers of households which participate in both the Humanitarian Play Lab program and the Humanitarian Play Lab program and those which only participate in HPL are different regarding time use, mindset and aspirations, knowledge and practices related to child development, gender attitudes and dynamics, mental health, well-being, stress, and post-traumatic stress disorder.
(iii) Analyse if children in households which participate in both the Humanitarian Play Lab program and the Humanitarian Play Lab program program have higher development outcomes than children of households that only participate in the Humanitarian Play Lab program

Uganda 2025-09-02 10:11:25 2028-09-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Fred  Bulamba
ID: UNCST-2020-R014888
 PErioperative respiratory care and outcomes for patieNts Undergoing hIgh risk abdomiNal surgery
REFNo: HS2178ES

To explore the cost-effectiveness of the different treatment combinations in reducing pneumonia and SSI at pre-selected centres.,To assess the impact of both interventions on postoperative mortality at 30-days, and the effect of 80-100% FiO2 only on the re-operation rate at 30 days after surgery.,To assess whether (1) preoperative 0.2% chlorhexidine mouthwash reduces the rate of postoperative pneumonia at 30-days compared to no mouthwash, and (2) 80-100% FiO2 used during surgery reduces the rate of postoperative SSI at 30-days compared to 21-35% FiO2, amongst patients aged 10 years or over undergoing elective or emergency midline laparotomy, with an anticipated abdominal incision of ≥5cm, for any indication except caesarean section.,
 Uganda 2025-08-28 10:15:49 2028-08-28 Medical and Health Sciences Clinical Trial Non-degree Award
Dickens Akena Howard
ID: UNCST-2019-R000179
 Neuropsychiatric Genetics of African Populations - Psychosis, II NeuroGAP-Psychosis II
REFNo: HS6452ES

i). Expand knowledge of the genetic architecture of schizophrenia and bipolar disorder in the African continent
through large-scale sample collection and analysis in Uganda
ii) Increase understanding of the genetics of African populations, through various methods for biospecimen
collection
iii) Enhance neuropsychiatric genetic research capacity in Africa through the training of scientists and supporting
the development of locally-led research programs
 Uganda 2025-08-27 14:38:09 2028-08-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Mfitundinda
ID: UNCST-2024-R015971
 Surveillance for recurrence and residual cervical intraepithelial neoplasia using high-risk human papillomavirus testing at Kawempe National Referral Hospital in Uganda, 2025
REFNo: HS5795ES

To improve surveillance for residual and recurrent CIN during follow up of women attending Kawempe National Referral Hospital (KNRH) in Uganda Specific objectives (i) To determine the prevalence of hr-HPV among women with CIN and those without CIN at Kawempe NRH, January-November, 2025 (ii) Determine the diagnostic/prediction accuracy of hr-HPV compared to the standard cytology for residual or recurrent CIN of any grade. (iii) Determine factors associated with progression of any CIN to a higher grade CIN or invasive cervical carcinoma (iv) Assess the level of acceptance of hr-HPV screening in women treated for CIN among health workers in the women's clinic at Kawempe National Referral Hospital
Uganda 2025-08-26 16:02:41 2028-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pamella Abwoyo
ID: UNCST-2024-R015875
 Prevalence And Associated Factors Of Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli In Wet Markets In Lira District, Uganda: A One-Health Cross Sectional Study
REFNo: SS3917ES

1. To determine the prevalence and associated factors of ESBL-E.coli in chicken sold in wet markets in Lira District 2. To determine the prevalence and associated factors of ESBL-E.coli in wastewater sources in wet markets in Lira District 3. To determine the prevalence and associated factors of ESBL-E.coli in humans (chicken traders) in wet markets in Lira District
 Uganda 2025-08-26 16:01:07 2028-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
David Oguttu Were
ID: UNCST-2024-R005275
 Onchocerciasis infection status in patients with Nodding Syndrome and epilepsy in Madi-Mid North focus, Uganda
REFNo: HS6224ES

To determine the prevalence of Onchocerca volvulus infection in people with a history of Nodding Syndrome in Madi-Mid North, Uganda
 Uganda 2025-08-26 15:55:47 2028-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jonathan Kitonsa
ID: UNCST-2025-R018208
 Investigating metabolic outcomes in African adults living with HIV after switching to injectable antiretroviral therapy
REFNo: HS6320ES

1. a) To compare changes in weight, body mass index, lipid profiles, and blood pressure, over one and two years among patients receiving 2-monthly long-acting cabotegravir and rilpivirine and compare this with those remaining on oral ART. b) To determine factors associated with changes in weight, BMI, lipid profiles, and blood pressure over the one- and two-year periods. 2. To describe the baseline glycaemic status of an African population with a history of suboptimal HIV control, and the change in HbA1c whilst on long acting cabotegravir and rilpivirine compared with patients remaining on oral dolutegravir - based ART through one and two years of follow-up. 3. To compare change in 10-year cardiovascular risk among patients on long acting cabotegravir and rilpivirine with those remaining on oral dolutegravir - based ART after one and two years of follow-up. 4. To quantify the impact of tenofovir disoproxil fumarate cessation on estimated glomerular filtration rate across one and two years of follow-up among patients receiving 2-monthly long-acting cabotegravir and rilpivirine compared with those remaining on oral ART. 5. To compare serum leptin and fasting insulin levels during follow-up in a subset of participants with significant weight gain and sample of similar participants without weight gain at 12 months.
Uganda 2025-08-26 15:48:19 2028-08-26 Medical and Health Sciences Non-Clinical Trial Degree Award
VIVIAN ARINAITWE
ID: UNCST-2024-R016282
 Developing a Feasibility Framework for MedTech in Low-Resource Settings: A Case Study of the NeoNest Device in Mbarara District, Uganda
REFNo: SIR537ES

1.4.1. Main Objective
To evaluate the feasibility of implementing the NeoNest neonatal transport incubator in selected health facilities in Mbarara District, Uganda, and to develop a structured, context-specific feasibility assessment framework for introducing medical technologies in low-resource settings.
1.4.2. Specific Objectives
To assess current neonatal transport and thermal care practices in health facilities in Mbarara District.
To evaluate the simulated performance, usability, and acceptability of the NeoNest device in a controlled setting.
To identify barriers and enablers for the adoption and scale-up of the NeoNest device.
To develop and validate a feasibility assessment framework for medical technology deployment in low-resource settings, using expert consensus (e.g., Delphi ≥ 80% agreement).

 Uganda 2025-08-26 15:46:45 2028-08-26 Engineering and Technology Non-Clinical Trial Non-degree Award
HELEN KEZIE-NWOHA EKENE
ID: UNCST-2024-R016104
 Loalising National Gender and Climate Policy in Uganda
REFNo: SS4066ES

• To examine the extent to which global and national climate policies are leading to change at the local level, improving the lives of women and gender relations, including the distribution of resources.
• To co- produce knowledge with women, women’s organisations, community organisations and local government officials, about the effects of climate change on the lives of women and their communities; identify obstacles; and propose solutions and pathways to climate resilience.
• To use research evidence from the research to influence national level policy making

 Nigeria 2025-08-26 15:44:37 2028-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Wilson Ngonzi
ID: UNCST-2024-R016516
 SMALL HOLDER FARMERS ADAPTATION STRATEGIES TO CLIMATE CHANGE IMPACTS IN KIBAALE, KAGADI AND KAKUMIRO DISTRICTS
REFNo: SS4100ES

To examine the temperatures, drought and precipitation climate change patterns that impacts small holder farmers adaptation strategies in Kibaale, Kagadi and Kakumiro Districts To examine the small holder farmers adaptation strategies to climate change impacts in Kibaale, Kagadi and Kakumiro Districts. To examine the small holder farmers adaptation strategies on accessing climate information and early warning systems in Kibaale, Kagadi and Kakumiro Districts
Uganda 2025-08-26 15:42:18 2028-08-26 Social Science and Humanities Non-Clinical Trial Degree Award
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