EDITH NAKKU-JOLOBA NAKKU
ID: UNCST-2021-R013931
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Performance of a novel, rapid Neisseria gonorrhoeae genotypic and phenotypic test and estimation of prevalence of 4 STI in a gonococcal surveillance program in Uganda
REFNo: HS455ES
Primary:
• To determine the accuracy (correlation, sensitivity, specificity) of a new mobile, dual purpose gonorrhea point-of-care (POC) STI test device [the Mobile NAAT (MobiNAAT)] against reference laboratory methods for diagnosis (Gram stain and/or culture).
Secondary:
• To determine agreement between self-collected meatal swabs and urine samples for the diagnosis of STI using a gold standard NAATs in Ugandan men (a population with high NG positivity).
• To assess acceptability of self-collected tests in men with UDS in Uganda.
• To validate MobiNAAT for gonorrhoea ciprofloxacin AMR in symptomatic men compared with gold standard (culture & disk diffusion).
• To estimate the prevalence of the following 4 STIs in a population of men with UDS: Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), Trichomonas vaginalis (TV), and Mycoplasma genitalium (MG) using NAATs.
• To compare sensitivity and specificity of GC NAAT with microscopy and culture in Ugandan samples.
• To assess the prevalence of HIV, syphilis and viral hepatitis, and compare HIV result to self-reported HIV status.
• To explore socio-demographic, behavioural and clinical factors associated with positive STI diagnosis (including NG NAAT-positive and NG culture-negative status).
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete).
• Test other STI diagnostics in future on available samples.
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Uganda |
2019-09-10 |
2022-09-10 |
Medical and Health Sciences |
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Non-degree Award |
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David Meya Bisagaya
ID: UNCST-2019-R000837
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High Dose Oral Rifampicin to Improve Survival from Adult Tuberculous Meningitis: A Double-blinded Randomised Controlled Phase III Trial. HARVEST trial
REFNo: HS428ES
Our primary objective is: To determine if high dose rifampicin, delivered orally at ~35 mg/kg/day for 8 weeks, is safe and improves 6-month survival compared to standard of care (rifampicin 10 mg/kg/day) for patients with TBM.
Secondary objectives are to compare the high dose rifampicin regimen to the standard of care regimen for:
1. 12-month survival
2. Neurological disability and functional outcomes from TBM
3. Safety and tolerability
4. Hospital outcomes related to TBM
5. Subsequent neurologic deterioration
6. Management of drug-induced liver injury
Tertiary objectives are to:
1. To describe the pharmacokinetics (PK) of high dose rifampicin in plasma and CSF, assess predictors of exposure to rifampicin in plasma and CSF, assess PK-PD relationships also considering exposures to the other first-line TB drugs and ART in HIV-infected patients, and determine the minimally desired rifampicin exposure for optimal treatment of TBM.
2. To determine the cost-effectiveness of the intervention.
3. To determine appropriate TBM diagnostic algorithms
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Uganda |
2019-09-05 |
2022-09-05 |
Medical and Health Sciences |
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Non-degree Award |
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Kevin Hunt Dean
ID:
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DRY HABITAT CHIMPANZEE ECOLOGY: IMPLICATIONS FOR HUMAN
EVOLUTION
REFNo: NS101ES
Document feeding, social and locomotor behavior using 1-minute focal observations. Record food items, ranging behavior, canopy use, feeding rate and habitat use. Collect hairs for trace element analysis. Collect skeletal material from any deceased individuals. Analyze skeletal material for distinctive characteristics. Analyse hormone profiles to determine if lower levels of aggression are due to low T levels. Look for poisons in Muguri River to find source of sex organ abnormalities. Examine dental micro wear and trace elements in hair to determine diet. Look at genetic variations
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USA |
2019-09-05 |
2022-09-05 |
Natural Sciences |
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Non-degree Award |
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Sangjin Kang
ID:
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Establishment of libraries of indigenous medicinal plants in Mount Elgon area
REFNo: NS86ES
To conserve knowledge and resources about indigenous medicinal plants in Mt. Elgon area through activities such as;
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Republic of Korea Reunion |
2019-08-27 |
2022-08-27 |
Natural Sciences |
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Non-degree Award |
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Mushagalusa Kasali Félicien Kasali
ID:
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Phytochemical and Pharmacological Study of Chenopodium ambrosioides L. and Physalis peruviana L., herbs used to treat diabetes in Congolese Traditional Medicine
REFNo: HS440ES
1. To test the activity of the bioguided fractions of the extracts obtained in-vivo, on acute, sub-acute and chronic hyperglycemia in experimental rats.
2. To determine the zootechnical, biochemical and histopathological markers of the extracts obtained in experimental rats.
3. To isolate and elucidate the structure of the bioactive components of the extracts obtained.
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Democratic Republic of Congo |
2019-08-27 |
2022-08-27 |
Medical and Health Sciences |
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Degree Award |
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Zubair Lukyamuzi
ID: UNCST-2021-R013107
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THE ROLE OF COMMUNITY HEALTH WORKERS IN FACILITATING DISCLOSURE AMONG HIV AFFECTED COUPLES IN GREATER LUWEERO DISTRICT, UGANDA.
REFNo: HS443ES
1. To determine the predictors of non-disclosure among HIV affected couples
2. To document perceptions of HIV affected couples on using CHWs to facilitate their HIV status disclosure
3. To explore CHW’s general and attitudes about HIV status disclosure among HIV affected couples
4. To explore CHW’s experience in facilitating disclosure among HIV affected couples.
5. To determine the proportion of HIV status disclosure among HIV affected couples that can be achieved using CHWs
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Uganda |
2019-08-26 |
2022-08-26 |
Medical and Health Sciences |
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Degree Award |
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Christa Kuntzelman Marie
ID:
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Refugee Perceptions of their Rights in Uganda
REFNo: SS305ES
The purpose of this study is to learn (a) learn what rights refugees believe they have in Uganda; (b) learn how refugees understand the roles and responsibilities of the Ugandan Government, UNHCR, InterAid, and other NGOs (non-governmental organizations) to provide for refugees in the cities and in the settlements, (c) gain understanding of to whom refugees turn when they need assistance, and (d) understand the role of refugee-led organizations to support other refugees for learning rights or gaining assistance.
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USA |
2019-08-20 |
2022-08-20 |
Social Science and Humanities |
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Degree Award |
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Teddy Kyomuhangi
ID:
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Using Digital Stories for Knowledge Translation in Rural South Western Uganda
REFNo: SS318ES
The main objectives of the study are to document evidence-based digital storytelling methods and enhance local capacity to create and disseminate digital stories for knowledge translation in rural southwest Uganda by: 1.Documenting the DST training process so as to contribute towards establishing a model-site offering ongoing mentorship in DST research methodology. 2.Describing experiences of trainees in using DST as a means of disseminating research findings.
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Uganda |
2019-08-20 |
2022-08-20 |
Social Science and Humanities |
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Non-degree Award |
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Andrew Mujugira
ID: UNCST-2019-R000871
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Understanding barriers and motivators to HIV self-testing uptake and clinic linkage among male partners of pregnant women in Uganda
REFNo: HS391ES
Aim 1: To qualitatively elucidate men and women’s personal narratives explaining beliefs, motivations, barriers and experiences influencing clinic HIV testing and linkage to HIV services.
Aim 2: To qualitatively identify attributes of a successful HIVST intervention to increase men’s HIVST uptake and clinic attendance after HIV self-testing. We will assess men and women’s knowledge/perceptions of HIVST and acceptability of strategies to optimize secondary distribution of HIVST from female partners.
Aim 3: To assess healthcare workers perspectives regarding the feasibility and acceptability of potential strategies of secondary distribution of HIVST from pregnant women to their male partners.
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Uganda |
2019-08-20 |
2022-08-20 |
Medical and Health Sciences |
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Non-degree Award |
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Jorem Awadu Emmillian
ID:
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Validation of autism screening assessments: Comparison of the Social Communication Questionnaire, Social Responsiveness Scale and 23-Q with DSM- 5 in assessing for autism spectrum disorder (ASD) in Uganda
REFNo: HS423ES
The study seeks to answer the questions below.
1) In the Ugandan context, do total scores for the three ASD measures (i.e., SCQ, SRS-2, and 23-Q) yield adequate internal consistency relative to values reported in the test manual or available studies for those with ASD?
2) In the Ugandan context, do total scores for the three ASD measures (i.e., SCQ, SRS-2, and 23-Q) yield adequate internal consistency relative to values reported in the test manual or available studies for non-ASD cases?
3) In the Ugandan context, do total scores from the three measures (i.e., SCQ, SRS-2, and 23-Q) yield substantial mean differences consistent with construct-related (i.e., ASD construct) differentiation between ASD and typically-developing groups?
4) In the Ugandan context, will use of the recommended screening cut scores for each of the three measures (i.e., SCQ, SRS-2, and 23-Q) result in adequate sensitivity and specificity using DSM-5 ASD diagnosis vs. typically developing cases as the outcome variable?
5) Beyond the recommended cut scores for screening reported in each test manual, are there more optimal cut scores for each of the three measures (i.e., SCQ, SRS-2, and 23-Q) in the Ugandan context?
6) Are there significant convergent relationships among the total scores of the three measures (i.e., SCQ, SRS-2, and 23-Q) in the Ugandan context?
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Uganda |
2019-08-20 |
2022-08-20 |
Medical and Health Sciences |
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Degree Award |
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