Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Jacob Negrey Douglas
ID:
Multisystem aging patterns in chimpanzees (Pan troglodytes schweinfurthii) living at Ngogo, Kibale National Park, Uganda
REFNo: NS727ES

To better understand the biological and ecological forces that shape primate aging, we will assess both longitudinal and cross-sectional, age-related patterns of social, physiological, and physical variation in adult chimpanzees of the notably long-lived groups at Ngogo, Kibale National Park, Uganda. This project will integrate behavioral, genetic, endocrinological, immunological, and microbial data collected from wild chimpanzees. We will combine tried-and-tried observational and laboratory analyses with innovative, noninvasive omics-based approaches to studying physiological function. The proposed research will elucidate the advantages and limitations of wild chimpanzees as models of human health and aging and build an extensive multisystem dataset for future comparative chimpanzee research. The three primary goals of this research are outlined below: 1) Characterize cross-sectional and longitudinal aging trajectories across functional domains. How do functional domains vary in the timing and rate of age-related decline? Do some systems (e.g., physical function, immune function) exhibit later onset and/or slower rates of decline than do others? 2) Determine the extent of sex biases in aging trajectories in Ngogo chimpanzees. Given that female chimpanzees at Ngogo have greater life expectancies at birth than do males [25], do female chimpanzees also show slower or delayed rates of aging across most / all functional domains? Are aging effects more pronounced in some functional domains than others, and if so, which domains show greater sex biases? 3) Develop methods to noninvasively study chimpanzee aging. Given that the study of wild chimpanzees is strictly noninvasive, we will continue to develop, validate, and implement new methods for studying aging across a range of functional domains. Notably, we will continue to refine the use of video recordings to measure walking speeds, which are an invaluable measure of physical function in humans and nonhuman primates alike [32, 33]. We will develop new urinary biomarkers for use in wild chimpanzee studies including biomarkers of neurodegeneration (e.g., Alzheimer’s-associated neuronal thread protein) and physical function (e.g., urinary pentosidine). Finally, we will validate and implement the study of genetic material from chimpanzee saliva samples, including bacterial and epigenetic information, by collecting and subsequently analyzing chimpanzee saliva samples onsite at Ngogo using transportable sequencing equipment (MinION Mk1C sequencer, Oxford Nanopore Technologies, Oxford, UK).
 USA 2024-01-29 14:57:37 2027-01-29 Natural Sciences Non-Clinical Trial Non-degree Award
joel lwasa njagala calls
ID: UNCST-2023-R006315
 ASSESSING THE IMPACT OF MEDICAL INTERNS ON HEALTHCARE DELIVERY AT KAWEMPE NATIONAL REFERRAL HOSPITAL
REFNo: SS2306ES

1.To compare hospital metrics at Kawempe National Referral Hospital when medical interns were present and when they were absent.
2.To compare patient outcomes at Kawempe National Referral Hospital when medical interns were present and when they were absent.
 Uganda 2024-01-29 14:56:29 2027-01-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jacqueline Kanywa Balungi
ID:
HPV Vaccine Survey: Determining reasons as to why girls have or have not received the HPV vaccine who attend the clinic at the Baylor Uganda center of excellence.
REFNo: HS3620ES

Primary objective:
To determine reasons as to why 10- to 18-year-old girls receiving health care services at the Baylor Uganda center of excellence have or have not received the HPV vaccine using a short survey during a study period of September 1, 2023 to December 31, 2023.

Long-term goal: To use the responses of this survey to develop educational and clinical counseling programs for increasing the uptake of the HPV vaccine among 9–13-year-old girls at the Baylor Uganda clinical center of excellence.

 Uganda 2024-01-29 14:03:23 2027-01-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hillary Kuteesa
ID:
PROFILES, REFERRAL PATHWAYS AND REASONS FOR REFERRAL FOR PATIENTS ADMITTED TO BUTABIKA NATIONAL REFERRAL MENTAL HOSPITAL.
REFNo: HS3412ES

1. To describe the socio-demographic characteristics of patients admitted to BNRH
2. To describe the referral pathways of patients admitted to BNRH
3. To describe the reasons for referral to BNRH

 Uganda 2024-01-25 18:41:36 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christine Nabirye
ID:
Hand hygiene interventions in Kampala's informal settlements: public health imaginaries local health realities.
REFNo: SS2188ES

1. To trace and characterise the framing of hand hygiene messaging by public health actors in Uganda since 1980.
2. To explore and describe the factors that maintain the preference for hand hygiene messaging among public health actors in Uganda.
3. To understand and compare the lived experiences informal settlement residents with the factors that maintain the preference for hand hygiene messaging by public health actors.

 Uganda 2024-01-25 18:40:37 2027-01-25 Social Science and Humanities Non-Clinical Trial Degree Award
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