Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Mikko Virtanen
ID:
Bidi Bidi Refugee Settlement: A study of how organisations effect social fields in a Uganda refugee settlement
REFNo: SS278ES

To observe how organizational forms of the help organizations effect the organizational forms of the refugees them selves. How the organizations effect the organization of home structure, education, religion, work and other aspects of every day life.
Norway 2019-03-19 2022-03-19 Social Science and Humanities Degree Award
Andrew Kambugu
ID: UNCST-2019-R000823
A randomised controlled trial of darunavir versus dolutegravir and tenofovir versus zidovudine in second-line antiretroviral therapy regimens for the public health approach in sub-Saharan Africa, THE NADIA Trial
REFNo: HS333ES

The aims of this trial are: To determine whether a regimen of DTG with two NRTIs is non-inferior to a regimen of DRV/r with two NRTIs as second-line therapy in patients failing on an NNRTI-based first-line regimen in the setting of the public health approach in sub-Saharan Africa, with substantial NRTI cross-resistance.

To determine whether continuing tenofovir and lamivudine is non-inferior to switching to zidovudine and lamivudine in a second-line therapy regimen in patients failing on an NNRTI-based first-line regimen in the setting of the public health approach.


Uganda 2019-03-19 2022-03-19 Medical and Health Sciences Non-degree Award
PAUL KATO KALYEBARA KALYEBARA
ID:
FACTORS HINDERING ACCESS TO ELECTIVE REPEAT CAESAREAN SECTION AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS259ES

General objective To determine factors hindering access to elective repeat Caesarean section and compare the immediate maternal and neonatal outcomes among elective repeat Caesarean section and mismatch emergency Caesarean deliveries at MRRH. Specific objectives 1.To determine the proportion of women with indications for elective repeat Caesarean section that deliver by a scheduled Caesarean section at Mbarara Regional Referral Hospital. 2.To determine the factors hindering access to elective repeat Caesarean section at Mbarara Regional Referral Hospital. 3.To compare the immediate maternal and neonatal outcomes among elective repeat Caesarean section and mismatch emergency Caesarean deliveries at Mbarara Regional Referral Hospital.
Uganda 2019-03-14 2022-03-14 Medical and Health Sciences Degree Award
Joseph Ochieng
ID:
Genetics and genomics research in Uganda: Towards context-specific ethics guidelines
REFNo: SS268ES

1. Assess stakeholder awareness of GGR, and the nature of ethical and social concerns associated with GGR in Uganda, to better understand local needs and issues and provide robust data for later guideline development 2. Evaluate existing guidance and guidelines on the ethics and oversight of GGR for applicability to the Ugandan setting, with a particular emphasis on guidance and guidelines developed by and for Africa. 3. Develop and disseminate a model guideline for the ethics of GGR in Uganda.
Uganda 2019-03-14 2022-03-14 Social Science and Humanities Non-degree Award
Hellen Opolot
ID: UNCST-2019-R001724
A BASELINE ASSESSMENT OF THE ETHICS AND REGULATORY REVIEW PROCESSES FOR CLINICAL TRIALS REGISTERED IN UGANDA BETWEEN JANUARY 2016 AND JULY 2017
REFNo: SS276ES

1. To establish the turnaround times for clinical trial applications reviewed by the Research Ethics Committees and the NRAs in Uganda between January 2016 and July 2017.
2. To document the challenges faced by each stakeholder group along the regulatory review pathway during the study period.
3. To document possible solutions to identified challenges and make some best-practice recommendations that could potentially improve efficiency in the ethics and regulatory review process for clinical trials in Uganda.

Uganda 2019-03-14 2022-03-14 Social Science and Humanities Non-degree Award
Elizabeth Namukwaya
ID:
“Understanding data and information needs for palliative care to target mobile –phone based intervention development in Uganda and Zimbabwe”
REFNo: HS325ES

1. Establish a consortium of academic researchers (from Uganda, the UK and Zimbabwe) including our research team, non-governmental organisations, palliative care providers, policymakers and mHealth development and implementation expertise, to catalyse mHealth research and generate evidence that can guide palliative cancer care development across sub-Saharan Africa
2. Understand the acceptability and optimal implementation of patient-level data collection (e.g. patient-reported outcome measures and patient-reported experience measures) using mHealth approaches in Uganda and Zimbabwe through patient and caregiver engagement
3. Determine information needs and pathways for leveraging evidence generated from mHealth approaches in service development in Uganda and Zimbabwe through health professional and service manager engagement
4. Determine information needs and pathways for leveraging evidence generated from mHealth approaches in policymaking in Uganda and Zimbabwe through policymaker engagement
5. Define the mechanisms for implementation of mHealth approaches to support development of palliative cancer care in sub-Saharan Africa

Uganda 2019-03-14 2022-03-14 Medical and Health Sciences Non-degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
IMPACT OF SYSTEMATIC EARLY TUBERCULOSIS DETECTION USING XPERT MTB/RIF ULTRA IN CHILDREN WITH SEVERE PNEUMONIA IN HIGH TUBERCULOSIS BURDEN COUNTRIES
REFNo: HS331ES

To evaluate the impact on all-cause mortality at 12 weeks of adding systematic early detection of TB with Xpert MTB/RIF Ultra performed on one NPA and one stool sample to the WHO standard of care (SOC) in young children with severe pneumonia, followed by immediate anti-TB treatment initiation in children with a positive Ultra result, in high TB incidence countries, as compared to the SOC alone.
Uganda 2019-03-14 2022-03-14 Medical and Health Sciences Non-degree Award
Satoru Mikami
ID: UNCST-2019-R000358
The Effect of Participation and Alignment on the Sustainability of Development Aid: Evidence from a Field Experiment of a Household Water Treatment and Safe Storage Project in Uganda
REFNo: SS285ES

The purpose of this study is to explore the ways in which development aid can become more sustainable and effective. Among others, this study focuses on the impact of participation and alignment on the stainability of aid projects. However, it would be futile to directly ask stakeholders about their opinions on the contested impact of participation and alignment on sustainability because their opinions are driven more by ideology than by analysis. Therefore, this study uses a specific, concrete field situation where abstract relationships between participation, alignment and sustainability can be translated into actual behaviours.


Japan 2019-03-14 2022-03-14 Social Science and Humanities Non-degree Award
Hella Peter Eszter
ID:
Variation in the leaf-tools of wild chimpanzees: Budongo Forest Reserve
REFNo: NS77ES

This research examines leaf-tool use and repertoire in the Budongo Forest Reserve, Uganda. In the forest, there are two habituated chimpanzee communities: Waibira, where habituation started in 2011, and Sonso, where habituation started in 1990. Both groups have a unique tool repertoire, without any stick or stone based tools, as opposed to those described at other long-term chimpanzee field sites. Additionally, the Waibira group faces an unusual ecological pressure during the dry season, when, despite being a forest living group, all permanent sources of water dry up. Describing their tool repertoire and investigating how it differs from the neighbouring Sonso community, who have permanent water sources all year around, will shed light on the ecological and social pressures driving the development of tool use. The project aims to provide a detailed description of the leaf-tool use of the Waibira chimpanzees of the Budongo forest, during the dry season lasting from December to end of February. Other aims are to determine variables that influence the use of leaf-tools, accurately measure leaf tools, and draw a developmental timeline for the most common type of leaf-tool, leaf-sponging. This will allow for detailed description of the leaf-tools of the community.
Hungary 2019-03-11 2022-03-11 Natural Sciences Degree Award
Stephen Ssematimba Kato
ID:
PREGNANCY OUTCOME AMONG WOMEN OF ADVANCED MATERNAL AGE WHO DELIVER IN MULAGO HOSPITAL.
REFNo: HS260ES

General objective 1) To determine the association between advanced maternal age and adverse pregnancy outcomes among women who deliver in Mulago hospital. Specific objectives 1. To determine whether advanced maternal age is associated with adverse maternal outcomes in mothers who deliver from Mulago hospital. 2. To determine whether advanced maternal age is associated with adverse perinatal outcomes among mothers who deliver from Mulago hospital
Uganda 2019-02-26 2022-02-26 Medical and Health Sciences Degree Award
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