Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Anthony Mugeere Buyinza
ID:
PEAK YOUTH, CLIMATE CHANGE AND THE ROLE OF YOUNG PEOPLE IN SEIZING THEIR FUTURE
REFNo: SS670ES

General Objective:

To explore how climate change in Uganda is affecting young lives and youth livelihoods in the regions of Karamoja and Jinja.

Specific objectives:
(i) To document the diverse lives and livelihood strategies of young people
in rural and urban settings;
(ii) To find out how climate change impacts upon young people's lives and livelihoods;

(iii) To identify youth solutions to the challenges they face.
 Uganda 2021-04-21 2024-04-21 Social Science and Humanities Non-degree Award
Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
 An education package to improve health worker communication with women and families after stillbirth or neonatal death: A feasibility study
REFNo: HS1102ES

1. To pilot an education package and associated resources, including train the trainer/training manuals and audio-visual aids to improve health worker communication in Malawi, Uganda, Zambia and Zimbabwe.
2. For feasibility
a. Explore the acceptability and implementation of the package with facility staff receiving training, trainers and service managers across settings.
b. Explore the acceptability and implementation of the package with undergraduate midwifery students receiving training.
c. Assess uptake and attendance/completion of the package.
d. Explore impacts of the research and education package on practice and clinical services.
3. To prepare for a full-scale evaluation:
a. Define the most appropriate primary and secondary outcomes to assess the effect of the educational package on health workers’ communication and parents’ experiences.
b. Assess the acceptability and burden of data collection for participants.
c. Use data to optimise the design and estimate the sample size for a full-scale trial.
d. Exploration of key resources associated with implementing the educational package will be completed to provide an economic understanding of the intervention and its potential impact.
e. To utilise existing and develop additional networks to identify potential sites for a full-scale trial.
4. To combine the feasibility, acceptability and uptake data to develop a full trial protocol by the end of the study.

 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 SARS-CoV-2 seroconversion: a sero prevalence study among cancer patients and health workers at the Uganda Cancer Institute
REFNo: HS1240ES

3. To describe the temporal trends in the anti- SARS-CoV-2 antibody sero-prevalence among cancer patients at the Uganda Cancer Institute,2. To describe the clinical and demographic characteristics associated with history of exposure to SARS-CoV-2 and severity of COVID-19 disease in cancer patients. ,1. To determine SARS-CoV-2 antibody sero-prevalence in cancer patients attending care at the Uganda Cancer Institute,
 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Conrad Muzoora Kihembe
ID: UNCST-2019-R001432
 A randomized clinical TriaL of early empiric Anti-Mycobacterium tuberculosis therapy for Sepsis in sub-Saharan Africa (ATLAS trial)
REFNo: HS1272ES

The primary hypothesis of this clinical trial protocol is that immediate and sepsis specific dose of anti-TB therapy will result in improved 28-day mortality for study participants admitted to hospital with HIV and sepsis in Tanzania and Uganda compared to standard care alone.

The primary objective is:
1) To conduct a randomized 2x2 factorial clinical trial of 1) immediate initiation of empiric anti-TB therapy plus standard care vs diagnosis dependent anti-TB therapy plus standard care alone and 2) sepsis-specific anti-TB therapy plus standard care vs conventional WHO weight-based anti-TB therapy plus standard care for patients presenting with sepsis to two hospitals in Uganda and Tanzania.
1a) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves 28 day mortality compared to diagnosis dependent anti-TB therapy plus standard care.
1b) To determine if sepsis-specific dose anti-TB therapy plus standard care improves 28 day mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.

The secondary objectives include:
1) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves in-hospital mortality compared to diagnosis dependent anti-TB therapy plus standard care
2) To determine if sepsis-specific dose anti-TB therapy plus standard care improves in hospital mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.
3) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves 6 month mortality compared to diagnosis dependent anti-TB therapy plus standard care
4) To determine if sepsis-specific dose anti-TB therapy plus standard care improves 6 month mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.
5) To determine the safety of increased dose anti-TB therapy for patients with sepsis
6) To determine if early achievement of target serum drug concentrations of isoniazid and rifampin, measured at day-2 of TB treatment, associates with more rapid clinical improvement among patients with confirmed TB.

 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
 A Survey Assessing Male Reproduction During or After Treatment Containing Pretomanid
REFNo: HS1340ES

To evaluate the paternity status in male participants who have received a pretomanid containing regimen in one of the following TB Alliance clinical trials: STAND, Nix-TB, SimpliciTB or ZeNix.
 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
 Using community influencer groups to address COVID-19 misinformation and vaccine hesitancy in Buikwe, Uganda
REFNo: HS1140ES

The evaluate the effect of community influencer groups on COVID-19 misinformation and potential COVID-19 vaccine hesitancy.,To form and empower community influencer groups against COVID-19 misinformation and potential COVID-19 vaccine hesitancy ,To explore the effect of COVID-19 misinformation on potential hesitancy towards a future COVID-19 vaccine,To determine the prevalence of potential hesitancy to a future COVID-19 vaccine in Buikwe,To determine the prevalence of COVID-19 misinformation in Buikwe,
 Uganda 2021-04-15 2024-04-15 Medical and Health Sciences Non-degree Award
Noleb Mugisha Mugume
ID:
Integrating cervical cancer screening in HIV clinics and assessing the effect of using a modified referral protocol on access to cancer services among HIV-positive women in Uganda
REFNo: HS1219ES

Major objective: To assess the effect of a modified referral protocol on access to cancer services among HIV-positive women with positive cervical cancer screening findings and describe acceptability of integrating cervical cancer screening services in HIV clinics and referring women with positive screening results using the modified referral protocol.

Specific objectives
1. To assess the effect of using a modified referral protocol on access to cancer services among HIV-positive women with positive cervical cancer screening findings.

2. To describe experiences of HIV-positive women and health care providers with implementation of integrated cervical cancer screening services in HIV clinics and referral using a modified referral protocol

3. To describe acceptability of a program that provides integrated cervical cancer screening services in HIV clinics to women presenting for routine HIV care and links those with positive screening findings to cancer care services using a modified referral protocol among health care providers and mangers in the clinics.

 Uganda 2021-04-15 2024-04-15 Medical and Health Sciences Degree Award
victoria nakibuuka
ID: UNCST-2020-R014741
 Developmental care packages to improve neonatal outcomes – a multidisciplinary approach
REFNo: HS1254ES

To survey current knowledge, practices and attitudes towards developmental care to assess potential barriers and facilitators to implementing and integrating developmental To observe current practice in NICU’s care packages in NICU’s in LMIC

 Uganda 2021-04-15 2024-04-15 Medical and Health Sciences Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
 D3 (PENTA 21) A randomised non-inferiority trial with nested PK to assess DTG/3TC fixed dose formulations for the maintenance of virological suppression in children with HIV infection aged 2 to <15 years old
REFNo: HS1288ES

The overall aim is to evaluate two-drug therapy with DTG/3TC FDC given once daily in comparison with triple-drug ART in HIV-1 infected children and adolescents who are virologically-suppressed on their ART regimen.

PRIMARY OBJECTIVE
To assess whether DTG/3TC is non-inferior to SOC, consisting of an anchor drug (NNRTI, PI or INSTI) and 2 NRTIs, in terms of virological suppression

HYPOTHESIS
Switching to DTG/3TC will provide non-inferior virological suppression to remaining on SOC over 96 weeks.

SECONDARY OBJECTIVES
 To evaluate clinical and laboratory adverse events associated with the trial antiretrovirals
 To evaluate new resistance mutations in participants with virological rebound (confirmed VL≥50 copies/mL)
 To assess low level viraemia and virological reservoirs
 To evaluate adherence, tolerability, acceptability, sleep and health-related quality of life
 To evaluate and model the pharmacokinetics and pharmacodynamics of dispersible and film-coated fixed-dose DTG/3TC formulations in children weighing 6-<40kg using WHO weight band-aligned dosing
 To evaluate cost-effectiveness of treatment maintenance with DTG/3TC FDC if DTG/3TC is shown to be non-inferior to SOC

Uganda 2021-04-15 2024-04-15 Medical and Health Sciences Non-degree Award
Godfrey  Siu
ID: UNCST-2021-R005439
 The impact of COVID-19 on domestic care work in Uganda
REFNo: SS770ES

1. To determine the burden and patterns of domestic care work during the COVID-19 response phase.
2. To determine the barriers and facilitators of domestic work during the lockdown.
3. To examine the effects of COVID-19 on the social, economic and family relations.
 Uganda 2021-04-15 2024-04-15 Social Science and Humanities Non-degree Award
James Katungyi
ID:
The effect of daytime circadian thermal variability on the well-being of building occupants. A case study of office type building occupants in Kampala.
REFNo: SIR41ES

The research objective is to compare short and long-term impacts, of variable indoor thermal conditions (which mimic the outdoor variability) versus static thermal conditions, on the wellbeing of building occupants.
 Uganda 2021-04-13 2024-04-13 Engineering and Technology Degree Award
Susannah Mayhew Harding
ID:
Rapid Qualitative Research to support integrated environment, livelihoods and health programming in Uganda (“Supporting Integrated Programming”)
REFNo: HS1137ES

The research objectives are to:
1) Determine the environmental, livelihood and health challenges facing communities living in/near Rushebeya wetland;
2) Identify how, and through what structures and processes, people in these communities make decisions about and respond to identified challenges; and identify whether these responses have changed over time;
3) Examine whether there are differences in responses by age, sex or socio-economic background.
4) Identify messages and intervention activities to address the challenges felt by different groups in these communities.

 UK 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Joseph Nkamwesiga
ID:
Epidemiology of Peste des Petits Ruminants (PPR) in Uganda
REFNo: A103ES

General Objective:
To determine national PPR risk profiles [low, medium and high], seroprevalence and incidence of different PPRV lineages, factors that influence PPRV transmission and hence develop a dynamic PPRV transmission model and the best control intervention(s) to limit PPRV transmission in selected livestock production systems in Uganda

The specific objectives of this study are to:
i. stratify Uganda districts into different PPR risk profiles [low, medium and high] by undertaking presence only ecological niche (MaxEnt) modeling of the past PPR outbreaks, small ruminant movements and vaccination coverage data sets
ii. estimate seroprevalence of PPRV and epidemiological factors that influence PPRV transmission within and between different PPR risk profiles and small ruminant production systems
iii. estimate PPR incidence and PPRV lineages involved in different PPR outbreaks across different small ruminant production systems [or agro-ecological zones] in Uganda
iv. develop a PPRV transmission dynamic and eradication model for PPR in selected small ruminant production systems [agro-ecological zones] in Uganda using compartmentalized SEIR mathematical modeling approach

 Uganda 2021-04-13 2024-04-13 Agricultural Sciences Degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
 Strengthening Antimicrobial Stewardship, Consumption and Use in Uganda (SAMSU)
REFNo: HS1155ES

To conduct Antimicrobial Consumption and Use by ATC/DDD Methodology and the WHO AWaRE classification Antimicrobials intended for use in Humans for the Years 2017, 2018, 2019 and 2020 using Medicine Imports and Local Manufacture Data in Uganda (SCACUS)To examine health facility bottlenecks and determinants of antimicrobial use that affect antibiotic stewardship practices at outpatient departments with the aim of strengthening healthcare professionals’ AMS capability in Eastern Uganda (SAMSEU)
Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Stavia Turyahabwe Stavia
ID: UNCST-2022-R011373
 From Directly-Observed Therapy (DOT) to Video Observed Therapy (VOT): A study on the use of evidence based Digital Adherence Technologies (DAT) for improving TB Treatment outcomes
REFNo: HS1183ES

a. Active Case Finding Strategy: To study the impact of increase in case finding of drugs susceptible case in the selected 2 TB units of Kabarole and Mbarara, where the component will be tested.
b. Active Patient Compliance Toolkits: To test the efficacy of patient led adherence using mobile based Video Observed Therapy approach in improving the TB adherence rate and overall improvement in TB treatment outcomes;
c. Active Community-Led Supervision: To test the improvement in TB treatment outcomes like TB Success Rates, Cure rates and Adherence rates in the community let supervision model;
d. Active Ground Building Activities; To assess the change in knowledge, attitude and practice (KAP) level of TB patients; their family members and the community around TB and related issues.

Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 SITUATIONAL ANALYSIS OF EXISTING CAPACITY AND RESOURCES AT MEAKERERE UNIVERSITY TO SUPPORT A RESEARCH TRAINING PROGRAM FOCUSING ON NON-COMMUNICABLE DIEASES AND AGEING AMONG PEOPLE LIVING WITH HIV/AIDS
REFNo: HS1252ES

General Objective
To describe existing research capacity, training and resources within the MakCHS that can be leveraged to design a successful NCD-HIV-Ageing training program at MakCHS
Specific Objectives
To describe existing NCD, HIV and ageing research at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex.
To define the existing NCD, HIV and ageing training activities at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex.
To outline the existing resources to support research and training on NCDs, HIV and ageing at Makerere University and other collaborating institutions within MakCHS and Mulago Hospital complex.
To define a pool of potential trainees that could be recruited for research training on NCDs, HIV and ageing at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex

 Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Barbara Balikuddembe  Ndagire Balikuddembe
ID:
Dental Practitioners’ Knowledge, Attitudes, and Practices Regarding Caries Risk Assessment in the Management of Dental Caries in Uganda: A Cross Sectional Study
REFNo: HS1275ES

i. To determine the knowledge of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan. ii. To determine the attitudes of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan. iii. To determine the practices of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan. iv. To explore the training needs of CRA among trainers of dental practitioners in Kampala metropolitan.
Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Degree Award
Victor Musiime
ID: UNCST-2021-R013794
 A randomized Trial to investigate strategies to reduce mortality among HIV-infected and HIV-exposed children admitted with severe acute malnutrition in Mulago Hospital, Kampala, Uganda
REFNo: HS1277ES

Primary objective
1. To investigate whether empirical use of an antibiotic with greater antimicrobial sensitivity (ceftriaxone) than standard of care (ampicillin plus gentamicin) will reduce mortality among 300 HIV-infected and HEU children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital in a randomised controlled trial.

Secondary objectives
2. To compare the length of hospitalization, weight-for-height, weight-for-age and height-for-age z-scores between ceftriaxone versus standard of care (ampicillin and gentamicin) treatment arms.
3. To ascertain the frequency of different bloodstream bacterial pathogens and their antimicrobial sensitivities among HIV-infected and HEU children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital participating in the randomised trial.
4. To ascertain the prevalence of, and factors associated with, HIV-infection among children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital in light of improved PMTCT approaches in a cross-sectional evaluation at admission, among 280 children.
5. To evaluate the pharmacokinetic (PK) parameters of LPV/r among severely malnourished HIV infected children using sparse PK samples. The PK parameter values obtained will then be used in pharmacokinetic-pharmacodynamic (PK-PD) models to determine a possible optimal dose of LPV/r among severely malnourished children, which could then subsequently be evaluated in a clinical trial.

Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
 Exploring access to health care and medicines during COVID-19 in Mukono and Luwero districts: critical challenges and feasible policy options for the medicines retail sector
REFNo: HS1302ES

To describe the practical, policy and political barriers to including pharmacies, drug shops and private clinics in the response to COVID-19 and the means to overcome them.,. To describe how national actors and district officials would like to involve the medicines retail sector in their pandemic planning and action for COVID-19. ,To explore how the medicines retail sector in Uganda could be involved in response to COVID-19 and future outbreaks,To document the impact of the COVID-19 pandemic and public health response on the ability of women and the parents of young children in Uganda to access medicines,To document the effect of the government response to COVID-19 on supply of healthcare services/ care provision by drug shops, pharmacies and private clinics in Uganda,To describe how policy can be adapted to ensure continuity of access to essential medicines and support the involvement of the retail sector in COVID-19 activities during this and future outbreaks,To understand how the public health response to COVID-19 is shaping the supply of and access to treatment in the medicines retail sector in Uganda;,
 Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Irene Mutuku M.
ID:
KNOWLEDGE, ATTITUDES AND PRACTICES TOWARDS COVID-19 PREVENTION MEASURES AMONG COMMUNITIES AT SELECTED GAZETTED INTERNATIONAL ENTRY-POINTS OF KIGEZI SUB-REGION, UGANDA
REFNo: SS660ES

General objective

To assess the knowledge, attitudes and practices towards COVID-19 prevention measures in communities living at gazetted international entry points of the Kigezi sub-region in Uganda.



Specific objectives
i. To establish the knowledge of the community members in selected gazette international entry points in the Kigezi region regarding measures instituted to stop the spread of COVID-19 in Uganda.

ii. To assess the attitudes of the community members in selected gazetted international entry points in the Kigezi region towards measures instituted to stop the spread of COVID- 19 in Uganda.

iii. To investigate the practices of community members in selected gazetted international entry points in the Kigezi region on measures instituted to stop the spread of COVID- 19 in Uganda.

 Kenya 2021-04-09 2024-04-09 Social Science and Humanities Non-degree Award
NEEMA NAKYANJO -
ID:
Fishing and inland communities – understanding transmission linkages and networks
REFNo: SS698ES

a) To understand the socio-structural context of migration of high risk persons/key populations to and from high HIV prevalence Lake Victoria fishing communities and other geographic areas with high HIV-prevalence
b) To use molecular, social and epidemiological data to identify and elucidate the factors/associations of transmission linkages/networks within key and general population cohorts/groups.
c) To increase our understanding of HIV prevention and care utilization of high risk persons/key populations moving to and from places with high rates of HIV infection
 Uganda 2021-04-09 2024-04-09 Social Science and Humanities Non-degree Award
JULIET MWANGA-AMUMPAIRE
ID: UNCST-2022-R009420
 Impact of malnutrition on pharmacokinetic of rifampicin, isoniazid, pyrazinamide and ethambutol in TB-HIV co-infected children
REFNo: HS1217ES

Primary Objective
To assess the effect of Severe Acute Malnutrition (SAM) on plasma concentration of rifampicin, isoniazid, pyrazinamide, and ethambutol in children with TB.

Secondary Objectives
1. To assess the effect of HIV-infection and antiretroviral treatment on plasma concentration of rifampicin, isoniazid, pyrazinamide, and ethambutol in children with TB and Severe Acute Malnutrition (SAM)
2. To assess whether new WHO-based dosages will achieve rifampicin, isoniazid, pyrazinamide, and ethambutol drug concentrations above the target therapeutic concentrations in HIV-TB co-infected children with and without SAM
3. To assess the effect of nutritional parameters, HIV-infection, antiretroviral treatment, and other factors (age, liver enzymes, NAT2 status) on PK parameters of rifampicin, isoniazid, pyrazinamide, and ethambutol in HIV-infected children with TB
4. To build a PK/PD relationship between drug concentrations and TB treatment outcomes
5. To assess rifampicin protein binding in relation with malnutrition and albuminemia
6. To derive an optimal dosing algorithm for rifampicin, isoniazid, pyrazinamide, and ethambutol that will adequately provide optimal exposures to malnourished and HIV infected children

 Uganda 2021-04-09 2024-04-09 Medical and Health Sciences Non-degree Award
Eva  Laker Odongpiny Agnes
ID: UNCST-2024-R004807
 A Toll-Free Call Intervention to Improve Adverse Events Reporting in Patients On Dolutegravir in Three Health Centers in Kampala, Uganda and a Prospective Cohort Study to Describe Adverse Events to Dolutegravir at the Infectious Diseases Institute (DOLUPHARM)
REFNo: HS1263ES

A) Primary objective (Objective 1)
To determine whether a toll-free phone system for reporting of adverse events by clinicians and patients improves adverse event reporting compared to standard reporting methods using paper based or online forms by clinicians in three health centers initiating/switching patients to DTG between November 2020 and October 2021.

B) Secondary objective (Objective 2)
To determine level of uptake and the experiences of clinicians and patients with using a toll-free phone system for reporting adverse events compared to standard reporting methods using paper based or online forms in three health centers initiating/switching patients to DTG between November 2020 and October 2021

Prospective Cohort Study
A) Primary objective (Objective 3)
To describe the incidence and factors associated with occurrence of different adverse events among patients being switched/initiated on a DTG-based regimen at the IDI.

B) Secondary objective (Objective 4)
To determine whether occurrence of adverse events affects adherence to medications among patients being switched/initiated on a DTG-based regimen at the

Uganda 2021-04-09 2024-04-09 Medical and Health Sciences Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
 NEW APPROACHES FOR THE EARLY DETECTION OF CERVICAL NEOPLASIA
REFNo: HS1161ES

1. Determine acceptability and accuracy of a low-cost smartphone confocal micro-endoscope imaging technique for the diagnosis of CIN 2+. Confocal images will be compared against gold-standard histopathology to obtain preliminary diagnostic performance characteristics.
2. Compare various cervico-vaginal fluid (CVF) biomarkers to gold-standard histopathology for the diagnosis of CIN 2+. Qualitative and quantitative levels of biomarkers will be compared against gold-standard histopathology to obtain diagnostic performance characteristics.


Uganda 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
Susan Tino
ID:
Scale-Up and Capacity Building in Behavioral Science to Improve the Uptake of Family Planning and Reproductive Health Services (SupCap)
REFNo: HS1196ES

1. To test if the BSci Package can lead to an increased uptake of modern contraceptive methods improvements in gender norms, an increase in knowledge of contraceptive methods, birth spacing, and childrearing among postpartum women.

2. To find out how we effectively and efficiently replicate and scale up the BSci Package across Eastern Uganda and elsewhere.

 Uganda 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa (SAPPHIRE)
REFNo: HS1239ES

Overall Objective: Our overall objective is to determine to reduce HIV incidence and to improve community health with multi-sector, scalable interventions.

Primary Objective: Reduce HIV incidence using innovative strategies for HIV prevention and treatment to simultaneously reach “persistent driver” populations.

Secondary Objectives:
1. Evaluate and optimize individual intervention component effects, alone (Phase A) and in combination (Phase B), versus control conditions on prevention coverage and HIV viral suppression
2. Assess the effect of the intervention package on other health outcomes (all-cause mortality, tuberculosis, hypertension linkage and control, heavy alcohol use and mother-to-child HIV transmission) in Phase B
3. Evaluate behavioral and other mechanistic pathways for intervention effects on proximal mediators of HIV incidence in Phase B
4. Assess the reach, effectiveness, patient and provider adoption, and fidelity and the maintenance of intervention components in Phase B
5. Use final study data to inform a strategic and sustainable investment model that maximally reduces HIV incidence and improves community health for the combination interventions tested in Phase B

 Uganda 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
CARL CHRISTIAN STECKER CHRISTIAN
ID:
Caregiver-Assisted Oral Fluid-based HIV Screening in Children: Estimation of Acceptability, Feasibility and Effectiveness Linked to Index Testing Services in Uganda.
REFNo: HS1258ES

The purpose of this study is to evaluate the acceptability, feasibility and effectiveness of a caregiver-assisted oral fluid based HIV test to screen children for HIV. The results of this study are intended to support expanded access to HIV testing and treatment services for children, and to ensure that all newly diagnosed children are linked to clinical care.

The primary objectives of this study are to:
1. Estimate the acceptability of implementing caregiver-assisted oral fluid-based HIV screening for children as part of index testing services for HIV-positive adults.
2. Estimate the feasibility of implementing caregiver-assisted oral fluid-based HIV screening for children as part of index testing services for HIV-positive adults.
3. Estimate the effectiveness of caregiver-assisted oral fluid-based HIV screening on testing yield, return to clinic, and linkage to ART for newly identified CLHIV.

The secondary objective of the study is to:
Estimate the cost of caregiver-assisted oral fluid-based HIV screening compared to the standard costs of the existing referral to testing program, from the perspective of the health care provider.

 USA 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
Leah Pauline
ID:
The Paradox of Being an Adolescent Girl in Uganda During a Global Pandemic
REFNo: SS765ES

My research aims to answer the following
research question and sub-questions:
How do adolescent girls in Uganda navigate the liminal period of COVID-19 when their
educational aspirations of empowerment are put on hold and they face exacerbating
pressures to abide by gender roles/expectations?
Sub-questions:
1- How do high school drop-outs in Uganda differ before and after the onset of the COVID-19 pandemic?
2- What factors influence adolescent girls’ reproductive health and
whether or not they return to school?
3- How do adolescent girls’ future aspirations play a role in their
continuation of schooling?
4- How do adolescent girls interpret peer drop-outs as they navigate their
own decision to continue their education or drop-out?
 USA 2021-04-08 2024-04-08 Social Science and Humanities Degree Award
Matthew Cooper
ID: UNCST-2021-R013904
 Legacy effects of land-use on tropical soils as constraints on the restoration success and service provision of tropical forests in Uganda
REFNo: NS157ES

The research subject of this project will be the evaluation of soil fertility, soil degradation, C sequestration in both soils and plants, and biodiversity along
tropical secondary forest successions in Western Uganda in three work
packages.
 UK 2021-04-06 2024-04-06 Natural Sciences Degree Award
FRANCIS KIBIRIGE
ID:
Do Legislatures Enhance Democracy in Africa, Uganda Chapter
REFNo: SS774ES

DLEDA Project seeks to understand how parliaments in (selected) African countries fulfill the core functions of parliament. This knowledge will enable DLEDA to answer three major questions, including:

Question 1: Which policy decisions are made in the national assembly?

Question 2: Who are the Members of Parliament (i.e. caliber) and how do they interact with each other?

Question 3: How do MPs represent their constituents and what are the existing mechanisms of political accountability?

 Uganda 2021-04-06 2024-04-06 Social Science and Humanities Non-degree Award
Allan Lugaajju
ID:
B-CELLS AND HUMORAL FACTORS MEDIATING MALARIA IMMUNITY IN CHILDREN AND ADULTS
REFNo: HS1267ES

1.To quantify reactive Plasmodium falciparum specific B cell subsets against parasite antigens in children and adults.

2.To functionally characterize anti-Plasmodium falciparum B cell subset downstream responses in children and adults

3.To compare the reactivity and proportions of Plasmodium falciparum specific B cell subsets in children and adults

Uganda 2021-04-06 2024-04-06 Medical and Health Sciences Non-degree Award
David Lwanga
ID:
CONFLICTING PRESSURES FOR CHANGE AND INSTITUTIONAL LEGITIMACY IN KAMPALA CAPITAL CITY AUTHORITY, UGANDA.
REFNo: SS780ES

5. To find out the extent to which quantitative results on institution legitimacy of KCCA supports the initial qualitative results.,4. To examine the extent to which the legitimacy of KCCA is a result of harmonizing conflicting pressures for change. ,3. To find out how KCCA dealt with pressures resisting change during the transformation period.,2. To establish the strategic responses that KCCA adopted to attain institutional legitimacy.,1. To establish what institutional pressures influenced the transformation of KCC to KCCA.,To understand how Kampala Capital City Authority attained institutional legitimacy amidst conflicting pressures for change, that is how change initiatives can be positively embraced, hence creating self-reinforcing sequences for institutional legitimacy. ,
 Uganda 2021-04-06 2024-04-06 Social Science and Humanities Degree Award
Borja Perez-Viana
ID:
Go for It while You Can: On Time Discounting in High-Risk Environments
REFNo: SS448ES

The poor populations of developing countries are extremely exposed to the vagaries of chance, with agricultural output and livelihoods dependent on highly variable weather patterns. Against this background, it is important to better understand how people in developing countries make decisions involving risk and time trade-offs. Our understanding of these decisions is still hampered by a number of issues. For one, decisions under risk and over time have long been treated separately, whereas in reality, they are closely linked. Investigations in developing countries have often focused on exceedingly simple preference measures that are presented in a theoretical vacuum. Likewise, the identification of causal determinants of preferences remains elusive. We propose to overcome these limitations by combining the modelling of preferences and their determinants with bespoke tools to measure preferences and beliefs. We further propose to combine the model-driven measurements with randomised controlled trials (RCTs) varying theoretically identified determinants of preferences to enable us to draw clear causal inferences. Combining such RCTs with a longitudinal design will further allow us to investigate interactions between the randomly allocated interventions and naturally occurring uncertainty. The study will be carried out in collaboration with the Field Lab, a non-for-profit research organisation, based in Mbale.

We divide our proposal into five work packages:

1. Modelling and measuring future uncertainty: The future is inherently uncertain. It is even more so in developing countries. This uncertainty may indeed drive both high levels of risk taking in the present and extreme time discounting. In this first work package, we aim to model this issue explicitly, and to measure the underlying quantities, with particular attention to future uncertainty.

2. Future probabilities are ambiguous: This work package extends the insights obtained in the first work package to explicitly take the uncertainty surrounding future probability estimates into account. The modelling and experimental measurements are further complemented by a randomised variation of the institution delivering the future payouts.

3. Gain, loss, and mixed inter-temporal prospects: In work package three, we propose to extend the theoretical and measurement apparatus deployed in the first two work packages to a full inter-temporal prospect theory model. This is important to model real decisions, which often involve trading off immediate expenditures against uncertain future outcomes.

4. Background risk and behaviour: Starting from a model of the influence of background risk on decisions under risk and over time, we aim to provide crop insurance to randomly selected subsistence farmers in order to shelter them from background risk. This ought to allow us to draw causal inferences on the effect of background risk on preferences and behaviour.

5. Training, aspirations, and locus of control: Taking risks and investing into the future may be mediated by psychological mechanisms such as aspiration levels or locus of control (beliefs on whether one can control one’s destiny). We aim to augment an existing training intervention by motivational elements aimed directly at shifting these psychological mechanisms, to try and nudge preferences and behaviour in desirable directions.
 Spain 2021-03-31 2024-03-31 Social Science and Humanities Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Surveillance and Epidemiology of Antimicrobial Resistance Programme (Pilot)
REFNo: HS1268ES

Primary

To evaluate AMR incidence through the establishment of a surveillance platform in LMICs based on Pfizer’s Antimicrobial Leadership Testing and Surveillance (ATLAS) core methodology, while facilitating the expansion of surveillance capacity in participating countries.
Secondary.
To strengthen the quality of identification and antimicrobial susceptibility testing of major bacterial pathogens by the participating laboratories through retesting at a central reference laboratory;
ï‚· To estimate and track the prevalence of resistance phenotypes of major public health importance notably extended spectrum cephalosporin resistance, Carbapenem resistance and MRSA;
ï‚· To generate WGS data that shall be used for epidemiological typing and determining mechanisms of resistance of major resistance phenotypes in participating countries.
 Uganda 2021-03-31 2024-03-31 Medical and Health Sciences Non-degree Award
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
 A Midline Evaluation for a 5 Year Family Planning Implementation Program: The RISE Project in Uganda
REFNo: HS1296ES

1. Describe the socio-demographic characteristics of men and women of reproductive age living in the seven RISE regions at midway of implementation of RISE programme
2. Assess the program progress from baseline to midline on each of the following program intervention areas
a. men and women’s knowledge of FP services and methods in the project areas
b. men and women’s attitudes towards FP in the project areas
c. FP practices amongst men and women of reproductive age in the project areas
d. the intention to use FP services in future among men and women of reproductive age in the project areas
e. Ability and willingness to pay for FP services among men and women of reproductive age group in the project areas
f. level of exposure to SBCC messages on FP amongst men and women of reproductive age in the project areas
g. status of FP user segments for both men and women of reproductive age in the project areas in terms of Knowledge, attitude, practices, intent to use, exposure
3. Assess the effect of COVID-19 on access of family planning services among men and women of reproductive age living in the seven RISE regions at midway of implementation of RISE programme

 Uganda 2021-03-31 2024-03-31 Medical and Health Sciences Non-degree Award
Moses Ocan
ID:
Predictors of local emergence and spread of Artemisinin resistance among Ugandan Plasmodium falciparum parasites
REFNo: HS1169ES

(i) To assess the extent of adherence to national malaria treatment guidelines/policy in malaria treatment in private hospitals, private pharmacies and public hospitals in low and high malaria transmission settings in Uganda
(ii) To determine the prevalence of Pfkelch13 gene mutations among P. falciparum parasites in low and high malaria transmission settings in Uganda
(iii) To determine the prevalence of fd (ferredoxin), arps10 (apicomplast ribosomal protein S10) , mdr-2 (multi-drug resistance protein -2) and crt (chloroquine resistance protein) mutations among Plasmodium falciparum parasites in low and high malaria transmission settings in Uganda

 Uganda 2021-03-26 2024-03-26 Medical and Health Sciences Non-degree Award
Pakoyo Kamba Fadhiru
ID:
Scaling up the Refugees and Host Community’s response towards COVID-19 in Northern Uganda
REFNo: SS755ES

1. To assess the refugee and host communities’ compliance with COVID-19 infection prevention and control measures such as social distancing, hand washing, hand sanitization, use of personal protective equipment, quarantine and notification of cross-border travellers and suspect cases to authorities. 2. To identify community-led initiatives towards COVID-19 infection prevention and control. 3. To build the capacity of refugee settlement and community leaders in COVID-19 infection prevention and control.
Uganda 2021-03-26 2024-03-26 Social Science and Humanities Non-degree Award
Shevin  Jacob Thomas
ID:
EVALUATION OF PHARMACOKINETICS, SAFETY AND FEASIBILITY FOR ADMINISTRATION OF TWO DOSES OF INTRAVENOUS VITAMIN C COMBINED WITH VITAMIN B1 FOR THE MANAGEMENT OF ADULT PATIENTS ADMITTED WITH SEPSIS TO KIRUDDU NATIONAL REFERRAL HOSPITAL Short Title: RANDOMISED EVALUATION OF A VITAMIN C BUNDLE FOR SEPSIS TREATMENT IN AFRICA (REVISTA-DOSE)
REFNo: HS1236ES

General objective: In the future REVISTA-RCT, we intend to evaluate the components of a metabolic bundle comprising vitamin C, vitamin B1, and corticosteroids in order to determine if a combined effect of the bundle has greater efficacy (than bundle components or placebo) in decreasing 28-day mortality due to sepsis in adult patients in SSA. In preparation for the RCT, we intend to utilize the REVISTA-DOSE study to answer key questions about optimal dosing and safety for intravenous vitamin C (in combination with vitamin B1) in patients hospitalized with adult sepsis in two Ugandan referral hospitals. Primary objectives: 1. Describe the dose-plasma concentration response from two different doses of intravenous vitamin C (in combination with vitamin B1) Secondary objectives: 1. Evaluate the safety and tolerability of intravenous vitamin C (in combination with vitamin B1) in adult medical patients with sepsis in Uganda 2. Assess the enrolment rates, adherence to protocol and feasibility of conducting an RCT in patients with sepsis within the ARCS cohort of patients Exploratory objectives: 1. Evaluate association of vitamin C and vitamin B1 levels on clinical parameters/markers, including those for: a. Disease severity: shock; lactate clearance; qSOFA score; ability to stand unaided b. Inflammation, infection: Procalcitonin c. Organ/metabolic function, including: renal function d. Adverse events: hemolysis; oxaluria e. Outcomes: re-hospitalization frequency; length of hospitalization; 6 or 7 and 28d morbidity and mortality
USA 2021-03-26 2024-03-26 Medical and Health Sciences Non-degree Award
Barbara Mukasa
ID:
Evaluating the Glycemic Effects of Dolutegravir (DTG) Among Patients Receiving Dolutegravir Based Regimens at Mildmay Uganda ART sites : A Prospective Cohort Study
REFNo: HS1273ES

1.To determine the incidence of hyperglycaemia among patients receiving DTG based regimen at Mildmay Uganda supported sites. 2.To determine the association between previous NRTI or NRTtI exposure and the incidence of hyperglycemia among patients on TLD.
3.Evaluate predictors of hyperglycaemia among patients on TLD. 4.Describe other adverse events reported by study participants during the study period.
Uganda 2021-03-26 2024-03-26 Medical and Health Sciences Non-degree Award
Agnes Kiragga
ID:
Community Pharmacies for Assessing STI Prevalence using Point of Care diagnostics study (COPHAS)
REFNo: HS1274ES

Aim 1: To estimate the prevalence of curable STIs and HIV among persons accessing health services at community pharmacies in Kampala and Wakiso Districts.

Aim 2: To determine the feasibility and uptake of pharmacy-based specimen collection and POC testing for curable STIs and HIV among persons seeking health care services at community pharmacies in Kampala and Wakiso Districts. Uptake will be measured among the three groups of persons i.e. Persons seeking EC (group 1), clients with STI symptoms (group 2) and persons without STI symptoms (group 3)
Secondary quantitative aims:
Aim 3: To determine treatment completion among persons diagnosed with an STI at the community pharmacies in Kampala and Wakiso Districts.

Aim 4: To determine linkage to care and ART initiation among newly diagnosed HIV positive persons at the community pharmacies in Kampala and Wakiso Districts.

Aim 5: To determine the baseline and 3-month knowledge about STI and STI treatment guidelines, and principles of antimicrobial stewardship of pharmacy staff. In addition, to assess the acceptability of POC STI diagnostics collocated with the pharmacy, to pharmacy owners and staff.

Qualitative aims
Aim 6: To assess the acceptability and client satisfaction of STI and HIV testing at community pharmacies in Kampala and Wakiso Districts.

Partner notification sub-study
Aim 7: To determine the effect of technology-supported partner notification and treatment initiation using Call for LifeTM technology among persons diagnosed with an STI or HIV at community pharmacies.


 Uganda 2021-03-26 2024-03-26 Medical and Health Sciences Non-degree Award
Moses Adriko
ID: UNCST-2019-R001787
 Information and Evidence Rapid Needs Assessment for COVID-19 in Uganda
REFNo: HS1285ES

A rapid needs assessment gives insights about the dissemination and utilisation of information and evidence related to the coronavirus (COVID-19) pandemic by individuals engaged at various levels of public health. The use of timely and accurate information about COVID-19 by public health workers will help to support the population in risk reduction through community education and the adoption of protective behaviours. As the outbreak progresses, it is important to understand: how health workers are getting their information (the sources); if the dissemination of official guidance is received, how it is perceived, and if it is followed; and the gaps in information and evidence at the subnational level; identify needs related to community and health facility COVID-19 information materials. Developing an understanding of and monitoring these issues will increase the use of timely and accurate information, and ultimately improve the dissemination of timely and accurate information to the population. The objectives of the project are as follows:
(1) To understand the different sources of information used by health workers in decision making on COVID-19.
(2) To identify the gaps in the dissemination of accurate information in the management of COVID-19 in Uganda.
(3) To improve the dissemination of timely and accurate information to the population about COVID-19 in Uganda.

 Uganda 2021-03-26 2024-03-26 Medical and Health Sciences Non-degree Award
Peter Olupot-Olupot
ID:
H-PRIME Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden
REFNo: HS818ES

TRIAL OBJECTIVES
The primary objective of the trial is to identify pragmatic, effective, safe and acceptable interventions to reduce short and longer-term mortality and morbidity in children with SCD in sub-Saharan Africa. There are three hypotheses being tested

1. [Randomisation, R1] Daily oral hydroxyurea at a fixed weight-band based dose given with clinically driven (rather than routine scheduled) laboratory monitoring, without titrating doses to the MTD, will reduce all-cause mortality compared with placebo
2. [R2] Enhanced antimalarial prophylaxis will reduce malaria-associated hospitalisation vs standard of care (SOC) (open-label)
3. [R3] Enhanced antimicrobial prophylaxis will reduce all-cause hospitalisation vs SOC (open-label)

Secondary objectives include
 To determine the efficacy of the strategies above on other measures of morbidity
 To determine the safety and tolerability of the strategies above
 To identify the most cost-effective interventions to reduce mortality and morbidity, and assess their budget impact
 To investigate the cardiac safety of DHA-PQP in children with sickle cell disease
 To investigate the resistance patterns of malaria parasites acquired by children on different forms of malaria prophylaxis

 Uganda 2021-03-24 2024-03-24 Medical and Health Sciences Non-degree Award
Emmanuel Bizimungu
ID:
The role of incentives for adoption of climate-smart agricultural innovations: An experimental evaluation in Uganda
REFNo: SS502ES

The main objective of this study is to assess the effectiveness of the incentives for the adoption of Climate-smart Agricultural (CSA) innovations, and ensuing impacts on farming systems resilience and household welfare, and examine the effects of weather, market, and payment uncertainties on investments in CSA innovations.

Specifically, this research will:
1. Assess the effects of different bundles of ‘push’ and ‘pull’ incentives on adoption intensity of climate-smart agricultural practices and technologies;

2. Determine smallholders’ behavioral responses to shocks and examine the extent to which uncertainties regarding weather, market and, timing of payment influence smallholders’ decisions to invest in inputs with/without incentives;

3. Analyze the effects of CSA adoption for intra-household decision-making;

4. Assess the impacts of CSA practices and technologies on farming systems’ resilience, factor productivity, revenues, income and, nutrition.

 Uganda 2021-03-24 2024-03-24 Social Science and Humanities Degree Award
EVA NATUKUNDA
ID: UNCST-2020-R014330
 Safety of alternative second- line anti-retroviral drugs in HIV- infected children living in Uganda and Zimbabwe
REFNo: HS1071ES

1. To evaluate the renal and bone adverse events associated with TAF when compared to ABC or ZDV among HIV infected children on second line ART
2. To evaluate the effect of TAF on BMD and turnover markers compared with ZDV or ABC among HIV infected children on second line ART.

3. To evaluate the effect of ritonavir boosted Atazanavir (ATV/r), Darunavir (DRV/r), Lopinavir (LPV/r) and DTG based regimens on lipid profiles and body fat distribution.
4. To determine the prevalence and baseline characteristics associated with low BMD among children starting second- line ART in Uganda.
5. To determine the sensitivity, specificity and predictive values of the QUA compared with DXA scan in measuring BMD among HIV infected children on second line ART.


 Uganda 2021-03-24 2024-03-24 Medical and Health Sciences Degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
 Family SuppleMented pAtient monitoRing afTEr suRgery (SMARTER) pilot trial
REFNo: HS944ES

To develop a training and support intervention, in accordance with the MRC complex intervention framework, to train family carers to perform and document basic vital signs, to supplement routine monitoring of patients by nursing staff, whilst they provide personal care to their relatives after surgery and to evaluate the effect of this intervention on frequency of documented vital signs for patients in the first three days after surgery in a stepped-wedge cluster trial.
To evaluate compliance with the trial intervention, and how this changes over the duration of the trial.
To evaluate the effect of the intervention on in-patient mortality, to inform the design of a subsequent international clinical trial across Africa
 UK 2021-03-23 2024-03-23 Medical and Health Sciences Degree Award
Robin NESBITT Clark
ID:
Impact of COVID-19 on HIV and TB patient care in Malawi and Uganda
REFNo: HS1218ES

To describe the impact of COVID-19 and the public health measures to control the spread of COVID-19, on HIV and TB patients and their care in the MSF projects in Chiradzulu, Malawi and Arua, Uganda, including patient perspectives and perceptions.
 Canada 2021-03-23 2024-03-23 Medical and Health Sciences Non-degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
 Pilot Randomized Controlled trial: Preventing infant Malnutrition (PrIM)
REFNo: HS1226ES

Primary Objective
To determine the effect of early small volume supplementation (ESVS) on weight-for-age Z-scores (WAZ) at 30 days of age.
Secondary Objectives
1. To determine the effect of ESVS on WLZ at 30 days of age.
2. To determine the effect of ESVS on WAZ, WLZ, and LAZ through 6 months
of age.
3. To measure the effect of ESVS on breastfeeding duration through 6 months of
age.
4. To determine the effect of ESVS on intestinal microbiota at 30 days of age.
 Uganda 2021-03-23 2024-03-23 Medical and Health Sciences Non-degree Award
Catherine Barasa Asekenye
ID:
Development of community-led approaches to support sexual and reproductive health among survivors of trafficking in Uganda
REFNo: SS746ES

1. Define survivor-led SRH priorities
2. Identify gaps in addressing priorities as identified by survivors and local healthcare providers
3. Test the methodological suitability of two participatory approaches (Photovoice and participatory action research) as transformative methods
4. Bring together stakeholders working with communities of survivors, and based on objectives 1–3, develop a Phase II intervention that supports transformative participatory research approaches among communities of survivors and works with local healthcare providers to provide integrated SRH, as per the needs and expectations of survivors
Uganda 2021-03-23 2024-03-23 Social Science and Humanities Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
 Prevalence and Economic Importance of Key Endemic Livestock Diseases in Kaabong and Amudat Districts, Karamoja Region
REFNo: NS163ES

The specific objectives of this project will be to determine: -
i.Sero-prevalence of FMD, CBPP and CCPP in Amudat and Kaabong districts, Karamoja region
ii.Prevalence of Tick-borne hemoparasites [TBHs] in cattle populations from Amudat and Kaabong districts, Karamoja region
iii.Prevalence of helminths Species of Veterinary importance in Amudat and Kaabong districts, Karamoja region
iv.Estimates of the socioeconomic impact of FMD, CBPP and CCPP in Amudat and Kaabong districts, Karamoja region
v.Estimates of the socioeconomic impact of TBHs in Amudat and Kaabong districts, Karamoja region
vi.Estimates of the socioeconomic impact of different helminths Species of Veterinary importance in Amudat and Kaabong districts, Karamoja region
Uganda 2021-03-23 2024-03-23 Natural Sciences Non-degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 PrEP Persistence and Risk of HIV and Sexually Transmitted Infections among Transgender Men in Uganda
REFNo: HS990ES

Aim 1: Characterize HIV and STI prevalence and risk among trans men Aim 2: Evaluate PrEP uptake and persistence among HIV-negative trans men Aim 3: Explore sexual health experiences and risk behaviours of trans men in Uganda
Uganda 2021-03-22 2024-03-22 Medical and Health Sciences Non-degree Award
Justin Willis
ID:
Uganda’s past, Uganda futures: debates over government, equality and justice, 1979-80
REFNo: SS473ES

· The building of an interdisciplinary research team that demonstrates the relevance of study of the past through a co-produced programme of research and capacity-building;
· Providing a cohort of early-career Ugandan scholars with mentored experience in the techniques of researching the past through interdisciplinary methods, academic writing, and writing for non-academic audiences;
· Producing a published volume showcasing the work of the team;
· Publishing a project blog presenting key findings of the research to non-academic audienc-es
· Creating media outputs that widen the audience and impact of the research
· Presenting the research to civil society organizations, policy makers and a wider audience through a final mini-conference
· The development of one or more applications for further external funding that will enable the career progression of these researchers and the sustainability of the network

 UK 2021-03-19 2024-03-19 Social Science and Humanities Non-degree Award
Ponsiano Ocama
ID: UNCST-2019-R000440
 Obesogenic Impact of Dolutegravir-based Antiretroviral Therapy among HIV-Infected Ugandans
REFNo: HS1029ES

The primary aim is to rigorously investigate the obesogenic effects of DTG switches including: 1. Body composition changes, using body mass index (BMI) and anthropometrics and whole body DXA to measure lean and fat mass (including whole body, trunk, and limb). 2. Ectopic fat changes, emphasizing hepatic fat as measured noninvasively using the continuous attenuation parameter (CAP) measured in dB/m by FibroScan. 3. Cardiometabolic changes, through measurement of HOMA-IR, hemoglobin (Hb)A1c, and fasting lipid panel. We will also explore a major potential mechanism of INSTIrelated weight gain by measuring orexigenic (ghrelin, adiponectin) and anorexigenic (leptin, PYY) hormones, which have been implicated in the pathogenesis of antipsychotic related weight gain, as well as weight loss related to bariatric surgery
 Uganda 2021-03-18 2024-03-18 Medical and Health Sciences Non-degree Award
Aisa Muhamad
ID:
Rewards Management and Performance of Selected Secondary Schools in the Central Region of Uganda
REFNo: SS713ES

i) To establishthe rewards provided in theselected secondary schools in central region of Uganda.
ii) To examine the relationship between monetary rewards andthe performance of secondary schools in central region of Uganda.
iii) To examine therelationships ofnon-monetary tangible rewardsand the performance of secondary schools in central region of Uganda.
iv) To establish the relationships ofnon-monetary intangible rewards and the performance of secondary schools in central region of Uganda.
v) To examine the level of school performance in the selected secondary schools in central region of Uganda.

Uganda 2021-03-18 2024-03-18 Social Science and Humanities Degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 Formative research to guide PrEP delivery within harm reduction services for people who use drugs in Uganda
REFNo: HS1202ES

Aim 1. To explore experiences with and willingness for PrEP for PWUD:
a.among PWUD in Kampala, Uganda, explore willingness to use PrEP.
b.among providers of oral PrEP and services for PWUD in Kampala, Uganda, explore willingness to prescribe PrEP

Aim 2. To explore experiences during the COVID-19 pandemic with regards to:
a.accessing services by PWUD
b.providing services for mental health, substance use, HIV prevention, and social services by harm reduction providers
 Uganda 2021-03-18 2024-03-18 Medical and Health Sciences Non-degree Award
ABDUL WALUSANSA
ID:
Drug Resistant Bacterial Contamination and Efficacy of Selected Herbal Medicines Sold in Kampala, Uganda
REFNo: HS1278ES

The broader aim of this study is examining the prevalence, antibiotic susceptibility, resistance genes in bacterial contaminants, and the antibacterial efficacy of selected herbal medicines sold in Kampala, in order to contribute to the mitigation of AMR.,To determine the antibacterial efficacy of some herbal medicines against selected drug-resistant bacterial isolates in Kampala. ,To examine the risk factors for bacterial contamination of herbal medicines sold in Kampala, Uganda ,To determine antibiotic resistance genes in multi-drug resistant bacteria isolated from herbal medicines sold in Kampala.,To determine the prevalence and antibiotic susceptibility of pathogenic bacterial contaminants such as, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Salmonella spp, Shigella spp, and Clostridium perfringens in herbal medicines sold in Kampala.,
 Uganda 2021-03-18 2024-03-18 Medical and Health Sciences Degree Award
Francis Kombe Kazungu
ID:
Implications of fieldworkers’ institutional support systems for research integrity practices in Africa
REFNo: SS760ES

i) Describe and analyse the existing literature, including concepts and theories related to fieldworkers’ institutional support systems and policies
ii) Identify and describe existing fieldworkers' institutional support systems at the participating research institutions.
iii) Critically evaluate how existing fieldworkers' institutional support systems and policies shape fieldworkers ethical and research integrity practices.
iv) Develop a best practice model and make recommendations to the participating institutions on fieldworkers’ institutional support systems

 Kenya 2021-03-18 2024-03-18 Social Science and Humanities Degree Award
John Rek
ID: UNCST-2024-R004373
 Bednet use across a spectrum of malaria transmission risk in Tororo and Busia Uganda
REFNo: SS769ES

1. Determine household- and individual-level characteristics that correlate with poor bednet use using novel metrics from an electronic adherence monitor.
2. Relate bednet use to malaria-related outcomes such as mosquito density, malaria infection and clinical malaria episodes.
3. Develop a theoretical behavioral model of bednet adherence using qualitative interviews.
4. Compare methods for objective bednet adherence monitoring using the SmartNet platform.

Uganda 2021-03-18 2024-03-18 Social Science and Humanities Non-degree Award
Aubryn Sidle Allyn
ID:
Barriers to Returning Girls to School After COVID-19 Related School Closures in East Africa
REFNo: SS750ES

1. Identify and disseminate information about the barriers that adolescent girls in Uganda are facing that may prevent school resumption once directives to resume are given.

2. Identify and disseminate information about promising best practice programming in distance education and returning formerly school-going adolescent girls to school, once schools

USA 2021-03-18 2024-03-18 Social Science and Humanities Non-degree Award
Agnes Kiragga
ID:
Piloting a HIV Risk assessment application to increase awareness and uptake of HIV prevention services among young adults in Uganda. (SIDARISK)
REFNo: HS1293ES

• To assess the extent of high-risk sexual behavior and related practices among young adults using a web-based individualized HIV risk platform (SIDARISK)
• To establish the feasibility of using an existing telehealth platform for the referral and linkage to HIV/STI testing and prevention services following risk assessment by the SIDARISK application.
• To understand acceptability of the SIDARISK application for HIV risk assessment among young adults in Uganda
• To establish the feasibility of using a telehealth platform for provision of information on HIV risk reduction and linkage to HIV and PrEP services following using of the SIDARISK application

 Uganda 2021-03-18 2024-03-18 Medical and Health Sciences Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
 Pilot feasibility study for uptake and implementation of a clinical algorithm for warfarin dosing in sub-Saharan African patients in the War-PATH Ugandan and South African clinical study sites.
REFNo: HS721ES

To evaluate whether the clinical algorithm improves anticoagulation control compared with local standards of care.
To determine the feasibility and acceptability of implementation of a clinical algorithm developed from the observational phase (phase 2) of the War-PATH study
 UK 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Ben Jones
ID:
Challenging categories: educated unemployed youth as institutional innovators in rural Uganda
REFNo: SS599ES

The objective of the study is to examine participation in local institutions to challenge understandings of youth, education and
unemployment. The outputs involve academic publications and advocacy work. The target population are educated unemployed youth and actors working with local institutions, including churches and courts. By “educated unemployed youth” we mean youth who are educated up to a minimum of S4.
 UK 2021-03-17 2024-03-17 Social Science and Humanities Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
 Gut Integrity and Metabolic Complications in Youth Living with HIV in Uganda.
REFNo: HS1036ES

The overall objective is to use surrogate markers to investigate the interplay between intestinal integrity, microbial translocation, immune activation, systemic inflammation and metabolic comorbidities in YLPHIV residing in urban and rural settings in Uganda.
Specific Aim 1: Assess differences in gut integrity, microbial and fungal translocation markers, as well as inflammation in YLPHIV compared to HIV-uninfected controls in Kampala (urban), and Gulu (rural), Uganda.
Specific Aim 2: Assess whether markers of gut integrity, translocation and inflammation are associated with adiposity, measured by dual-energy X-ray absorptiometry (DXA) and levels of the homeostatic assessment of insulin resistance (HOMA) in YLPHIV and HIV-uninfected participants in Kampala and Gulu.
Specific Aim 3: Assess the relationship between gut and inflammatory biomarkers and diet, physical activity, socioeconomic status and air pollution.
Uganda 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Christine Kiconco
ID:
Management of Agricultural Indigenous Knowledge in Agricultural Research Organizations in Uganda.
REFNo: SS739ES

1. To establish the efforts of AR4D organizations towards AIK management
2. To examine how AR4D researchers’ perceptions of AIK influence their attitudes towards AIK management
3. To assess how facilitating conditions influence AIK management efforts in AR4Ds
4. To explore strategies that can enhance AIK management in AR4Ds to prevent continued AIK loss and increase possibilities for its access and utilization in agricultural development.
 Uganda 2021-03-17 2024-03-17 Social Science and Humanities Degree Award
Shevin  Jacob Thomas
ID:
Understanding Drivers of Antimicrobial Resistance Among Mothers and Children in Uganda (DRUM+)
REFNo: HS1185ES

Understanding Drivers of Antimicrobial Resistance Among Mothers and Children in Uganda (DRUM+)
Specific Objectives:
Determine the prevalence of ESBL-E and ESBL-K bloodstream infections (BSI) and colonization among peripartum women and neonates/children < 5yo hospitalized with suspected sepsis.
2. Among peripartum women and neonates/children < 5yo hospitalized for suspected sepsis, determine the clinical outcomes, including morbidity (e.g., incidence of chronic kidney disease), mortality percentage (in-hospital and up to 4 months after the date of hospitalization) and frequency of readmission up to 4 months after the date of hospitalization.
3. Determine whether there is a molecular epidemiologic linkage between household carriage (including humans, associated domestic animals, and environment) of ESBL-E and ESBL-K AND patients (peripartum women or neonates/children < 5yo) hospitalized with sepsis who have ESBL-E and ESBL-K BSI or colonization.
4. Among patients (peripartum women or neonates/children < 5yo) hospitalized with sepsis who have ESBL-E and ESBL-K BSI or colonization, evaluate drivers of AMR transmission in Uganda (e.g., directionality of transmission and independent risk factors for transmission) using a dynamic agent-based model incorporating their microbiologic resistance data AND the data from linked households describing microbiological resistance and WASH observations.
 USA 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Coleen Sabatini
ID: UNCST-2019-R001321
 Outcomes of Vascularised Fibula Flaps for Reconstruction of Segmental Bone Defects at CoRSU Rehabilitation Hospital
REFNo: HS1203ES

General Objectives To assess if vascularised fibula flap surgery for long segmental bone defects results in good outcomes for patients with an acceptable complication profile. Specific objectives 1.To determine the functional and aesthetic outcomes of vascularised fibula flaps for treatment segmental bone defects from osteomyelitis. 2.To determine outcomes of use of vascularized fibula flap in reconstruction for pseudarthrosis of the tibia, benign tumor, trauma and infection 3.To determine the complications related to the use of vascularized fibula flap in the patient populations of infection, trauma, tumour, and pseudarthrosis.
USA 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Jakob Svensson
ID: UNCST-2021-R013843
 The impact of value chain participation for smallholder farmers: evidence from the coffee sector in Uganda
REFNo: SS754ES

This proposal builds on our earlier work by trying to answer a logical follow-up question. Given what we know, namely: (i) supply side interventions tend to raise adoption rates (although the effect sizes are typically modest) but at best tend to have a marginal effect on farmer income, (ii) improved market access (a demand intervention) resulted in upgrading and large positive effect on both farm profit and productivity, but quantitatively small effects on adoption rates, there may be important complementarities between the supply and demand side.

The main objective of this study is to study the impact on productivity (yield) and income (farm profit) of relaxing both supply constraints and a demand constraint (access to a market for quality produce). Or in other words, what is the impact on productivity and income of farmers gaining access to a market where quality produce is paid a premium (i.e. participates in a high-value chain) and at the same time get access to subsidized inputs? By studying such complementarities between demand and supply factors, our proposed study is unique.
Sweden 2021-03-17 2024-03-17 Social Science and Humanities Non-degree Award
Janet SEELEY
ID:
Rapid assessment of secondary school physical and social environments for menstraul health in Uganda
REFNo: HS1270ES

1)To describe the current status of schools and menstrual health programmes being implemented
2)To describe the social and physical school environment, access and type of basic WASH facilities and school facilities for illness management.
3)To develop an understanding of the interactions between school staff, students and parents and the social and physical school environment relating to menstraul health.
 UK 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Herve Monka Lekuya Monka
ID:
Depressed Skull fractures: Timing of surgery, systemic inflammatory response, intraoperative blood loss, surgical site infection, and post-traumatic seizures - (DESTINE study)
REFNo: HS1284ES

5) To compare the risk of developing a delayed PTE up to 6 months of postoperative period between early and delayed surgery of DSFs ,4) To compare the risk of SSI within 3 months of postoperative period between early and delayed surgery of DSFs ,3) To compare the volume of intraoperative blood loss during the elevation of the DSFs between early and delayed surgery ,2) To compare the changes of serum levels of inflammatory cytokines among TBI patients regarding the timing of the elevation of DSFs ,1) To describe the epidemiology, clinical and radiological presentations of patients with DSFs ,This study aims to determine whether the timing of surgery of DSFs has a relationship with the changes of the biological markers of SIR, the risk of excessive intraoperative blood loss, the occurrence of SSI, and the incidence of PTE; this could optimize the clinical management of patients with head trauma in LMIC settings.,
 Democratic Republic of Congo 2021-03-17 2024-03-17 Medical and Health Sciences Degree Award
VINCENT KIBERU MICHEAL
ID:
Implementing and evaluation of a low-resource digital infrastructure in Uganda: Visualization and Interpretation of Radiographic Images (VIoRI) to improve access to imaging services at Mulago and Kayunga regional referral hospitals.
REFNo: HS1287ES

a) To determine the diagnostic accuracy (specificity and sensitivity) of ordinary core i3 PC based display systems when compared to the dedicated PACS Workstations.
b) To determine the quality of JPEG images on ordinary core i3 PC’s compared to the DICOM images generated by the PACS workstations.
c) To determine the turnaround time of patient’s diagnosis processes using ordinary core i3 PC based digital display systems relative to the PACS workstations.
d) To strengthen research capacity and collaborations with the Ministry of Health so as to allow continuity of innovative digital health research that informs improved service provision.

 Uganda 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
 Availability and use of essential medicines and health supplies
REFNo: HS1122ES

4. Explore the effect of centralized funding mechanism on the availability of essential medicines in private not for profit facilities,3. Assess the impact of SPARS on the quality of HMIS health facility logistics data.,2. Determine the effect of SPARS on the availability of essential medicines and health supplies in public and private not for profit health facilities,1. Determine the effect SPARS has had on medicines management practices within health facilities during the scale-up period beyond one year,
 Uganda 2021-03-16 2024-03-16 Medical and Health Sciences Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
 Understanding the trajectories of individuals in Uganda with trace M. tuberculosis nucleic acid in sputum- The TURN-TB study (Trace Ultra Result iNsight in TB screening)
REFNo: HS1177ES

1.To characterize baseline evidence for current or past TB disease and infection among individuals with Ultra-trace-positive sputum.
2.To longitudinally evaluate the incidence of TB and the dynamics of molecular, imaging, and immunological findings among individuals with trace-positive Ultra but no active TB at study entry.
3.To quantitatively and qualitatively explore the implications of trace-positive results and associated patient trajectories for active TB case finding strategies.

Uganda 2021-03-16 2024-03-16 Medical and Health Sciences Non-degree Award
Stephen  Ojiambo Wandera
ID: UNCST-2021-R012147
 Parent-Child Communication on Sexual and Reproductive Health in border districts of Eastern Uganda
REFNo: SS748ES

The aim of the study is to assess parents’ knowledge, attitudes, and practices (KAP) and preferred approaches to PCC on sexual and reproductive health in eastern Uganda. Specific objectives are:
1. To assess parents’ knowledge, attitudes, and practices about parent-child communication about sexual and reproductive health in eastern Uganda.
2. To determine the prevalence and determinants of PCC on SRH in eastern Uganda using survey data.
3. To examine the facilitators and barriers of PCC on SRH using qualitative data among parents in eastern Uganda.
4. To identify parents’ and children’s preferred approaches to PCC on SRH in eastern Uganda.

 Uganda 2021-03-16 2024-03-16 Social Science and Humanities Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Strategies for resolving the gap in Adolescent TB care in Uganda: A pilot cluster randomized-controlled trial
REFNo: HS1042ES

1.To develop an adolescent friendly TB screening package in Ugandan health facilities.
2.To evaluate the effectiveness of an adolescent friendly screening package for TB in Ugandan health facilities
3.To ascertain the cost effectiveness of rolling out an adolescent friendly TB screening intervention in Ugandan health facilities

 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Immaculate  Nankya Lillian
ID: UNCST-2020-R014784
 Validation of an Antigen ELISA based assay for the detection of SARS-CoV-2 RNA: A COVID-19 rapid diagnostic test method
REFNo: HS1103ES

• Demonstrate the ability of the AirJump ESP Platform, a simplified RNA isolation method to extract SARS COV-2 RNA from patient samples
• Evaluate an ELISA based assay to detect RNA converted to cDNA and bound to biotin labeled primers
• Assess accuracy of the ELISA assay in detecting SARS-CoV-2 from paired Nasal Pharyngeal swabs and saliva samples collected from COVID-19 positive and negative participants.
• Determine the Reproducibility of the Antigen ELISA Assay

 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
JOSEPH SSUUNA
ID: UNCST-2024-R016102
 Epidemiology and impact of HIV, NCD and urbanization syndemic in Africa.
REFNo: HS1188ES

Aim 1: Characterize HIV-related and -unrelated risk factors for cardiopulmonary non-communicable diseases (CP-NCDs) in a novel Rural-to-Urban (R2U) African cohort.

Aim 2: Characterize the impact of air pollution and moderating effects of HIV on cardiopulmonary clinical outcomes among R2U migrants.

Aim 3: Assess HIV and CP-NCDs health services utilization patterns among R2U migrants and design an integrated HIV/CP-NCD intervention.

 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
CHRISTOPHER  OPIO KENNETH
ID:
Knowledge, Attitudes and Practice of doctors in Uganda regarding screening, diagnosis and management of colorectal cancer.
REFNo: HS1198ES

To improve early detection, screening and the management of colorectal cancer in Uganda,
 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Amanda Murungi Eunice
ID:
Comparing the two transition feeding approaches in management of severe acute malnutrition among children 6-59 months: a randomized controlled trial (RCT)
REFNo: HS1200ES

To compare the effectiveness and outcomes of two transition phase feeding approaches (RUTF supplemented with F75 and RUTF only) children 6-59 months hospitalized with severe acute malnutrition in Mulago National Referral Hospital
 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Degree Award
Yahaya Gavamukulya
ID: UNCST-2019-R001017
 EVALUATION OF THE ANTI-SARS-CoV-2 ACTIVITY OF COMPOUNDS FROM Tephrosia linearis, Zanthoxylum chalybeum and Albizia coriaria AND FORMULATION OF HERBAL PRODUCT(S) FOR MANAGEMENT OF COVID-19
REFNo: HS1222ES

The general objective
To evaluate the antiviral potential of Tephrosia linearis, Zanthoxylum chalybeum and Alibizia coriaria, against SARS-CoV-2 and formulate herbal product(s) for management of COVID -19.

Specific objectives
i. To determine the in vitro anti-SARS‐CoV‐2 activity of the three selected medicinal plants in singular and in combination using SARS‐CoV‐2 infected mammalian cell lines (VeroE6).
ii. To determine the cytotoxicity and acute toxicity of the active medicinal plant(s) on mammalian cell lines (VeroE6) and swiss albino mice respectively.
iii. To determine the effects of the extracts on the immunological profile of cell lines
iv. To formulate and evaluate herbal product (s) from the most active medicinal plants for management of COVID-19.

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Kelly Mannion Ray
ID:
Understanding how variation in food effort and intake correlate with tool use in Bugoma Forest Chimpanzees
REFNo: NS155ES

To understand the potential drivers of tool use and how ecology plays a role
 USA 2021-03-15 2024-03-15 Natural Sciences Degree Award
Allen Kabagenyi
ID:
Adolescent Motherhood, Vulnerability Assessment and Newborn care practices, in Eastern Uganda (AMNEP)
REFNo: HS1248ES

The general objective of this study is to develop and test adolescent motherhood vulnerability assessment tool and to examine the knowledge, behavioral practices and perceptions of maternal and new born care among adolescent mothers in Luuka District.
Specific objectives
1. To examine the knowledge levels and awareness of maternal and newborn care among adolescent mothers and the community in Luuka District
2. To develop and test a community based adolescent mothers Vulnerability Assessment Tool
3. To assess the pre and postnatal maternal and newborn care practices and among adolescent mothers and the community in Luuka District
4. To explore the perceptions, vulnerability risk and barriers to unborn and newborn care management among adolescent mothers and the community in Luuka District

 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Degree Award
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