Joel HARTTER Nathan
ID:
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Population, Environment, and Climate in the Albertine Rift
REFNo: NS37ES
To Determine how coupled climate and anthropogenic landscape change impacts the dynamics and resilience of a protected areas and the surrounding human population, including impacts to human and wildlife health, food security, and governance.
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USA |
2018-05-18 |
2021-05-18 |
Natural Sciences |
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Non-degree Award |
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Fiona Cresswell
ID:
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High dose oral and intravenous rifampicin for adult tuberculous meningitis: an open-label phase II randomised controlled trial
REFNo: HS136ES
1. To determine whether higher-dose rifampicin, delivered orally at 35mg/kg/day or delivered intravenously at 20 mg/kg/day (for 2-weeks, followed by orally at 35 mg/kg/day for 6-weeks) provide equivalent plasma and CSF exposures, and whether the exposure profiles are favourable compared to the standard dose oral rifampicin. The pharmacokinetically optimal dose and route of administration of rifampicin can then be taken forward into a phase III clinical trial.
2. To observe whether greater rifampicin exposure in CSF is associated with any clinical benefit including more rapid resolution of coma, reduced neurocognitive deficit or reduced mortality.
3. To determine the diagnostic accuracy of Xpert MTB/Rif Ultra for TBM (ancillary study 1)
4. To describe the concentration of rifampicin in brain tissue in each treatment arm (ancillary study 2)
5. To explore the use of bedside ultrasound as a monitoring tool to improve supportive care for people with TBM (ancillary study 3)
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UK |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Degree Award |
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Moses Ocan
ID: UNCST-2020-R014731
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Antimalarial resistance in Sub-Saharan Africa: Assessing spread of artemisinin resistance and chloroquine resistance reversal among Plasmodium falciparum parasites
REFNo: HS168ES
1) To determine through a systematic review, the extent of chloroquine resistance reversal among Plasmodium falciparum parasites in malaria endemic countries since the change in policy
2) To determine the association between four (4) most reported K13 gene polymorphisms in Sub-Saharan Africa and artemisinin susceptibility among Plasmodium parasites
3) To predict using a model the spread to Sub-Sahara African (Uganda) Plasmodium falciparum parasite population of the K13 propeller gene polymorphisms detected in Southeast Asia and associated with artemisinin resistance
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Uganda |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Degree Award |
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Kirsten Ward
ID:
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Evaluation of delivery practices for multiple vaccines at a single immunization visit in low- and middle-income countries Uganda
REFNo: HS170ES
Aim: This evaluation aims to describe current preparation, administration and communication practices in the delivery of more than one vaccine to a single child at a single immunization visit in Uganda.
Objectives: 1. To document the processes and techniques used to prepare and administer more than one vaccine, primarily injectable vaccines, to children in Uganda;
2. To understand the timing, content, and extent of communication messages about co-administration of one or more vaccines and post-vaccination care delivered by providers to caregivers in Uganda; and
3. To use results from 1 & 2 to develop recommendations about best practices for: a) the preparation and delivery of multiple vaccines with a focus on injectable vaccines, and b) provider communication to the caregiver about delivery of multiple vaccines and post-vaccination care.
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Australia |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Non-degree Award |
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Damalie Nakanjako
ID:
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Inflammation and immune aging among HIV-infected adults with at least 12 years of antiretroviral therapy in an African cohort.
REFNo: HS194ES
1. To describe innate system phenotype and function [Natural killer (NK) cells, monocytes and innate lymphoid cells (ILCs)], after long-term suppressive HAART for at least 12 years of HAART, within the Infectious Diseases Institute (IDI) HIV treatment cohort.
2. To determine levels of immune aging markers among HIV-infected adults with suppressive ART, relative to age-and gender-matched HIV negative counterparts, despite twelve years and more of suppressive ART.
3. To describe those biological pathways which remain deranged after at least 12 years of suppressive HAART, and identify markers/pathways that are known to increase the risk of non-AIDS complications of chronic HIV.
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Uganda |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Non-degree Award |
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Joy Gumikiriza- Onoria Louise
ID:
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SELF - PERCEPTIONS OF AGING AND QUALITY OF LIFE AMONG THE ELDERLY IN UGANDA
REFNo: HS195ES
To 1) Examine the association between quality of life and perceptions of aging among older people in rural and urban Uganda, 2) Translate and culturally adapt the Brief Aging perceptions questionnaire (B-APQ), and 3) Translate and culturally adapt the Older People’s Quality of Life questionnaire (OPQOL) for use with Luganda speaking older people in Uganda.
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Uganda |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Non-degree Award |
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Caitlin Jenks Alexandra
ID:
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EVALUATION OF ANEMIA PREVENTION EFFORTS AFFECTING YOUTH IN IGANGA, UGANDA; CASE OF MUSANA COMMUNITY DEVELOMENT ORGANIZATION
REFNo: HS198ES
General Objective
To evaluate the quality of the current anemia prevention efforts at MCDO, as well as the behavior and beliefs around anemia from healthcare workers and other staff, so the findings can be used to enhance the organization’s strengths, and implement recommended changes.
Specific Objectives
Objective 1
To evaluate, through staff interviews and a research survey tool, the MCDO staff’s current knowledge and beliefs on anemia and how much emphasis they deem should be placed on prevention efforts.
Objective 2
To find out, through staff interviews and observations, if there are any current prevention efforts surrounding anemia on MCDO’s campuses including nutrition education, supplementation, deworming policies, and malaria prevention strategies.
Objective 3
To observe and evaluate qualitative data on the student’s consumption of food on a weekly basis, living quarters, classrooms, dining areas, and footwear of the nursery and primary school students at MCDO.
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USA |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Degree Award |
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Pakoyo Kamba Fadhiru
ID:
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Burden and drivers of controlled prescription drug abuse among selected populations in Uganda
REFNo: HS203ES
The goal of this project is to determine the magnitude and factors associated with controlled prescription drug abuse among selected high risk populations in Uganda. There are five specific objectives:
• To establish the prevalence of controlled prescription drug abuse among health care workers in Uganda.
• To establish the prevalence of controlled prescription drug abuse among patients with mental disorders in Uganda.
• To establish the drivers of controlled prescription drug abuse among health care workers and patients with mental disorders in Uganda.
• To establish the compliance of Uganda’s medicine supply chain to regulations on controlled prescription drugs.
• To establish the factors associated with compliance of Uganda’s medicine supply chain to regulations on controlled prescription drugs
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Uganda |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Non-degree Award |
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Sylvia Nabukenya
ID: UNCST-2019-R000906
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ASSESSMENT OF THE INFORMED CONSENT PROCESS FOR STUDIES INVOLVING GENETIC RESEARCH AMONG PEOPLE LIVING WITH HIV AT THE INFECTIOUS DISEASES INSTITUTE (IDI)
REFNo: HS199ES
1. To assess the adequacy of informed consent documents used for pharmacogenetic research and the collection, storage and future use of human samples.
2. To determine the methods used by researchers to ensure research participants’ understanding during the informed consent process in pharmacogenetic research.
3. To assess the factors that influence participants’ understanding during the consent process in pharmacogenetic research
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Uganda |
2018-05-04 |
2021-05-04 |
Medical and Health Sciences |
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Degree Award |
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Jenna Wozniak Marie
ID:
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Community Knowledge, Attitudes, and Practices Around Individual Blackfly Control and the Diseases They Transmit in Northern Uganda
REFNo: HS200ES
The objective of this research project is to determine what individual level control efforts are being used to protect against blackfly biting within communities. Although large-scale control efforts have been implemented in onchocerciasis endemic regions, individual level control efforts are not well recorded or understood. Through the use of a KAP (knowledge, attitudes, and practices) survey it is hoped that this will be understood. Demographic data will also be collected to find correlations between knowledge and education level. Future application of this information can be used to either modify existing methods or to suggest personal control methods for communities where onchocerciasis and nodding syndrome are endemic. This project will take place in the district of Kitgum and Lamwo in northern Uganda were both onchocerciasis and nodding syndrome have been observed. Over a five-week period, I will travel to several communities within each district to conduct my survey. The research question of this project is what do individuals in communities where onchocerciasis and nodding syndrome are observed know as well as perceive about blackflies and what practices do they use to prevent blackfly biting?
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USA |
2018-05-04 |
2021-05-04 |
Medical and Health Sciences |
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Degree Award |
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