Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Benard Nsubuga
ID: UNCST-2024-R002324
Factors influencing the Functionality of Medicines and Therapeutic Committees in Public Health Facilities in Uganda: A Longitudinal Assessment
REFNo: HS5391ES

a) Provide the current functionality of MTCs in public HFs
b) Determine the factors associated with the functionality of MTCs in public HFs

Uganda 2025-02-07 17:56:57 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eve Nakabembe
ID: UNCST-2024-R015226
PReparing for OptimalPhase III/IV maTErnal Group B StreptococCal vaccine Trials in Africa
REFNo: HS5463ES

1. To generate longitudinal cohort data on pregnancies, deliveries and infant outcomes for maternal Group B Streptococcus vaccine safety assessment
2. To develop and strengthen capacities for Group B Streptococcus disease surveillance in infants less than 90 days old at Kawempe National Referral Hospital, using microbiological and molecular detection methods.
3. To explore the perceptions of pregnant women, health care providers, community members and other relevant stakeholders about the barriers and drivers for pregnant women to participate in Group B Streptococcus vaccine trials.
4. To co-create a communication/education toolkit to enhance understanding of the importance of maternal Group B Streptococcus vaccine trials and improve enrolment of pregnant women in vaccine trials in Uganda.

Uganda 2025-02-07 17:52:29 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tonny Okecha
ID: UNCST-2022-R011105
CLINICOPATHOLOGICAL AND MOLECULAR PROFILE OF MALE BREAST CANCER AT THE UGANDA CANCER INSTITUTE
REFNo: HS5435ES

2. To describe the mutational profile of male breast cancer at the Uganda Cancer Institute.,1. To describe the clinico-pathological features of male breast cancer at the Uganda Cancer Institute,To describe the clinicopathological and molecular profile of male breast cancer at the Uganda Cancer Institute.,
Uganda 2025-02-07 17:49:22 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrea Spray Lynn
ID: UNCST-2023-R007304
Maternal mental health and early childhood development in Kawempe
REFNo: HS5448ES

PRIMARY: To assess the associations between symptoms of common MMH conditions (depression and anxiety) and child care practices and outcomes (physical growth and ECD) in the Kawempe Division of Kampala, Uganda.
SECONDARY: To assess the associations between symptoms of common MMH conditions (depression and anxiety) and underlying individual, interpersonal, and household factors.
SECONDARY: To explore what "mental health" means to mothers of children under two years of age currently living in Kawempe, how their mental health effects their daily life; the activities they do that contribute to "good" and "bad" mental health.
TERTIARY / EXPLORATORY: To determine the prevalence of common MMH conditions (depression and anxiety) in the KYC catchment area.
TERTIARY / EXPLORATORY: To create Luganda versions of the CREDI, GSED, RSES, PSS, and CFAT.
TERTIARY / EXPLORATORY: To compare the CREDI and GSED tools for measuring ECD in this context.
USA 2025-02-07 17:47:50 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
MIRIAH KEMIGISHA
ID: UNCST-2022-R009927
Evaluating Ventricle Size and Shunt Failure Rates in Ugandan Children Shunted Early in Life
REFNo: HS5382ES

General objective
To study proximal shunt obstruction and its predictors among patients with hydrocephalus secondary to myelomeningocele or encephalocele at CCHU from 2010 to 2023.

Specific Objectives.

1.To determine the rate of proximal obstruction among shunted patients with hydrocephalus secondary to myelomeningocele or encephalocele.
2.To determine the incidence of small ventricles among shunted patients with hydrocephalus following myelomeningocele or encephalocele closure.
3.To assess if ventricle size and catheter environment can predict proximal shunt failure in shunted patients with hydrocephalus secondary to myelomeningocele or encephalocele.

Uganda 2025-02-07 17:46:28 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JOYCE NAMWASE
ID: UNCST-2024-R005002
ACCEPTABILITY, FEASIBILITY AND EFFECTIVENESS OF INVOLVING LAY HEALTH WORKERS IN RECOGNIZING AND LINKING PEOPLE WITH ALCOHOL USE DISORDER TO PRIMARY HEALTH CARE PROVIDERS
REFNo: HS5364ES

1.
To explore the perceived capability, opportunities, and motivation of LHWs to identify AUD in Ibanda district, southwestern Uganda.
2.
To implement a strategy of training lay health workers in the use of CAGE screening tool to identify AUD in Ibanda district, southwestern Uganda.
3.
To evaluate the acceptability, appropriateness, and feasibility of involving LHWs in screening for AUD in the community of Ibanda district, southwestern Uganda
Uganda 2025-02-07 17:44:48 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clare Bangirana Ahabwe
ID: UNCST-2021-R012842
UBUMWE 2.0 Integrating Arts for Education and Psychosocial Support with Children & Youth affected by Displacement in Uganda
REFNo: SS3567ES

1. To document how the Ubumwe curriculum influenced the roles and responsibilities of the teachers;
2. To identify additional teacher professional development opportunities that teachers feel are needed to be successful in teaching the Arts;
3. To explore the ways in which the art curriculum impacted Learners’ academic and psychosocial development;
4. To assess overall feasibility, acceptability, strengths and limitations of the Ubumwe curriculum for teachers.

Uganda 2025-02-07 17:43:07 2028-02-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Benard Nsubuga
ID: UNCST-2024-R002324
Factors influencing the availability and use of Electronic Medical Records Systems in Public Health Facilities in Uganda: A landscape assessment
REFNo: HS5379ES

i. Assess the extent of EMR adoption in public health facilities.
ii. Identify the types of EMR systems currently in use.
iii. Evaluate the functionality and integration of existing EMR systems.
iv. Understand the challenges and barriers to effective implementation of EMR integration.
v. Identify the factors influencing the use and adoption of EMR systems in public health facilities.
vi. Provide recommendations for enhancing EMR adoption and utilization.

Uganda 2025-02-07 17:42:08 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Prossy Bibangambah Kyasimire
ID: UNCST-2024-R002215
Pericoronary Adipose Tissue, Inflammation, and Subclinical Coronary Artery Disease in People with HIV in Uganda
REFNo: HS5418ES

Aim 1: Perform CCTA -based segmentation of PCAT (1a) and compare the density between PWH and PWOH (1b) in Uganda.
Aim 2: Extract PCAT radiomics features (2a) and compare differences in PCAT radiomics signatures between PWH and PWOH (2b) in Uganda.
Aim 3: Determine whether the PCAT density (from Aim 1) or radiomics signatures (from Aim 2) improve the performance of cardiovascular risk prediction in Uganda.
Uganda 2025-02-07 17:38:35 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
Bone Health in Older Ugandan Women with and without HIV
REFNo: HS5455ES

To examine bone mineral density (BMD) and body composition in older (peri-menopausal and postmenopausal) African women who are living with HIV and taking antiretroviral therapy (ART) drugs compared to women representing similar age and background characteristics who are HIV-negative.
Uganda 2025-02-07 17:30:13 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
Universal Protocol for Standardizing emerging Assays and Advancing vaccine Immunogenicity Assessments for Emerging and Re-emerging viral Threats through UVRI’S Partnership with the coalition for Epidemic Preparedness Innovations (CEPI)’s Centralized Clinical Laboratory Network (CLN).
REFNo: HS5330ES

To standardize and accelerate the evaluation of vaccine candidates against CEPI priority diseases, including Ebola, Marburg, Lassa, Nipah, Rift Valley Fever, SARS-CoV-2, MPOX and unidentified emerging threats, by leveraging UVRI's infrastructure and expertise.

To contribute to accelerated global vaccine development and licensure by ensuring rapid, accurate, and consistent data generation, while enhancing regional outbreak preparedness through technology transfer and capacity building.
Uganda 2025-02-04 8:15:09 2028-02-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald  Bahati
ID: UNCST-2023-R007024
NAVIGATING MENTAL HEALTH IN SCHOOLS PROJECT: EDUCATORS’ MENTAL HEALTH LITERACY CONCERNING ANXIETY, DEPRESSION AND NON-SUICIDAL SELF INJURY
REFNo: HS5381ES

To ascertain the educators’ confidence in providing help to affected school aged adolescents in selected schools in southwestern Uganda.,3. To assess educators’ level of mental health literacy about non-suicidal self-injury among school aged adolescents in selected schools in southwestern Uganda.,2. To assess educators’ level of mental health literacy about depression among school aged adolescents in selected schools in southwestern Uganda,1. To assess educators’ level of mental health literacy about anxiety among school aged adolescents in selected schools in southwestern Uganda,To assess educator’s mental health literacy about anxiety, depression and non-suicidal self-injury and their confidence in providing help to affected school aged adolescents in selected schools in southwestern Uganda.,
Uganda 2025-01-31 8:00:54 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shevin  Jacob Thomas
ID: UNCST-2022-R010715
The Sub-Saharan Africa ConsorTium for the Advancement of Innovative Research and Care in Sepsis (STAIRS) Cohort Study: A prospective multi-country network cohort of hospitalized sepsis patients
REFNo: HS5205ES

1. Describe the cohort’s epidemiologic, sociodemographic, clinical and management characteristics and to identify risk factors for disease severity and outcomes. 2. Characterize etiologic (and antimicrobial resistance patterns when relevant) and host response profiles and to evaluate their potential associations with clinical presentation, disease severity and outcome. 3. Determine the performance characteristics of innovative sepsis diagnostic platforms for pathogen identification, host response profiling and risk stratification in comparison with diagnostic testing available for usual care (including blood culture and existing sepsis scores).
USA 2025-01-31 7:59:00 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sabiti Makara
ID: UNCST-2024-R003444
Crisis Emergencies, State Responses and ‘Windows’ of Corruption in Uganda
REFNo: SS3621ES

To implement bottom-up strategies for fighting corruption in emergency responses ,To examine the possibilities of grassroots actions and pressures that could have significant impacts on the fight against corruption,To establish the extent to which political considerations abate corruption with a focus on procurement and contracting during emergency crisis responses,To establish the gaps in regulatory frameworks that are opportunistically exploited by corrupt officials and their cronies to undermine anti-corruption efforts during emergency responses,Establish the actual costs of corruption and find out if the population is aware of its effects on public service delivery for the ordinary citizens,To examine the forms, practices, and patterns of corruption in emergency crisis responses in Uganda,Our main objective is to highlight and deepen our understanding of the extent which the risk of corruption intensifies during emergencies and to develop grassroots-based strategies to fight the vice.,
Uganda 2025-01-31 7:50:39 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Vincent Ferrer Bukenya
ID: UNCST-2024-R004868
Examination of the relationships between refugee settlements and wood energy consumption: A case study of Bidibidi refugee settlement in northwest Uganda
REFNo: A527ES

This research will examine the relationships between refugee settlements and household access to sustainable wood energy. 1. To establish what forms the bulk of wood energy used by refugees and host communities in Bidibidi Refugee Settlement in North-Western Uganda. 2. To assess wood energy consumption patterns in refugee and host communities in relation to the right to energy in Bidibidi Refugee Settlement in North-Western Uganda. 3. To examine how the refugee response framework provides for household access to wood energy by refugees and host communities in Bidibidi Refugee Settlement in North-Western Uganda. 4. To determine the contribution of the refuge-host community relationships to households’ ability to sustainably access wood energy.
Uganda 2025-01-31 7:43:24 2028-01-31 Agricultural Sciences Non-Clinical Trial Degree Award
Ikuomola  Orire Emmanuel
ID: UNCST-2024-R003700
EFFECT OF DIFFERENT FRACTIONS OF BRASSICA OLERACEA (COLLARD GREENS) ETHANOL EXTRACT ON CIMETIDINE INDUCED REPRODUCTIVE TOXICITY IN MALE WISTAR RATS.
REFNo: HS5192ES

i. Identify and quantify the constituents of crude aqueous leaf extract and fractions of Uganda collard green plant using gas chromatography mass spectrometry (GCMS);
ii. Evaluate the impact of crude aqueous leaf extract and fractions of Uganda collard greens on the relative weights of the testes, epididymis and anterior pituitary gland compared to body weight in male Wistar rats with cimetidine-induced reproductive toxicity by [specific date] male Wistar rats;
iii. Assess the effects of crude aqueous leaf extract and fractions of Uganda collard greens on sperm parameters, including motility, morphology, viability, agglutination, and total sperm count in Wistar rats with cimetidine-induced reproductive toxicity;
iv. Analyze the effect of crude aqueous leaf extract and fractions of Uganda collard greens on serum levels of steroid androgens (LH, FSH, Testosterone and antioxidant enzyme activities (catalase, Malondialdehyde, superoxide dismutase) in male Wistar rats with cimetidine-induced reproductive toxicity in male Wistar rats;
v. Examine the histological changes in the testes, epididymis, and anterior pituitary gland in male Wistar rats with cimetidine-induced reproductive toxicity following treatment with crude aqueous leaf extract and fractions of Uganda collard greens in male Wistar rats.

Nigeria 2025-01-31 7:40:27 2028-01-31 Medical and Health Sciences Non-Clinical Trial Degree Award
Miriam  Amutuheire
ID: UNCST-2024-R001859
Home-based tourism businesses and destinaion sustainability in Kabale Municiplaity, Kabale District, Uganda.
REFNo: SS3399ES

i.To assess the effect of the home-based tourism business operations on destination sustainability in Kabale municipality, Kabale District, Uganda.    
ii. To determine the influence of home-based tourism businesses competitiveness on destination sustainability in Kabale municipality, Kabale District, Uganda.  
iii. To establish the influence of government policies, impart on home-based tourism businesses that affect destination sustainability in Kabale municipality, Kabale District, Uganda.  
Uganda 2025-01-31 7:38:46 2028-01-31 Social Science and Humanities Non-Clinical Trial Degree Award
Karugahe Wilber
ID: UNCST-2023-R005686
Effectiveness of Cognitive behaviour therapy for mental health problems among adult patients with type-II diabetes mellitus: a controlled study
REFNo: SS3413ES

a. To assess the effectiveness of CBT in treating mental health problems (psychological distress, depression, anxiety, quality of life, treatment adherence, hopelessness, pessimism) among adult patients with T2DM
b. To assess whether CBT affords a better control of glycaemia and the metabolic disturbances associated with T2DM.

Uganda 2025-01-31 7:37:29 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
Maternal immunization readiness network for the introduction of potential new maternal vaccines to prevent early childhood infectious diseases in Uganda
REFNo: HS5271ES

General objective:

To identify, characterize and support the platform, policy, and preparedness requirements for the introduction of potential new maternal vaccines to prevent infectious diseases in Uganda


Specific objectives:

1. To identify and implement approaches to assess health systems, facilities, and community readiness to introduce new maternal vaccines in Uganda
a. Identify and implement approaches to assess MI readiness for respiratory syncytial virus / Group B streptococcus vaccinations across the health system, including mapping key regulatory and financing requirements.
b. Map professional societies within the country and initiate country-based communities of practice for MI.
2. Generate and synthesize health economic evidence, in the Ugandan context, to support decision-making of respiratory syncytial virus / Group B streptococcus vaccination program adoption in low- and middle-income countries (LMICs).
3. Prospectively develop nationally tailored maternal vaccine demand strategies to support the uptake and sustained demand for existing and new maternal vaccines in Uganda.
4. Identify and effectively engage with diverse stakeholders, in a harmonized manner, to incorporate their views and expertise in the study’s outputs, to advance the maternal immunization readiness agenda in Uganda.

Uganda 2025-01-31 7:35:56 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Rukundo NSHAKIRA
ID: UNCST-2021-R012277
Improving School Management in a Low-Income Country: Experimental Evidence from Uganda
REFNo: SS3462ES

To evaluate the impact of the Inspect and Improve (I&I) program on student outcomes (learning, safeguarding, and inclusion) and school quality, focusing on both short-term and long-term effects.
Uganda 2025-01-31 7:32:19 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
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