Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
FREDDIE SSENGOOBA Peter
ID: UNCST-2021-R011834
Balancing safety and good care in the context of infectious disease outbreak: learning systems for Infection Prevention and Control (IPC) in Uganda
REFNo: HS2821ES

4. To explore viable channels and methods for strengthening learning health systems in the context of IPC for ID outbreaks. ,3. To examine how caregivers provide care and mitigate risk in the context of infectious disease outbreaks.,2. To examine how geographic and social hierarchies impact on IPC and care practices in clinics and communities,1. To document the recent history of ID epidemic outbreaks and health systems preparedness, including IPC measures and their influence on institutional memory and practice. ,to strengthen epidemic preparedness in Uganda through a learning health systems approach that takes into account lived experience and institutional memory of the health workforce, lay care-givers and recipients of care during and beyond the COVID-19 crisis. ,
Uganda 2023-05-29 20:33:11 2026-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Performance Evaluation of the Alinity m HIV-1 Assay using DBS for HIV Viral load Determination
REFNo: HS2878ES

• To assess Alinity m HIV-1 DBS viral load agreement with Abbott RealTime HIV-1 DBS viral load results by evaluating: o Quantitative assessment of bias, limits of agreement and correlation, o Misclassification above or below the clinical threshold o Comaparison of non-suppression rates in participants tested with the Alinity m HIV-1 DBS assayvs. the Abbott RealTime HIV-1 assay.,• To assess Alinity m HIV-1 DBS viral load agreement with Alinity m HIV-1 plasma viral load results by evaluating: o Quantitative assessment of bias, limits of agreement and correlation o Misclassification above or below the clinical threshold o Comparison of non-suppression rates in participants when using plasma vs. DBS as sample types on the Alinity m HIV-1 assay ,
Uganda 2023-05-29 20:29:43 2026-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Grace Ahimbisibwe Miriam
ID: UNCST-2021-R012129
Pediatric HIV Cure Collaborative Study Version 2.0 dated 16 Sep 2021
REFNo: HS2671ES

1. Identify correlates of susceptibility to proviral reactivation through immune profiling, which will be analyzed by multiparameter by flow cytometry methods, antibody profiling and transcriptomic analyses by bulk RNA-seq of PBMCs and CD4+ T cells in perinatal and adult infections.
2. To quantitatively and qualitatively characterize viral reservoirs, in children, adolescents and youth living with HIV compared with adults through determining and comparing the size, composition, and inducibility of the latent HIV reservoir in different geographic locations and subtypes, and characterizing their differences. The size will be determined by HIV DNA quantitative assays and inducibility by TILDA. The composition will be determined by near full-length sequencing for intact and defective genomes.
Uganda 2023-05-26 8:39:02 2026-05-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Kinyanda
ID: UNCST-2023-R008028
Proposal to address the medium- to long-term EBOLA associated psychological Distress and psychosocial problems in Mubende District in central Uganda (Ebola+D Project)
REFNo: HS2870ES

To undertake a project to address the medium- to long-term EBOLA associated psychological Distress and psychosocial problems in Mubende District in central Uganda. Aims i) To develop, implement and evaluate the Ebola+D mental health intervention in Mubende district ii) To investigate the nature of mental health problems of community members accessing the Ebola+D mental health intervention and factors associated with treatment outcomes including immunological biomarkers iii) To explore the EVD associated negative beliefs and lived out experiences of affected members of the community (including health care workers)
Uganda 2023-05-26 8:34:43 2026-05-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kamwine Monicah
ID:
MICROBIAL AND METAGENOMIC ANALYSIS OF BACTERIAL COMMUNITIES IN MILK PRODUCTS PRODUCED IN MBARARA CITY, UGANDA
REFNo: HS2673ES

General objective
To characterize bacterial communities in milk products produced in Mbarara City, Uganda using culture techniques and metagenomic analysis
Specific Objectives
1. To determine the presence, levels of overall bacterial contamination load and bacterial profile in different milk products produced in Mbarara city, Uganda
2. To characterize the predominant microbiota in each milk product, determine the percentage of relative abundance of main identified bacterial genera, in each of the milk products produced in Mbarara city, Uganda.
3. To determine Virulence factors of the isolated bacteria
4. To determine the antimicrobial susceptibility patterns of pathogenic bacteria isolated from milk products produced in Mbarara city, Uganda

Uganda 2023-05-25 12:11:40 2026-05-25 Medical and Health Sciences Non-Clinical Trial Degree Award
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