Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Sylvester Onzivua
ID:
Postmortem study on patients with neuropsychiatric manifestations of unknown etiology, nodding syndrome, and other forms of epilepsy who died in Gulu, Kitgum, Lamwo and Pader
REFNo: HS64ES

• Use postmortem examination to determine cause of death in a selected study population. • Use histopathology to describe the post-mortem findings of individuals who die of neuropsychiatric manifestations of unknown origin, NS and other forms of epilepsy in villages with high epilepsy prevalence in Gulu, Kitgum, Lamwo and Pader. • Use histopathology to investigate whether Ov microfilariae are able to penetrate the brain by evaluating histologic tissue for the products of Ov microfilariae
Uganda 2017-10-03 2020-10-03 Medical and Health Sciences Non-degree Award
othiniel musana mambya
ID: UNCST-2019-R001339
Prospective, Single Arm, Pivotal Clinical Trial Designed to Assess the Safety and Effectiveness of the InPress Device In Treating Primary Postpartum Hemorrhage
REFNo: HS92ES

Evaluate the safety and effectiveness of the InPress Device in the control and reduction of primary postpartum hemorrhage.
Uganda 2017-10-03 2020-10-03 Medical and Health Sciences Non-degree Award
Christopher Mayanja Samuel
ID:
Leadership and Gender: Exploring female students’ lived experiences in leadership in Ugandan public University Councils
REFNo: SS117ES

The main research question of the study is: What are the lived leadership experiences of female student leaders who are members of public university councils in Uganda? 1. Who are female student leaders participating in public university councils in Uganda? 2. How do female student leaders who participate in public university councils in Uganda experience their relations with other council members? 3. What challenges (if any) do female student leaders face on public university councils in Uganda? 4. What lessons can be drawn about gender and leadership from the experiences of female student leaders participating in public university councils in Uganda?
Uganda 2017-10-03 2020-10-03 Social Science and Humanities Degree Award
Moses Kamya R
ID:
Cohort and entomology studies to estimate longitudinal changes in malaria metrics in Nagongera, Uganda
REFNo: HS119ES

Objectives of epidemiology studies 1. To estimate the incidence of malaria, parasite prevalence, and the molecular force of infection among cohort study participants. 2. To characterize factors determining the malarial force of infection. 3. To determine factors affecting the duration, density, and clinical consequences of blood stage malaria infection. 4. To assess the associations between overnight travel and the risk of malaria infection. 5. To estimate measures of transmission intensity including the human biting rate, sporozoite rate, and the entomological inoculation rate at the household level. 6. To characterize the species composition of mosquito vectors and the host source of mosquito blood meals. Objectives of transmission studies 7. To characterize factors associated with gametocyte production. 8. To evaluate the impacts of human, parasite, and mosquito factors on parasite infectivity to mosquito vectors. 9. To characterize the human infectious reservoir for malaria. Objectives of immunology studies 10. To measure antibody responses to malaria antigens and associations between antibodies responses and protection from /exposure to infection with malaria parasites. 11. To characterize malaria specific cellular immune responses in naturally exposed children and adults. Objectives of resistance studies 12. To assess the impact of genotypic markers of antimalarial drug resistance on malaria transmission. 13. To assess the impact of genotypic markers of insecticide resistance on malaria transmission.
Uganda 2017-09-29 2020-09-29 Medical and Health Sciences Non-degree Award
Irene Andia Biraro Rebecca
ID: UNCST-2019-R001475
The Link Between Tuberculosis Infection and Type-2 Diabetes Mellitus: Contribution of Innate Lymphoid Cells
REFNo: HS66ES

Primary objective: To investigate the exposure prevalence of latent and active tuberculosis among newly diagnosed type 2 diabetes mellitus (T2DM) patients attending the diabetic clinic at Mulago National Referral Hospital (MNRH)-Kiruddu, compared to healthy non diabetic community controls in Kampala, Uganda Nested Secondary objective: To assess the frequency of innate lymphoid cells (ILCs), T-helper (Th)17, Th1 cells, and immune responses among T2DM patients.
Uganda 2017-09-26 2020-09-26 Medical and Health Sciences Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Reducing exposure to household air pollution
REFNo: HS71ES

To evaluate the feasibility, acceptability and effectiveness of proven household air pollution reduction interventions in households using traditional way of cooking and heating methods in selected communities in four countries of Uganda, Vietnam, the Kyrgyz Republic and Greece. Research questions will be: 1. What is the feasibility and acceptability of clean cooking and heating interventions compared to traditional cooking and heating? 2. What is the effectiveness of a clean cooking intervention on health outcomes? 3. What is the effectiveness of household air pollution reduction on health outcomes?
Uganda 2017-09-26 2020-09-26 Medical and Health Sciences Non-degree Award
Kelly Sambucci Marie
ID: UNCST-2019-R001513
Parasite occurrence and genetic relatedness in overlapping populations of Mountain Gorilla (Gorilla beringei beringei), livestock, and the Batwa community in Bwindi Impenetrable National Park (BINP), Uganda
REFNo: NS22ES

1. To collect faecal samples for analysis, using light microscopy to identify intestinal helminth eggs and PCR for protozoan diagnosis. 2. Use targeted PCR and amplicon sequencing to confirm parasite identity and genotype those species detected, allowing for investigation into cross-host species transmission. 3. Focus on the occurrence and genetic diversity of Entamoeba species, comparing to existing data which defines the Entamoeba infecting mountain gorilla, livestock and humans in BINP in 2015, exploring changes in prevalence and diversity.
UK 2017-09-26 2020-09-26 Natural Sciences Degree Award
Richard Wamimbi Wotti
ID:
Utilizing Information Communication Technology (ICT) to prevent violence against children in and around schools.
REFNo: SS108ES

The general research purpose is understanding the utilization of ICT in preventing violence against children in and around schools and developing a model that can be applied by agencies to prevent violence against children. Specific objectives: 1.Establish the role of ICT in driving, sustaining and mitigating behavior that contributes to violence against children in and around schools 2.Examine the benefits of ICT use to prevent violence against children specifically for knowledge generation and transfer, capabilities enhancement and social enabler 3.Establish when and how ICT - enabled child sexual violence and exploitation starts, is maintained and perpetuated in and around schools. 4.Examine the inter-related constraints to ICT utilization to prevent violence against specifically social cultural, infrastructural, economic and technological. 5.Find out how ICT (telephone sms, whatsapp, etc.) is promoting values and influencing ICT that can prevent violence against children 6.Suggest the strategies and actions that can be adopted by formal ( law enforcement, teachers, social workers) and non-formal ( children, families, religious, traditional leaders ) actors to better address ICT enabled child sexual abuse and exploitation
Uganda 2017-09-26 2020-09-26 Social Science and Humanities Non-degree Award
Carolyn Auma Imelda
ID:
Women's Dietary Practices in Contemporary Uganda
REFNo: HS111ES

a. To describe the dietary practices of rural and urban Ugandan women of reproductive age b. To assess the healthiness and environmental sustainability of the diets of rural and urban Ugandan women of reproductive age c. To explore the social, cultural and physical influences behind the current Ugandan dietary practices among women of reproductive age d. To identify the points at which it might be possible to implement appropriate healthy and environmentally sustainable food-based dietary guidelines aimed at women of reproductive age in Uganda
Uganda 2017-09-26 2020-09-26 Medical and Health Sciences Degree Award
Emmanuel Kiiza Mwesiga Kiiza
ID: UNCST-2019-R001588
PREDICTORS OF COGNITIVE IMPAIRMENT AMONG PATIENTS WITH FIRST EPISODE PSYCHOSIS IN UGANDA.
REFNo: HS88ES

i) To determine the genetic (COMT, DISC1, HT2RA, BDNF) and environmental (substance use and childhood trauma) factors associated with cognitive impairment among patients with a psychotic episode for the first time. ii) To determine the frequency of BDNF gene polymorphism and its association with serum BDNF levels and cognitive impairment among patients with a psychotic episode for the first time.
Uganda 2017-09-20 2020-09-20 Medical and Health Sciences Non-degree Award
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