Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Helen Byakwaga
ID: UNCST-2019-R001168
Study of Newly Diagnosed Kaposi's Sarcoma
REFNo: HS157ES

1) Describe the clinical and laboratory characteristics of HIV-infected patients who develop KS. 2) Determine survival after KS occurrence in both ART-treated and ART-untreated HIV-infected patients.
Uganda 2018-02-13 2021-02-13 Medical and Health Sciences Non-degree Award
Stephen Kyakulumbye
ID:
A framework for developing citizen-centric e-government applications in developing contexts: The design-reality gap
REFNo: IS9ES

To document a feasible participatory design methodology for citizen e-government applications.
Uganda 2018-02-13 2021-02-13 Social Science and Humanities Degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Steady-state pharmacokinetics of efavirenz (Sustiva/Stocrin) 400 mg once daily in the presence of rifampicin and isoniazid (Rifinah or the local generics)
REFNo: HS161ES

Primary Objective: To evaluate the steady-state pharmacokinetics of efavirenz (Sustiva/Stocrin) 400 mg once daily during co-administration with rifampicin and isoniazid (Rifinah or local generic) Secondary Objectives: 1. To assess the safety and tolerability of efavirenz (Sustiva/Stocrin) 400 mg once daily during co-administration with rifampicin and isoniazid (Rifinah or local generic) 2. To investigate the association between genetic polymorphisms in drug disposition genes and drug exposure.
Nigeria 2018-02-06 2021-02-06 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
A PHARMACOKINETIC EVALUATION OF ETONOGESTREL IMPLANT IN HIV-INFECTED WOMEN ON DARUNAVIR VERSUS RIPILVIRINE-BASED ANTIRETROVIRAL THERAPY (DRIVE-I)
REFNo: HS145ES

Primary objective: To compare the PK of ENG (68 mg) contraceptive implant over 6 months in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART versus historical controls Secondary objectives: (1) To predict the disposition of ENG over the subsequent 2.5 years of intended use through PK modeling of ENG concentrations beyond 12 months of use in HIV-infected women using DRV- or RPV-based ART (2) To describe the PK exposure over 12 months of ENG contraceptive implant in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART (3) To describe the pharmacokinetics of DRV 12 hours post-dose (C12) and RPV 24 hours post-dose (C24) prior to and during 12 months of combined use with ENG. (4) To describe the safety and tolerability of combined use of DRV/RTV or RPV and ENG during 12 months of combined use. (5) To describe the relationship between ENG concentrations and participant specific covariates including body weight, albumin, sex-hormone binding globulin and pharmacogenetic factors.
Nigeria 2018-01-29 2021-01-29 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
A PHARMACOKINETIC EVALUATION OF LEVONORGESTREL IMPLANT IN HIV-INFECTED WOMEN ON DARUNAVIR VERSUS RIPILVIRINE-BASED ANTIRETROVIRAL THERAPY (DRIVE-II)
REFNo: HS146ES

Primary objective: To compare the PK of LNG (150 mg) contraceptive implant over 6 months in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART versus historical controls. Secondary objectives: (1) To compare the PK of LNG over 12 months among women receiving DRV-based ART or RPV-based ART versus historical controls (2) To predict the disposition of LNG over the subsequent 4 years of intended use through PK modeling of LNG concentrations beyond 12 months of use in HIV-infected women using DRV- or RPV-based ART (3) To describe the pharmacokinetics of DRV 12 hours post-dose (C12) and RPV 24 hours post-dose (C24) prior to and during 12 months of combined use with LNG. (4) To describe the safety and tolerability of combined use of DRV/r or RPV and LNG during 12 months of combined use. (5) To describe the relationship between LNG concentrations and participant specific covariates including body weight, albumin, sex-hormone binding globulin and pharmacogenetic factors.
Nigeria 2018-01-29 2021-01-29 Medical and Health Sciences Non-degree Award
Charlotte Hawkins
ID:
The Anthropology of Smartphones and Smart Ageing
REFNo: SS141ES

This project will investigate fundamental changes in people’s relationship to age and health associated with the global rise of the smartphone. The aim is to combine an intellectual challenge in understanding the contemporary nature of age and the impact of new media, with an applied challenge to use this knowledge to help make mHealth (mobile health) interventions more effective. mHealth has potential both for helping those with limited access to professional care but also threatens to bypass and undermine professional medical services. Our aim is to complement technology-led mHealth interventions with ethnography-led participatory design, consisting of a three-way collaboration between mHealth professionals, our ethnographically informed team and our informants in the field. We aim to demonstrate how such collaborations can lead to more culturally appropriate mHealth interventions and more effective improvements in people’s lives.
UK 2018-01-29 2021-01-29 Social Science and Humanities Degree Award
Rose Gawaya
ID:
Challenges faced by women’s organisations in the AID space: Case studies in South Africa and Uganda
REFNo: SS90ES

The purpose of the research is to explore how women’s organisations access and utilise development aid. Access and utilisation of development aid impact on how women’s organisations achieve their organisational goals to address problems faced by women. The specific study objectives are to: 1.Determine how women’s organisations define and respond to the development aid space. 2.Identify what functions determine the participation of women in the development aid space. 3.Examine how access and utilisation of development aid contributes to feminist agendas.
Uganda 2018-01-16 2021-01-16 Social Science and Humanities Degree Award
Charles Okuonzi
ID:
Follower Voice Behavior and Leadership Competencies of Owner-managers in SMEs in Uganda
REFNo: SS142ES

The objective of thestudy is to establish the relationship between follower voice behaviour and leadership competencies of Ugandan SME owner-managers. The study is purely academic and shall involve owner-managers from 65 SMEs and 500 of their followers as respondents
Uganda 2018-01-11 2021-01-11 Social Science and Humanities Degree Award
Afra Nuwasiima
ID:
Incentives for Increased Access to Comprehensive Family Planning for Urban Youth Using a Benefits Card: A Pilot Study
REFNo: HS98ES

1) To evaluate the effectiveness of the FPBC program in increasing uptake of comprehensive family planning services among urban youth aged 18 to 30 years. 2) To evaluate the acceptability and usability of the FPBC program among the urban youth aged 18 to 30 years 3) To estimate the cost-effectiveness and potential budget impact of the FPBC program on the taxpayer. 4) To pilot test a corporate social responsibility financing model that will pay for and potentially sustain the FPBC program.
Uganda 2018-01-08 2021-01-08 Medical and Health Sciences Non-degree Award
Jeroen  Lorist
ID:
(Re-)ordering Meaning and Masculinities in Holland and Uganda: the Gender Transformative Approach
REFNo: SS127ES

For many years research and development interventions towards gender equality have focused on women and their empowerment. Recently discourse seems to have shifted to include the engagement of men and boys towards gender equality. Through multi-sited ethnography this project examines how the idea of the Gender Transformative Approach travels and is (re-)ordered between different nodes of a distributed knowledge network. Rutgers, a Dutch NGO, acts as a major node in this global knowledge network and is the main ethnographic site (i.e. organizational ethnography of the NGO in Holland). Other research sites are Uganda and Malawi, where Rutgers' development partners operationalise GTA through various development interventions. Objective of the study is to find out, through multi-sited ethnography, what the Gender Transformative Approach really does. Is the engagement of men for gender equality really changing gender relations to be more equal, as it claims it is, or is it old wine in new bottles as some within the women’s movement claim (i.e. is it doing more than women’s empowerment?). The study will also hold a critical development perspective and will critically look at any unintended effects of the interventions.
Netherlands 2018-01-08 2021-01-08 Social Science and Humanities Degree Award
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