Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Moses Ochora
ID: UNCST-2021-R012659
 RUNYA-PHIV: Rural Uganda Neurocognitive Youth Assessment with Perinatally acquired HIV
REFNo: HS5534ES

To explore the differences in NeuroScreen performance among adolescents aged 12-19 years with Perinatally acquired HIV in urban (Kampala) vs rural areas (Mbarara).,To adapt NeuroScreen to assess neurocognition among Runyankole-speaking adolescents aged 12-19 years with Perinatally Acquired HIV ,
 Uganda 2025-01-31 7:31:16 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Samuel Kyobe
ID: UNCST-2019-R000108
 DSpace – Ethical Implications of Pediatric EHR Use in Medical Research in Uganda and Botswana
REFNo: HS5301ES

1. Analyze the ELP issues raised by the use of pediatric EHR in medical research in Uganda and Botswana
2. Determine/analyze the implications of data linkage on participant consent and privacy
 Uganda 2025-01-31 7:27:19 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Maleka
ID: UNCST-2024-R015301
 Sex differences in alcohol consumption and its impact on vulnerability and susceptibility to develop dementia in rural Uganda.
REFNo: SS3477ES

1. To determine the patterns of alcohol consumption among men and women aged 60 years and above in Ibanda and Lira districts.
2. To assess the association between alcohol consumption and cognitive impairment among men and women in rural Uganda
3. To determine the socio-cultural factors that contribute to gender differences in the vulnerability to alcohol-related cognitive impairment in Ibanda and Lira districts.

 Uganda 2025-01-31 7:24:38 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
john semuwemba
ID: UNCST-2022-R015225
 Association between prenatal alcohol exposure and Cognitive and Behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.
REFNo: HS5331ES

General Objective.
To determine the prevalence of prenatal alcohol exposure and the association between prenatal alcohol exposure and cognitive and behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.
Specific Objectives.
1 To determine the prevalence of prenatal alcohol exposure in rural Rwampara and Lira districts.
2 To determine the prevalence of cognitive and behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.
3 To determine the association between prenatal alcohol exposure and cognitive and behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.

Uganda 2025-01-31 7:22:50 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David Mukunya
ID: UNCST-2022-R010707
 A phase III, randomized, open-label, clinical trial to evaluate the safety and efficacy of emollient therapy for very low birthweight infants (<1500g) in Uganda in promoting survival, health, growth and development compared to no emollient treatment
REFNo: HS5338ES

To evaluate the efficacy of emollient therapy with SSO – compared to standard care without use of emollients – among hospitalised very low birth weight (VLBW, <1500g) infants in Uganda on: the rate of in-hospital mortality, serious infections, hypothermia, growth, intraventricular haemorrhage, and skin condition; maternal depression and anxiety; maternal and neonatal interaction; infant growth and neurodevelopment at 12 month corrected age (chronological age reduced by the number of weeks born before 40 weeks of gestation); and infant mortality.
Uganda 2025-01-31 7:21:53 2028-01-31 Medical and Health Sciences Clinical Trial Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
 Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study.
REFNo: HS5389ES

To evaluate the impact of a structured antimicrobial review on rates of antimicrobial density, redundancy and associated indicators of antimicrobial utilisation.,To determine whether a structured antimicrobial review can be implemented in LMIC ICUs,
 UK 2025-01-31 7:20:18 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
WAYENGERA Misaki
ID: UNCST-2024-R002503
 DECIPHERING HOST GENETICS AND VIRAL DETERMINANTS OF MPOX PATHOGENESIS IN THE DEMOCRATIC REPUBLIC OF CONGO AND THE NEIGHBORING COUNTRIES (DECIPHER-MPOX)
REFNo: HS5409ES

The goal of the DECIPHER-MPOX project is to determine the host genetic and viral determinants of mpox in Uganda and in the Democratic Republic of Congo (DRC) among survivors of mpox and their house hold contacts ,
 Uganda 2025-01-31 7:18:46 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jackson Tumwine Bwagiro
ID: UNCST-2024-R004504
 Promotion of integrated and sustainable community interventions to prevent GBV and strengthen Adolescent Sexual Reproductive health and rights. A realistic evaluation protocal from Uganda
REFNo: SS3540ES

The overall objective is to promote integrated and sustainable community interventions to prevent GBV and Strengthen SRHR,
 Uganda 2025-01-31 7:17:15 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Andrew Kanyike Marvin
ID: UNCST-2020-R014554
 Optimizing Hypertension and Type 2 Diabetes Mellitus Management among People Living with HIV using a HEARTS-Based Strategy in Eastern Uganda: A Feasibility and Preliminary Effectiveness Study.
REFNo: HS5399ES

To identify the barriers and facilitators to the optimal management of HTN and T2DM among PLHIV at Mbale Regional Referral Hospital in Eastern Uganda.

To develop and implement a HEARTS-based strategy for optimized management of HTN and T2DM among PLHIV at Mbale Regional Referral Hospital in Eastern Uganda.

To determine the feasibility, acceptability, and preliminary effectiveness of the HEARTS-based strategy in optimizing the management of HTN and DM among PLHIV at the Mbale Regional Referral Hospital in Eastern Uganda.

To evaluate the reach, adoption, implementation, and maintenance of the HEARTS-based strategy for optimizing hypertension and diabetes mellitus management among PLHIV at Mbale Regional Referral Hospital.

 Uganda 2025-01-31 7:16:22 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mordecai Tayebwa
ID: UNCST-2024-R002437
 Expanded Strengthening of Makerere University's Research Administration Capacity Program (E-SMAC)
REFNo: HS5531ES

Test knowledge and skills change over time of faculty prior to and following the SOP trainings and implementation activities ,Test knowledge and skills change over time of participating RA staff prior to and following the SOP trainings and implementation activities ,Test knowledge and skills change over time of participating RA staff and faculty prior to and following the SOP trainings and implementation activities ,
 Uganda 2025-01-30 18:30:42 2028-01-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
 Evidence Synthesis To Inform Strengthening Medical Oxygen Systems in low- and middle-income countries”. (ESTISMOS)
REFNo: HS5437ES

10. To assess the implementation outcomes and impact of the Oxygen-as-a- service intervention in Uganda, Kenya, Tanzania, and Nigeria,9. To determine the health facility readiness, also known as “change valence”, to implement the Oxygen-as-a- service intervention in Uganda, Kenya, Tanzania, and Nigeria.,8. To assess the capability (real and perceived) of the selected health facilities, also known as, “change efficacy” to implement the Oxygen-as-a- service intervention in Uganda. ,7. To examine the coordination mechanisms at national, district, health facility levels that facilitate availability of medical oxygen at health facilities.,6. To examine the stakeholder positions, interests, and influences along the medical oxygen supply chain on access to medical oxygen at health facilities.,5. To characterize processes and tools for information flow and management for medical oxygen and oxygen related equipment.,4. To map the medical oxygen supply chain system and explore the nodes and links from the medical oxygen sources to health facilities where it is needed.,3. To synthesize the extent to which healthcare packages have incorporated oxygen therapy solutions to promote their adoption, scale up and sustainability. ,2. To summarize the implementation outcomes of oxygen therapy solutions from published intervention studies in LMICs. ,1. To synthesize determinants of implementation outcomes of oxygen therapy solutions in low- and middle-income countries.,
 Uganda 2025-01-30 18:27:31 2028-01-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adityavarman Mehta Umesh
ID: UNCST-2024-R002841
 The Role of Global Health Diplomacy in Achieving Peacebuilding in Post-Conflict Northern Uganda
REFNo: SS3590ES

In this context, the thesis will examine the use of global health diplomacy, which aims to bridge the disciplines of public health, international relations, and public policy, as a peacebuilding instrument in northern Uganda. With numerous health initiatives such as those that addressed the increasing incidence of HIV/AIDS and Ebola during the civil war between 1986 and 2006, and psychosocial programs following the conclusion of the war, there is scope to determine whether these health initiatives contributed to the cessation of violence and ultimately, peacebuilding. This thesis will arrive at this determination by assessing if health initiatives implemented in northern Uganda during and after the conflict fostered social cohesion and afforded Ugandans, particularly women, agency or the opportunities to follow through on their choices. The twenty-year conflict in northern Uganda provides an effective context for this thesis because the violence was largely a product of its political and social history (Kustenbauder, 2010). The violence had ethnic and religious dimensions as well, with academic literature on the subject suggesting that the largest rebel group fighting the national army, the Lord’s Resistance Army, viewed its struggle against the government of Uganda as a divine cause, which was guided by God through its leader, Joseph Kony (Van Acker, 2004). Against this political and historical backdrop, this thesis will aim to determine if global health diplomacy was able to, in whole or in parts, achieve peacebuilding objectives in northern Uganda.
Uganda 2025-01-30 18:24:54 2028-01-30 Social Science and Humanities Non-Clinical Trial Degree Award
Hilary Muheezangango
ID: UNCST-2024-R002492
 GOVERNANCE PRACTICES AND ECONOMIC SECURITY IN PINEAPPLE VALUE CHAIN COMMUNITIES IN SELECTED DISTRICTS; CENTRAL UGANDA.
REFNo: SS3466ES

Main Objective: To examine the relationship between governance practices, and economic security of Pineapple Value Chain Communities in Central Uganda.

Specific objectives
i. To examine the contribution of shared goals among stakeholders on the economic security of Pineapple Value Chain Communities in the Districts of Luweero, Kayunga and Mukono; Central Uganda.
ii. To examine the relationship between shared roles and economic security of Pineapple Value Chain Communities of Luweero, Kayunga and Mukono Districts; Central Uganda.
iii. To analyze the relationship between shared knowledge and economic security of Pineapple Value Chain Communities of Luweero, Kayunga and Mukono Districts; Central Uganda.
iv. To assess the mediating effect of work environment on the relationship between governance practices and economic security in Pineapple Value Chain Communities of Luweero, Kayunga and Mukono Districts; Central Uganda.

 Uganda 2025-01-24 14:40:20 2028-01-24 Social Science and Humanities Non-Clinical Trial Degree Award
Norah Babirye
ID: UNCST-2024-R015349
 Optimising Indigenous Food Consumption for Improved Metabolic Health among Adults in Uganda.
REFNo: A549ES

1. To evaluate indigenous vegetable and fruit consumption patterns among adults in Wakiso district, Uganda.
2. To identify the sources of indigenous vegetable and fruit consumed among adults in Wakiso district, Uganda.
3. To document the cardiometabolic health profile of adults in Wakiso district, Uganda.

Uganda 2025-01-24 14:38:11 2028-01-24 Agricultural Sciences Non-Clinical Trial Degree Award
Laura Twubahe
ID: UNCST-2024-R002589
 Nutritional, Physical-chemical, and Microbiological changes in the properties of cooking oil and street-vended deep-fried foods in Wakiso District, Central Uganda: A case study of Kira Municipality.
REFNo: HS5308ES

General objective
The general objective of this study is to evaluate the physical-chemical changes in cooking oil and the Microbiological safety of street vended deep fried foods in Kira Municipality, Wakiso District, Uganda.

Specific Objectives
The specific objectives of the study are to;
1. Assess the changes in the physical-chemical properties including trans fatty acids of cooking oil used by street vendors of Rolex and deep-fried chicken in Kira Municipality.
2. Assess the microbiological safety of street vended rolex and deep-fried chicken in Kira municipality.
3. Assess the knowledge, attitudes, and practices of street vendors of rolex and deep-fried chicken in Kira Municipality.

 Uganda 2025-01-22 9:56:29 2028-01-22 Medical and Health Sciences Non-Clinical Trial Degree Award
Robertson Turyamwijuka
ID: UNCST-2024-R015990
 A sustainable Public procurement implementation framework for Public Sector Entities in Uganda.
REFNo: SS3597ES

3.1 PRIMARY OBJECTIVE The primary objective of this study seeks to develop and propose a sustainable public procurement implementation framework that will guide Ugandan public entities on how to enhance sustainable public procurement performance through the effective implementation of sustainable public procurement practices and approaches. This will enable these public entities to also address the unique challenges and opportunities they face, with the aim to enhance efficiency, accountability, and sustainability in public procurement processes. The accomplishment of the ensuing secondary objectives will enable this. 3.2 SECONDARY OBJECTIVES OF THE STUDY The following secondary objectives have been determined in order to fulfil the study's main goal: 3.2.1 To identify the drivers influencing the implementation of sustainable public procurement in public sector entities in Uganda. 3.2.2 To identify the sustainable public procurement practices currently implemented among Ugandan public sector entities. 3.2.3 To identify the challenges and their consequences faced by Ugandan public sector entities when implementing sustainable public procurement. 3.2.4 To identify sustainable public procurement approaches within public sector entities in Uganda. 3.2.5 To determine the influence of sustainable public procurement drivers on sustainable public procurement performance. 3.2.6 To determine the influence of the drivers of sustainable public procurement on sustainable public procurement approaches. 3.2.7 To assess the influence of sustainable public procurement drivers on the adoption of sustainable public procurement practices. 3.2.8 To assess the influence of sustainable public procurement approaches on sustainable public procurement practices. 3.2.9 To assess the influence of sustainable public procurement practices on sustainable public procurement performance. 3.2.10 To assess the influence of sustainable public procurement approaches on sustainable public procurement performance. 3.2.11 To assess how sustainable public procurement approaches, in Ugandan public sector organizations, mediate the relationship between sustainable public procurement drivers and sustainable public procurement performance. 3.2.12 To assess the mediating influence of sustainable public procurement practices on the association between sustainable public procurement drivers and sustainable public procurement performance in Ugandan government agencies. 3.2.13 To assess the mediating influence of sustainable public procurement practices on the association between sustainable public procurement approaches and sustainable public procurement performance within public sector entities in Uganda. 3.2.14 To provide a conceptual framework for Ugandan public sector entities to embrace sustainable public procurement.
Uganda 2025-01-22 17:09:13 2028-01-22 Social Science and Humanities Non-Clinical Trial Degree Award
Betty Adoch
ID: UNCST-2024-R003825
 Land Conflicts and Livelihood Nexus in Gulu City, Northern Uganda
REFNo: SS3531ES

To assess the attitude and perceptions of inhabitants on effectiveness of land conflict resolution mechanisms in Gulu city,To assess the effects of land conflicts on livelihood capitals of inhabitants in Gulu city,To examine the drivers of land conflict among inhabitants in Gulu city,To determine the nature of land conflicts among inhabitants in Gulu city,The study aims to examine the nature and extent of land conflicts, explore how these conflicts affect the livelihood assets of the local population, and assess the effectiveness of existing mechanisms for conflict resolution. This study seeks to provide insights that can inform policy, and interventions aimed at improving land management and enhancing the livelihoods of the affected communities.,
 Uganda 2025-01-22 17:07:20 2028-01-22 Social Science and Humanities Non-Clinical Trial Degree Award
Stavia Turyahabwe Stavia
ID: UNCST-2022-R011373
 Evaluating the performance, feasibility, acceptability and impact of treatment-decision algorithms for pulmonary tuberculosis in children in Uganda and their unmet social needs;TDA4Child
REFNo: HS5390ES

(i) To compare the diagnostic accuracy of the study TDAs with the Uganda national algorithm for the diagnosis of TB in children
(ii) To compare adults and children TB notifications before and after study initiation;
(iii) To describe the caregiver’s (parents or guardians) acceptability in introducing TB treatment based on the TDA outcome
(iv) To describe healthcare workers’ (HCWs) experience, acceptability of and satisfaction with and feasibility of algorithm the TDAs’ implementation
(v) To describe the unmet social needs, social protection coverage, and dissaving among children under 10 years old being evaluated for pulmonary TB and their households in Uganda.
Uganda 2025-01-22 17:04:40 2028-01-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eve  Namisango
ID: UNCST-2021-R014038
 Validation of the Quality of Dying and Death-Revised Global Version scale in Uganda
REFNo: SS3429ES

3) To assess the relationship between quality of death and dying and grief and bereavement symptoms reported by caregivers,2) To determine the reliability of the QODD-RGV,1) To examine face and content validity of the QODD-RGV index.,The main objective of this study is to undertake a psychometric evaluation of the Quality of Death and Dying Index. ,
 Uganda 2025-01-22 16:56:37 2028-01-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 Clinical Performance Evaluation of Kwiq-Test HIV-1/2 (Whole Blood/Serum/ Plasma): Diagnostic sensitivity & diagnostic specificity, specimen equivalence, Anticoagulant equivalence and qualification of usability
REFNo: HS5368ES

The objectives of this study are:
1. To establish the diagnostic sensitivity and diagnostic specificity of the Kwiq HIV-1/2 test (Serum/Plasma/wholeblood) in plasma samples according to the WHO TSS-1 Part 2.1
2. To demonstrate the equivalence of serum, plasma (EDTA-K2), venous whole blood (EDTA-K2) and fingerprick whole blood collected from HIV positive patients according to WHO TSS-1 Part 1: 1.1.1.
3. To demonstrate anticoagulant equivalence of serum, venous whole blood (EDTA-K2, EDTA-K3, sodium citrate, sodium heparin), plasma (EDTA-K2, EDTA-K3, sodium citrate, sodium heparin) and fingerprick whole blood
4. To demonstrate the usability of this rapid diagnostic test when performed by the intended users. It will be assessed whether the intended users comprehend all key messages from labelling and packaging (i.e. label comprehension study) and whether they can correctly interpret pre-determined test results (i.e. result interpretation study).
To meet all the requirements as set out in the WHO TSS-1study will be conducted in Uganda

 Uganda 2025-01-22 16:53:12 2028-01-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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