Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Francis Omujal
ID: UNCST-2019-R000428
 INVITRO PROPAGATION, PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF Prunus africana, Warburgia ugandensis, Leonotis nepetifolia AND Aspilia africana OF UGANDA
REFNo: NS130ES

1. To develop an efficient in vitro propagation protocol for P. africana, W. ugandensis, L. nepetifolia, and A. africana.
2. To conduct genetic fidelity assessment and also use Fourier Transform Near-Infrared (FT-NIR) Spectrometer and Soil-Plant Analyses Development (SPAD) to characterize and compare the chemical and chlorophyll content parameters respectively in vitro generated plants.
3. To analyze the phytochemicals in P. africana, W. ugandensis, L. nepetifolia, and A. africana.
4. To evaluate the in vitro and/or in vivo medicinal activities of the different parts of the plants (stem bark, roots, and leaves) on targeted disease conditions i.e. P. africana (prostate cancer and related disease conditions); W. ugandensis (malaria and other conditions including its anti-inflammatory); L. nepetifolia (Malaria), A. africana (Malaria, wound healing).

Uganda 2022-05-16 13:11:09 2025-05-16 Natural Sciences Non-degree Award
Silver Bahendeka Karaireho
ID: UNCST-2019-R000876
 THE UGANDA NON-COMMUNICABLE DISEASE (NCD) RISK FACTORS SURVEY 2022
REFNo: HS2184ES

6. To examine the trends of NCD and associated risk factors in the Ugandan population in relation to the 2014 NCD Risk Factors Survey and in relation to interventions against NCD that were informed by results of the 2014 NCD Risk Factors Survey.,5. To assess preventive measures for selected non-communicable conditions namely cervical cancer screening.,4. To collect data on clinical parameters important in the control and management of NCDs: weight, waist circumference, height, blood pressure, heart rate. ,3. To collect data on socio-demographic characteristics important in the control and management of NCDs: age, gender, level of education, employment, income, marital status,2. To assess the magnitude of biochemical risk factors important in the management of NCDs: raised blood glucose and total cholesterol.,1. To assess the magnitude of the following behavioural risk factors for NCDs:- physical inactivity, tobacco use and harmful use of alcohol and unhealthy diet. ,To determine the magnitude and the associated risk factors of non-communicable diseases (NCDs) among the Ugandan population.,
 Uganda 2022-05-16 10:36:32 2025-05-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
LWABI PETER SOLOMON
ID:
Quality of Life in Ugandan Children and Young Adults with Repaired Congenital Heart Disease: Mixed Methods Approach Research objectives
REFNo: HS2115ES

Primary Objective: Assess quality of life in Ugandan children and young adults who have undergone surgery or interventional catheterization for congenital heart disease (CHD).
Secondary Objective(s): Assess clinical and demographic factors that impact quality of life in CHD
population.
 Uganda 2022-05-16 10:33:45 2025-05-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Timothy  Muwonge Ronald
ID: UNCST-2020-R014680
 Pharmacy Delivery of PrEP and HIVST for Adolescent Girls and Young Women seeking Emergency Contraception at Community Pharmacies in Uganda: Formative Research
REFNo: HS2037ES

Aim 1: To assess the willingness of providing HIV self-testing and PrEP to AGYW seeking emergency contraception at community pharmacies.
Approach: Using the social-ecological model, fig 2, we will conduct surveys with AGYW approximately 130 seeking EC at community pharmacies within a radius of 45km from the Infectious Diseases Institute-Kasangati (IDI-K) research center, to evaluate knowledge of HIVST and PrEP and acceptability of accessing HIVST and PrEP through a pharmacy. In addition, we will purposefully select a subsample of up to 30 to undergo in-depth interviews (IDIs) to explore potential barriers and facilitators of HIVST and PrEP delivery at community pharmacies.
Hypothesis: AGYW seeking EC at community pharmacies will be willing to use HIVST and PrEP and will highlight potential barriers and facilitators to accessing PrEP at community pharmacies
Aim 2: To identify readiness of pharmacy providers regarding AGYW sexual health and specifically HIVST, emergency contraception, and PrEP
Approach: To assess the readiness, knowledge gaps, and training needs of community pharmacists to deliver HIVST and PrEP alongside EC, we will conduct up to 20 IDIs with providers (pharmacy technicians, nurses, and pharmacists) from private pharmacies who under the pharmaceutical society of Uganda have agreed to be included in the study.
Hypothesis: Addressing knowledge gaps of pharmacy providers will inform delivery of sexual health services to AGYW.

Uganda 2022-05-13 9:02:19 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
John Mukisa
ID:
Host genetic variation and association with HIV disease progression among pediatric cohorts in Botswana and Uganda
REFNo: HS1841ES

1) To identify common host genetic variants associated with HIV disease progression among pediatric HIV cohorts from Botswana and Uganda. 2.) To evaluate the performance of genotype imputation methods with whole genome sequences as a gold standard for determining missing genotypes among samples from Botswana and Uganda. 3.) To identify and validate KIR genotypes among children with HIV in Botswana and Uganda. 4.) To determine the KIR haplotypes associated with HIV disease progression among children with HIV from Botswana, and Uganda.
Uganda 2022-05-13 7:48:00 2025-05-13 Medical and Health Sciences Non-Clinical Trial Degree Award
Agnes Kiragga
ID:
SARS-CoV-2 international biorepository and diagnostic test performance
REFNo: HS1808ES

Primary:
• To create a biorepository to test retrospectively the performance of investigational, emerging diagnostic technologies in the intended population or setting compared to a reference comparator for diagnosing SARS-CoV-2 infection using frozen samples.
Secondary
• To test prospectively the accuracy of investigational, emerging diagnostic technologies in the intended population or setting compared to a standard comparator for diagnosing SARS-CoV-2 infection
• To determine agreement between self-collected nasal swabs, saliva and clinician-collected nasopharyngeal swab samples for the diagnosis of SARS-CoV-2 using a reference test in Uganda.
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete) and turn-around time compared to reference test.
• To assess acceptability of self-collected nasal swab tests and saliva for testing SARS-CoV-2 in both participants and healthcare workers in Uganda.
• To explore socio-demographic, behavioural and clinical factors associated with positive SARS-CoV-2 diagnosis.


Uganda 2022-05-13 7:45:44 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kristina Roesel
ID:
Boosting Uganda's investments in livestock development (BUILD)
REFNo: A139ES

The program is divided into four different components that will be aligned and integrated, especially on activities that involve national stakeholder engagement and capacity building. Component 1 on Peste de petits ruminants (PPR) combines socio-economic studies, vaccine targeting and delivery, regional Pan-African networking activities (e.g. PENAPH, PPR alliance GPRA) and capacity development at the Biosciences eastern and Central Africa (BecA)-Hub at ILRI Nairobi: Objective1: Develop a socio-economic framework to assess the impact of PPR interventions Activities: Household survey in different livestock production systems; Longitudinal study-sentinel households; System dynamic modeling; Focus group discussions Outputs: Livelihoods impacts of different PPR control options Objective 2: Update the epidemiological status of PPR to allow assessment of control options Activities: Cross-sectional survey in different livestock productions systems; Post vaccination sampling; Genetic characterization of PPRV isolates; Participatory disease search; Slaughter house surveillance; Develop PPR risk maps Outputs: Updated risk map of PPR, circulating PPR genotypes, other important SR diseases Objective 3: Capacity development Activities: Support review of National PPR control strategy; Review of animal health services; Multi-stakeholder platform for AH service delivery to discuss gaps and define new mechanisms for control and surveillance; Strengthen passive surveillance system; Awareness creation of farmers; Post vaccination sampling Outputs: Novel models of animal health service delivery, strengthened surveillance system, capacity enhanced Component 2 on Rift Valley fever (RVF) includes the characterization of animal and human samples from outbreaks in 2016 and 2018, socio-economics, development of a risk and vulnerability map for Uganda as a decision-making tool Objective 1: Improved knowledge on RVF epidemiology Activities: Genotyping (RVF and other viruses); Serology (establish Gn/Gc distribution); Outbreak response; Entomological studies; Risk mapping Objective 2: Socio-economic studies Activities: Ex-ante analyses of control options; KAP questionnaire surveys; Gender assessments – exposure and constraints on uptake of interventions Objective 3: Develop National action plans/policy work and extension Activities: Contingency plans/decision support tools; Community trainings Outputs: RVF risk map, genetic characterization of circulating strains (informs vaccine interventions), Improved RVF national action plans, Training and communication materials, capacity building, improved capacity on vector sampling/surveys and biological sampling; PhD/MSc training Component 3 on Antimicrobial resistance (AMR) will contribute to the finalization of the National AMR action plan, describe and quantify the use of antimicrobials in the peri-urban poultry value chain. Objective 1: Understand knowledge, attitude, practices, and incentives for AMU in poultry value chains in Uganda, and the role of formal and informal markets Activities: Literature review on AMR and AMU in the poultry sector in Uganda; Gender sensitive rapid appraisal with AMUSE tool; Identify possible intervention entry points to improve AMU Objective 2: Assess risks to humans from poultry-associated AMR: Research on AMR transmission risks at the human-animal-environmental interface in different poultry production systems (smallholder and commercial; rural and peri-urban) in Uganda Activities: Map possible transmission pathways within the production system; Conduct AMR and residue prevalence surveys; In-depth AMR transmission studies that include environmental samples, and farm workers, and samples from other animal species potentially housed together with poultry; Outline risk pathways for human exposure to AMR from poultry production Objective 3: Design and evaluate interventions to reduce AMU in poultry value chains in Uganda Activities: Design interventions (co-design with poultry producers), closely monitor implementation over time to understand incentives to motivate change; Establish drug use monitoring system in poultry farms to allow M&E; Qualitative and quantitative analysis of intervention impact Objective 4: Support evidence-based policy dialogue for antimicrobial surveillance and AMR strategies Activities: Organise multi-stakeholder workshops to discuss feasibility, challenges, and constraints in implementing NAP in poultry sector, involve representatives from other countries and support continued review of NAP Objective 5: Build capacity in value chain actors, implementers, researchers Activities: Conduct capacity development need assessment; Develop capacity development plan for different stakeholder groups Component 4 on Veterinary Public health (VPH) at the point of slaughter includes scaling of already piloted butcher training curricula and implementation of abattoir-based sentinel studies for animal disease surveillance Objective 1: development of curriculum for capacity building of meat handlers on good hygienic practices (slaughter house personnel, butchers, meat transporters); meat inspectors on carcass inspection and mobile reporting; Public engagement of consumers; laboratory personnel (GLP and quality assurance) Activities: Baseline assessment of meat handlers’ knowledge and practices; hygiene indicators, selected pathogens; Consolidation and adaptation of existing materials for training of butchers; assessment of suitability of consolidated training materials and delivery mode with stakeholders; delivery of the training; endline study to assess success of the intervention Objective 2: proof-of-concept slaughterhouses as sentinels for zoonotic disease Activities: Mapping slaughterhouses through key informants and GIS; grey and published literature review; prioritization of disease in slaughterhouses/ identification of critical control points – KII and FGD with vets, meat inspectors, public health staff; Ethnographic observation of slaughterhouses; biological survey in animals and humans
Germany 2022-05-13 7:44:12 2025-05-13 Agricultural Sciences Non-Clinical Trial Non-degree Award
REBECCA CLAIRE LUSOBYA
ID:
Knowledge, Attitudes and Practices of Pediatricians, Neonatal Nurses and Parents of Preterm Infants towards Retinopathy of Prematurity in Tertiary Hospitals Uganda.
REFNo: HS2228ES

To determine the attitudes and practice patterns regarding ROP and its risk factors among pediatricians, neonatal nurses and caregivers at Kawempe National Referral Hospital and Mulago Specialized Women’s and Neonatal Hospital.,2 To determine the level of knowledge of ROP and its risk factors among caregivers attending Kawempe National Referral Hospital and Mulago Specialized Women’s and Neonatal Hospital.,1. To determine the level of knowledge of ROP and its risk factors among pediatricians and neonatal nurses in Kawempe National Referral Hospital and Mulago Specialized Women’s and Neonatal Hospital.,To determine the knowledge, attitude and practice patterns regarding ROP among the pediatricians, neonatal nurses and the preterm caregivers at Kawempe National Referral Hospital and the Mulago Specialised Women’s and neonatal Hospital.,
 Uganda 2022-05-13 16:09:48 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JUSTUS BARAGEINE KAFUNJO
ID: UNCST-2020-R014150
 Identifying Opportunities for Prevention of Adverse Outcomes Following Female Genital Fistula Repair
REFNo: HS2033ES

Identify predictors of post-repair fistula breakdown and recurrence

Identify predictors and characteristics of post-repair incontinence

Identify feasible and acceptable strategies for modifying key risk factors of adverse
outcomes
 Uganda 2022-05-13 16:09:08 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Rukundo NSHAKIRA
ID: UNCST-2021-R012277
 COVID-19 Risk,Electoral Violence and Civic Participation in the 2020/2021 Ugandan General Elections
REFNo: SS1218ES

To establish the extent to which COVID-19 fear affected civic participation in the 2021 elections,Compare the level of fear of Covid-19 and fear of electoral and post-electoral violence on voter turn-out,Assess the effect or concern and fear of COVID-19 affect voter turnout,Assess the effect of COVID-19 on campaign rally participation and candidate interface,
 Uganda 2022-05-13 15:52:13 2025-05-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jackson Orem
ID: UNCST-2021-R012016
 Factors that affect the timely diagnosis and treatment of neutropenic fever in Ugandan patients with cancer and HIV
REFNo: HS2175ES

1. To understand the current process of antibiotic initiation for patients with cancer and neutropenic fever at the UCI. 2. To identify factors that influence timely initiation of guideline-recommended antibiotics which can be addressed using targeted implementation strategies. 3. To identify the unique barriers to diagnosis and treatment of neutropenic fever for patients with HIV who are receiving treatment for cancer at UCI.
 Uganda 2022-05-13 10:09:59 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Charles Batte
ID: UNCST-2021-R013587
 Validation of the Chronic Obstructive Pulmonary Disease Assessment Tool (CAT) Among COPD patients in rural Uganda.
REFNo: HS2145ES

To validate CAT among COPD patients in Nakaseke, Uganda. Specific objectives: • To determine the validity of CAT in assessing quality of life among COPD patients in rural Uganda using Saint George Respiratory Questionnaire (SGRQ) as the gold standard • To determine the internal reliability of the CAT in diagnosis of QOL among COPD patients in rural Uganda. Secondary objective: • To determine factors associated with poor QoL among patients with COPD in rural Uganda.
Uganda 2022-05-13 10:05:27 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Claude Raisaro
ID:
Driving Behaviors, Monetary Incentives and Norms: Experimental Evidence from the Ugandan Transit Industry
REFNo: SS1217ES

• To better understanding the underlying mechanisms to understand and incentivize safe driving behaviors for bodaboda drivers
• Examine how financial incentives affect driving behavior and to which extent is road safety impacted on an individual basis?.
• To learn whether beliefs about safe driving change in the presence of financial incentives.

 Italy 2022-05-13 10:01:06 2025-05-13 Social Science and Humanities Non-Clinical Trial Degree Award
Travis Baseler Andreas
ID:
The Effects of Voluntary Relocation and Forced Displacement by Natural Disasters: Evidence from Ugandan Landslides
REFNo: SS1263ES

We intend to study the economic effects of displacement following environmental disasters, with a focus on the displaced population. Our goal is to identify mechanisms behind economic outcomes for the displaced, to inform future adaptation policy and humanitarian responses. The setting of this study is landslide episodes in Eastern Uganda in 2010-2019, which have displaced nearly 10,000 people.
 USA 2022-05-12 8:00:58 2025-05-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
Stella Neema
ID: UNCST-2019-R000814
 Knowledge, acceptability and Perception of Schistosomiasis and its treatment in Pre-school aged Children in Uganda
REFNo: SS1269ES

To ascertain knowledge on and perception of (pediatric) Schistosomiasis and acceptability of its treatment in PSAC on different levels To identify the demand of health education to inform the social mobilization and advocacy WP2 To analyse facilitators and barriers towards implementation of L-PZQ distribution for PSAC on different levels To inform planned interventions of the subsequent work packages on advocacy, social mobilization and communication strategies for the L-PZQ rollout based on the above-mentioned outcomes and assess L-PZQ implementations in the study sites
Uganda 2022-05-12 7:59:47 2025-05-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
Femke Bannink Mbazzi Bannink
ID: UNCST-2023-R008308
 YOUNG AFRICA WORKS: DISABILITY INCLUSION RESEARCH PARTNERSHIP.
REFNo: SS1195ES

• To examine the policy environment and available programmes related to employment, education of youth with disabilities
• To explore the lived experiences around inclusion in education and employment from the perspective of youth with disabilities
• To identify key challenges, facilitators, gaps and opportunities relating to inclusion in education and employment for youth with disabilities

 Netherlands 2022-05-10 9:21:32 2025-05-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Herbert Kayiga Kayiga
ID:
EFFECTIVENESS, ACCEPTABILITY AND UPTAKE OF EARLY VERSUS STANDARD INTRAUTERINE CONTRACEPTION FOLLOWING PROVISION OF FIRST TRIMESTER MEDICAL POST ABORTION CARE IN CENTRAL UGANDA
REFNo: HS2111ES

1. To determine the proportion of women who take up IUC after mPAC for 1st trimester incomplete abortion. 2. To compare the expulsion rates at six months between early versus standard IUC insertions post mPAC treatment for first trimester incomplete abortion. 3. To compare the IUC continuation rates at six months between early versus standard IUC insertion post mPAC treatment for first trimester incomplete abortion. 4. To explore the women and their spouses' perception on Long Acting Reversible Contraceptives (LARC) and IUC following mPAC treatment. 5. To explore the Healthcare providers' perception on LARC and IUC following mPAC treatment.
Uganda 2022-05-10 9:21:09 2025-05-10 Medical and Health Sciences Clinical Trial Degree Award
Kizito Omona
ID: UNCST-2022-R011106
 Exploring Child-based Strategies in addressing Child-to-Child Violence in Primary Schools in Kitgum District, Northern Uganda
REFNo: SS1277ES

3) To find out how children use formal peer group-based strategies to overcome child-to-child violence in primary schools in Kitgum district.,To investigate how children involve their teachers and counsellors to overcome child-to-child violence in primary schools in Kitgum district.,To find out how children use formal peer group-based strategies to overcome child-to-child violence in primary schools in Kitgum district,To establish how children apply informal peer group-based strategies to overcome child-to-child violence in primary schools in Kitgum district.,To find out the individual child-based strategies used to overcome child-to-child violence in primary schools in Kitgum district,The general objective is to explore child-based Strategies in addressing child-to-child violence in Primary Schools in Kitgum District. ,
 Uganda 2022-05-10 9:19:59 2025-05-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Toke Wolff Moldrup
ID:
CERTIZENS: Certifications of Citizenship in Africa
REFNo: SS958ES

CERTIZENS is concerned with the ways in which states and citizens respectively get made, remade or unmade through inter-related systems, policies and practices associated with citizen classification, identification and certification.
 Denmark 2022-05-10 9:14:40 2025-05-10 Social Science and Humanities Non-Clinical Trial Degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
 A multi-country, epidemiologic study to assess the interferon gamma release assay (IGRA) positivity, and to build capacity to conduct a tuberculosis (TB) vaccine efficacy study, in populations with a high TB disease burden
REFNo: HS2187ES

•To describe the proportion of IGRA positivity by site.
•To assess the association of age with proportion of IGRA positivity, by site.
•To describe the overall incidence of suspected and laboratory-confirmed pulmonary TB (disease).
•To describe changes in the proportion of IGRA positivity, by site.
•To describe the association between IGRA interferon gamma (IFN???concentration at screening and progression to pulmonary TB.


 Uganda 2022-05-10 9:13:30 2025-05-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Musisi
ID: UNCST-2020-R004472
 IDENTIFICATION AND EVALUATION OF BIOMARKERS FOR MYCOBACTERIUM TUBERCULOSIS DETECTION AND MONITORING RESPONSE TO ANTI-TUBERCULOSIS THERAPY
REFNo: HS1378ES

(i) To measure the accuracy of TB-MBLA in detecting TB in sputum and non-sputum samples with reference to standard of care tests (Xpert MTB/ RIF/Ultra, sputum microscopy and culture)

(ii) To determine accuracy and utility of TB-MBLA in monitoring TB treatment response and predicting treatment outcomes in comparison with standard of care tests

(iii) To examine the correlation of TB-MBLA-measured sputum bacillary load and host gene markers for monitoring treatment response and outcome

Uganda 2022-05-10 18:22:50 2025-05-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Agnes  Nakakawa
ID:
Towards an ICT-driven Community-based Nutrition Education network for increasing awareness and knowledge transfer on Maternal Nutrition (NEMAT)
REFNo: SS1224ES

AIM:
The research aims at increasing community-level awareness on maternal nutrition and adoption of healthy nutrition practices among women of reproductive age, through establishing an ICT-driven community-based nutrition education network for supporting transfer of information/knowledge on maternal nutrition aspects.

SPECIFIC OBJECTIVES
Specifically, this research will:
1) Increase availability and accessibility of maternal nutrition information/knowledge, through developing an ICT platform for disseminating IEC materials on maternal nutrition.
2) Enable timely sharing of information/knowledge on challenges in maternal nutrition and solution/best practices, through supporting interactive dialogue between health and nutrition specialists and women at community level.
3) Enable contextual understanding of maternal nutrition aspects and required interventions, through prompting women to provide feedback on IEC materials and devising control measures for continuous improvement of IEC materials.
4) Ensure existence of an operational multidisciplinary and community-based stakeholder network, through leveraging on the role of community health extension workers to establish the network and continuously monitor its performance.

 Uganda 2022-05-10 17:20:25 2025-05-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Samuel Okech George
ID:
Assessing ethical conflicts and moral distress among veterinarians in Uganda.
REFNo: A177ES

1. Establish the awareness of veterinarians in Uganda about ethical dilemmas and moral distress
2. Determine causes, nature and extent of ethical dilemmas and the degree of moral distress they cause.
3. Determine coping mechanisms employed by veterinarians against ethical dilemmas and moral distress.
 Uganda 2022-05-09 19:06:32 2025-05-09 Agricultural Sciences Non-Clinical Trial Non-degree Award
Angela Gallego Sala Victorina
ID:
TroPeaCC: Tropical Peatlands and the Carbon Cycle
REFNo: NS310ES

Tropical peatlands are the most carbon-dense ecosystems in the world and they store the equivalent of ~10 years of global anthropogenic CO2 emissions. Despite their importance, crucial questions remain about carbon cycling in tropical peatlands and improving understanding is critical as they are at high risk from deforestation and drainage for oil palm cultivation.
TroPeaCC will provide a step-change gain in our understanding of tropical peatland functioning and in projecting their response to climate change.
PI Gallego-Sala will use her unique background that bridges peatland modelling and observations to deliver a novel interdisciplinary approach to tackle four outstanding questions about tropical peatlands:
Q1: What controls the geographical distribution of peatlands in the tropics? TASK1: To assess the tropical peatland extent using a combination of models
Q2: How large is the tropical peatland CO2 sink and what are its main climatic drivers? TASK2: To characterize the drivers of carbon accumulation rates in tropical peatlands using the palaeo-archive.
Q3: How large is the methane flux in tropical peatlands? What are the main controls at the intercontinental scale? TASK3: To determine the main controls on methane fluxes in tropical peatlands, using eddy covariance, chamber-based gas flux measurements, and ground penetrating radar.
Q4: What is the overall carbon balance of tropical peatlands and how will this change in the future? TASK4: To forecast future changes of the extent of tropical peatlands, of their carbon store and of methane emissions, using the results of tasks 1-3 to parameterise and evaluate a global dynamic vegetation model that includes tropical peatlands for the first time.

The interdisciplinary approach will lead to a comprehensive understanding of the role of tropical peatlands in the global carbon cycle, allowing their inclusion in earth system models, and improving their management to optimise provision of ecosystem services including carbon capture and storage.

 Spain 2022-05-09 19:05:30 2025-05-09 Natural Sciences Non-Clinical Trial Non-degree Award
Geoffrey Kachiko
ID:
Pharmacognostic Analysis, Safety, and Effect of Immuno-Kachiks®, a Ugandan Herbal Product, on Liver Tumours, Macrophages, and Alpha-N-acetylgalactosaminidase in Wistar Rats
REFNo: HS1926ES

1. To identify the phytochemicals in the Immuno-Kachiks® herbal product.
2. To determine the acute and delayed toxicity of the Immuno-Kachiks® herbal product in male Wistar rats.
3. To determine the curative effect of the Immuno-Kachiks® herbal product against liver tumours induced in male Wistar rats.
4. To determine the effect of the Immuno-Kachiks® herbal product on serum alpha-nagalase in male Wistar rats with induced liver tumours.
5. To evaluate the effect of the Immuno-Kachiks® herbal product on the total and differential white blood cell count of male Wistar rats with induced liver tumours.
 Uganda 2022-05-09 14:32:25 2025-05-09 Medical and Health Sciences Non-Clinical Trial Degree Award
Mwijuka Julius Julius
ID: UNCST-2020-R014640
 Visual Art Therapy and Artistic Expression of Violence Expressed by Students in Selected Secondary Schools in Bundibugyo District
REFNo: SS825ES

2. To assess the relationship between therapeutic painting and artistic expression of sexual violence expressed by students in selected Secondary Schools in Bundibugyo District. ,1.To assess the relationship between therapeutic drawing and physical Violence expressed by students in selected Secondary Schools in Bundibugyo District.,The purpose of the study is to explore the relationship between Visual art therapy and artistic expression of violence expressed by students in selected Secondary Schools in Bundibugyo District.,
 Uganda 2022-05-09 14:28:39 2025-05-09 Social Science and Humanities Non-Clinical Trial Degree Award
Alexandra Sacco
ID:
Population Health in Endangered Red Colobus Monkeys in Kibale National Park
REFNo: NS336ES

1) Disentangle the impact of various factors on gut microbial community structure of female red colobus monkeys (Piliocolobus tephrosceles) that live in disturbed and old-growth areas across Kibale National Park, Uganda, and (2) characterize the interactions between gut microbes and female sex hormones over the reproductive cycle.
USA 2022-05-06 13:44:47 2025-05-06 Natural Sciences Non-Clinical Trial Degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 Peer led outreach to engage male partners of pregnant women in Uganda
REFNo: HS2206ES

Aim 1: To assess whether a male peer-delivered, status-neutral outreach to male partners of pregnant women increases the proportion of partners who test compared to the standard of care (invitation letters for fast-track testing and HIVST delivered by the pregnant woman).

Rationale: Innovations are needed to address the challenges associated with reaching male partners of pregnant women with HIV testing and linkage to ART or PrEP depending on their HIV serostatus.
Hypothesis: A male peer delivered, status-neutral approach to male partner engagement may overcome male partners reluctance to be tested for HIV and women’s reluctance to approach their male partners about HIV testing. Approach: We will randomize women 1:1 to the intervention or delayed arm and determine the proportion of male partners who test for HIV within 1 month after the female partner is randomized. The outcome will male partner testing based on male HIV testing in the two arms.

Aim 2: To determine the proportion of male partners who test HIV-negative and have an indication for PrEP who initiate PrEP and the proportion of partners who test HIV-positive who initiate ART compared to the SOC arm.

Rationale: Men who are HIV-negative are a priority for PrEP if they have a known HIV-positive partner or multiple partners, including during late pregnancy and postpartum when men are more likely to have sex with outside partners.
Hypothesis: Trained male peers will be effective in addressing men’s reluctance to link to ART or PrEP and facilitating linkage to care or prevention.
Approach: Men who test for HIV through either arm will be referred for ART (if HIV-positive) or PrEP (if HIV-negative and reports multiple partners or an HIV positive partner) through the trained male peer counselor in the intervention arm or health care provider in the SOC arm. We will evaluate linkage to PrEP or ART among men who test for HIV, by arm.

Aim 3: To qualitatively assess acceptability of peer-delivered, status-neutral outreach to promote HIV testing among male partners of pregnant women.

Rationale: Assessment of acceptability is a key component of evaluating any novel intervention. We will use qualitative methods to investigate acceptability and preferences for HIV testing services among male partners of pregnant women in the cohort.
Hypothesis: A peer delivered, status-neutral approach to male partner engagement will be acceptable to recipients.
Approach: We will conduct individual qualitative interviews with a randomly selected subsample of 20 male partners who received peer-delivered outreach to evaluate intervention acceptability.

Population: 150 pregnant women and ?18 years of age, with male partners of unknown status, will be recruited from ANC programs in Kampala.

Study Site: The Infectious Diseases Institute (IDI) Kasangati and Kitebi Health Center III antenatal care (ANC) clinic in Kampala, Uganda

 Uganda 2022-05-05 11:31:35 2025-05-05 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Betty NAKASIBA LINNET
ID:
Food security and dietary diversity in urban settings of Wakiso District Central Uganda
REFNo: SS1271ES

(iii) Explore the socio-economic and demographic factors that have a bearing on household food security and diet diversity in Urban settings of Wakiso District.,(ii) Determine the dietary diversity of households in Urban settings of Wakiso district.,(i) Assess the household food security situation and related coping strategies in Urban settings of Wakiso District.,The general objective of the study will be to establish the food security situation and dietary diversity in Urban settings of Wakiso District. ,
 Uganda 2022-05-05 11:25:49 2025-05-05 Social Science and Humanities Non-Clinical Trial Degree Award
Iacopo Bianchi
ID:
Clustering at the Business Level: Micro-Firm Markets, Competitive Forces, and Innovation
REFNo: SS1259ES

Get insights into the market structure of clusters of informal micro business and understand the potential to promote growth through product experimentation,
 Italy 2022-05-05 11:24:34 2025-05-05 Social Science and Humanities Non-Clinical Trial Degree Award
ANTHONY NUWA
ID: UNCST-2022-R011102
 A hybrid effectiveness-implementation study to assess the effectiveness and chemoprevention efficacy of implementing seasonal malaria chemoprevention in five districts in Karamoja region, Uganda
REFNo: HS2212ES

5) To monitor the safety and torelabilty of DP as compared to SPAQ among children 6-59 months in Karamoja when used in SMC,4) To understand the SMC implementation model, determining process, costing and acceptability outcomes for the intervention,3) To investigate the presence and change of SPAQ and DP resistance markers over time as a result of SMC implementation ,2) To determine chemoprevention efficacy of SPAQ and DP when used for SMC in Karamoja region, Uganda, and the extent to which efficacy is impacted by drug resistance and/or drug concentrations. ,1) To determine the effectiveness of SMC with DP and SPAQ in terms of its reduction in incidence of malaria infection among children aged 3–59 months,Phase 2 of this study aims to test the feasibility, effectiveness and chemoprevention efficacy of SMC with SPAQ and DP in Karamoja region in Uganda, where malaria transmission is highly seasonal, and inform malaria policy in Uganda. Accelerated adoption and scale-up of SMC will support efforts to accelerate progress in malaria control in high-burden countries.,
 Uganda 2022-05-05 11:23:22 2025-05-05 Medical and Health Sciences Clinical Trial Non-degree Award
Joeri Smits Smits
ID: UNCST-2021-R013841
 Increasing savings among low-income households in Uganda study
REFNo: SS922ES

This randomized field experiment seeks to evaluate the effectiveness of several account features/add-ons in mobilizing savings and helping individuals achieve their savings goals.
 Netherlands 2022-05-05 11:02:58 2025-05-05 Social Science and Humanities Non-Clinical Trial Non-degree Award
DANIEL MUHANGUZI
ID:
A Collaborative Knowledge Management Framework for Enhancing Value of Agricultural Information in Smallholder Farming Systems
REFNo: SIR100ES

The main objective of this research is to develop a collaborative information and knowledge management approach that will enable smallholders extract more value from agricultural information.,To evaluate the framework for collaborative information and knowledge management.,To investigate the ability of collaborative knowledge management in enhancing value of agricultural information and adopt it to design a framework that will enhance smallholders capacity to extract value from agricultural information.,To determine the essential elements that are important in enabling smallholders extract more value from agricultural information and formulate a theory based on literature that explains these elements.,To investigate the challenges smallholders face in extracting value from agricultural information. This was done by reviewing existing literature and conducting an exploratory survey among smallholders. ,
 Uganda 2022-05-04 18:38:35 2025-05-04 Engineering and Technology Non-Clinical Trial Degree Award
MARY AJIKO MARGARET
ID:
IMPACT OF COVID 19 ON ACCESS TO PAEDIATRIC SURGERY IN TESO SUB-REGION in Uganda: A Mixed methods study
REFNo: HS2205ES

2. Explore factors that are limiting and promoting the timely and safe management of children with surgical conditions in Eastern Uganda during the COVID-19 pandemic,1.1. Compare volume and types of surgical procedures performed in. children in all hospitals and HC IVs in the entire Teso-subregion before and during the Covid-19 pandemic , The overall objective is to assess the impact of the COVID-19 pandemic on paediatric surgical activity in Teso subregion in Eastern Uganda,
 Uganda 2022-05-04 14:26:05 2025-05-04 Medical and Health Sciences Non-Clinical Trial Degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 Performance evaluation of an improved point-of-care test (dual target) SAMBA HIV-1 qualitative test for early infant diagnosis of HIV-1 infection in resource-poor healthcare settings
REFNo: HS2219ES

To verify the field performance (sensitivity and specificity) of the improved, dual-target SAMBA II HIV-1 Qual Test against routine Cobas Ampliprep/Taqman HIV-1 Qualitative Test Version 2.0 (DBS)- for early diagnosis of HIV-1 in exposed infants and adults. In addition, discrepant results will be analysed using Cepheid Xpert HIV-1 Qual ,
 Uganda 2022-05-04 11:32:24 2025-05-04 Medical and Health Sciences Clinical Trial Non-degree Award
Peter Jackson Durham
ID: UNCST-2022-R010933
 Investigation of Serologic and Pulmonary Mediators of post-Tuberculosis Lung Fibrosis in a Ugandan cohort
REFNo: HS2172ES

Primary objective:
-To analyze the levels of cytokines and SPM’s in the blood and exhaled breath of patients with pulmonary TB at diagnosis, 6 months and one year to determine if there are differences in cytokine and SPM expression among patients who develop PTLI and those who do not.
Secondary objectives
-To identify socio-demographic and clinical risk factors associated with PTLI development and investigate associations of these characteristics with specific PTLI phenotypes.
-To document the quality of life among patients who develop PTLI. ? To develop a biobank of EBC and serum samples from subjects with PTLI and those with resolution of their lung impairment at diagnosis, conclusion of treatment and at one year from diagnosis.
 USA 2022-05-04 11:28:09 2025-05-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JOYCE SHOMI ANDREW
ID:
FACTORS AFFECTING ADHERENCE TO ANTIHYPERTENSIVE MEDICATION AMONG HYPERTENSIVE PATIENTS IN WAKISO PUBLIC HOSPITALS.
REFNo: HS2163ES

I. To determine the level of adherence to antihypertensive medication among hypertensive patient in Wakiso and Kasangati public health facilities.
II. To determine patient related factors affecting adherence to antihypertensive medication in Wakiso and Kasangati public health facilities.
III. To determine clinical related factors affecting adherence to antihypertensive medication in Wakiso and Kasangati public health facilities.
IV. To determine medication related factors affecting adherence to antihypertensive medication in Wakiso and Kasangati public health facilities.

 Tanzania 2022-05-03 14:26:47 2025-05-03 Medical and Health Sciences Non-Clinical Trial Degree Award
Hedwig Acham
ID: UNCST-2022-R011459
 Developing a photographic Figure-Rating Scale to reduce malnutrition among infants and young children of mothers with a low level of literacy in Buyende district
REFNo: HS2137ES

1) To develop an innovative photographic figure-rating rating scale, for use at local level to assess nutritional status of children at 9 months
2) To determine accuracy, perception and satisfaction of mothers with use of the tool for predicting the nutritional status of their children.

 Uganda 2022-05-03 13:39:52 2025-05-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
MILTON NUWABIMPA RWIITA
ID:
THE QUALITY OF HIGHER EDUCATION AND EMPLOYABILITY OF GRADUATES FROM SELECTED UNIVERSITIES IN SOUTH WESTERN UGANDA
REFNo: SS1275ES

1. To determine the relationship between the quality of curriculum and the employability of graduates from selected Universities in South Western Uganda.
2. To establish the relationship between the quality of students enrolled in the University and the employability of graduates from selected Universities in South Western Uganda.
3. To establish the relationship between the quality of teaching and the employability of graduates from selected Universities in South Western Uganda.

 Uganda 2022-05-03 13:06:09 2025-05-03 Social Science and Humanities Non-Clinical Trial Degree Award
Emmanuel Sendaula
ID: UNCST-2020-R014767
 Utility of the interRAI Check-Up Comprehensive Geriatric Assessment (CGA) Tool: Evaluating Check-Up Acceptability in Assessing Frailty and Care Needs of Older Adults with Human Immunodeficiency Virus (HIV) in Kampala District of Uganda
REFNo: HS2229ES

- determine the acceptability and perceptions of using a standardized instrument for assessment and care planning for older persons living with HIV,- identify specific care needs of older adults living with HIV,- estimate the association between HIV status and (i) one primary outcome; activities of daily living, and (ii) two secondary outcomes; health stability and cognitive function in older persons,- characterize the sociodemographic, clinical, neuropsychiatric, and functional characteristics of older persons living with and without HIV,
 Uganda 2022-05-03 13:04:16 2025-05-03 Medical and Health Sciences Non-Clinical Trial Degree Award
Moses Mukuru
ID:
A LANDSCAPE ANALYSIS OF THE LOCAL CONTEXT, CHALLENGES, AND OPPORTUNITIES FOR DIGITIZED HEALTH WORKER PAYMENTS IN AFRICA
REFNo: HS2216ES

7. To develop a research and policy reform agenda for digital Payment for health workers during implementation of ng health programs Africa.,6. To explore the influence of gender on digital payment for health workers in Uganda,5. To describe successes and challenges encountered in using health worker digital payments in Africa,4. To describe contextual factors influencing e-payment uptake and use in Africa. ,3. To determine the availability of the technical tools needed to implement digital payments in Africa,2. To describe access to existing digital payment systems and modalities for health workers (formal/informal workers) in Africa. ,1. To map the key stakeholders and programs, their influence, and their role in digital payment for health workers in Africa,The overall objective of this landscape analysis is to synthesize evidence on existing digital payment systems in Africa with a focus on policies/laws, technology, actors/stakeholders, programs, challenges/barriers, enablers, and benefits/impact of digital payment for health workers. ,
 Uganda 2022-05-03 12:57:24 2025-05-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joshua Parker Allen David Franz
ID:
HIV in Epidemiologyland: the politics of transnational research in the age of global health
REFNo: SS1262ES

(1) understand the perspectives of those working in public health research partnerships on research design, implementation, analysis, and findings-dissemination in the context of transnational collaborations; (2) to generate ideas of how research collaborations can be made more equitable; (3) to understand how the social sciences feature in scientific public health research.
UK 2022-05-03 12:54:51 2025-05-03 Social Science and Humanities Non-Clinical Trial Degree Award
IBRAHIM KASIRYE
ID:
Evaluating the Refugees in East Africa: Boosting Urban Innovations for Livelihoods Development (Re:Build) Program, Uganda
REFNo: SS1243ES

The overall goals of the RCT will be to test the effectiveness of a mentorship program for microentrepreneurs. The RCT will be informed by previous and ongoing activities undertaken by IRC as part of their regular programming. We will (i) measure the economic and psychological impacts of this intervention; (ii) measure whether a “shared fate” structure encourages mentors to invest additional effort in the mentees’ business and/or disclose valuable information or techniques, by giving mentors a stake in the mentees’ business; and (iii) evaluate whether matching between mentors and microenterprise participants across different demographics (Ugandans, refugees, men, women, etc.) confers greater benefits to participants than matching within demographics.
 Uganda 2022-05-03 12:52:39 2025-05-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Freda Wolfenden Janet
ID:
Strengthening School Leadership Towards Improving School Resiliency: An Improvement Science Approach
REFNo: SS893ES

General Objective: Contribute to improved quality and equity of the continued learning and well-being of girls and boys in the Global South during the prolonged school closures of the COVID-19 crisis, and future emergencies

Specific Objectives1.Knowledge Generation. Deepen understanding of how an improvement science approach can strengthen instructional school leadership towards school resiliency in a range of Global South contexts.

2.Capacity Building. Build the capacity of school leaders for data-driven decision-making and problem-solving leading to improvement.

3.Policy and Practice Influence. To inform education policy and practice on strengthening instructional school leadership and building school resiliency using the improvement science approach.
 UK 2022-04-29 2025-04-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
Irene Mbatidde
ID:
ANTIMICROBIAL USE AND RESISTANCE IN POULTRY PRODUCTION CHAINS IN SOROTI AND WAKISO DISTRICT, AND THE ASSOCIATED OCCUPATIONAL HEALTH RISKS
REFNo: A166ES

General Objective Understanding antimicrobial use patterns, their influence on the development of AMR along the poultry value chains and associated health risk factors among value chain workers in Wakiso and Soroti districts Specific Objectives Describe antimicrobial use patterns under intensive and free-range poultry production systems in Wakiso and Soroti respectively • Explain AMR for selected antibiotics at various points along the poultry production chain in Wakiso and Soroti districts • Develop a risk pathway for poultry associated AMR in Wakiso and Soroti • Quantify residues of (sulphurdiazine, tetracycline, neomycin) in poultry meat
Uganda 2022-04-28 2025-04-28 Agricultural Sciences Non-Clinical Trial Degree Award
Simon Peter Kibira Peter Sebina
ID: UNCST-2019-R000492
 Covid-19 vaccine hesitancy among school teachers: a qualitative exploration of the driving factors
REFNo: SS1242ES

1.To explore the contextual, vaccine-specific, individual and group-specific drivers of Covid-19 vaccine hesitancy among school teachers in Uganda.
2.To explore facilitators of vaccine uptake for Covid-19 among school teachers in Uganda.
3.To describe the product attributes of the ideal Covid-19 vaccine from the perspective of school teachers.
 Uganda 2022-04-27 2025-04-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
 Evaluation of the Safety , Efficacy and Stability of Sangatraz®-125 & Sangatraz®-250: A Randomised Single-Blinded Positive Controlled Multi-Site Acaricides Field Trial
REFNo: A186ES

General objectives To determine the efficacy, safety and stability of Sangatraz®-125 & Sangatraz®-250(Sanga Vet. Chem. Ltd, Kampala Industrial Park, Namanve ) when applied onto cattle by hand spraying and plunge dipping for tick control. Specific objectives The specific objectives of this acaricide field trial will to to determine; i.efficacy of Sangatraz®-125 & Sangatraz®-250 when applied onto cattle by hand spraying and plunge dipping for tick control. ii.safety of Sangatraz®-125 & Sangatraz®-250 when applied onto cattle by hand spraying and plunge dipping for tick control. iii.Stability of Sangatraz®-125 & Sangatraz®-250 when applied onto cattle by plunge dipping for tick control.
Uganda 2022-04-25 2025-04-25 Agricultural Sciences Clinical Trial Non-degree Award
Marie Sabacka
ID:
Microbial diversity of disappearing tropical glaciers in Uganda
REFNo: NS348ES

Study microbial diversity of disappearing glaciers in Uganda
Czech Republic 2022-04-25 2025-04-25 Natural Sciences Non-Clinical Trial Non-degree Award
Gladys Ayot Florence
ID:
Exploring Experiences of Domestic Violence for Female Teachers in Secondary Schools in Uganda
REFNo: SS1273ES

4. Explore the support mechanism available to female teachers affected by domestic violence.,3. Provide a description of female teachers’ reports on how staff affected by domestic violence negotiates through the challenges of domestic violence in performing their duties.,2. Assess the female teachers’ perspectives about the impact of domestic violence on the administrative roles of teachers.,1. Assess from the female teachers’ perspective how domestic violence affects teachers’ teaching function/roles.,The purpose of this study is to explore the experiences of female teachers affected by domestic violence, describe how domestic violence affects the professional roles of a teacher of secondary schools and to establish how administrators manage the situation for affected staff in schools in northern Uganda.,
 Uganda 2022-04-22 2025-04-22 Social Science and Humanities Non-Clinical Trial Degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 LINKAGES BETWEEN SUSTAINABLE DEVELOPMENT GOALS IN UGANDA - A FOCUS ON HEALTH
REFNo: HS2015ES

To understand how stakeholders in Uganda perceive and assess linkages between health and non-health determinants and their impact.,To determine the strength, position, and nature of linkages between health and other SDGs in Uganda using the SDG synergies approach. ,The overall aim of this project is to identify, describe, and classify linkages between SDGs focusing on health at the country level in Uganda.,
 Uganda 2022-04-22 2025-04-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stavia Turyahabwe Stavia
ID: UNCST-2022-R011373
 EXPLORING THE PATHWAYS OF LEPROSY FROM COMMUNITIES TO DIAGNOSIS TO FINE-TUNE INTERVENTIONS IN THE DISTRICTS OF MAYUGE, YUMBE AND KASESE, UGANDA
REFNo: SS1182ES

1. To describe the reasons for delay in seeking health care for leprosy patients diagnosed in three districts of Mayuge, Yumbe and Kasese
2. To describe the knowledge, attitude and practice among members of communities and health care providers in reference to leprosy

Uganda 2022-04-22 2025-04-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Francis Kakooza
ID:
Molecular Epidemiology and Antimicrobial Resistance Determinants of Neisseria gonorrhoeae among males with urethritis in Kampala, Uganda
REFNo: HS2191ES

Main Objective
To elucidate the genomic epidemiology and AMR determinants associated with NG strains circulating in Kampala Uganda
Specific Objectives
• To describe the NG AMR Surveillance Programme in Kampala, Uganda and the emerging phenotypic antimicrobial susceptibility data generated using E-test method
• To determine the genomic epidemiology of NG strains circulating in Kampala, Uganda using WGS and compare findings with behavioural, demographic and clinical metadata
• To identify the molecular AMR determinants associated with decreased susceptibility and/or resistance to NG using WGS and correlate with phenotypic AMR data

Uganda 2022-04-22 2025-04-22 Medical and Health Sciences Non-Clinical Trial Degree Award
Shana Warren
ID:
Vitamin A Supplementation (VAS) Post Event Coverage Survey (PECS) in Uganda
REFNo: SS1261ES

To conduct a PEC survey for the October-November 2021 round of the ICHD in Uganda,
 USA 2022-04-21 2025-04-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 Routine SARS CoV-2 screening using Antigen Rapid diagnostic test to detect and control transmission of infections in markets and trade hubs in Kampala City – A pilot study.
REFNo: HS2197ES

4. To estimate the cost of implementing routine use of SARS CoV-2 Ag RDTs in markets and trade hubs,3. To assess the feasibility of use of Ag-RDTs in contact tracing for early identification of SARS-CoV-2 infections,2. To identify high risk groups that drive SARS-CoV-2 transmission in markets and trade hubs ,1. To pilot the use of routine SARS-CoV-2 Ag-RDT for the early detection of SARS-CoV-2 infections in markets and trading hubs within Kampala to control transmission ,
 Uganda 2022-04-21 2025-04-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Phillip Ssekamatte
ID:
IMMUNOLOGICAL, METABOLIC AND GENETIC CHANGES AMONG PATIENTS WITH TUBERCULOSIS AND TYPE 2 DIABETES MELLITUS IN UGANDA
REFNo: HS1696ES

Study objectives

General objective
To assess the effect of type 2 DM on Mtb-specific T-cell subset functional phenotypes during metformin and isoniazid therapy, and type 2 DM on the immunological, metabolic and genetic TB responses.

Specific objectives
(i) To determine the effect of type 2 DM on frequency, function (activation and cytokine secretion), and survival of Mtb-specific T-cell subsets (CD4+ and CD8+) in patients having both type 2 DM and LTBI during metformin and isoniazid therapy.
(ii) To assess baseline differences in Mtb-specific T-cell subset functional phenotypes to LTBI between people with and without type 2 DM.
(iii) To profile baseline immune-metabolic changes among type 2 DM and LTBI patients.
(iv) To investigate baseline differences in gene expression signatures (TB Risk-11) to LTBI between people with and without type 2 DM.

 Uganda 2022-04-21 2025-04-21 Medical and Health Sciences Non-Clinical Trial Degree Award
Barnabas Bakamutumaho
ID: UNCST-2021-R012636
 Maintenance and transmission of Rift Valley Fever Virus and other emerging infectious diseases in East and Central Africa: Version number: 1.0
REFNo: HS1713ES


(i) Determine whether low-level RVF virus transmission and disease among or between animals and humans occurs during the inter-epidemic periods (IEPs)
(a). To describe host immune responses to RVF infections in humans and livestock during inter-epidemic periods.
(ii) Conduct detailed niche modelling of RVF high risk and low risk ecologies to determine the important ecological risk factors associated with persistence of RVF virus and recurrence of outbreaks in animals and humans.
(iii) Investigate impact of climate change on the RVF permissive ecologies and its effect on RVF virus transmission
2.2.2 Secondary objective
(iv) Conduct pathogen discovery on human, livestock, and wildlife samples collected from ECA countries to identify other circulating emerging infectious pathogens which are of epidemic or pandemic potential.

Uganda 2022-04-21 2025-04-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Etheldreda Nakimuli-Mpungu
ID: UNCST-2020-R014808
 Tele-Psychotherapy for Youth using Mobile Phones during Covid-19 Pandemic
REFNo: HS2106ES

1. We aim to conduct online and community-based participatory qualitative research to obtain information on the potential usefulness of individual tele-support psychotherapy in addressing depression during the Covid-19 pandemic.
2. We will compare the effectiveness of individual tele-support psychotherapy (TSP) delivered by trained lay counsellors in combination with standard mental health services (SMHS) for depression with use of SMHS alone.
3. We aim to compare the effects of TSP combined with SMHS and SMHS alone on other psychosocial variables including self-esteem, anxiety, alcohol and substance use, social support, stigma, number of disability days, asset possession, poverty indices, and cost-effectiveness measures.
4. To conduct a process evaluation of trial activities informed by Linnan and Steckler’s process evaluation frameworks to specifically determine indicators of feasibility, acceptability, fidelity, and to explore causal mediating processes and contextual influences
5. We will also explore whether or not the effects of TSP and SMHS are moderated by alcohol and drug use.
6. We shall explore whether the strength of a therapeutic relationship will mediate the effects of TSP and SMHS on depression
 Uganda 2022-04-21 2025-04-21 Medical and Health Sciences Clinical Trial Non-degree Award
Joseph Erume
ID:
Profiling virulence markers and drivers enabling Escherichia coli to cause neo-natal and post-weaning piglet diarrhea in major pig producing districts of Uganda
REFNo: A190ES

1. To determine the adhesins in the 157 E. coli previously isolated from Kayunga and Mityana districts, Central Uganda
2. To determine the significance of E. coli species in the etiology of piglet diarrhea in the major pig producing districts of Uganda.
3. To determine drivers which underlie the dynamics and perpetuation of E. coli infections of pigs in the major pig producing districts of Uganda.
4. To molecularly characterize virulence markers of E. coli species involved in diarrheal outbreaks in piglets in the small holder pig production systems in major pig producing districts of Uganda.
5. To determine the antimicrobial susceptibility of E. coli isolates isolated from diarrheic piglets in the small holder pig production systems in selected major pig producing districts of Uganda.
 Uganda 2022-04-21 2025-04-21 Agricultural Sciences Non-Clinical Trial Non-degree Award
Paula Rabaey Ann
ID:
A seat for every child: Ensuring safe and dignified mealtimes for children with disabilities
REFNo: SS1247ES

Determine in country stakeholder interest in promoting and using the chair,Determine percent change in caregiver stress level while feeding child in the chair versus current position (without adaptive equipment),Determine ability and level of ease/difficulty with which caregivers can independently position their child correctly in the chair ,Determine change in feeding position and tolerance for using the chair (from child’s current feeding position to being fed in the chair),To pilot test SPOON Foundation’s low-cost feeding chair for acceptability, usability, and feasibility for families with a child with a disability (CWD) in Uganda. ,
 USA 2022-04-20 2025-04-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ali Ssetaala
ID: UNCST-2021-R011817
 CHILI- Analysis of Cervical cancer burden and screening practices in Uganda
REFNo: HS2167ES

1. To understand the current cervical cancer burden, screening, and management practices in Uganda.
2. To obtain relevant stakeholders’ input before starting the development of the cervical cancer screening intervention with a self-sampling device.
 Uganda 2022-04-20 2025-04-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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