ERIC WOBUDEYA
ID: UNCST-2019-R001047
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Evaluation of novel diagnostics and biomarkers for childhood TB
REFNo: HS169ES
Our primary specific aim is:
1. To determine the diagnostic accuracy of a novel breath sensor for diagnosis of childhood TB.
Our secondary aims are:
1. To determine if breath volatile organic compounds (VOCS) (methyl nicotinate and methyl-p-anisate) can be used to monitor response to anti-TB treatment in children.
2. To assess the accuracy of point of care (POC) C-Reactive Protein (CRP) as a triage test among children suspected of having TB
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Uganda |
2018-05-22 |
2021-05-22 |
Medical and Health Sciences |
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Non-degree Award |
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Priya Kumar
ID:
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Technology to Enable Universal Health Coverage - Watsi Implementation Research
REFNo: HS181ES
General Objective - To determine if a technology intervention reduces the time and cost of administering community based health insurance compared to a paper based system.
The specific objectives of conducting the research include:
1. To estimate with excellent accuracy and precision the mean and median time of each of the five components of the CBHI system (member enrollment, identification, claims submission, claims approval, reporting), and of the total time for both intervention and the control cohort.
2. To estimate with excellent accuracy and precision the mean and median cost of each of the five components of the CBHI system, and of the total cost for both intervention and the control cohort.
3. To estimate with excellent accuracy and precision the difference in the mean and median time and cost between the intervention and the control cohort for each of the five components, and the total of all five components for the CBHI system.
4. To identify factors other than the technology intervention that could potentially be associated with total duration time and cost.
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USA |
2018-05-22 |
2021-05-22 |
Medical and Health Sciences |
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Non-degree Award |
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HUSSEIN ORIA
ID:
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ARV Medicines usage in farm chicken; exploring the perceptions of the community: a case for Wakiso district.
REFNo: HS188ES
Determine extent of use of ARVs in farm chicken and explore the perceptions of the community on use of ART medicines in farm chicken.
With specific objectives as;
Understand the extent of ARV usage in farm chicken.
Explore community perceptions on ARV misuse in farm chicken.
Examine the extent of ARV usage in preparation of chicken feeds.
Determine ARV content in farm chicken.
Determine the content of ARV in chicken feed
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Uganda |
2018-05-22 |
2021-05-22 |
Medical and Health Sciences |
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Non-degree Award |
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Bethany WILLIAMS LIN
ID:
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Testing the functional significance of divergent reproductive traits in an African cichlid fish (Pseudocrenilabrus multicolor victoriae)
REFNo: NS52ES
The goal of the proposed research is to better understand the influence of environmental stressors (such as turbidity, hypoxia, and increased temperature) on the divergence of reproductive traits in an African cichlid fish (Pseudocrenilabrus multicolor victoriae).
My specific objectives will be to
(a) determine the functional role of physiological and behavioral trait changes
between populations of P. multicolor, and
(b) test the adaptive significance of trait changes by assessing performance of lab-reared fish on reproductive tasks.
(c) present conservation education materials about the importance of biodiversity to water quality to local schools through The Water Project
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USA |
2018-05-22 |
2021-05-22 |
Natural Sciences |
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Degree Award |
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William NESBITT Alexander
ID:
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Causes and implications of the depletion of effective calcium concentrations in Lake Nabugabo, Uganda, East Africa
REFNo: NS53ES
To re-evaluate the work of Beadle (1981) and accurately measure the calcium and other major ion concentration of Lake Nabugabo and the surrounding wetlands.
To identify the sink of calcium in the system to see why the concentration is so low compared to other lakes in the LVB.
To explore the implications of low calcium by investigating the Ca/P ratio in Nile perch and mukene in both Lake Nabugabo and Lake Victoria to determine the effects on its bone strength, density and growth.
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Canada |
2018-05-22 |
2021-05-22 |
Natural Sciences |
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Degree Award |
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Joel HARTTER Nathan
ID:
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Population, Environment, and Climate in the Albertine Rift
REFNo: NS37ES
To Determine how coupled climate and anthropogenic landscape change impacts the dynamics and resilience of a protected areas and the surrounding human population, including impacts to human and wildlife health, food security, and governance.
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USA |
2018-05-18 |
2021-05-18 |
Natural Sciences |
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Non-degree Award |
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Fiona Cresswell
ID:
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High dose oral and intravenous rifampicin for adult tuberculous meningitis: an open-label phase II randomised controlled trial
REFNo: HS136ES
1. To determine whether higher-dose rifampicin, delivered orally at 35mg/kg/day or delivered intravenously at 20 mg/kg/day (for 2-weeks, followed by orally at 35 mg/kg/day for 6-weeks) provide equivalent plasma and CSF exposures, and whether the exposure profiles are favourable compared to the standard dose oral rifampicin. The pharmacokinetically optimal dose and route of administration of rifampicin can then be taken forward into a phase III clinical trial.
2. To observe whether greater rifampicin exposure in CSF is associated with any clinical benefit including more rapid resolution of coma, reduced neurocognitive deficit or reduced mortality.
3. To determine the diagnostic accuracy of Xpert MTB/Rif Ultra for TBM (ancillary study 1)
4. To describe the concentration of rifampicin in brain tissue in each treatment arm (ancillary study 2)
5. To explore the use of bedside ultrasound as a monitoring tool to improve supportive care for people with TBM (ancillary study 3)
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UK |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Degree Award |
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Moses Ocan
ID: UNCST-2020-R014731
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Antimalarial resistance in Sub-Saharan Africa: Assessing spread of artemisinin resistance and chloroquine resistance reversal among Plasmodium falciparum parasites
REFNo: HS168ES
1) To determine through a systematic review, the extent of chloroquine resistance reversal among Plasmodium falciparum parasites in malaria endemic countries since the change in policy
2) To determine the association between four (4) most reported K13 gene polymorphisms in Sub-Saharan Africa and artemisinin susceptibility among Plasmodium parasites
3) To predict using a model the spread to Sub-Sahara African (Uganda) Plasmodium falciparum parasite population of the K13 propeller gene polymorphisms detected in Southeast Asia and associated with artemisinin resistance
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Uganda |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Degree Award |
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Kirsten Ward
ID:
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Evaluation of delivery practices for multiple vaccines at a single immunization visit in low- and middle-income countries Uganda
REFNo: HS170ES
Aim: This evaluation aims to describe current preparation, administration and communication practices in the delivery of more than one vaccine to a single child at a single immunization visit in Uganda.
Objectives: 1. To document the processes and techniques used to prepare and administer more than one vaccine, primarily injectable vaccines, to children in Uganda;
2. To understand the timing, content, and extent of communication messages about co-administration of one or more vaccines and post-vaccination care delivered by providers to caregivers in Uganda; and
3. To use results from 1 & 2 to develop recommendations about best practices for: a) the preparation and delivery of multiple vaccines with a focus on injectable vaccines, and b) provider communication to the caregiver about delivery of multiple vaccines and post-vaccination care.
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Australia |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Non-degree Award |
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Damalie Nakanjako
ID:
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Inflammation and immune aging among HIV-infected adults with at least 12 years of antiretroviral therapy in an African cohort.
REFNo: HS194ES
1. To describe innate system phenotype and function [Natural killer (NK) cells, monocytes and innate lymphoid cells (ILCs)], after long-term suppressive HAART for at least 12 years of HAART, within the Infectious Diseases Institute (IDI) HIV treatment cohort.
2. To determine levels of immune aging markers among HIV-infected adults with suppressive ART, relative to age-and gender-matched HIV negative counterparts, despite twelve years and more of suppressive ART.
3. To describe those biological pathways which remain deranged after at least 12 years of suppressive HAART, and identify markers/pathways that are known to increase the risk of non-AIDS complications of chronic HIV.
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Uganda |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Non-degree Award |
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