Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
alfred andama andama
ID: UNCST-2022-R011051
 TONGUE SWAB TUBERCULOSIS DIAGNOSTIC YIELD STUDY
REFNo: HS3761ES

Aim 1. To determine the proportion of people presenting to primary health centers with signs and symptoms of TB who: a. can provide a sample for TB testing (sputum vs. tongue swab) b. have a valid molecular test result (sputum vs. tongue swab) c. are detected as TB-positive (sputum vs. tongue swab) d. prefer providing a sputum vs. tongue swab sample
Uganda 2024-02-26 13:32:44 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 SOLIDARITY TRIAL-A phase I/II Randomized Placebo controlled trial to evaluate the Safety and Immunogenicity of Sudan Ebolavirus in Uganda
REFNo: HS3190ES

Phase I (rVSV-SUDV)
1. To determine the safety of rVSV-SUDV candidate SUDV vaccine among adult healthy volunteers in Uganda.
2. To determine the immunogenicity of rVSV-SUDV candidate SUDV vaccine.

Phase II (ChAdox1, CAd3 and rVSV-SUDV)
Primary objectives
1. To determine the safety of ChAdox1, CAd3 and rVSV-SUDV candidate SUDV vaccines among healthy volunteers and persons with stable comorbidities.
2. To determine the immunogenicity of ChAdox1, CAd3 and rVSV-SUDV candidate SUDV vaccines.
Secondary objectives
1. To determine the durability of SUDV-specific induced immune responses following vaccination.
2. To determine the factors associated with optimal vaccine-induced immune responses.
3. To determine the putative cross reactivity by the SUDV vaccine candidates against other ebolaviruses (e.g. Bundibugyo ebolavirus (BUDV) and EBOV).

Exploratory objectives
1. To determine the effect of SUDV vaccines on host gene expression.
2. To determine the T and B cell specific responses and immune profiling in response to vaccination.
3. To determine the effect of SUDV vaccines on the host metabolome.
4. To determine the effect of SUDV vaccines on host innate immune responses.

 Uganda 2024-02-26 13:31:25 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
Rhona Mijumbi M
ID: UNCST-2023-R006843
 Building a Culture of Evidence-informed Policy-Making in Uganda (B-CuE)
REFNo: SS2257ES

3) To improve collaboration for better coordinated and complementary support to EIDM in Uganda.,2) To design a sustainable and relevant capacity-building program for pre- and in-service training to ensure individuals and institutions acquire relevant and adequate knowledge and skills to support timely EIDM.,1) To scale-up the activities of the Center for Rapid Evidence Synthesis as a knowledge brokerage institution to strengthen support for timely EIDM in Uganda.,
 Uganda 2024-02-26 13:23:45 2027-02-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moses Adroma
ID: UNCST-2019-R000360
 Exploring the potential of a lower blood pressure threshold for diagnosing hypertension in pregnancy: Implications for pre-eclampsia and stroke.
REFNo: HS3784ES

1. To compare the incidence rate of preeclampsia between pregnant women with SBP from 130 to 139 mmHg and/or DBP from 80 to 89 mmHg and those with normotensive blood pressure below 130/80 mmHg.

2. To compare the incidence rate of stroke between pregnant women with SBP from 130 to 139 mmHg and/or DBP from 80 to 89 mmHg and those with normotensive blood pressure below 130/80 mmHg.

3. To investigate potential risk factors and biomarkers associated with the development of preeclampsia and stroke in pregnant women with elevated blood pressure within the range of 130/80 to 139/89 mmHg.

4. To compare the maternal and foetal outcomes between pregnant women with SBP from 130 to 139 mmHg and/or DBP from 80 to 89 mmHg and those with blood pressures below 130/80 mmHg.


Uganda 2024-02-26 13:20:46 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rawlance  Ndejjo
ID: UNCST-2022-R010993
 Health Systems Resilience in the Face of Climatic Change in Bududa, Kasese and Moroto Districts in Uganda
REFNo: HS3758ES

To explore the barriers and facilitators of building health systems mitigation, adaptation, and resilience mechanisms to deal with the adverse effects of extreme weather events in Bududa, Kasese and Moroto districts in Uganda.,To describe the mitigation and adaptation mechanisms that health systems in Bududa, Kasese and Moroto districts in Uganda employ to deal with the adverse effects of extreme weather events?,To explore how extreme weather events are impacting the disease burden in Bududa, Kasese and Moroto districts in Uganda.,To assess how extreme weather events are impacting disease burden and explore the resilience of health systems in Bududa, Kasese and Moroto districts so as to inform strategies for building resilient and low carbon health systems in the face of climatic changes in sub-Saharan Africa,
 Uganda 2024-02-26 13:19:29 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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