Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Isaac Ssewanyana
ID: UNCST-2020-R014336
 HBsAg Rapid Test Device (Whole Blood/Serum/Plasma) (AssureTech) - diagnostic specificity, specimen equivalence and qualification of usability. "CPSP nr ASH-CPH 23-045"
REFNo: HS4685ES

The objective of this evaluation is to establish the performance of the HBsAg Rapid Test Device (Whole Blood/Serum/Plasma) in accordance with the COMMISSION IMPLEMENTING REGULATION (EU) 2022/1107 of 4 July 2022 laying down common specifications for certain class D in vitro diagnostic medical devices in accordance with Regulation (EU) 2017/746 of the European Parliament and of the Council and, the Technical Specifications Series (TSS) for submission to WHO Prequalification – Diagnostic Assessment: TSS-13.,
 Uganda 2024-08-22 16:24:28 2027-08-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 Anti-HCV Rapid Test Device (Whole Blood/Serum/Plasma) (AssureTech) - diagnostic specificity, specimen equivalence and qualification of usability.
REFNo: HS4703ES

The objective of this evaluation is to establish the performance of the HCV Rapid Test Device (Whole Blood/Serum/Plasma) in accordance with the COMMISSION IMPLEMENTING REGULATION (EU) 2022/1107 of 4 July 2022 laying down common specifications for certain class D in vitro diagnostic medical devices in accordance with Regulation (EU) 2017/746 of the European Parliament and of the Council and, the Technical Specifications Series for submission to WHO Prequalification – Diagnostic Assessment: TSS-16 (2021 update).,
 Uganda 2024-08-22 16:20:33 2027-08-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Linda Grace  Alanyo
ID:
The Role of Social Capital in Enhancing the Reproductive Autonomy of Adolescent Girls in Uganda
REFNo: SS2627ES

To explore the perspectives of immediate caretakers and other stake holders on barriers and facilitators to Reproductive autonomy of adolescent girls,To Assess the Reproductive autonomy of Adolescent girls in Uganda and associated socio-ecological factors ,To synthesize evidence on factors associated with the reproductive autonomy of adolescent girls.,To understand the role of social capital in enhancing the Reproductive Autonomy of Adolescent girls in Uganda,
 Uganda 2024-08-22 16:15:47 2027-08-22 Social Science and Humanities Non-Clinical Trial Degree Award
Viola  Nyakato Nilah
ID: UNCST-2021-R013698
 Promotion of a Safe Workplace Environment, Free from Gender-based Discrimination and Violence: A Policy Review and Action Research on the Prevalence of Workplace Gender Discrimination and Violence within the Agriculture, Tourism and Hospitality Sectors in the Rwenzori and Albertine Regions in Uganda
REFNo: SS2600ES

Develop action plans (1 per sector) based on research findings to address gender-based discrimination and violence, and create safe and inclusive work environments.,Identify support structures and mechanisms for work related Gender based discrimination and violence victims available in the region. ,Analyse existing policies and their gaps to address gender-based discrimination and violence at the workplace targeting selected sectors in Albertine and Rwenzori regions. ,To conduct action-oriented research on gender-based discrimination and gender-based violence (GBV) at the workplace targeting agriculture, tourism, and hospitality sectors in the Albertine and Rwenzori regions.,To contribute to the promotion of a Safe Workplace Environment, free from gender-based discrimination and gender-based violence.,
 Uganda 2024-08-22 15:26:06 2027-08-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Kelsey Shaw
ID:
In-situ assessment and collection of fecal sludge from non-sewered sanitation containments: Linking demographic, environmental and technical parameters to microbial activity
REFNo: SIR275ES

The overall objective of this PhD project is to better understand and characterize anaerobic degradation pathways in containment of non-sewered sanitation systems (NSS) in resource constrained settings representative of both urban and rural areas. In view of this, the specific objective linked to this research pertaining to this ethics application is to understand the influence of demographic, environmental and technical (DET) data on measurable fecal sludge parameters as well as microbial community composition within NSS containment across variable geographic regions. The proposed project aims to answer the following specific research questions: - What are the effects and variations associated with physical location, use, and operating conditions on wastewater quality and microbial composition? - What is the relationship between location of sanitation system and behaviors associated with operational parameters? - Is there a link between main concentration gradients in containment and spatially analyzable factors (i.e., demographic, environmental and technical)?
Canada 2024-08-22 15:18:53 2027-08-22 Engineering and Technology Non-Clinical Trial Degree Award
Luke Nyakarahuka
ID: UNCST-2023-R008138
 Surveillance and Research of Viral Hemorrhagic Fever Outbreaks in Uganda: Acute Case Investigation and Survivor Follow-up for Strategic Public Health Intervention
REFNo: HS2964ES

The primary objective is to enhance Uganda’s capacity to rapidly detect, diagnose, respond to, and prevent VHFs including those caused by Ebola, Marburg, CCHF, RVF, Sosuga, and other emerging viruses. To do this, it is critical to understand the incidence, distribution, risk factors for emergence and transmission, immunogenicity and clinical progression (including potential asymptomatic infection), and potential for transmission following clinical recovery of these diseases throughout Uganda, which will enable improved VHF case outcomes, identification of unknown chains of transmission, survivor monitoring, and strategic targeting of public health and animal health resources to prevent and control transmission of these high-consequence viruses.
 Uganda 2024-08-22 15:14:36 2027-08-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rebecca Nuwematsiko
ID: UNCST-2022-R010501
 Effect and implementation factors of a contextually adapted short message service or phone call intervention to reduce loss to follow-up among presumptive TB patients in North Central Uganda
REFNo: HS3000ES

1.To determine the proportion of pre-diagnosis LTFU among presumptive TB patients and influencing factors in North Central Uganda (Sub-study 1). 2.To explore stakeholder’s perceptions on use of an SMS or phone call intervention to reduce LTFU among presumptive TB patients in health care facilities in North Central Uganda and contextually adapt the interventions (Sub-study 2). 3.To assess the effect of a contextually adapted SMS or phone call intervention to reduce LTFU among presumptive TB patients in health care facilities in North Central Uganda (Sub-study 3). 4.To explore factors that influence implementation of a locally adapted SMS or phone call intervention to reduce LTFU among presumptive TB patients in North Central Uganda (Sub-study 3). 5.To synthesize evidence on effectiveness of mHealth interventions to reduce LTFU in the TB presumption phase in LMICs (Sub-study 4)
Uganda 2024-08-22 13:00:28 2027-08-22 Medical and Health Sciences Clinical Trial Degree Award
AHUMUZA VIANNEY JOHNMARY
ID:
The Refugee Question In Ugandan History 1942-2010
REFNo: SS2297ES

iii. To study the evolution of the relationship between refugees and their host communities,ii. To analyse the changing push and pull factors that shaped refugee flows into and exiting post-Colony Uganda up to 2010.,i. To examine the refugee problem in colonial Uganda.,
 Uganda 2024-08-22 12:54:21 2027-08-22 Social Science and Humanities Non-Clinical Trial Degree Award
Mark Okwir
ID: UNCST-2021-R013417
 PREVENTION OF MOTHER-TO-CHILD TRANSMISSION OF HEPATITIS B VIRUS BY ESTABLISHING AN ANTENATAL SCREENING AND VIRAL LOAD TESTING UNIT AND TENOFOVIR DISOPROXIL FUMARATE TREATMENT IN LIRA, NORTHERN UGANDA
REFNo: HS3861ES

To assess the viral load and effectiveness of the TDF therapy.,To assess and enhance knowledge and perceptions of hepatitis B, with the aim of reducing stigma and improving awareness among pregnant women. ,To optimise linkage to care and engagement in the recommended care after receiving a positive HBsAg test during the antenatal period.,To determine the prevalence and risk factors associated with hepatitis B virus infection among pregnant women attending the antenatal clinic in Lira University Hospital and Lira Regional Referral Hospital. ,To assess the implementation of the HBV DNA viral load threshold of ≥10,000 IU/mL for initiating TDF treatment in pregnant women during gestation week 24 or beyond in order to prevent HBV mother-to-child transmission in Lira, Northern Uganda.,
 Uganda 2024-08-22 12:33:06 2027-08-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Francis Mutekanga
ID: UNCST-2020-R014725
 GEC II Uganda Project
REFNo: SS3024ES

What were the implementation factors behind the GEC-T projects\' success or lack of success? ,To what extent and how did external contextual factors for different projects across the GEC-T portfolio influence their performance?,What were the unexpected or unintended results across the GEC-T portfolio?,What intermediate outcomes did the GEC-T portfolio deliver?,What results did the GEC-T portfolio deliver between the baseline and end line?,The primary objective of the Effectiveness Evaluation will be to assess the effectiveness of the GEC II projects that were designed and implemented through the GEC-T Window. ,
 Uganda 2024-08-22 12:28:28 2027-08-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Grace Kisitu Paul
ID: UNCST-2024-R004102
 Universal2: Pharmacokinetics, safety and acceptability of a solid paediatric fixed-dose combination of darunavir/ritonavir (DRV/r) 120/20mg for children living with HIV
REFNo: HS4762ES

To evaluate the pharmacokinetics and safety of DRV/r 120/20 mg tablets in children greater than or equal to 3 years of age and weighing 10 to less than 25 kg

To evaluate the pharmacokinetics and safety of DRV/r 120/20 mg tablets in children greater than or equal to 3 years of age and weighing 10 to Less than 25 kg

To evaluate the acceptability of DRV/r tablets in children greater than or equal to 3 years of age and weighing 10 to less than 25 kg

To evaluate the short-term efficacy of the DRV/r 120/20 mg tablets in children greater than or equal to 3 years of age and weighing 10 to less than 25 kg

To describe RTV PK parameters as well as darunavir unbound plasma concentrations.

 Uganda 2024-08-22 11:45:22 2027-08-22 Medical and Health Sciences Clinical Trial Non-degree Award
Ioana Lungu
ID: UNCST-2024-R004378
 Study protocol for baseline data collection on sexual and reproductive health outcomes in Wakiso district
REFNo: SS3049ES

At baseline and prior to the intervention, assess the uptake of HIV testing, ART and PrEP for AYP in our sample in study locations.,At baseline and prior to the intervention, assess the knowledge, perceived norms and attitudes towards contraception and HIV services (testing, ART and PrEP) for AYP in our sample in study locations.,At baseline and prior to the intervention, assess the modern Contraceptive Prevalence Rate (mCPR) for young women and girls in our samplein study locations.,At baseline and prior to the intervention, assess the level of access to high quality, youth friendly health services for AYP in our sample in study locations.,At baseline and prior to the intervention, assess the share of unintended pregnancies for our sample.,
 Romania 2024-08-22 11:39:54 2027-08-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Agaba Katureebe Ishmael
ID: UNCST-2024-R004089
 Getting a GRIP on Hypertension in Uganda: Giving Repetitive Isometric Exercise for Blood Pressure Control (GRIP in Uganda)
REFNo: HS4712ES

To assess knowledge, attitudes, and practices (KAP) about HTN and experience with IHT (if applicable) ,To measure HTN medication adherence for those prescribed HTN medication during their follow-up, which will be measured through pill counting (counting the remaining amount of pills for prescribed medication).,To assess the need for HTN medication at endline, as per clinical and MOH guidelines, which will be measured through changes in BP levels at week 12,To evaluate the effects of Isometric Hand Training (IHT) on resting diastolic Blood Pressure when compared to standard care after 12 weeks ,To evaluate the effects of Isometric Hand Training (IHT) on resting Systolic Blood Pressure when compared to standard care after 12 weeks ,To determine the efficacy of Isometric Hand Training (IHT) in a population of Hypertension (HTN) patients compared to standard care after 12 weeks of care,
 Uganda 2024-08-22 11:38:26 2027-08-22 Medical and Health Sciences Clinical Trial Non-degree Award
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
 ASSESSING THE CONTEMPORARY ECHOCARDIOGRAPHIC DIAGNOSIS AND SECONDARY PROPHYLAXIS OF EARLY-STAGE RHEUMATIC HEART DISEASE
REFNo: HS4694ES

a) To determine the diagnostic accuracy of the 2023 World Heart Federation (WHF) echocardiographic screening criteria for RHD, estimate the cost of RHD screening using the WHF 2023 active case finding algorithm, and a cost analysis of two RHD screening models in Uganda; b) To compare patient-reported outcomes (i.e, treatment adherence, treatment satisfaction and health-related quality of life) among children receiving intramuscular and oral forms of penicillin prophylaxis; and c) To evaluate the cost effectiveness of oral versus intramuscular penicillin for treating early-stage RHD.
Uganda 2024-08-22 11:35:35 2027-08-22 Medical and Health Sciences Non-Clinical Trial Degree Award
Wilson Mathembele
ID:
School Inspection and the Quality of Education in Secondary Schools in Uganda: A case Study of Kasese District
REFNo: SS2957ES

To assess the influence of school inspection on the quality of education in secondary schools in Kasese District,To evaluate the quality of education in secondary schools in Kasese District ,To examine the quality of inspection in the secondary schools in Kasese District,The purpose of this study is to determine the effectiveness of school inspection in ensuring the quality of education in secondary schools in Kasese District in order to improve educational standards and quality outcomes.,
 Uganda 2024-08-22 11:30:39 2027-08-22 Social Science and Humanities Non-Clinical Trial Degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Assessment of Longitudinal Lung Function and Sleep Disordered Breathing in COPD Patients in Uganda
REFNo: HS4817ES

1.Assess longitudinal lung function and respiratory symptoms among adults with COPD in Uganda.

2.Determine whether baseline radiographic imaging and inflammatory markers can predict exacerbations at one year among those with COPD.

3.Assess nocturnal sleep patterns and the association between sleep disordered breathing and quality of life.


Uganda 2024-08-22 11:27:08 2027-08-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Proscovia Nabunya
ID: UNCST-2019-R000970
 Testing the Feasibility and Acceptability of a Combination Intervention to Address Mental Health among Refugee Youth in Uganda
REFNo: SS2834ES

This proposed two-year study will be conducted in two phases. The first phase seeks to understand whether the COVID-19 pandemic had differential impact on refugee youth living in different settings. The second phase will test the feasibility and acceptability of an innovative combination intervention that has not been previously tested among refugee youth to address psychological problems that have increased since the onset of the COVID-19 pandemic. Aim 1. To examine the mental health impact of COVID-19 on refugee youth living in Bidibidi refugee settlement compared to refugee youth living in urban centers (Arua town) in northern Uganda. Aim 2. To test the feasibility, acceptability and preliminary short-term impact of an innovative intervention combining the youth readiness intervention (YRI) with youth development accounts and financial literacy training (YDA-FLT) to address the mental health impact of COVID-19 among refugee youth living in Bidibidi refugee settlement in northern Uganda.
Uganda 2024-08-19 11:03:04 2027-08-19 Social Science and Humanities Clinical Trial Non-degree Award
Peter Olupot-Olupot Olupot
ID: UNCST-2020-R014798
 SMAART-MAP trial Severe Malaria A Research and Trials consortium - Multisite Adaptive Platform trial
REFNo: HS4547ES

OBJECTIVES
The objective of the SMAART-MAP trial is to identify promising adjunctive therapies to take forward into a large Phase III trial in severe malaria with a mortality endpoint. The adaptive platform design enables additional domains to be added so a range of adjunctive therapies can be tested, across multiple clinical presentations of severe malaria, in a timely manner.

PRIMARY OBJECTIVE(S)
To explore within each domain the therapeutic efficacy of the intervention using an early indicator such as a biomarker or clinical assessment at 24-72 hours.

SECONDARY OBJECTIVE(S)
 To assess the impact of the interventions on clinical outcomes (readmission and
mortality) on all children 28 days and 90 days after randomization
 To assess the impact of the interventions on Grade 3 or 4 adverse events, and adverse
events of any grade related to the interventions or comparators.
 To assess the impact of proposed definitions for severe malaria based on platelet counts
≤150,000/µL and plasma pfHRP2 concentrations ≥800 ng/mL on differences between
randomized groups
 In a sub study, to determine the performance characteristics of a POC pfHRP2 test
compared with quantitative plasma pfHRP2 concentrations determined from plasma.

 Uganda 2024-08-16 11:01:14 2027-08-16 Medical and Health Sciences Clinical Trial Non-degree Award
SYLVIE NAMWASE
ID: UNCST-2024-R003958
 Charcoal Conflict in Climate Change’s Decarbonisation Dilemmas: Knots of Livelihood, Nutrition, Communities, Gender, Migration and Energy in East Africa. RefNo: CoBAMS-REC-2024-39
REFNo: SS2909ES

To examine the East African challenges in the context of the global political landscape of climate strategies and identify how success-criteria are derived from global dynamics, and what lessons from these local cases should be fed into global policy-making.,To identify and examine the ways in which Uganda and Tanzania have initiated local solutions to the charcoal and climate change crisis and how they can each harmonise their legal and policy framework change in a way that is responsive to their local realities while in tandem with global climate change and decarbonisation trends.,To understand the legal and policy frameworks governing the climate change, charcoal and decarbonisation dilemma in Uganda and Tanzania. ,To understand local processes of charcoal transition in Uganda and Tanzania in order to capture the impact of possible changes on livelihoods, food, nutrition and health as well as social stability, and relations among different social identity groups, where gender, youth, women and migration are particularly central. ,The main objective is to understand how global climate change mitigation policies (decarbonisation) condition charcoal politics and socio-economic dynamics in energy-stressed countries down to local levels, and how to manage conflicts.,
 Uganda 2024-08-12 10:56:54 2027-08-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
PATRICIA  ATUKUNDA
ID:
Staff Welfare Strategies and Performance of Healthcare Providers in Government -aided Health Facilities in Bushenyi District, Uganda
REFNo: SS2783ES

To find out the extent to which career growth strategy affects the performance of healthcare givers in government-aided health facilities in Bushenyi District, Uganda.,To determine the extent to which financial well-being strategy impacts the performance of healthcare workers in government-aided health facilities in Bushenyi District, Uganda,To establish the extent to which work-life balance strategy influences the performance of healthcare workers in government-aided health facilities in Bushenyi District, Uganda.,To assess the extent to which health and safety strategy influences the performance of healthcare givers in government-aided health facilities in Bushenyi District, Uganda.,To analyze how the well-being of staff influences the performance of healthcare givers in government-aided health facilities within Bushenyi District, Uganda.,
 Uganda 2024-08-12 10:55:47 2027-08-12 Social Science and Humanities Non-Clinical Trial Degree Award
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