Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Ravinder Bhavnani D
ID:
MERIAM: Modelling Early Risk Indicators to Anticipate Malnutrition
REFNo: HS245ES

The central aim of the MERIAM project is to identify, test and scale up cost-effective means to improve the prediction and monitoring of undernutrition in difficult contexts, in such a way that it enables an effective response to manage and mitigate nutritional risk. The objectives of the overall, multi-year multi-country MERIAM research project include: (a) the creation of high-quality, relevant research that fills gaps in the evidence base on the prediction of undernutrition in response to shocks (e.g., conflict, drought, spikes in food prices); (b) the accessibility of results and evidence to both technical and non-technical audiences, including facilitation of audience engagement with data and the predictive model via a user-friendly online platform; and, (c) the successful uptake of MERIAM research by key stakeholders in policy and practice, with a focus on national-level actors and their utilization of the data and analysis to inform humanitarian response. The objectives of the Uganda-specific field visit for the computational modelling component include: (1) Visit locations where nutrition crises have occurred to get an understanding of the context, terrain, conditions, and populations (2) Administer questionnaires to identify and gauge key attributes, assets, choice sets, behavioral rules and practices (including adaptation and learning), drivers, constraints, and interventions. (3) Conduct simple vignette-based experiments where interviewees are presented with scenarios to which they answer with how they would respond to or judge various situations (4) Conduct open-ended discussions to make “explicit” the mental models practitioners use for assessment and decision-making
USA 2019-02-26 2022-02-26 Medical and Health Sciences Non-degree Award
Gavin Ackers Johnson
ID:
Assessing the Resistance Patterns of Bacteria Isolated from Cases of Maternal Sepsis at Fort Portal Regional Referral Hospital, Uganda; and Further Investigating the Potential Mechanisms of Antibiotic Resistance in the Staphylococcus aureus isolates obtai
REFNo: HS249ES

1. To determine the most common bacterial species that are associated with maternal sepsis at Fort Portal Regional Referral Hospital and their resistance profiles. 2. To use molecular typing to assess Staphylococcus aureus isolates and determine whether patients are being infected by the same strains, which may provide clues as to sources of infection 3. To identify the mechanisms of any antibiotic resistance observed.
UK 2019-02-26 2022-02-26 Medical and Health Sciences Degree Award
Agnes Kiragga
ID:
A Pilot Test of a Technology-delivered HIV Self-Testing Intervention in Kampala, Uganda
REFNo: HS307ES

1) An established 24-hour call-in center staffed by medical providers who will deliver accurate HIV/STI information, perform pre- and post-test counselling, assist with conducting HIVST and interpreting the HIVST results, and referral and linkage to appropriate post-test prevention and treatment care; and 2) The use of SMS and social media streams – specifically private Facebook and Twitter messages - to “push” theoretically-grounded messages that promote HIVST and provide additional private communication routes between participants and medical provider research staff. The study aims are: Aim 1: Develop HIVST messages and finalize study procedures and materials with input from a Community Advisory Board (CAB), and beta test the intervention with 6 sexually active Ugandan adults (18-49 years old; 50% female). Aim 2: Using a pre-post design, assess the feasibility, acceptability and preliminary impact of the HIVST intervention developed in Aim 1 for Ugandan adults (n=100; 70% 18-24 years old, 30% 25-49 years old; 50% female). Feasibility will be assessed by whether enrollment targets are reached and the proportion of completed 1- and 3-month follow-ups calls. Acceptability items will be gathered at 1- and 3-month assessments. Preliminary impact will be determined by the percentage of participants who perform HIVST in the 3 months after enrollment. Aim 3: Analyze process indicators of the overall use of the HIVST intervention, including the number of HIVST kits requested, the volume of callers requesting HIVST during the study period, the number of persons calling for assistance with self-testing procedures, the number of post-test counseling calls received, and the number of persons linked to follow-up prevention and care services.
Uganda 2019-02-26 2022-02-26 Medical and Health Sciences Non-degree Award
Julie Hennegan Maree
ID:
Assessing girls’ menstrual practices and experience: development of a menstrual practices questionnaire and the menstrual perceptions scale.
REFNo: SS279ES

Background
After a history of neglect and taboo, the role of the menstruation in women and girls’ dignity, health, education, employment, and wellbeing has begun to receive attention. Stakeholders from governments to local charities have started to recognize the barriers that poor menstrual management and menstrual stigma present to gender equality. This has resulted in a rapid increase in the dissemination of interventions; from small-scale sanitary pad or puberty education provision to national policies such as large-scale sanitary pad distribution for schoolgirls in Ghana and Kenya. Despite this increased action, there is limited research available to inform intervention development or evaluation.
There is a lack of comprehensive, validated survey tools with which to measure women and girls’ menstrual practices and experiences. This limits the quality of cross-sectional and intervention research as well as monitoring and evaluation by NGOs and governments.

General Objective
This project aims to improve the measurement of menstrual practices and experiences in low resource settings through field testing and assessment of the psychometric properties of new measures of practices and perceptions.

Specific Objectives
1. To field-test acceptability and responses to a newly developed Menstrual Practices Questionnaire (MPQ), and Menstrual Perceptions Scale (MPS).
2. To assess the test-retest reliability of the MPQ and MPS.
3. To assess the factor structure of the MPS through exploratory and confirmatory factor analysis.
4. To assess convergent and divergent validity of the MPS, that is, association of the scale scores with hypothesized correlates.

Australia 2019-02-26 2022-02-26 Social Science and Humanities Non-degree Award
Eve Smeltzer Ann
ID:
Conflict and Consensus: The Impacts of Socio-Ecological Contexts on Vervet Collaborative Movements
REFNo: NS83ES

This research will examine how vervet monkeys (Chlorocebus pygerythrus) use social strategies and democratic processes to mitigate conflicts of interests during collaborative movements and how their decisions are impacted by varying social and ecological contexts.
USA 2019-02-19 2022-02-19 Natural Sciences Degree Award
Denis Muhangi
ID:
ROLE OF ASFV LATENTLY INFECTED PIGS AND SOFT TICKS IN AFRICAN SWINE FEVER EPIDEMIOLOGY IN ACHOLI SUB REGION, NORTHERN UGANDA
REFNo: A40ES

(i) Establish the prevalence of ASFV latently infected pigs in a post-outbreak situation. (ii) Investigate the existence of the soft tick O. moubata and their ASFV status.
Uganda 2019-02-19 2022-02-19 Agricultural Sciences Non-degree Award
Esther Uwimaana
ID:
Heme oxygenase-1 and neopterin plasma levels and their role in distinguishing active from latent TB in HIV/TB co-infected patients
REFNo: HS301ES

1. To determine and compare the median plasma levels of HO-1 1(in pg/ml) and neopterin (in ng/ml) among HIV patients co-infected with active TB, latent TB infection and individuals without TB infection alone attending Rubaga hospital. 2. To determine the diagnostic performance (sensitivity, specificity, positive predictive values and negative predictive values) of HO-1 and neopterin in diagnosis of latent tuberculosis infection using QuantiFERON2-TB test for latent TB infection as the gold standard. 3. To determine the diagnostic performance (sensitivity, specificity, positive predictive values and negative predictive values) of HO-1 and neopterin in diagnosis of active tuberculosis using sputum culture as the gold standard. 4. To determine the correlation between neopterin and HO-1 plasma levels with QuantiFERON2-TB Gold test in diagnosing latent TB infection.
Uganda 2019-02-19 2022-02-19 Medical and Health Sciences Degree Award
Kathryn LaRusso E
ID:
Access to Essential Surgical Care and Bellwether Procedures for Children in Uganda: A Public-Sector Evaluation
REFNo: HS231ES

Primary objectives: 1. To conduct a nationwide survey using a convenience sample of two regional and two general referral hospitals in each region (Northern, Eastern, Western, and Central) of Uganda, and the national referral hospital (17 total facilities), using surgical capacity assessments to assess the availability of essential and emergency surgical care (EESC) for children. i. To pilot the new WHO-PGSSC-GICS Children’s Surgical Assessment Tool (CSAT) and compare the results with PediPIPES to assess the validity, usability and reliability of the new CSAT tool. 2. To identify candidate bellwether procedures for children’s surgery that can be used as a benchmark for essential surgical care for children based on national, regional and general hospital logbook data, surgical capacity assessments, and perioperative mortality if available. Secondary objectives: 3. To identify if the ratio of emergent surgery to elective surgery (Ee ratio) using logbook data from national, regional and general hospitals can be a simple and valid indicator of access to pediatric surgical care. 4. To verify if a convenience sample of 1-month of logbook data collection can reliability predict perioperative mortality rate vs 3- or 6-months of logbook data collection at MRRH.
USA 2019-02-18 2022-02-18 Medical and Health Sciences Non-degree Award
Sarah Baird
ID:
INCORPORATING MENTAL HEALTH PROGRAMMING INTO ADOLESCENT EMPOWERMENT PROGRAMMING.
REFNo: HS318ES

Despite adolescent girls being at high risk of anxiety, depression, and other forms of psychological distress, there is little extant evidence on how to treat mood disorders among adolescents in developing countries in a cost-effective manner. The aim of our research projects is to evaluate the use of group based interpersonal therapy (IPT-G) in reducing the prevalence of anxiety and depression among adolescents in developing countries. The specific objectives of the research project are the following: 1. To estimate the causal effect of IPT-G on the psychological wellbeing of adolescent females who are identified as at risk of anxiety and depression at baseline 2. To estimate the marginal effects of adding income support following the intervention, on the sustainability of IPT-G results on anxiety and depression. 3. To investigate the relationship between improved psychological wellbeing among adolescents (as a result of the intervention) and school attainment, teenage pregnancy, child marriage and risky behavior. 4. To find if ELA clubs can serve as a pathway to reach and engage adolescent females who are most affected by mental health disorders.
New Zealand 2019-02-12 2022-02-12 Medical and Health Sciences Non-degree Award
GODFREY OSINDE
ID:
The association between ABCB1 gene C3435T polymorphism and Doxorubicin pharmacokinetics in Breast Cancer patients at Uganda Cancer Institute
REFNo: HS239ES

1. To determine the pharmacokinetics of doxorubicin in breast cancer patients in Uganda. 2. To determine the frequencies of the ABCB1 gene: C3435T SNP in breast cancer patients in Uganda. 3. To determine the association between the ABCB1 gene: C3435T SNP and PK of doxorubicin in breast cancer patients.
Uganda 2019-02-12 2022-02-12 Medical and Health Sciences Non-degree Award
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