Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Riley Ravary
ID:
Governance in Transboundary Protected Areas: Analyzing Community Experiences at Mount Elgon National Park in Uganda
REFNo: SS148ES

The overall objective of this project is to understand the concept of protection by identifying who or what transboundary protected areas protect. (1) The first specific objective is to understand how governance of transboundary protected areas impacts local resources, residents, and resources users. (2) The second specific objective is to determine how protections are enacted in transboundary protected areas. (3) The third specific objective is to assess how persons who work, reside, and move through transboundary conservation areas balance the trade-off between protection and vulnerability.
USA 2018-08-07 2021-08-07 Social Science and Humanities Degree Award
Ronald Mayanja
ID:
CERVICAL CANCER AND ITS PRECURSORS IN HIV INFECTED YOUNG (BELOW THIRTY YEARS OLD) WOMEN AT MBARARA REGIONAL REFERRAL HOSPITAL, UGANDA.
REFNo: HS178ES

General Study Objective The main objective of this study is to determine the prevalence and factors associated with cervical cancer and its precursors among HIV infected young (below thirty years old) women at Mbarara Regional Referral Hospital. Specific Objectives 1. To compare the prevalence, histological types, trends and factors associated with cervical cancer amongst HIV-positive and HIV-negative young (below thirty years old) women attending the colposcopy and cervical pathology clinic of Mbarara regional referral hospital. 2. To determine the prevalence of high grade cervical intraepithelial lesions and associated factors among HIV infected young (below thirty years old) women at Mbarara Regional Referral Hospital. 3. To determine the factors associated with cervical intraepithelial neoplasia tissue Immunological response among HIV infected young (below thirty years old) women attending the colposcopy and cervical pathology clinic of Mbarara regional referral hospital? 4. To determine the epidemiological and prognostic factors associated with cervical cancer precursors among HIV infected young (below thirty years old) women at Mbarara Regional Referral Hospital.
Uganda 2018-08-07 2021-08-07 Medical and Health Sciences Degree Award
James Musinguzi
ID:
Evaluating the Efficacy of Institutional Systems in the Management of Wildlife Trade in Uganda
REFNo: SS215ES

To establish the nature of the management of wildlife trade in Uganda 2. To examine the influence of the institutional framework on the management of wildlife trade in Uganda 3. To investigate the influence of the legal framework on the management of wildlife trade in Uganda 4. To examine the moderating effect of management factors on the relationship between the institutional and legal framework and the management of wildlife trade in Uganda.
Uganda 2018-08-07 2021-08-07 Social Science and Humanities Degree Award
Zuzana Uhde
ID:
Transnational Migration and Challenges for Global Justice: EU–Africa Relations
REFNo: SS217ES

In the project I will study the perspective of Eastern Africa in order to understand the emerging global governance of migration and identify limits of the nation-state defined framework for global justice, which prevails in the social sciences as well as in the UN migration agenda and European migration policy. I will examine how global political economy impacts on Sub-Saharan Africa and to what extent it constitutes factors shaping migration between African countries and trans-continentally. Under the guidance of MISR I intend to learn from the local colleagues about the Eastern African and Ugandan context in order to understand its relation to the international migration regime. The project will connect a macro-structural perspective analysing global interactions with an analysis of international migration regime and its local effects. The innovative theoretical contribution of the project lies in developing a comprehensive framework that connects migration studies to the broader social theory of global interactions. The main objectives of the project are twofold: 1. developing a conceptual framing of migration in the context of global political economy juxtaposing the double approach of borderless for trade and border-restricted for responsibilities and social protection of migrants; 2. analysing emerging global governance of migration with a special assent on Africa–EU relations and the Ugandan context, and identifying key challenges for global justice.
Czech Republic 2018-08-07 2021-08-07 Social Science and Humanities Non-degree Award
Jade Siu
ID:
Trade Costs and cross border traders
REFNo: SS226ES

Broad objective: *To understand challenges to cross-border traders’ trading activities Specific objectives: *Understand how cross-border traders’ perspective of the One-Stop-Border-Post *Understand the barriers cross-border traders’ face in their day-to-day trading activities
UK 2018-08-07 2021-08-07 Social Science and Humanities Degree Award
Julius Okuni Boniface
ID: UNCST-2019-R000963
Molecular evolution of Mycobacterium avium subsp. paratuberculosis in Africa
REFNo: A35ES

1. Study of MAP prevalence in two African countries (Sudan and Uganda) and evaluation in comparison to data of Europe and worldwide (To be done in Uganda and Sudan) 2. Analysis of the phylogeny of MAP strains from Africa based on genotyping and complete genomes (To be done in Sudan with samples from Sudan and Uganda) 3. Identification of virulence factors of selected MAP strains (To be done in Uganda). 4. Investigation of susceptibility and resistance genes of cattle to MAP (To be done in Uganda). 5. Creation of a risk map for paratuberculosis in Africa.
Uganda 2018-07-31 2021-07-31 Agricultural Sciences Non-degree Award
Andrew Kambugu
ID: UNCST-2019-R000823
Improving HIV treatment in pregnancy: A qualitative study on late antenatal care initiation, maternal disengagement from antiretroviral therapy, and the acceptability of dolutegravir in Uganda and South Africa.
REFNo: HS216ES

1. To investigate the barriers to and facilitators of the uptake of antenatal care early in pregnancy among women in urban and peri-urban communities in South Africa and Uganda. 2. To critically examine key factors that are associated with ART disengagement among women in urban and peri-urban communities in South Africa and Uganda, including: i. the barriers to and facilitators of ART initiation and adherence among late presenting pregnant women; ii. the role of pregnancy, breast-feeding and other post-delivery household and healthcare practices in ART disengagement among women; iii. the differences and similarities in the perceived side effects of dolutegravir and efavirenz among pregnant and post-partum women; iv. the role of community health workers in the delivery of HIV treatment services among pregnant and post-partum women. 3. To understand the key factors that are likely to influence a potential policy transition to and acceptability of dolutegravir in communities and health facilities in South Africa and Uganda.
Uganda 2018-07-27 2021-07-27 Medical and Health Sciences Non-degree Award
Barbara Castelnuovo
ID: UNCST-2019-R000802
PREVALENCE OF GESTATIONAL DIABETES AMONG HIV-INFECTED WOMEN ATTENDING AN URBAN OUT-PATIENT CLINIC IN KAMPALA, UGANDA: A PILOT STUDY
REFNo: HS219ES

Primary • To determine the prevalence of GDM among HIV positive pregnant women using standard OGTT. Secondary • To describe the association between GDM and maternal/fetal outcome in HIV positive women. • To determine the prevalence of diabetes mellitus among HIV positive women previously diagnosed with GDM after birth using standard OGTT.
Uganda 2018-07-27 2021-07-27 Medical and Health Sciences Non-degree Award
Adriena De Visser
ID:
Global Health Electives: Ethical Engagement in Building Global Health Capacity
REFNo: SS229ES

Research Question: At sites where the Cumming School of Medicine (CSM) and other international institutions have long-standing collaborations in support of global health electives, what are the relationship dynamics as perceived by stakeholders in sub-Saharan Africa in regards to visiting medical trainee global health electives? Specific Objectives We aim to: 1)Explore and explain perspectives regarding the harms and benefits of global health electives from multiple stakeholders. 2)Explore and explain perspectives on how to create more equitable and mutually beneficial global health electives from multiple stakeholders. The stakeholder perspectives which we plan to include are those at the host site in Mwanza, Tanzania and Mbarara, Uganda: health facility administrators, host physicians, medical officers, nurses, local trainees, patients and/or family members, and a community leader.
Canada 2018-07-26 2021-07-26 Social Science and Humanities Degree Award
David Meya Bisagaya
ID: UNCST-2019-R000837
High Dose AMBISOME on a Fluconazole Backbone for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: A Phase 3 Randomised Controlled Non-Inferiority Trial
REFNo: HS213ES

Primary Objective: To determine whether short-course high-dose L-AmB is as effective as 7-day amphotericin B deoxycholate-based treatment courses (current standard of care) in averting all-cause mortality in HIV-associated CM patients in a phase-III clinical endpoint trial. Secondary Objectives: 1. To determine the EFA in both treatment arms. 2. To examine the proportions of patients in each arm with clinical and laboratory-defined grade III/IV adverse events; median % change from baseline in laboratory defined parameters, by treatment arm. 3. To determine health service costs by treatment arm. 4. To determine all-cause mortality within the first 2 and 4 weeks. 5. To determine whether short-course high-dose L-AmB is superior to 7-day amphotericin B-based treatment courses (current standard of care) in averting all-cause mortality. 6. To determine rates of cryptococcal relapse / IRIS within the first 10 weeks by treatment arm. 7. To determine rates of disability at 10 weeks by treatment arm.
Uganda 2018-07-26 2021-07-26 Medical and Health Sciences Non-degree Award
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