Patricia NAHIRYA Ntege Nahirya
ID: UNCST-2019-R001117
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Long-Term Follow-Up of CAB LA for Participants in HPTN 083 and HPTN 084 CAB PrEP Studies at Risk of HIV Acquisition.
REFNo: HS3876ES
Primary Objective
• To describe new HIV infections in adult and adolescent participants at risk of HIV acquisition included in the HPTN 084 studies and their associated sub-studies.
Secondary Objective
• To describe any serious adverse events (SAEs), Grade 3 and Grade 4 ISRs, and AEs leading to withdrawal in adult and adolescent participants included in the HPTN 084 studies and their associated sub-studies.
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Uganda |
2024-04-04 8:20:33 |
2027-04-04 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Firminus Mugumya
ID:
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FORMATIVE RESEARCH ON EARLY CHILDHOOD DEVELOPMENT IN NAKIVAALE REFUGEE SETTLEMENT
REFNo: SS2041ES
The overall aim of the implementation research study is to co-design, implement and evaluate an innovative integrated ECD intervention that promotes positive outcomes for refugee children in Nakivaale refugee settlement. This study protocol outlines the formative research to support the development of the intervention, The specific objectives of the formative research are as follows:
1. To describe the current developmental status of children (0-5) in Nakivaale refugee settlement
2. To map formal and informal ECD services in the Nakivaale refugee settlement
3. To understand the current caregiving knowledge, attitudes and practices, in the five domains of the nurturing care framework in the refugee and host setting of Nakivaale refugee settlement;
4. The understand the enabling and influencing factors and barriers to ECD service provision and caregiving among service providers and caregivers
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Uganda |
2024-04-04 8:07:24 |
2027-04-04 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Joseph Kiva S.
ID:
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Exploring the role of participatory communication in the promotion of maternal health care programmes: A case study of 89.2 Central Broadcasting Services FM in Uganda.
REFNo: SS2231ES
4. To find out in what ways has the programme facilitated community dialogue in the promotion of maternal health among pregnant women and mothers.,3. To explore the pregnant women/mothers’ perceptions of the participatorycommunication channels used during the health programme,2. To explore the participatory communication approaches used in the health programme,1. To find out in what ways maternal health communication occurred in radio,The general objective of this study is to explore the role of participatory communication in the promotion of maternal health care programmes,
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Uganda |
2024-04-04 22:25:28 |
2027-04-04 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Simpson Nuwamanya
ID:
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Feasibility of setting up solar powered oxygen supply in Rukungiri District, Uganda and in Butembo, DRC
REFNo: HS3587ES
Main Objective
This proposal seeks to demonstrate the feasibility of solar powered oxygen cylinder filling stations to supply medical oxygen to health facilities in Rukungiri District, Uganda and in Butembo, DRC.
Specific Aims
Describe the oxygen needs (survey of oxygen demand) and willingness-to-pay (market survey) at 14 medical facilities in Rukungiri District, Uganda, and 95 facilities in Butembo, DRC.
a. Specific: The aim is narrowly defined to include cylinder demand and price point.
b. Measurable: Survey data will measure cylinder need at each facility and price point (willingness to pay).
c. Achievable: The 14 sites in Uganda and 95 sites in DRC. We anticipate this survey will take approximately 30 minutes to complete, with on-site interview. Thus, the aim is achievable.
d. Relevant: These data are important for understanding the feasibility of supplying cylinders from a solar powered oxygen filling station.
e. Time-bound: Once approved, the study is anticipated to take 3 to 6 months to complete data collection. Data analysis and write-up of results is anticipated to take another 6 months.
2. Evaluate if solar powered cylinder filling is a feasible model to improve oxygen access.
a. Specific: The aim is narrowly defined to test the feasibility of the proposed cylinder filling stations.
b. Measurable: In order to be feasible, the costs and revenues need to be defined. These will be directly measured (recorded) based on the project activities (cylinder sales, equipment procurement).
c. Achievable: With partners (LeanMed), the cylinder filling stations can be implemented. Thereafter, the evaluation will be achievable.
d. Relevant: These data are important for understanding the real-world implementation of solar powered oxygen filling stations.
e. Time-bound: Once the study is approved and equipment is shipped and installed, we will evaluate project costs and revenues over a well-defined 12-month period.
Hypothesis
The working hypothesis is that solar powered oxygen filling stations are feasible and can generate revenue to maintain the ongoing provision of oxygen in areas where access is limited.
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Uganda |
2024-03-29 9:38:07 |
2027-03-29 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Richard Idro
ID: UNCST-2021-R013599
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Etiological role of parasitic exposure and familial susceptibility in nodding syndrome- related epilepsies
REFNo: HS3940ES
The central aim of this study is to investigate if families with nodding syndrome (NS) share common electrophysiological and clinical features forming a distinct familial epilepsy syndrome and if this phenotype is conferred by parasite, Onchocerca volvulus (OV)-associated hu-Leiomodin-1 antibodies in genetically susceptible individuals. This project provides a unique opportunity to mechanistically understand how the onchocerca parasite exposure modifies the risk for epilepsy among susceptible individuals.
Aim1: Characterize the epilepsy sub-phenotypes that aggregate within the NS-affected families. We hypothesize that a common electroclinical feature forms a distinct NS-associated familial syndrome.
Aim 2: Determine if distinct genetic polymorphism in the human host is associated with the pathogenesis of NS-and related epilepsies. Whole-exome/genome sequencing will be performed to test whether a genetic variant of major effect size co-segregates with NS and related epilepsies.
Aim 3: Evaluate the relationship between exposure to OV-associated Hu-leiomodin-1 antibody and host susceptibility that jointly confers risk for NS-and related epilepsies. We will test the hypothesis that OV -associated Hu-Leiomodin-1 antibodies in genetically susceptible individuals cause NS- related epilepsies.
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Uganda |
2024-03-28 19:51:45 |
2027-03-28 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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