Denis Muhangi
ID:
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ROLE OF ASFV LATENTLY INFECTED PIGS AND SOFT TICKS IN AFRICAN SWINE FEVER EPIDEMIOLOGY IN ACHOLI SUB REGION, NORTHERN UGANDA
REFNo: A40ES
(i) Establish the prevalence of ASFV latently infected pigs in a post-outbreak situation.
(ii) Investigate the existence of the soft tick O. moubata and their ASFV status.
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Uganda |
2019-02-19 |
2022-02-19 |
Agricultural Sciences |
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Non-degree Award |
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Esther Uwimaana
ID:
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Heme oxygenase-1 and neopterin plasma levels and their role in distinguishing active from latent TB in HIV/TB co-infected patients
REFNo: HS301ES
1. To determine and compare the median plasma levels of HO-1 1(in pg/ml) and neopterin (in ng/ml) among HIV patients co-infected with active TB, latent TB infection and individuals without TB infection alone attending Rubaga hospital.
2. To determine the diagnostic performance (sensitivity, specificity, positive predictive values and negative predictive values) of HO-1 and neopterin in diagnosis of latent tuberculosis infection using QuantiFERON2-TB test for latent TB infection as the gold standard.
3. To determine the diagnostic performance (sensitivity, specificity, positive predictive values and negative predictive values) of HO-1 and neopterin in diagnosis of active tuberculosis using sputum culture as the gold standard.
4. To determine the correlation between neopterin and HO-1 plasma levels with QuantiFERON2-TB Gold test in diagnosing latent TB infection.
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Uganda |
2019-02-19 |
2022-02-19 |
Medical and Health Sciences |
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Degree Award |
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Kathryn LaRusso E
ID:
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Access to Essential Surgical Care and Bellwether Procedures for Children in Uganda: A Public-Sector Evaluation
REFNo: HS231ES
Primary objectives:
1. To conduct a nationwide survey using a convenience sample of two regional and two general referral hospitals in each region (Northern, Eastern, Western, and Central) of Uganda, and the national referral hospital (17 total facilities), using surgical capacity assessments to assess the availability of essential and emergency surgical care (EESC) for children.
i. To pilot the new WHO-PGSSC-GICS Children’s Surgical Assessment Tool (CSAT) and compare the results with PediPIPES to assess the validity, usability and reliability of the new CSAT tool.
2. To identify candidate bellwether procedures for children’s surgery that can be used as a benchmark for essential surgical care for children based on national, regional and general hospital logbook data, surgical capacity assessments, and perioperative mortality if available.
Secondary objectives:
3. To identify if the ratio of emergent surgery to elective surgery (Ee ratio) using logbook data from national, regional and general hospitals can be a simple and valid indicator of access to pediatric surgical care.
4. To verify if a convenience sample of 1-month of logbook data collection can reliability predict perioperative mortality rate vs 3- or 6-months of logbook data collection at MRRH.
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USA |
2019-02-18 |
2022-02-18 |
Medical and Health Sciences |
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Non-degree Award |
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Sarah Baird
ID:
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INCORPORATING MENTAL HEALTH PROGRAMMING INTO ADOLESCENT EMPOWERMENT PROGRAMMING.
REFNo: HS318ES
Despite adolescent girls being at high risk of anxiety, depression, and other forms of psychological distress, there is little extant evidence on how to treat mood disorders among adolescents in developing countries in a cost-effective manner.
The aim of our research projects is to evaluate the use of group based interpersonal therapy (IPT-G) in reducing the prevalence of anxiety and depression among adolescents in developing countries.
The specific objectives of the research project are the following:
1. To estimate the causal effect of IPT-G on the psychological wellbeing of adolescent females who are identified as at risk of anxiety and depression at baseline
2. To estimate the marginal effects of adding income support following the intervention, on the sustainability of IPT-G results on anxiety and depression.
3. To investigate the relationship between improved psychological wellbeing among adolescents (as a result of the intervention) and school attainment, teenage pregnancy, child marriage and risky behavior.
4. To find if ELA clubs can serve as a pathway to reach and engage adolescent females who are most affected by mental health disorders.
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New Zealand |
2019-02-12 |
2022-02-12 |
Medical and Health Sciences |
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Non-degree Award |
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GODFREY OSINDE
ID:
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The association between ABCB1 gene C3435T polymorphism and Doxorubicin pharmacokinetics in Breast Cancer patients at Uganda Cancer Institute
REFNo: HS239ES
1. To determine the pharmacokinetics of doxorubicin in breast cancer patients in
Uganda. 2. To determine the frequencies of the ABCB1 gene: C3435T SNP in
breast cancer patients in Uganda. 3. To determine the association between the
ABCB1 gene: C3435T SNP and PK of doxorubicin in breast cancer patients.
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Uganda |
2019-02-12 |
2022-02-12 |
Medical and Health Sciences |
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Non-degree Award |
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EMMANUEL NAMBALE BUKUWA NAMBALE
ID:
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THE ROLE OF SAVINGS GROUPS ON SMALLHOLDER AGRO-INPUT USE IN SIRONKO DISTRICT, UGANDA
REFNo: A38ES
The main objective of this study is to investigate the impact of membership in a savings group on Agro-input use by smallholder farmers.
Specific objectives
1. To determine the proportion of group savings spent on agro-inputs by group members 2. To determine the difference in use of agro-inputs between members and non-members of savings groups
3. To identify factors determining the level of spending on agro-inputs
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Uganda |
2019-02-12 |
2022-02-12 |
Agricultural Sciences |
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Degree Award |
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Provia Ainembabazi
ID:
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BREAST CANCER RISK PERCEPTION AND RISK REDUCTION BEHAVIOURS OF FIRST DEGREE FEMALE RELATIVES OF BREAST CANCER PATIENTS AT UGANDA CANCER INSTITUTE, KAMPALA, UGANDA
REFNo: HS277ES
General Objective
The general objective of this study is to explore self-perceived risk of breast cancer and intentions for screening and adoption of risk reduction behaviors among first degree female relatives of breast cancer patients attending Uganda Cancer Institute so as to inform design of interventions to enhance uptake of early detection and prevention services.
Specific Objectives
1. To explore self-perceived risk of breast cancer and intended risk reduction behaviors among first degree female relatives of breast cancer patients at UCI.
2. To determine factors associated with self-perceived risk of breast cancer among the first degree female relatives of breast cancer patients at the UCI.
3. To determine the factors associated with risk-reduction behaviors among the first degree female relatives of breast cancer patients at UCI
4. To describe perceived barriers for adoption of risk reduction behaviors among first degree female relatives of breast cancer patients at the UCI.
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Uganda |
2019-02-12 |
2022-02-12 |
Medical and Health Sciences |
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Non-degree Award |
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Stephen KIIRYA Kisembe
ID:
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Psychosocial predictors of sexual risk behaviour among HIV infected and affected adolescents in HIV affected homes of Uganda
REFNo: SS270ES
Despite the long-lasting psychosocial impacts of HIV and the rising number of children progressing to adolescence and reproductive stages with HIV infection and or exposure in Uganda, the extent and factors of psychosocial and sexual risks among adolescents in HIV-exposed homes is unknown. Existing studies have ignored this population yet they are many and prone to psychosocial risks of HIV and focused on either older HIV-infected adolescents attending HIV care or young orphans. Additionally, these studies mainly examined levels and demographic factors of psychological distresses and risky sexual practices and do not therefore offer ample knowledge about the psychosocial situation and sexual risk behaviour among varied adolescents in HIV-affected homes to facilitate inclusive programming. This knowledge deficit begets three research questions, namely 1) What is the psychosocial and sexual risk behaviour situation of HIV infected and affected adolescents living in HIV-affected homes of Uganda? 2) How do HIV infected and affected adolescents compare concerning the psychosocial and sexual risk behaviour situations? 3) Does the psychosocial situation predict sexual risk behaviour in these groups?
The proposed research therefore aims to: 1) determine the psychosocial and sexual risk behaviour situation of HIV infected and affected adolescents in HIV-affected homes across three HIV-burdened districts in Uganda; 2) compare the socio-demographic contexts and levels of community stressors, psychosocial distresses, coping ways and sexual risk behaviours of the two groups; 3) examine the coping mediated psychosocial predictors of sexual risk behaviour in these groups; and 4) evaluate if socio-demographic factors (age, sex, etc.) moderate the coping mediated associations between community stressors, psychosocial distresses and sexual risk behaviour in this population.
|
Uganda |
2019-02-12 |
2022-02-12 |
Social Science and Humanities |
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Degree Award |
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Alfredo Guarino
ID:
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Acute gastroenteritis as a presenting symptom for malaria
REFNo: HS225ES
The aim of the study is to investigate the prevalence of Acute Diarrhea in Children with Malaria in Northern Uganda, a high-transmission malaria setting where there is paucity of data on the etiological agents of childhood diarrhea.
There is a solid scientific basis that could explain the pathogenesis of diarrhea in severe malaria.
The starting point for our working hypotheses is the positive feedback of Ugandan and Italian Doctors who have been working in Lacor Hospital’s Children Ward, whose practical and clinical experience seems to confirm an increased rate of GI symptoms in children with malaria.
There are previous clinical controlled Studies on the subject, however, despite the scientific premises and the clinical observations, these Studies have produced inconsistent and inconclusive results, and eventually failed to demonstrate a statistically significant prevalence of diarrhea in children with malaria. Moreover, setting, study groups and secondary endpoints differ from our Study.
In conclusion and to the best of our knowledge, our Study would be the first to show a statistically significant association between acute diarrhea and malaria. The Study would also be the first to be performed since the introduction of artemisinin-based therapies for the treatment of malaria. Investigating the time of response, and the factors affecting an early (< 24 h) or late resolution (>24h) of diarrhea could provide new extra information on the clinical outcomes of children with GI symptoms during severe malaria treated with IV artesunate and ACTs and provide new prognostic factors on admission.
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Italy |
2019-02-05 |
2022-02-05 |
Medical and Health Sciences |
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Non-degree Award |
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Irene Lubega
ID: UNCST-2019-R000658
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Immunogenicity of Fractional One-fifth and One-half Doses of Yellow Fever Vaccine Compared to Full Dose in Children 9-23 months old in Uganda
REFNo: HS244ES
Primary
• Assess whether seroconversion following one-fifth (0.1 ml) and one-half (0.25 ml) doses of YF 17DD vaccine is non-inferior to seroconversion following a full dose (0.5 ml) at 4 weeks post-vaccination in children aged 9 – 23 months
Secondary
• Assess whether the proportion of baseline seronegative children that are seropositive following one-fifth (0.1 ml) and one-half (0.25 ml) doses of YF 17DD vaccine is non-inferior to the proportion seropositive following a full dose (0.5 ml) of vaccine at 12 months post-vaccination
•
Compare the geometric mean antibody titers following the fractional doses to the geometric mean titer following the full dose at 4 weeks and 12 months post vaccination
• Describe the safety profile of fractional and full-dose YF 17DD vaccine in children 9-23 months
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Uganda |
2019-02-05 |
2022-02-05 |
Medical and Health Sciences |
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Non-degree Award |
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