Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Julia Downing
ID:
Impact of the Ugandan Palliative Care Nurse Leadership Project
REFNo: HS274ES

The study is aimed at assessing the impact of the original Ugandan Palliative Care Nurse Leadership Programme
UK 2018-12-20 2021-12-20 Medical and Health Sciences Non-degree Award
Jane Francis Namukasa Wanyama
ID:
Antiretroviral therapy outcomes, barriers and facilitators of linkage into care and adherence among individuals initiating treatment under “Test and Start” guidelines in urban HIV clinics in Uganda
REFNo: HS281ES

General Objective: To establish treatment outcomes, barriers and facilitators of adherence and linkage to care among individuals initiating ART under “Test and Start” guidelines in six urban HIV clinics in Uganda. Specific objectives: The study has three specific objectives: Specific objective 1: To describe treatment outcomes among HIV positive individuals initiated on ART under “Test and Start” guidelines over a 2-year period. This will be a retrospective evaluation of prospectively collected data of all HIV positive individuals who were initiated on ART under “Test and Start” guidelines at Kisenyi, Kisugu, Kawaala, Komamboga and Kiswa HC III. Our extracted dataset will include all eligible ART patients who started ART between January 2017 and January 2018. Follow up period for each participant will be two years until January 2020. We shall describe the proportion of participants achieving virological suppression, incidence of OIs, retention rates, mortality rates and adherence patterns for patients retained on ART at 6,12 and 24months. Specific Objective 2: To explore barriers and facilitators for linkage into care following HIV diagnosis under “Test and Start” guidelines. This will be a qualitative study in which a purposively selected sample of individuals who tested HIV positive but were not linked into care or those who were linked into care but declined to initiate ART will participate in In-depth interviews (IDIs). We shall also conduct IDIs to explore facilitators and barriers for linkage into care among those who were linked into care at any of the five Health Center(HC) IIIs following HIV diagnosis. Specific Objective 3: To explore barriers and facilitators for adherence to ART among individuals initiated on ART under the “Test and Start” guidelines. This will be a qualitative study in which a purposively selected sample of individuals initiated on ART under “Test and Start” guidelines will participate in IDIs. Adherence scores will be extracted from the ART clinic databases as assessed by the health care providers. We shall explore facilitators for ART adherence among adherers (reporting adherence ≥95%) with corresponding viral suppression as a proxy marker for adherence. To explore barriers for adherence, participants with poor adherence will be categorized as irregular (inconsistent) and lost to follow up (LTFU). Both adherers and non-adherers will be stratified by gender, marital status, employment status and age. Additionally, Key Informant Interviews (KIIs) will be conducted with healthcare providers to assess their experiences regarding barriers and facilitators for ART adherence among patients initiated on ART under “Test and Start” guidelines.
Uganda 2018-12-20 2021-12-20 Medical and Health Sciences Non-degree Award
Anthony  Fuller
ID:
A Community-Based Cross-sectional Study of Epilepsy Prevalence and Barriers to Epilepsy Treatment in Uganda
REFNo: HS291ES

Main objective: The first objective of this study is to estimate the countrywide prevalence of epilepsy in Uganda. The second objective is to characterize the community-held beliefs and barriers affecting epilepsy treatment in Uganda. Specific Objectives: AIM 1: To estimate the countrywide prevalence of epilepsy in Uganda 1A- To describe geographic variation, if any, of epilepsy prevalence AIM 2: To characterize the community-held beliefs about epilepsy in Uganda. 2A- To assess knowledge, attitudes, and other factors associated with epilepsy treatment barriers in Uganda.
USA 2018-12-20 2021-12-20 Medical and Health Sciences Non-degree Award
Daniel Kabugo
ID: UNCST-2019-R000502
Developing and assessing the feasibility, acceptability and scalability of a Hospital to Home Programme for high-risk newborns discharged from the Kiwoko Hospital neonatal unit
REFNo: HS292ES

The primary aim of this study is to develop and pilot a discharge and follow-up programme for high-risk newborns discharged from the Kiwoko Hospital neonatal unit, and to examine its feasibility, acceptability and potential for impact on the health and wellbeing of the child and their caregivers.
Uganda 2018-12-20 2021-12-20 Medical and Health Sciences Non-degree Award
Joanna Hill
ID:
Understanding movement patterns and habitat use of crop raiding African elephants in Northern Murchison Falls Conservation Area, Uganda
REFNo: NS80ES

Objective 1: Create an elephant identification database Objective 2: Determine range patterns and habitat use of elephants using GPS collars Objective 3:Create human and elephant activity maps using satellite imagery Objective 4: Design a package of conflict and poaching reduction measures
UK 2018-12-20 2021-12-20 Natural Sciences Non-degree Award
Adrienne Guignard
ID:
The semantics of the alarm calling system of wild blue monkeys
REFNo: NS67ES

Examine empirically if blue monkeys maximise informativity when producing vocalizations and interpret calls as a function of the meaning of other calls
Switzerland 2018-12-19 2021-12-19 Natural Sciences Degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
HIV self-testing to increase testing of male partners in antenatal care in Uganda
REFNo: HS273ES

Primary objective: Determine whether secondary distribution of HIV self-testing to male partners of HIV-negative pregnant women increases the proportion of male partners who test for HIV compared to standard of care invitation letters for fast track testing. Secondary objective: Evaluate whether HIV testing of male partners is associated with PrEP interest among HIV-negative women whose partner tests HIV-positive or refuses testing.
Uganda 2018-12-11 2021-12-11 Medical and Health Sciences Non-degree Award
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
A randomized, four-arm open label Phase IIb clinical trial to evaluate the Pharmacokinetics, Safety/tolerability and Efficacy of High Dose Rifampicin in TB-HIV co-infected patients on Efavirenz- or dolutegravir-based antiretroviral therapy (SAEFRIF)
REFNo: HS262ES

Primary objective 1. To determine the effect of a high dose of rifampicin (35 mg/kg orally) on the pharmacokinetics of first-line antiretroviral drugs (efavirenz and dolutegravir) in TB-HIV co-infected patients on TB treatment. Secondary objectives 1. To investigate the safety/tolerability of a high dose of rifampicin in TB-HIV co-infected patients on TB treatment and first-line antiretroviral therapies. 2. To determine if TB-HIV co-infected patients on a high dose of rifampicin are more likely to have negative sputum cultures by the end of the intensive phase of TB treatment than patients on standard-dose rifampicin. 3. To explore the relationships between exposure to rifampicin, efavirenz and dolutegravir and the tolerability and efficacy of these drugs (Pharmacokinetic-Pharmacodynamic analysis).
Uganda 2018-12-04 2021-12-04 Medical and Health Sciences Non-degree Award
Nurait Nambogo
ID:
Mobile based application for appointment scheduling by health professionals
REFNo: HS251ES

•To assess the acceptability of MobiCare among health professionals and Patients/Clients. •To pilot test MobiCare application at selected private health facilities in Mbarara municipality.
Uganda 2018-12-04 2021-12-04 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Clinical Evaluation of the FilmArray Global Fever (GF) Panel
REFNo: HS265ES

To evaluate the clinical sensitivity and specificity of the assays comprising the FilmArray GF Panel when used to test whole blood specimens. It is hypothesized that the FilmArray GF Panel assays will detect clinically relevant levels of the pathogens included in the panel and give no false detections.
Nigeria 2018-12-04 2021-12-04 Medical and Health Sciences Non-degree Award
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