Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
REBECCA NANTANDA
ID: UNCST-2019-R001533
Assessment of feasibility, acceptability, hesitancy, safety, effectiveness and immunogenicity of COVID-19 vaccines among children in Uganda
REFNo: HS2910ES

1. To assess the feasibility and acceptability of COVID-19 vaccination of children in Uganda.
2. a) To determine the prevalence of hesitancy to COVID-19 vaccination for children in
Uganda.
b) To describe the drivers of hesitancy for vaccination of children against COVID-19 in
Uganda.
3. To assess the safety of COVID-19 vaccines among children aged 12-17 years in Uganda.
4. To determine immunogenicity the BioNTecg/Pfizer of among children aged 12-17 years in Uganda.
5. To determine the effectiveness of COVID-19 vaccines among children aged 12-17 years in Uganda.

Uganda 2023-08-18 9:40:38 2026-08-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
A pilot study evaluating the feasibility, acceptability and impact of use of highly sensitive malaria RDTs (NxTek™) vs ordinary malaria RDTs on malaria incidence in Uganda: a cluster-randomised trial
REFNo: HS2988ES

1. To determine the impact of detecting and treating additional malaria cases on malaria morbidity, 2 years following introduction of HS-RDTs for diagnosis of malaria in Uganda.
2. To assess feasibility of use (ease of test interpretation, delivery, restocking, storage, invalid tests, and reporting rates) of HS-RDTs among implementers in Uganda.
3. To compare clinical care outcomes for malaria cases diagnosed with HS-RDTs and cRDTs in Uganda.
4. To estimate the cost-effectiveness of delivering HS-RDTs, as compared to cRDTs.

Uganda 2023-08-18 9:13:55 2026-08-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
An adaptive, randomized, active-controlled, open-label, sequential cohort, multicenter study to evaluate the efficacy, safety, tolerability and pharmacokinetics of intravenous cipargamin (KAE609) in adult and pediatric participants with severe Plasmodium falciparum malaria (KARISMA – KAE609’s Role In Severe Malaria)
REFNo: HS1980ES

Primary objective
To assess the efficacy of different doses of
intravenous cipargamin vs artesunate by evaluating the proportion of
participants with ? 90% reduction of parasitemia at 12 hours post
administration of the first dose.

Secondary Objectives
1. To assess the presence/absence of severe malaria related individual
signs over time
2. To evaluate parasite clearance dynamics and proportion of participants
with recrudescence and reinfection
3. To assess recovery of participants as measured by time (days and hours)
to discharge from hospital or recovery from prostration
4. To evaluate the safety and tolerability of IV cipargamin
5. To assess the risk of long term neurological sequelae for participants at
Day 29
6. The assess the risk of hemolysis (early and delayed) during the study
duration
7. To characterize the plasma pharmacokinetics of IV cipargamin

Uganda 2023-08-18 9:05:14 2026-08-18 Medical and Health Sciences Clinical Trial Non-degree Award
Juliane Etima
ID: UNCST-2022-R008983
Young Generation Alive Survey: Determining Knowledge, Aspirations, and Behaviors of Ugandan Adolescents and Young People Living with HIV.
REFNo: SS1910ES

To understand the HIV knowledge and behaviors among HIV+ and perinatally exposed adolescents and young people in Uganda with respect to achieving career aspirations, financial security, and safe intimate relationships.,
Uganda 2023-08-15 15:43:39 2026-08-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Fiona Ssozi Catherine
ID:
PATHWAYS TO CHANGE: TOWARDS GENDER JUSTICE IN SCIENCE, ENGINEERING, TECHNOLOGY AND MATHEMATICS (STEM) RESEARCH IN AFRICA (GEJUSTA)
REFNo: SIR240ES

Primary objective: Examine causes of under-representation and reframe Gender Analysis in STEM in Africa
Secondary objectives: Map under-representation, barriers and support mechanisms; explore STEA+M approaches; Develop Gender-aware design methodologies; Develop a support network for mentoring early-career female researchers

Uganda 2023-08-15 15:42:06 2026-08-15 Engineering and Technology Non-Clinical Trial Non-degree Award
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"A prosperous Science and Technology Led Ugandan Society."