Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Anthony Nuwa
ID:
Evaluating the feasibility, acceptability and protective efficacy of seasonal malaria chemoprevention in two districts in Karamoja, Uganda
REFNo: HS1182ES

Objective 1: To document the adaptation of SMC in Karamoja region in Uganda
Objective 2: To Assess the process of implementing SMC in Uganda, with regards to coverage and quality of implementation
Objective 3: To assess the acceptability of SMC among policy makers, implementers, and beneficiaries.
Objective 4: To determine the impact of SMC on malaria incidence and prevalence among children under 5 years in the Karamoja region and assess the protective efficacy of SPAQ
Objective 5: To analyse cost of SMC delivery to children 3-59 months in Karamoja region
Objective 6: Monitor the safety of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) when used in SMC among children 3-59 months in Karamoja region.

 Uganda 2021-02-10 2024-02-10 Medical and Health Sciences Non-degree Award
Noah Kiwanuka
ID: UNCST-2021-R010125
 Capturing spatial patterns of new M. tuberculosis infection in Kampala, Uganda
REFNo: HS1230ES

To map the geo-spatial incidence of Mtb infections in a prospective community cohort study of HIV+ and HIV- adults in Kampala Uganda. GPS tracking technology will be used to trace and map subjects to locate areas of high Mtb transmission, or hotspots. Study participants without tuberculous infection will be followed for IGRA/TST conversion for up to 2 years with serial plasma samples taken quarterly.
To determine and validate whether a defined plasma signature found in other studies can identify recent Mtb infection in persons who developed LTBI. Using a paired analysis, we will evaluate baseline and follow-up samples within individuals to determine whether changes associated with new Mtb infection in the community can be detected in plasma with published and newly developed biomarkers. Using a nested case control design, we will compare incident infections with randomly selected controls from the cohort who did not convert

 Uganda 2021-02-10 2024-02-10 Medical and Health Sciences Non-degree Award
Daphine Namara Arinaitwe Namara
ID:
The Risk of Diabetes and pre-Diabetes associated with use of Dolutegravir based Antiretroviral Therapy among adult persons living with HIV: A Case-control study at Mulago ISS clinic, Kampala, Uganda
REFNo: HS1077ES

Primary objective: To determine the risk of DM and pre-DM associated with the use of DTG-based ART among adult PLHIV at Mulago ISS Clinic.
Secondary objective; To determine other risk factors for DM and pre-DM among PLHIV adult PLHIV at Mulago ISS Clinic.

 Uganda 2021-02-09 2024-02-09 Medical and Health Sciences Non-degree Award
Christine Nalwadda Kayemba
ID: UNCST-2020-R014220
 A BASELINE ASSESMENT FOR THE ADVANCING SEXUAL REPRODUCTIVE HEALTH AND RIGHTS (ANSWER) PROGRAM IN THE WEST NILE AND ACHOLI SUBREGIONS IN UGANDA
REFNo: HS1079ES

General objective

To analyse the situation of sexual and reproductive health and rights (SRHR) aspects as well as GBV in the intervention districts of UNFPA’s programme targeting to advance SRHR in the Acholi and West Nile sub regions in Uganda, in order to generate scientific evidence that will inform evidence based planning, implementation and form a basis for monitoring and evaluation of the program interventions.

Specific objectives

1.To conduct Health facility assessment at targeted health facilities in West-Nile and Acholi sub regions in regards to offering quality equitable SRHR services (FP/Maternal health/Post abortion Care, HIV testing and Post GBV) that is responsive to the needs of women, girls, boys and men, refugees, and people with disabilities

2.To undertake an assessment of SRHR Knowledge, Attitudes and Practices (KAP) of adolescents and youth in school including refugees and people with disabilities from a sample of 1,800 targeted schools (primary & secondary) in the study districts on GBV and SRHR.

3.To conduct an assessment of SRHR Knowledge, Attitudes and Practices (KAP) of adolescents and youth out of school including refugees and people with disabilities in the study districts on GBV and SRHR.

4.To conduct a budget and expenditure analysis of key sectors at national level and the district local governments focusing on implementation of and accountability towards the demographic dividend priorities.
 Uganda 2021-02-09 2024-02-09 Medical and Health Sciences Non-degree Award
RUTH NAKATO
ID:
A model for assessing the Banking Sector Employees’ Ethical Behavior towards Cyber security.
REFNo: SIR34ES

1. To examine the extent to which cardinal virtue constructs can influence the cyber security behavioral intention of employees towards cyber security ethical behavior in commercial banks in Uganda. 2. To analyze the moderation effect of ethical climate on the virtue constructs in connection with the behavioral intention of employees towards cyber security ethical behavior in commercial banks in Uganda. 3. To examine the mediation effect of behavior intention on the influence of virtue ethics towards cyber security ethical behavior in commercial banks in Uganda. 4. To develop a model for assessing the Employees’ Ethical Commitment and Behavior towards Cyber security in commercial banks in Uganda. 5. To test and validate the developed model.
Uganda 2021-02-08 2024-02-08 Engineering and Technology Degree Award
Tadele Yadesa Mekuriya
ID: UNCST-2022-R010338
 Incidence, predictors and risk prediction of adverse drug reactions among inpatients 60 years and older at Mbarara Regional Referral Hospital, Mbarara, Uganda
REFNo: HS992ES

1. To determine the incidence and prevalence of ADRs among elderly inpatients at MRRH
2. To characterize (types, severity and preventability) the ADRs detected among elderly inpatients at MRRH
3. To determine the risk factors of ADRs among elderly inpatients at MRRH
4. To develop and validate an ADR risk score tool (to be named as PADR-HE) for elderly inpatients at MRRH
 Ethiopia 2021-02-08 2024-02-08 Medical and Health Sciences Degree Award
Angua Amis Mao
ID:
Energy access as a dividend for designing just transition pathways (EAJT)
REFNo: SIR48ES

1. To assess the effectiveness of different renewable energy technologies in accelerating green jobs creation and a low carbon trajectory; 2. To analyse the equity and distributional implications of energy transition in vulnerable communities across gender, age, and income groups;

3. To develop potential financial and business models to deliver a just transition pathway; and

4. To explore appropriate policy and regulatory frameworks required to support a just transition at multiple levels from grassroots to the national and regional level.

 Uganda 2021-02-08 2024-02-08 Engineering and Technology Non-degree Award
David Musoke
ID:
Distribution of antibiotic profiles and antibiotic resistance associated with tuberculosis treatment regimens from wastewater treatment plants in Africa
REFNo: HS1017ES

Specific objectives
1. To determine the profile and concentration of antibiotics used in TB treatment in raw and treated sewage.
2. To investigate the efficiency of the WWTP treatment process in relation to removal of antibiotics post chlorination.
3. To determine the prevalence of antibiotic resistant bacteria (ARB) in raw and treated wastewater in these WWTPs.
4. To evaluate the prevalence of antibiotic resistance genes (ARGs) in raw and treated wastewater.

 Uganda 2021-02-08 2024-02-08 Medical and Health Sciences Non-degree Award
Francis Ssali
ID: UNCST-2021-R012134
 An open-label, roll-over study with rilpivirine in combination with a background regimen containing other antiretrovirals (ARVs) in human immunodeficiency virus type 1 (HIV-1) infected subjects who participated in rilpivirine pediatric studies
REFNo: HS1083ES

In view of the primary objective of the study to provide continued access to RPV, no primary endpoint is defined for this study.Secondary Endpoint
The secondary endpoints are applicable for all subjects until data collection is terminated, as indicated.
Major Secondary Endpoints
The proportion of subjects experiencing adverse events (AEs) considered to be at least possibly related to RPV, AEs leading to discontinuation, serious adverse events (SAEs), pregnancies, and grade 3/4 rash regardless of causality throughout the study. Results of routine safety laboratory tests will only be collected if related to these types of AEs.
Other Secondary Endpoint
The proportion of subjects maintaining viral suppression (ie, <50 HIV-1 RNA copies/mL) based on available viral load data throughout the study. In case of virologic failure, emergence of resistance will also be evaluated based on available genotype/phenotype data.


 Uganda 2021-02-08 2024-02-08 Medical and Health Sciences Non-degree Award
Jonathan Mwiindi Thuranira
ID:
EMERGENCY CESAREAN SECTION AND LENGTH OF STAY IN HOSPITALS IN UGANDA
REFNo: HS1093ES

1. To determine if payer-type (SAFE vs. self-pay) is associated with the decision to delivery interval (DDI) for rural Uganda women undergoing an emergency C-section in Nyakibale Hospital and Rushoroza Hospital. The DDI is the first phase of the aggregated LOS. 2. To determine if payer-type (SAFE vs. self-pay) is associated with the aggregate LOS for rural Uganda women undergoing an emergency C-section in Nyakibale Hospital and Rushoroza Hospital in rural Uganda while adjusting for the Decision to Delivery Interval (DDI). 3. To describe the experience of eight young mothers (aged 18-25) having their second (or more) C-Section delivered by emergency C-section in Southwest Uganda under the SAFE program during April 2020.
 Kenya 2021-02-08 2024-02-08 Medical and Health Sciences Degree Award
Bonaventure Ssebyanzi Wasswa
ID:
PRIMARY SCHOOL SUPPORT SYSTEMS TO DEAF CHILDREN LEADING TO THEIR TRANSITION TO POST-PRIMARY EDUCATION IN UGANDA
REFNo: SS590ES

(i) To investigate the support systems for deaf children at the completion of primary school studies.
(ii) To examine the situation of deaf children at the completion of primary studies.
(iii) To explore the self of deaf children at the completion of primary studies.
(iv) To establish the strategies for transition to post-primary level of deaf children at the completion of primary studies.

Uganda 2021-02-05 2024-02-05 Social Science and Humanities Degree Award
Alex Taremwa Taremwa
ID: UNCST-2020-R014302
 VIABILITY OF DIGITAL SUBSCRIPTION IN EAST AFRICA – AN ANALYSIS OF VIUSASA AND CHIMPREPORTS’ PAYWALLS
REFNo: SS629ES

1. To identify critical success factors for subscription-based models in digital media platforms.
2. To establish the barriers to subscription uptake among digital media in East Africa.
3. To assess the critical success factors against the ChimpReports and Viusasa’s strategies.
4. To analyse the consumption habits of audiences in line with payment for digital content on Viusasa and Chimp.

Uganda 2021-02-05 2024-02-05 Social Science and Humanities Degree Award
Joseph Lutaakome
ID: UNCST-2020-R008323
 An open-label, roll-over study with rilpivirine in combination with a background regimen containing other antiretrovirals (ARVs) in human immunodeficiency virus type 1 (HIV-1) infected subjects who participated in rilpivirine pediatric studies
REFNo: HS1013ES

Primary Endpoint
The primary objective of the study is to provide continued access to RPV, however there is no primary endpoint defined for this study.
Secondary Endpoint
The secondary endpoints are applicable for all subjects until data collection is terminated, as indicated.
Major Secondary Endpoints
The proportion of subjects experiencing adverse events (AEs) considered to be at least possibly related to RPV, AEs leading to discontinuation, serious adverse events (SAEs), pregnancies, and grade 3/4 rash regardless of causality throughout the study. Results of routine safety laboratory tests will only be collected if related to these types of AEs.
Other Secondary Endpoint
The proportion of subjects maintaining viral suppression (ie, <50 HIV-1 RNA copies/mL) based on available viral load data throughout the study. In case of virologic failure, emergence of resistance will also be evaluated based on available genotype/phenotype data.
 Uganda 2021-02-05 2024-02-05 Medical and Health Sciences Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
 Preparation of an Inactivated covid-19 vaccine at UVRI for pre-clinical evaluations at COVAB and an Outsourced primate centre
REFNo: HS1018ES

Collect nasopharyngeal swab of circulating virus strains b. Isolate local and globally representative wildtype SARS-CoV2 stocks c. Generate inactivated SARS-CoV-2 products (The Vaccine). d. Generate SARS-CoV-2 and other b-CoVs pseudovirus stocks
e. Develop assays to distinguish SARS-CoV-2 binding antibodies
f. Develop assays to distinguish SARS-CoV-2 functional neutralizing antibodies
g. Assess inactivated vaccine in Humanized ACE2 mice challenge models
h. Challenge Macaque models to assess safety, immunogenicity and protectiveness
i. Assess immunized mice for vaccine-induced antibody responses
j. Assess immunized mice for vaccine induced cellular responses
k. Assess immunized mice plasma for inflammatory responses
l. Immuno/histopathology of immunized mice organs/tissues
m. Train and develop capacity for skill transfer
The research questions are;
• Will the inactivated vaccine protect challenged mice against developing COVID-19
disease?
• Will the vaccine elicit potent neutralizing antibodies against diverse SARS-CoV-2
strains and how potent are these antibodies?
• Will the vaccine protect the challenged mice against severe inflammatory responses
and organ pathology?
• Will the inactivated vaccine elicit potent and protective effector T -Cell responses?
 Uganda 2021-02-05 2024-02-05 Medical and Health Sciences Non-degree Award
Athanansio Bashaija
ID:
Occupational Stress, Hope, and Alcohol Use among Secondary School Teachers in Greater Bushenyi, Uganda
REFNo: SS671ES

To examine the level of occupational stress among secondary school teachers in Greater Bushenyi.
To assess the level of alcohol use among secondary school teachers in Greater Bushenyi.
To examine the level of hope among secondary school teachers in Greater Bushenyi.
To determine the relationship between occupational stress and alcohol use among secondary school teachers in Greater Bushenyi.
To establish the moderation effect of hope on the relationship between occupational stress and alcohol use among secondary school teachers in Greater Bushenyi.

 Uganda 2021-02-05 2024-02-05 Social Science and Humanities Degree Award
Victor Musiime
ID: UNCST-2021-R013794
 A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease (IMR-SCD-301)
REFNo: HS1119ES

Primary Objectives:
1. To evaluate the HbF response to IMR-687 versus placebo
2. To evaluate the safety of IMR-687 versus placebo

Secondary Efficacy Objectives:
1. To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
2. To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
3. To evaluate the effect of IMR-687 versus placebo on indices of RBC adhesion
4. To evaluate the effect of IMR-687 versus placebo on the incidence of VOCs
5. To evaluate the effect of IMR-687 versus placebo on quality of life (QoL) measures

Pharmacokinetic Objectives:
To evaluate the PK of IMR-687 and any major circulating metabolites

Exploratory Efficacy Objectives:
1. To evaluate the effect of IMR-687 versus placebo on changes in RBC characteristics and total Hb
2. To evaluate the effect of IMR-687 versus placebo on renal function
3. To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk

Uganda 2021-02-05 2024-02-05 Medical and Health Sciences Non-degree Award
Sheila Balinda Nina
ID: UNCST-2021-R013804
 Novel Adenovirus-based Vaccine for Uganda SARS COV-2 viruses
REFNo: HS1153ES

To develop a Novel SARS-Cov-2 Adeno-Vectored Vaccine against COVID-19. Briefly, we propose two adenovirus vector constructs using both S1 and S2 SARS-CoV-2 glycoproteins previously generated for the subunit vaccine design at CoVAB. Alternatively, these genes can also be amplified directly from the genome at the UVRI laboratories. Although most of the world is focused on SARS-CoV-2 Spike as an antigen, there are additional viral capsid proteins that should also be considered including the Envelope and N proteins.
 Uganda 2021-02-05 2024-02-05 Medical and Health Sciences Non-degree Award
Kinyaa Rufina Ayia
ID:
Teachers use of formative assessment in teaching reading comprehension in transition class, Moyo Sub County, Moyo district.
REFNo: SS582ES

To investigate teachers’, use of formative assessment in teaching reading comprehension in the transition class.
> To examine the strategies teachers’, use for formative assessment in reading comprehension in the transition class.
> To establish the challenges teachers’ encounter when administering formative assessment in reading comprehension in the transition class

 Uganda 2021-02-04 2024-02-04 Social Science and Humanities Degree Award
AGNES NAGGIRINYA BWANIKA
ID: UNCST-2019-R001126
 DETERMINATION OF CROSS-SPECIES TRANSMISSION OF COVID-19 AT ANIMAL-HUMAN INTERFACE USING A ONE HEALTH APPROACH FOR IMPROVED DISEASE SURVEILLANCE AND CONTROL
REFNo: HS905ES

General Objectives
To assess existence of SARS-CoV-2 in domestic and wild animals (in Amuru/ Greater Rakai and UWEC) and corona virus antibody in humans (Amuru/ Greater Rakai) with no history of infection, using a one health approach.
Specific Objectives
• Assess prevalence of SARS-CoV-2 in wild, livestock and companion animals, which may act as reservoirs of the causative agent in areas with confirmed cases of COVID-19 in Uganda
• Assess prevalence of the virus-specific antibodies in humans with no known history of contact with confirmed COVID-19 cases
• To determine the genetic relatedness between the human virus isolates with those obtained from the animals in order to confirm cross-host species transmission in Amuru and Greater Rakai districts.

 Uganda 2021-02-04 2024-02-04 Medical and Health Sciences Non-degree Award
Caroline Delaire
ID:
Evaluating the potential of point-of-collection chlorination and village savings and loans associations to improve water safety management in rural Uganda
REFNo: SIR47ES

1. To evaluate the effectiveness of an inline handpump chlorinator (PurAll 50H) at improving water safety.
2. To understand the contexts that are favorable for bundling maintenance and chlorination, and the contexts where bundling is not appropriate.
3. To understand the contexts where VSLA-managed “water funds” are successful at increasing financial resources available for handpump maintenance, and the contexts where this strategy is less effective.

 France 2021-02-04 2024-02-04 Engineering and Technology Non-degree Award
Eve  Namisango
ID: UNCST-2021-R014038
 Health Systems Strengthening through person-centred care: development of a feasible and acceptable theory-based workforce approach to improve quality
REFNo: HS1000ES

i) To adapt the conceptual framework of person-centred care for serious illness (MONTHS 1-10).
ii) To determine professional views on the feasibility, acceptability and necessary requirements for health systems change to deliver person-centred and values-based care (MONTHS 11-12).
iii) To design a systems-oriented strategy to enhance the person-centredness of care based on evidence from objectives i+ii (MONTHS 13-16).
iv) To refine and determine psychometric properties of a brief measure of person-centredness for subsequent evaluation of the health systems strengthening strategy (MONTHS 17-24).

Uganda 2021-02-04 2024-02-04 Medical and Health Sciences Non-degree Award
Nathan Fiala
ID: UNCST-2022-R009060
 “An exploration of groundnut Seed Quality Along the distribution chain in Uganda.”
REFNo: A109ES

The general objective of this study is to conduct an analysis of seed quality along the supply chain of groundnuts in Uganda. The selected crop for this study is important and the seed system is largely informal. Groundnuts is nearly 100% self-pollinating (98-99%) and farmers keep the seeds often beyond the recommended replacement period.
 USA 2021-02-04 2024-02-04 Agricultural Sciences Non-degree Award
Aloysius Ssennyonjo Ssennyonjo
ID: UNCST-2021-R013504
 COVID-19 Lockdown in Slums Informal Urban Settlements: Social and- Health Effects, Coping Strategies and Lessons for Improving the Livelihood of the Urban Poor in Kisenyi, Kampala, Uganda
REFNo: HS887ES

General Objective
To explore the social and health effects of COVID-19 lockdown, coping strategies and lessons for improving the livelihood of the urban poor in Kisenyi, Kampala, Uganda
Specific Objectives

1. To assess the immediate health effects of COVID 19 lockdown among the urban poor in Kampala
2. To assess the immediate social effects of COVID 19 lockdown among the urban poor in Kampala
3. To explore how the urban poor households coped with selected effects of the COVID-19 lockdown
4. To explore lessons for mitigating the effects of COVID 19 lockdown in the immediate recovery phase and consider implications for long term programming for urban poor.

 Uganda 2021-02-02 2024-02-02 Medical and Health Sciences Non-degree Award
Julius Tumusiime
ID:
Dynamics of Snail Species and Interventions to Reduce associated Schistosoma and Fasciola Parasitic Infections: A Citizen Scientists’ approach in Western Uganda
REFNo: NS148ES

1. determining the diversity and spatial-temporal distribution of freshwater snail intermediate hosts of Schistosoma/Fasciola parasites.
2. evaluating the diversity of Schistosoma/Fasciola trematodes shed per snail host: comparison of traditional and molecular methods.
3. examining the biotic (macrophyte, vertebrate hosts) and abiotic (rainfall, pH, DO, EC, temperature, inorganic ions) factors that influence the occurrence of Schistosoma/Fasciola snail hosts.
4. assessing the dependability/reliability of citizen researchers’ malacological survey, snail species identification and disease risk hotspot identification.

Uganda 2021-01-29 2024-01-29 Natural Sciences Degree Award
Alex Saturday
ID: UNCST-2023-R007459
 INVESTIGATION OF SPATIO-TEMPORAL VARIATION IN BIOLOGICAL AND PHYSICO-CHEMICAL WATER QUALITY PARAMETERS IN LAKE BUNYONYI, SOUTH-WESTERN UGANDA
REFNo: NS149ES

i. To determine the Spatio-temporal variations of bacterial fecal indicators of water in Lake Bunyonyi.
ii. To assess the Spatio-temporal variations in phytoplankton composition and biomass in the water of Lake Bunyonyi.
iii. To determine the Spatio-temporal variations of physicochemical quality of water in Lake Bunyonyi.
iv. To examine the seasonal variations of the trophic state conditions of Lake Bunyonyi ecosystem
v. To investigate the processes that governs nutrient dynamics in Lake Bunyonyi ecosystem.

Uganda 2021-01-28 2024-01-28 Natural Sciences Degree Award
Emily Otali
ID:
A study of health and forage patterns of wild African honeybees (Apis mellifera scutellata) and their impact on the survival of Kibale National Park, its threatened chimpanzees and elephants.
REFNo: A82ES

The general objective for this study is to engage farmers and students living around Kibale National Park, Uganda, in an accessible and culturally relevant participatory science project that collects and analyzes data measuring colony health and foraging plants of wild African honeybees for a period of two years. This will be achieved through:
• Developing participatory science project appropriate for rural Ugandan farmers and partnering students.
• Establishing baseline colony health and forage patterns for the wild African honey bee in the Kibale National Park ecosystem.
• Determining if colony health and forage patterns for the wild African honey bee knowledge will help achieve maximum honey yields and increased forage diversity.

 Uganda 2021-01-28 2024-01-28 Agricultural Sciences Non-degree Award
Jackson Mukonzo
ID: UNCST-2021-R013916
 IDENTIFICATION, VALIDATION AND OPTIMIZATION OF AVAILABLE DRUG MOLECULES FOR CLINICAL TREATMENT OF COVID-19.-IVCOM
REFNo: HS1065ES

1. Explore the clinical use of combination anticoagulant: lower dose aspirin and ivermectin, an FDA-approved anti-parasitic drug therapy in treatment of COVID-19 patients in an exploratory randomized trial.
2. To identify target molecules through testing and screening for SARS-CoV-2 activity of existing substances, molecules or formulations on basis of registered activity claims or scientific evidence for anti- SARS-CoV-2 activity including herbal preparations, quinolone derivatives (chloroquine and hydroxyquinoline) in combination with zinc, HIV entry and protease inhibitors, HCV protease inhibitors and entry inhibitors as well as agents with inhibitory and down regulatory effect on ACE2 and those that might be identified thorough literature search.
3. Use bioinformatics tools to perform structural optimization of molecules identified in objective 2 above for efficacy and safety of COVID-19 patents and conduct early phase clinical trials on the resulting molecules.
Uganda 2021-01-28 2024-01-28 Medical and Health Sciences Non-degree Award
Alex Mabirizi
ID:
ASSESING THE EFFECT OF CONCURRENT VACCINE ADMINISTRATION FOR PESTE DES PETITS RUMINANTS, CAPRIPOX AND CONTAGIOUS CAPRINE PLEUROPNEUMONIA ON IMMUNITY OF SHEEP AND GOATS IN UGANDA
REFNo: A106ES

1. To determine antibody titres against PPR, CCPP and Capripox Virus following single and concurrent administration of two or three vaccines.
2. To determine cytokine responses to PPR, CCPP and Capripox Virus following single and concurrent administration of two or three vaccines.

Uganda 2021-01-28 2024-01-28 Agricultural Sciences Degree Award
faith mbabazi musinguzi
ID:
Role conflict and Burnout among university administrators in selected universities in Uganda
REFNo: SS552ES

4. To assess the influence of role conflict on burnout for administrators across universities.,3. To establish the administrators’ experience with role conflict and burnout among administrators.,2. 2. To examine the degree to which role conflict constructs predict burnout among non-academic administrators.,1.To establish the extent to which role conflict constructs predict burnout among academic administrators.,
 Uganda 2021-01-27 2024-01-27 Social Science and Humanities Degree Award
Ponsiano Ocama
ID: UNCST-2019-R000440
 Clinical and immunological impact of Schistosoma mansoni infection and treatment on the course of chronic hepatitis B virus (HBV) infection in HIVuninfected patients in Uganda
REFNo: HS1002ES

To determine Clinical and immunological impact of Schistosoma mansoni (Sm) infection and treatment on the course of chronic hepatitis B virus (HBV) infection in Uganda. This will be done through the following aims: Aim 1: To define and quantify Sm infection, treatment response, and reinfection rates within a cohort of chronic HBV patients Aim 2: To determine the impact of Sm infection and treatment on HBV virological markers, disease stage, and longer-term progression among urban Ugandans Aim3: To determine if HBV-specific immunological responses in the periphery and within the liver are altered in response to Sm infection and treatment

Uganda 2021-01-27 2024-01-27 Medical and Health Sciences Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
 Understanding CIN2+ among HIV infected women after LEEP: An epidemiological and immunohistochemical study
REFNo: HS1154ES

1. To assess the incidence and risk factors for “recurrent” CIN2/3 after LEEP among HIV- infected women.
2. To determine baseline HR-HPV types (in tissue) among HIV-infected women with CIN2/3 undergoing LEEP compared to the HR-HPV types with “recurrent” cervical lesions after a second LEEP.
3. To determine the immunohistochemical differences between the initial and repeat LEEP specimens among HIV-infected women with “recurrent” CIN2/3

 Uganda 2021-01-27 2024-01-27 Medical and Health Sciences Non-degree Award
Edward Nsubuga
ID:
Work place violence and interventions used at mental health units in uganda
REFNo: HS435ES

Identifying the patterns of workplace violence,contributing factors ,and remedial interventions available in place for such victims.
 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Joseph Kagaayi
ID: UNCST-2024-R015946
 Hard to reach populations in Uganda; An observational cohort study
REFNo: HS607ES

Aim 1-We will first determine CHP coverage and HIV incidence among hard-to-reach persons using enhanced surveillance techniques.

Aim 2-We will then characterize ongoing sources of incident HIV infection through partner tracing of newly HIV-infected participants and matched HIV-negative controls, viral phylogenetics, and sexual network analyses.

Aim 3-Finally, we will determine if state-of-the-art CHP can engage hard-to-reach populations and reduce population-level HIV incidence to a level sufficient for HIV elimination by 2030.



Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Evaluation of impact of National Research Information Management System on the research regulatory process in Uganda
REFNo: HS906ES

The general objective of this proposal is to determine the usage of NRIMS as well as evaluate the experiences and attitudes of users of the systems at Makerere University, Mulago Hospital and UCI RECs.
2.1.1 Primary Objective
1. To determine the turnaround time between submission of protocols to review and approval, and time to receipt of feedback from REC for one year before and one year after roll out of NRIMS for RECs in Makerere Hospital Complex and UCI
2.1.2 Secondary Objectives
1. To qualitatively document and compare stakeholders’ experiences regarding use of the paper based and the NRIMS for research protocol review and approval in Makerere University, Mulago Hospital complex and UCI at start of roll out and one year after of roll out.
Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
RACHEAL ALINAITWE
ID: UNCST-2020-R014509
 The feasibility of involving Village Health Team Members in identifying and referring older persons with cognitive impairment in Wakiso District, Uganda.
REFNo: HS988ES

1. To assess the feasibility of involving Village Health Team Members in identifying older persons with cognitive impairment in Wakiso district, Uganda.
2. To assess the feasibility of involving Village Health Team members in referring older persons with cognitive impairment to health centre III for care in Wakiso district, Uganda.

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Juliana Namutundu
ID:
DEVELOPMENT AND VALIDATION OF A CERVICAL CANCER RISK SCORING SYSTEM FOR PREDICTING CERVICAL CANCER AMONG UGANDAN WOMEN AGED 25-49 YEARS
REFNo: HS1043ES

1) To develop a cervical cancer risk scoring system for Ugandan women based on major sexual, behavioral, and reproductive risk factors.
2) To validate a cervical cancer risk scoring system for Ugandan women based on major sexual, behavioral, and reproductive risk factors.

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Patrick Tumusiime Kagurusi
ID:
Documenting lived experiences of youth in Sub Saharan Africa during the covid-19 pandemic: implications for policy and program considerations
REFNo: SS650ES

General Objective
To document the lived experiences of youth in Sub Saharan Africa and programmatic considerations for their health and well-being in the wake of the COVID-19 pandemic.
Specific Objectives:
1. To document the lived experiences of the youth in Sub Saharan Africa across health and socio-economic tiers during the COVID-19 pandemic
2. To document coping strategies by the youth on health and socio-economic effects during the COVID-19 pandemic
3. To assess how the coping strategies employed help youth navigate the health and socio-economic effects of the pandemic.
4. To document recommendations that can mitigate health and socio-economic effects of the pandemic for future policies and programmes targeting the youth
 Uganda 2021-01-25 2024-01-25 Social Science and Humanities Non-degree Award
GRACE NAMBATYA KYEYUNE
ID:
A Phase IIa randomized double-blind, placebo-controlled clinical trial to determine the preliminary safety and efficacy of UBV-01N in adult patients infected with SARS-COV-2 (COVID-19) in Kampala, Uganda.
REFNo: HS1207ES

a) To evaluate the preliminary safety and of UBV-01N, in adult patients diagnosed with COVID-19 and treated with UBV-01N
b) To assess the preliminary efficacy of UBV-01N + standard of care, compared to UBV-01N placebo + standard of care, in adult patients diagnosed with COVID-19, in Kampala, Uganda.

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Ruth Namazzi
ID: UNCST-2020-R014305
 Health-related Quality of Life (HRQoL) of Ugandan children with Sickle Cell Disease (SCD): A comparative study of HRQoL outcomes in the Zinc for Infection Prevention (ZIPS) trial and at the Nalufenya Sickle Cell Clinic (NSCC)
REFNo: HS1069ES

This proposal is designed as a sub-study nested within the ‘Zinc for Infection Prevention in Sickle cell anemia (ZIPS) trial, and has 3 specific aims –

Aim 1: To determine, using a SCD-specific testing instrument, if HRQoL outcomes of children with SCD enrolled in a clinical trial (ZIPS) differ from children with SCD who receive standard of care at the Nalufenya Sickle Cell Clinic (NSCC) in Jinja, Uganda

Aim 2: To determine, using an SCD-specific testing instrument, if HRQoL of children with SCD in the ZIPS study differs between those on zinc supplementation vs. those on placebo

Aim 3: To document caregiver perceptions regarding factors influencing HRQoL of children with SCD in the ZIPS study (those on zinc supplementation vs. those on placebo) and those receiving standard of care at the Nalufenya Sickle Cell Clinic (NSCC) in Jinja, Uganda

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
 Evaluating the effect of private provider engagement on access to TB screening and diagnostic services in two large urban districts in Uganda: an observational study.
REFNo: HS1106ES

The overall aim of this study is to determine the effect of private health providers on access to TB diagnostic services in two large urban cities in Uganda.

The primary objective will be to:
1. To examine the effect of community pharmacies’ engagement on a) time to TB treatment and b) costs incurred while seeking care for TB by patients with bacteriologically confirmed TB in the PRES project in Kampala and Wakiso

The secondary objectives will be to
2. To understand community pharmacies’ perspectives towards provision of TB screening services and linkage to treatment.
3. To identity other infectious causes of cough among patients who are screened for TB at community pharmacies

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
JUSTINE NAMWAGALA MUKOSE
ID:
Explorative investigation of the burden and risk factors of uvula infections and associated traditional uvulectomy practices in Luwero district and surrounding areas
REFNo: HS1167ES

OBJECTIVES


The overarching objective of this explorative research study is to investigate and document, in a scientifically sound manner, the condition called “akamiro”; determine the case definition, describe its general epidemiology including the beliefs and perceptions around it and the traditional surgical procedure, and commence etiological investigations.


Our proposed specific objectives are;

1. To determine the clinical case definition of the uvula infections called “akamiro” – general and age-specific case definitions for infants, children, adolescents and adults.
2. To investigate major risk factors of uvula infections /“akamiro”.
3. To determine the magnitude and associated factors of uvula infections /“akamiro”, and geo-map its spread.
4. To determine the prevalence of traditional uvulectomy and its outcomes and sequelae.

5. To establish the community beliefs, perceptions and practices associated with “akamiro”.

 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Munshi Sulaiman
ID:
Women’s Leadership in Village Savings and Loan Associations (VSLAs) in Uganda
REFNo: SS685ES

The research has two key objectives. The first is to understand the current starus and barriers of women to take leadership roles in VSLA committees. The second objective is to identify possible interventions that can strengthen their leadership roles.
Bangladesh 2021-01-25 2024-01-25 Social Science and Humanities Non-degree Award
Janet SEELEY
ID:
The direct and indirect effects of HIV/AIDS on the Health and wellbeing of older people. Wave 5 Study protocol
REFNo: SS696ES

The aim of the study is to describe longitudinally the survival, health and wellbeing of older people who are directly and indirectly affected by HIV and AIDS, with special attention to the effects of the introduction of ART. In addition, we aim to investigate the impact of the COVID-19 pandemic on health and wellbeing of WOPS participants

Specific objectives

1. To describe the effects of HIV and HIV treatment on the (physical and mental) health and wellbeing of older people
2. To determine the effects of HIV in older people especially older women on their social situation, with special focus on care giving.
3. Document some of the biomarkers associated with chronic inflammation and immune function in the ageing process
4. To document the causes and risk factors for mortality among older people with and without HIV in Uganda.
5. To document the patterns of multimorbidity in older people with and without HIV in Uganda
6. Investigate the impact of the COVID-19 pandemic and the lockdown on the WOPS participants


 UK 2021-01-25 2024-01-25 Social Science and Humanities Non-degree Award
Gloria Nakato Valentine
ID:
Developing and deploying aflatoxin biological control products for integrated aflatoxin management in Uganda and making it accessible through private sector engagement
REFNo: A114ES

Obj. 1: Develop, validate, and register at least one biocontrol product (Aflasafe) for aflatoxin management in maize, sorghum and groundnut.
Obj. 2: Create awareness among stakeholders (e.g., farmers, traders, consumers) along the maize, sorghum, and groundnut value chains of the health and trade impacts of aflatoxins, and to improve knowledge and use of strategies for mitigating aflatoxin that are centered on pre-harvest use of biocontrol products, best agricultural and post-harvest management practices.
Obj. 3: Develop and implement a strategy for commercializing Aflasafe to ensure wide distribution and availability to stakeholders through private sector engagement.

 2021-01-25 2024-01-25 Agricultural Sciences Non-degree Award
Denis Muhangi
ID: UNCST-2020-R014258
 Social – Behavioral / Anthropological Study on COVID-19 in Uganda
REFNo: SS700ES

The overall objective of this anthropological study is to generate evidence-based insights on why people behave the way they do in response to COVID-19 and the recommended preventive measures; and to provide recommendations on potential approaches that are culturally and socially acceptable that can be applied to improve compliance and enhance adoption of sustainable behavior change across different groups and the general public in Uganda.

The specific Objectives are:

To assess the extent and how different sections of the population adhere to / comply with the set of desired behaviors / practices as recommended by Government.

To establish trends in behaviour change since the beginning of the COVID-19 crisis.

To establish why people behave the way they do, taking into account the different target groups (individual or group), differences in culture and the immediate context (social economic and structural factors).

To assess the changing community dynamics and the effect of the COVID-19 measures on individual and communal norms that have a bearing on COVID-19 transmission such as - mass gatherings in school set-ups, religious, social and cultural congregations e.g., entertainment, weddings and burial practices.

To establish what each target group thinks would be the prerequisites to protect themselves from COVID-19.

To identify potential culturally and socially acceptable approaches/solutions to health problems which can be applied to improve compliance and enhance adoption of sustainable behavior change - across different groups.
 Uganda 2021-01-25 2024-01-25 Social Science and Humanities Non-degree Award
Innocent Besigye Kabahena
ID: UNCST-2019-R001025
 Evaluating the use of the primary care assessment tool to improve primary care performance in Tororo District, Uganda
REFNo: HS1174ES

1. To adapt and validate the patients'. managers' and health care providers' primary care assessment tools.
2. To measure primary care performance using adapted and validated PCAT tools.
3. To evaluate the implementation of the designed intervention to improve primary care performance.
 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Degree Award
Eddy Walakira Joshua
ID: UNCST-2022-R009077
 Uganda Commercial Sex Exploitation of Children
REFNo: SS724ES

1) Estimate the prevalence of children at of, and engaged in commercial sex exploitation in Karamoja

2) Estimate the proportion of children in Kampala involved in commercial sex exploitation

3) Measure Knowledge, attitudes and practices around CSEC in Karamoja
 Uganda 2021-01-25 2024-01-25 Social Science and Humanities Non-degree Award
Evelyn Avalos
ID:
The impact of protracted refugee displacement and disrupted intergenerational relations on the secure and healthy futures of older people in Uganda
REFNo: SS462ES

-To identify later-life forcibly displaced survival strategies/sustainable livelihoods in a context of family separation
- To understand who covers the needs of aged refugees and to what extent they are covered. Specifically when family relationships and State's social security are disrupted
- To explain the role of place in shaping lives and ageing experiences of aged refugees
-To discover how later-life identities and attachments could be shaped at different social and spatial scales
 El Salvador 2021-01-22 2024-01-22 Social Science and Humanities Non-Clinical Trial Degree Award
Sona Shah
ID:
Adoption of a wireless vital sign monitor for observation of COVID-19 patients
REFNo: HS733ES

1. To evaluate the feasibility of a wireless vital sign monitor for use on critical patients in COVID-19 treatment facilities
2. To assess the accuracy of a wireless vital sign monitor (neoGuard) on adult patients
 USA 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Christine Nalwadda Kayemba
ID: UNCST-2020-R014220
 Understanding Leadership and Accountability mechanisms in delivering a responsive Maternal and Newborn care in a decentralized health system, Uganda: Lessons for SRHS improvement
REFNo: HS1024ES

Broad objective:

The main objective of this study is to assess leadership and accountability mechanisms for maternal and newborn health in decentralized health systems in Uganda in order to formulate a theory of change for delivering an efficient health services for maternal and newborn health


Specific Objective:

1.Review existing health systems policies in order to highlight leadership and accountability guidelines/policies for maternal and newborn health
2.Explore health systems managers’ understanding and interpretation of leadership and accountability guidelines/policy directives for maternal and newborn health
3.Describe how decentralized health systems managers adapt and implement leadership and accountability policies in maternal and newborn health

 Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Warren Phipps
ID:
Attitudes and Practices of Antimicrobial Resistance and Stewardship at the Uganda Cancer Institute
REFNo: HS871ES

We will investigate the knowledge, attitudes, and practices about antimicrobial use and antimicrobial resistance among the doctors (including medical officers, fellows, oncologists, and surgeons), nurses, and pharmacists at the Uganda Cancer Institute (UCI).

The aims of the study are;
Aim 1: To examine the current knowledge and attitudes of UCI healthcare providers towards antimicrobial resistance.
Aim 2: To determine the current knowledge and attitudes of UCI healthcare providers towards antimicrobial stewardship.
Aim 3: To understand perceived barriers to the diagnosis and management of infections in patients at UCI

USA 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
 Characterising the Global Immune Response to SARS-CoV-2 in COVID-19 Acutely Infected and Recovered Ugandans
REFNo: HS997ES

To describe the frequencies and phenotypes of SARS-CoV2 induced immune
responses in qrt-PCR COVID-19 confirmed Ugandan cases.
b) To describe the evolution and durability of the induced responses.
c) To describe factors associated with COVID-19 disease outcome.
d) To isolate and clone SARS-CoV-2 spike specific human monoclonal antibodies with
potent virus neutralising capabilities
 Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
David Musoke
ID:
A feasibility study for a randomised controlled trial on integrated malaria prevention in Wakiso district, Uganda
REFNo: HS999ES

1. To explore community willingness to participate in an RCT on integrated malaria prevention.
2. To assess stakeholder perspectives on the RCT on integrated malaria prevention.

Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
David Musoke
ID:
Use of Photovoice to explore community members perspectives on health and healthcare challenges in Mukono District, Uganda
REFNo: HS1058ES

To use photovoice as a community-based participatory research method to explore healthcare delivery including barriers and challenges in Mukono district so as to provide information to inform future research and interventions to improve health of the community.
Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
ALEX NDYABAKIRA
ID:
Durability monitoring of Long Lasting Insecticidal Nets in Uganda, distributed during the 2020 mass campaign
REFNo: HS1109ES

Primary objective
1.To assess the physical durability of 5 different brands of nets over a three-year period, estimate median LLIN survival and identify major determinants of field performance
Secondary objectives
1. To describe major behavioral aspects of net care and repair and their impact on physical durability
2. To assess the insecticidal effectiveness (bio-efficacy) and chemical residue of 5 ITN brands during three years of field use

 Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
 Clinical manifestations and Outcomes of SARS-CoV-2 Infection in pregnancy in Africa: Novel Insights from the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa and Uganda (AFRE-Mom-CoV-19) protocol
REFNo: HS1164ES

To retrospectively investigate the socio-demographic and clinical characteristics and maternal/infant outcomes of pregnant patients with RT-PCR-confirmed SARS‐CoV‐2 infection in six west, east, central and southern African countries: DRC, Ghana, Kenya, Nigeria, South Africa and Uganda.
Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Amon Nuwahereza
ID: UNCST-2022-R011428
 Ride and Arrive Safe (RAS). A Case study of Mbarara Municipality
REFNo: HS577ES

i. To explore the feasibility of the community facilitation and engagement approach in equipping the Boda-boda cyclists with safety riding knowledge and skills.
ii. To develop a Boda-boda safety user check the mobile application for passengers using Boda-boda a means of transport
iii. To evaluate the effect of Boda-boda cyclist training and community engagement in reducing the number of Boda-boda road traffic accident-related admissions at Mbarara Regional Referral Hospital.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Denis  Bwayo
ID:
Program Assessment and Implementation Learning for the University Research Co., LLC - Department of Defense HIV Prevention Program – Uganda
REFNo: HS959ES

1.To determine compliance to program set targets for the URC-DHAPP program between October 2018 and September 2021
2.To assess the quality of HIV services delivered at 28 UPDF HIV clinics
3.To determine program outcomes across key program implementation strands in line with 95:95:95 frameworks
4.To share implementation experiences across key program implementation strands including HIV testing, ART services, TB diagnosis and management, PMTCT, OVC and systems strengthening.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 ENHANCED ENTOMOLOGICAL SURVEILLANCE(EES) TO INFORM MALARIA CONTROL IN UGANDA
REFNo: HS1059ES

1. To examine the impact of current vector control interventions on malaria vector densities, vector behaviour, and species composition.
2. To monitor the status and intensity of insecticide resistance.
3. To establish the entomological inoculation rates in the selected districts.
4. To build the capacity of districts to conduct routine entomological surveillance

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
 Manifestations and Outcomes of Hospitalized African children and Adolescents with SARS-CoV-2 Infection: Insights from the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa and Uganda (AFRE-Ped-CoV-19) protocol Version November 06 2020. Grant No. 1R25TW011217-01
REFNo: HS1168ES

Study Aims

a) To describe the socio-demographic features; clinical WHO COVID-19 staging at admission, clinical characteristics, laboratory features including inflammatory and
cardiac markers; imaging investigations and associated abnormalities, treatments applied; and comparisons within and across participating African countries.
b) To estimate the prevalence of comorbidities at presentation and recent/current treatment with immunosuppressive drugs and comparisons within and across
participating African countries.
c) To estimate the prevalence of associated tuberculosis (past, current), HIV status (HIV-exposed uninfected or HIV-infected, and type of treatment if HIV-infected), malaria, bacterial infections influenza and other viral infections and comparisons within and
across participating African countries.
d) To assess overall mortality and independent factors associated with mortality and comparisons within and across participating African countries.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Grace Ndeezi
ID: UNCST-2019-R001802
 A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease IMR-SCD-301
REFNo: HS1130ES

Primary Objectives
To evaluate the HbF response to IMR-687 versus placebo
To evaluate the safety of IMR-687 versus placebo
Secondary Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
To evaluate the effect of IMR-687 versus placebo on indices of WBC adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of VOCs
To evaluate the effect of IMR-687 versus placebo on quality of life (QoL) measures

Pharmacokinetic Objectives
To evaluate the PK of IMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in RBC characteristics and total Hb
To evaluate the effect of IMR-687 versus placebo on renal function
To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk

Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
FRED SEMITALA COLLINS
ID: UNCST-2020-R014096
 Strengthening Integrated Screening for TB and COVID19 in Kampala, Uganda
REFNo: HS1152ES

The overall goal is to establish the acceptability, feasibility and potential for scaling up the use of COVID19-TB Screening algorithm at Kiruddu National Referral Hospital.
Specific objectives

(1) To explore the perspectives of healthcare providers on the integration of COVID19 and TB screening at Kiruddu National referral Hospital.
(2) To determine the effect of the COVID19-TB algorithm on the proportion of patients screened for TB at Kiruddu National Referral Hospital over a 4-month period.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Kirsten Beyer M
ID: UNCST-2021-R013472
 Assessing Health Professionals’ Knowledge, Perspectives and Practices Regarding HPV and Cervical Cancer Prevention and Control among Women Living with Human Immunodeficiency Virus Infection in Uganda
REFNo: HS782ES

General Objective The proposed study seeks to examine the role that health professionals play in influencing WHIVs’ perceptions of HPV and cervical cancer and their associated health behaviors in Uganda.

Specific Objective
Interview public health and health care professionals (including clinicians, nurses, counselors, other/public health professionals, and community health workers/village health teams) to examine the following:
1. Knowledge regarding how HPV or cervical cancer impacts WHIV, which populations are impacted most, and frequency of HPV vaccination, screening and treatment. 2. Perspectives regarding barriers/facilitators of cervical cancer and HPV prevention and treatment among WHIV. 3. Practices regarding HIV professionals’ work in cervical cancer and HPV.
USA 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Emmanuel Sendaula
ID: UNCST-2020-R014767
 Clinical profile of HIV-infected patients receiving a holistic approach of care model attending Reach Out Mbuya facilities in Kampala district
REFNo: HS903ES

Main Objective

To describe the clinical profile and the factors associated with viral suppression status among HIV-infected patients receiving a holistic approach of care model in Kampala District.
Specific objectives

1. To describe the clinical profile of HIV-infected patients receiving a holistic model of care in Kampala District.
2. To determine the socio-demographic factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.
3. To determine the clinical factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
FRANK MULINDWA
ID:
Glucose metabolism changes in HIV patients starting dolutegravir based antiretroviral treatment in Uganda
REFNo: HS1032ES

1) To determine the incidence and predictors of diabetes at week 48 in Ugandan HIV patients initiating dolutegravir.
2) To describe temporal changes in insulin resistance, pancreatic beta cell function, body mass index and blood glucose in Ugandan HIV patients on dolutegravir for 48 weeks.
3) To determine the effect of DTG on intracellular magnesium levels in Ugandan HIV patients on dolutegravir for 48 weeks.
4) To compare insulin kinetics in patients who develop diabetes while on dolutegravir and those that don’t in Ugandan HIV patients.
5) To determine the difference in DTG pharmacokinetics in HIV positive patients with incident hyperglycemia and those without in Ugandan HIV patients.

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Proscovia Nabunya
ID: UNCST-2019-R000970
 SAY NO TO STIGMA”: Making Mental Health Visible Among School-Going Children in Rural Uganda
REFNo: SS637ES

The objective of this proposed study is to develop a set of new age-appropriate, culturally relevant signage and messaging around mental health and stigma for this study. The visual solutions will be developed through a set of extensive hands-on creative workshops and focus groups with children as well as school administrators and teachers working in one primary school in the Masaka region of Uganda. After visual and message development, the visuals will be presented to a different group of students within the school to gather feedback on their effectiveness and clarity in portraying mental health and stigma.
 Uganda 2021-01-20 2024-01-20 Social Science and Humanities Non-degree Award
Polycarp Komakech
ID:
Incentivizing Action to Reduce Air Pollution and Susceptibility to COVID-19
REFNo: SS667ES

The main objective is to investigate a number of practical and scalable strategies to reduce waste burning through voluntary behavioral change and thereby reduce the exposure of residents to harmful air pollution. The specific objectives are (a) to investigate whether the provision of information about the link between air pollution and the chances of contracting and dying from COVID-19 can spur action to stop waste burning, (b) to test the efficacy of a novel design where social competition that is not imposed top-down but is organized horizontally can help leaders to organize communities for positive action towards reducing waste burning.
Uganda 2021-01-20 2024-01-20 Social Science and Humanities Non-degree Award
SHAFIC MAKUMBI
ID:
Voluntary Consent to Research on Children: A sub-study of the CHAPAS-4 and ODYSSEY Trial
REFNo: SS677ES

1.2 Overall objective
The aim of this study is to assess parental perception of voluntariness of consent in Paediatric HIV clinical trials and associated factors.

1.4 Specific objectives
1.4.1. To describe the process in which parents and guardians consent for their children to be enrolled in two pediatric HIV Clinical Trials.
1.4.2. To measure the level of perceived voluntariness of consent using the voluntariness ladder
1.4.3. To identify the social demographic, situational and external control factors that influence parental perception of the voluntariness of their consent

 Uganda 2021-01-20 2024-01-20 Social Science and Humanities Degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 Impact of Masks on Community Spread of COVID-19: Evidence from Uganda
REFNo: HS1124ES

2.1 General Objective

The aim of this study is to provide policy makers with the first population-based estimate of the extent to which face coverings reduce the spread of SARS-CoV-2. We also intend to provide evidence to the Ministry of Health in Uganda (and public health officials more generally) with evidence about effective communication and education tools for increasing the proper use of masks in the general population.


2.2 Specific Aims

The specific objectives of our study are as follows:

Aim 1: To test whether free mask distribution increases the proper use of masks in intervention communities
Aim 2: To test whether combining free mask distribution with education and communication about masks and COVID-19 increases the proper use of masks in intervention communities Aim 3: To evaluate whether increased mask use affects seroprevalence of SARS-CoV-2
Aim 4: To evaluate potential spillovers, or whether higher mask use in intervention communities affect mask use and probability of infection in neighboring non-intervention communities

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 COVID-19 sydromic and sero-surveillance using established Uganda malaria surveillance sites.
REFNo: HS1125ES

To establish COVID-19 syndromic surveillance through existing Uganda Malaria Surveillance sites by collecting additional data on COVID-19 specific symptoms.

To perform enhanced surveillance for COVID-19 and assess for serological evidence of past infection with SARS-CoV-2 in patients, in order to estimate disease burden and map the geographic spread of the epidemic.

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Edgar Agaba
ID:
One Nutrition in Complex Environments (ONCE), a cluster-randomized trial of nutrition education and access to simple supportive technologies in improving agricultural practices and water quality management
REFNo: HS492ES

Aim 1: Implement and test a social and behavior change (NIPP) program alone (free-standing) and in combination with a “value-added” approach (NIPP+). The latter includes access to innovative low-cost tools and technologies relating to WASH and agriculture.

Aim 2: Identify best-practices emerging from the implementation of both approaches through process and program monitoring for effective integration, implementation, scale-up, and uptake of multi-sectoral and multi-level packages in complex environments to ascertain potential for scale up.

Aim 3: Study the sustained impact of the NIPP approach and the “value added” package (NIPP+) on knowledge and practices by gender within participating households, environmental risk factors, child health and nutritional status through a rigorous impact evaluation and longitudinal monitoring system.
 Uganda 2021-01-12 2024-01-12 Medical and Health Sciences Non-degree Award
Henry Ddungu
ID: UNCST-2019-R000966
 A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease.
REFNo: HS1078ES

Primary Objectives:
(a)To evaluate the fetal hemoglobin (HbF) response to IMR-687 versus placebo
(b)To evaluate the safety of IMR-687 versus placebo.
Secondary Efficacy Objectives
(a)To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
(b)To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
(c)To evaluate the effect of IMR-687 versus placebo on indices of white blood cell (WBC)
adhesion
(d)To evaluate the effect of IMR-687 versus placebo on the incidence of vaso-occlusive crises(VOCs)
(e)To evaluate the effect of IMR-687 versus placebo on quality of life measures

Pharmacokinetic Objectives
(i)To evaluate the PK of IMR-687 and any major circulating metabolites

Exploratory Efficacy Objectives
(ii)To evaluate the effect of IMR-687 versus placebo on changes in red blood cell (RBC)
characteristics and total Hb
(iii)To evaluate the effect of IMR-687 versus placebo on renal function
(iv)To evaluate the effect of IMR-687 versus placebo on indices associated with
cardiovascular pathophysiology and ischemic stroke risk.
 Uganda 2021-01-12 2024-01-12 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 Impact of long-lasting insecticidal nets (LLINs) treated with pyrethroid plus pyriproxyfen vs LLINs treated with pyrethroid plus piperonyl butoxide on malaria incidence in Uganda: a cluster-randomised trial
REFNo: HS1097ES

Primary Objective:
To evaluate the impact of LLINs treated with a pyrethroid insecticide plus pyriproxyfen (PPF LLINs), as compared to LLINs treated with a pyrethroid plus piperonyl butoxide (PBO LLINs), on malaria incidence in Uganda. We will test the hypothesis that malaria incidence will be lower in intervention clusters (randomised to receive PPF LLINs) than in control clusters (randomised to receive PBO LLINs).

Secondary Objectives:
To evaluate the impact of PPF LLINs vs PBO LLINs on parasite prevalence, anaemia, and vector density.
To estimate the cost-effectiveness of delivering PPF LLINs, as compared to PBO LLINs
To assess net durability, survivorship and use of PPF LLINs vs PBO LLINs.

Uganda 2021-01-11 2024-01-11 Medical and Health Sciences Non-degree Award
Robert Opika Opoka
ID: UNCST-2021-R014036
 The Influence of Comprehensive Follow-Up in Pediatric Sickle Cell Disease in an African Setting: a retrospective cohort Study
REFNo: HS636ES

General Objectives: To compare a set of sickle cell-related outcomes (mortality, stroke, blood transfusions, and hospitalizations) between children with SCA on a comprehensive follow up schedule under clinical trials setting and that of a cohort of children with SCA receiving routine care at a specialized sickle cell clinic.


Primary Objective: To compare sickle cell-related outcomes in the NOHARM children who were on the placebo arm to those of children of similar age group from the MHSCC who fulfilled the inclusion criteria for the NOHARM study at the time the study was recruiting patients but who were not enrolled.

Secondary Objectives: To assess the added effect of hydroxyurea therapy (in addition to comprehensive follow up schedule) on sickle cell-related outcomes. This shall be done by comparing sickle cell related outcomes in
1) NOHARM children randomized to hydroxyurea arm and that of the cohort of non-study MHSCC children with SCA over the time period of the NOHARM study (calendar years 2015-17).
2) NOHARM children on the MTD dose of hydroxyurea to that of the cohort of non-study MHSCC children with SCA over the time period of the MTD study (calendar years 2018-19).

 Uganda 2021-01-08 2024-01-08 Medical and Health Sciences Non-degree Award
JANE  BWIRUKA FRIDA
ID:
Student teachers Narratives on Pedagogical Practices that inform their Competences at Makerere University, Uganda
REFNo: SS518ES

1)Explore the narratives of student teachers on teaching practices that inform their competences at Makerere University.
2)Explore the narratives of student teachers on mentoring practices that inform their competences at Makerere University.
3)Explore the narratives of student teachers on supervision practices that inform their competences at Makerere University.
 Uganda 2021-01-08 2024-01-08 Social Science and Humanities Degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
 Using new genomic approaches to investigate causes of maternal sepsis among women delivering in sub-Saharan Africa
REFNo: HS969ES

Primary objectives
1)To compare the pathogen profiles using routine microbiology (blood cultures, urinalysis, malaria tests, complete blood count) among women with fever at delivery and those without fever at KNRH
2)To compare the prevalence of Streptococcus agalactiae in placental samples using qPCR among women with fever at delivery and those without fever at KNRH

Secondary objectives
1)To compare the composition and diversity of the nasal and ano-vaginal microbiota among women with fever at delivery and those without fever at KNRH
2)To compare the composition and diversity of the nasal and ano-vaginal microbiota among newborns of women with fever at delivery and the newborns of those without fever at KNRH
3)To compare the single-cell RNA-seq transcriptome of the placentae of women with placental malaria and those without placental malaria at Kawempe National Referral Hospital (KNRH).


 Uganda 2021-01-08 2024-01-08 Medical and Health Sciences Non-degree Award
Moreen Kiiza
ID:
The Right to Rehabilitation for the Survivors of Torture: A Case Study of Urban Refugees in Katwe-Kinyolo, Kampala-Uganda
REFNo: SS630ES

1. To assess the adequacy of the legal and policy framework governing rehabilitation for refugee survivors of torture in Uganda.
2. To ascertain the rehabilitation needs of refugee survivors of torture in Uganda.
3. To establish the adequacy of available mechanisms for the rehabilitation of refugee survivors of torture in Uganda.
4. To establish the challenges to the rehabilitation of refugee survivors of torture in Uganda.

 Uganda 2021-01-08 2024-01-08 Social Science and Humanities Degree Award
VICTOR BEWAYO
ID: UNCST-2024-R003092
 ASSESSMENT OF THE LEVEL OF REPORTING ADVERSE DRUG REACTIONS AND ASSOCIATED FACTORS AMONG HEALTH CARE PROFESSIONALS IN COMMUNITY PHARMACY PRACTICE IN KAMPALA CITY, UGANDA
REFNo: HS956ES

1. To establish the proportion of community pharmacy staff that have reported an ADR in the past one year in Kampala City
2. To identify the factors associated with ADR reporting among community pharmacy staff in Kampala City

 Uganda 2021-01-07 2024-01-07 Medical and Health Sciences Degree Award
Erica Harrison
ID:
COVID-19 VACCINE UPTAKE STUDY IN UGANDA
REFNo: SS661ES

Research Questions
What is the public’s knowledge, attitude and perceptions towards COVID-19 vaccine in Africa?
Is there an association between the public perception of COVID-19 vaccine and background vaccine confidence and hesitancy levels.

Specific Objectives
Examine the public’s knowledge of COVID-19 and a future COVID-19 vaccine.
Assess the public’s background vaccine confidence and hesitancy levels.
Assess the public’s perceived risks/benefits of a future COVID-19 vaccine.
Determine the willingness of the public to accept and or recommend a future COVID-19 vaccine.
Examine the influence of the knowledge and perceptions of COVID-19 vaccine on the expected uptake of a potential vaccine.
Examine the public’s handling of COVID-19 related rumors.

 UK 2021-01-07 2024-01-07 Social Science and Humanities Non-degree Award
Mariam Namasaba
ID:
A school-based resilience training program for caretakers of children with disabilities in Uganda: a cluster-randomized controlled study
REFNo: HS1027ES

To examine the impact of a resilience training program on the mental well-being and coping strategies of caretakers of CWDs in schools in Uganda.

To assess the impact of a resilience training program on the sense of self-efficacy of school caretakers of CWDs in schools in Uganda.
 Uganda 2021-01-06 2024-01-06 Medical and Health Sciences Degree Award
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