Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Simon  Sensalire
ID:
Assessment of Effectiveness and Cost-effectiveness of the Quality Improvement Guide on Maternal and Newborn Care in Uganda
REFNo: HS162ES

1 Evaluate the change in QI-related actions (defined as; establishing improvement team, identifying gaps in quality of care and particular barriers causing the gap, deciding what to improve, plan, test and implement interventions to address identified gap, routinely monitor the progress of improvement and institutionalize improvement and successful changes in the facility) and knowledge among health care providers and managers from targeted health facilities using different implementation strategies vs business as usual (control group). 2 Determine the change in quality of maternal and newborn care processes (defined as every patient receiving the recommended services every time it is appropriate) and outcomes from pre-intervention to post-intervention in health facilities which have been exposed to the three different implementation strategies. 3 Determine the incremental cost-effectiveness ratio of the different implementation strategies in terms of expenditure per unit of patient care improvement achieved by the implementation strategy to each other and the control group with no incremental costs related to particular control group strategy. 4 Explore key informants perceptions of and experiences with the different intervention strategies.
Uganda 2018-03-06 2021-03-06 Medical and Health Sciences Non-degree Award
Susan Whyte Reynolds
ID:
Aging as a Human Condition: Radical Uncertainty and the Search for the Good (Old) Life
REFNo: SS150ES

Through a comparative ethnographic research design, we explore the universal and the culturally specific in experiences of aging, with an eye to how local cultural resources and social structures can both afford and constrain people’s search for the good life in later years. The specific objectives are to explore experiences of four main themes: the mindful body, intimate others, time lived, and home space
USA 2018-03-06 2021-03-06 Social Science and Humanities Non-degree Award
Aya Tsubota
ID:
Work empowerment of Health Care Workers in the Republic of Uganda
REFNo: HS172ES

This research aims to identify effective factors of work empowerment for health care workers in the Republic of Uganda using the Focus Group Interview method.
Japan 2018-03-06 2021-03-06 Medical and Health Sciences Degree Award
KYALIMPA Paul
ID:
LEADERSHIP COMPETENCIES AND SUSTAINABLE FUNDING OF NON-GOVERNMENTAL ORGANISATIONS IN UGANDA
REFNo: SS156ES

1.To determine the competences of Nocal NGO (LNGO) leaders in Uganda; 2.To establish the level of LNGO financial sustainability in Uganda; and 3.To establish the influence of competences of LNGO leaders on sustainable funding of LNGOs in Uganda.
Uganda 2018-03-06 2021-03-06 Social Science and Humanities Degree Award
John Sentongo Luyimbazi
ID:
Increasing Efficiency and Improving Quality of Secondary Education in Sub Saharan Africa: A Case Study of Uganda
REFNo: SS163ES

Review and document evidence, background literature and policies on school efficiency in the secondary education context, 2. Develop a theoretical framework to structure evidence and approaches to improving school level efficiency, 3. Assess how secondary schools are governed, managed, resourced, monitored and how resources are allocated and utilized against a benchmark or a framework, 4. Identify opportunities to increase the efficiency and effectiveness of secondary schools through implementation of local solutions and actionable interventions, and 5. Recommend contextually relevant and innovative school efficiency measures to empower schools to sustainably finance, effectively govern, and improve the quality of secondary education.
Uganda 2018-03-06 2021-03-06 Social Science and Humanities Non-degree Award
Vitaliano Cama
ID:
Evaluation of the Diagnostic Tests in Areas Hypoendemic for Onchocerciasis –Uganda
REFNo: HS90ES

) Evaluate the distribution of anti-OV-16 antibody and other markers of O. volvulus infection in multiple age groups. Data from this study may allow to determine the force of infection (rate at which susceptible individuals acquire an infection) using catalytic models
USA 2018-02-21 2021-02-21 Medical and Health Sciences Non-degree Award
Payal Chakraborty
ID:
Characterizing Treatment/Management and Patient Outcomes of Epilepsy in Uganda: A Prospective Cohort Study
REFNo: HS99ES

1. Characterize management of epilepsy in Mulago National Referral Hospital (MNRH), Butabika National Mental Hospital (BNMH), and Mbarara Regional Referral Hospital (MRRH). 1a. To assess treatment options available for epilepsy patients by site (MNRH, BNMH, and MRRH). 1b. To assess knowledge, attitudes, and other factors associated with treatment barriers. 2. Characterize treatment outcomes in hospital-based epilepsy care, specifically at MNRH, BNMH, and MRRH. 2a. To determine etiological risk factors and common seizure patterns associated with epilepsy that present in patients at study sites. 2b. To determine the seizure severity, quality of life, and seizure outcomes among patients with epilepsy. 2c. To determine the adherence levels and factors associated with non-adherence of anti-epileptic drugs.
USA 2018-02-21 2021-02-21 Medical and Health Sciences Degree Award
Alicia Rich Michelle
ID:
Chimpanzee Highways: Gene Flow and Connectivity at Itwara Forest Reserve
REFNo: NS36ES

This study will focus on a chimpanzee metapopulation, which likely spans several protected areas in western Uganda by utilizing Itwara Forest Reserve (hereafter ‘Itwara’) as a connective corridor. Contrasting environments characterize at least two of those areas; closed-forest habitat dominates Itwara Forest Reserve (Howard 1991), while closely neighboring Toro-Semliki is usually described as an “open habitat,” (Hunt and McGrew 2002). Initial observations suggest that chimpanzees utilize a connective corridor of ~4 km between those two reserves, not only for rare dispersal events, but also for regular ranging within a single community’s territory (Rich et al. in prep). Here we are proposing to test whether chimpanzees do use a connective corridor between the two reserves, where the chimpanzee-selected corridor is, and what motivates travel through it (i.e. dispersal, foraging, etc.). We will examine the evolutionary and conservation-based implications of corridor-use by Toro-Semliki/Itwara chimpanzees and lay the groundwork for long term, multi-species connectivity research in and around Itwara Forest Reserve using indirect methods. If chimpanzees are using this corridor, then we will expand our research to examine other potential connective corridors that extend from Itwara Forest Reserve into other protected areas such as Kibale National Park and Muhangi Forest Reserve.
USA 2018-02-21 2021-02-21 Natural Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Pharmacokinetic and pharmacodynamic evaluation of etonogestrel dose escalation with efavirenz-based antiretroviral therapy in HIV-infected Ugandan women (DoublET)
REFNo: HS163ES

Primary objective: To compare the rate of ovulation (by weekly endogenous progesterone at months 3, 6, and 12) when women receive two 68 mg ENG implants (dose-escalated) compared to one 68 mg ENG implant (standard dose) in combination with EFV-based ART. Secondary objectives: 1. To determine cervical mucus quality (by collecting weekly WHO cervical mucus scores at months 3, 6, and 12) when women receive two 68 mg ENG implants (dose-escalated) compared to one 68 mg ENG implant (standard dose) in combination with EFV-based ART. 2. To compare the PK parameters of two ENG implants (136 mg total) with combined EFV use versus the standard dose 68 mg ENG implant with no ART (historical controls in the same population using the same laboratory1) over 6 months of combined use. 3. To evaluate the safety and tolerability of two ENG implants with combined EFV-based ART use. 4. To describe the relationship between ENG concentrations and participant specific variables, specifically body weight, albumin, sex hormone binding globulin, pharmacogenetic polymorphisms, and ART concentrations. 5. To describe the long term feasibility and tolerability of increased dose ENG (136mg) subdermal implant use in HIV-infected women receiving EFV-based ART after weeks 96 and 144 of combined use.
Nigeria 2018-02-21 2021-02-21 Medical and Health Sciences Non-degree Award
Emmanuel Isingoma
ID: UNCST-2019-R001057
Prevalence of Brucella antibodies in livestock in Karamoja, northeastern Uganda
REFNo: A28ES

1. To determine by district the prevalence of Brucella antibodies in cattle, goats and sheep in Karamoja sub-region 2. To determine the distribution of Brucella antibodies by sex of the different species of livestock 3. To determine the distribution of Brucella antibodies by age of the different species of livestock
Uganda 2018-02-21 2021-02-21 Agricultural Sciences Degree Award
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