Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
EVA NATUKUNDA
ID: UNCST-2020-R014330
 Safety of alternative second- line anti-retroviral drugs in HIV- infected children living in Uganda and Zimbabwe
REFNo: HS1071ES

1. To evaluate the renal and bone adverse events associated with TAF when compared to ABC or ZDV among HIV infected children on second line ART
2. To evaluate the effect of TAF on BMD and turnover markers compared with ZDV or ABC among HIV infected children on second line ART.

3. To evaluate the effect of ritonavir boosted Atazanavir (ATV/r), Darunavir (DRV/r), Lopinavir (LPV/r) and DTG based regimens on lipid profiles and body fat distribution.
4. To determine the prevalence and baseline characteristics associated with low BMD among children starting second- line ART in Uganda.
5. To determine the sensitivity, specificity and predictive values of the QUA compared with DXA scan in measuring BMD among HIV infected children on second line ART.


 Uganda 2021-03-24 2024-03-24 Medical and Health Sciences Degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
 Family SuppleMented pAtient monitoRing afTEr suRgery (SMARTER) pilot trial
REFNo: HS944ES

To develop a training and support intervention, in accordance with the MRC complex intervention framework, to train family carers to perform and document basic vital signs, to supplement routine monitoring of patients by nursing staff, whilst they provide personal care to their relatives after surgery and to evaluate the effect of this intervention on frequency of documented vital signs for patients in the first three days after surgery in a stepped-wedge cluster trial.
To evaluate compliance with the trial intervention, and how this changes over the duration of the trial.
To evaluate the effect of the intervention on in-patient mortality, to inform the design of a subsequent international clinical trial across Africa
 UK 2021-03-23 2024-03-23 Medical and Health Sciences Degree Award
Robin NESBITT Clark
ID:
Impact of COVID-19 on HIV and TB patient care in Malawi and Uganda
REFNo: HS1218ES

To describe the impact of COVID-19 and the public health measures to control the spread of COVID-19, on HIV and TB patients and their care in the MSF projects in Chiradzulu, Malawi and Arua, Uganda, including patient perspectives and perceptions.
 Canada 2021-03-23 2024-03-23 Medical and Health Sciences Non-degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
 Pilot Randomized Controlled trial: Preventing infant Malnutrition (PrIM)
REFNo: HS1226ES

Primary Objective
To determine the effect of early small volume supplementation (ESVS) on weight-for-age Z-scores (WAZ) at 30 days of age.
Secondary Objectives
1. To determine the effect of ESVS on WLZ at 30 days of age.
2. To determine the effect of ESVS on WAZ, WLZ, and LAZ through 6 months
of age.
3. To measure the effect of ESVS on breastfeeding duration through 6 months of
age.
4. To determine the effect of ESVS on intestinal microbiota at 30 days of age.
 Uganda 2021-03-23 2024-03-23 Medical and Health Sciences Non-degree Award
Catherine Barasa Asekenye
ID:
Development of community-led approaches to support sexual and reproductive health among survivors of trafficking in Uganda
REFNo: SS746ES

1. Define survivor-led SRH priorities
2. Identify gaps in addressing priorities as identified by survivors and local healthcare providers
3. Test the methodological suitability of two participatory approaches (Photovoice and participatory action research) as transformative methods
4. Bring together stakeholders working with communities of survivors, and based on objectives 1–3, develop a Phase II intervention that supports transformative participatory research approaches among communities of survivors and works with local healthcare providers to provide integrated SRH, as per the needs and expectations of survivors
Uganda 2021-03-23 2024-03-23 Social Science and Humanities Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
 Prevalence and Economic Importance of Key Endemic Livestock Diseases in Kaabong and Amudat Districts, Karamoja Region
REFNo: NS163ES

The specific objectives of this project will be to determine: -
i.Sero-prevalence of FMD, CBPP and CCPP in Amudat and Kaabong districts, Karamoja region
ii.Prevalence of Tick-borne hemoparasites [TBHs] in cattle populations from Amudat and Kaabong districts, Karamoja region
iii.Prevalence of helminths Species of Veterinary importance in Amudat and Kaabong districts, Karamoja region
iv.Estimates of the socioeconomic impact of FMD, CBPP and CCPP in Amudat and Kaabong districts, Karamoja region
v.Estimates of the socioeconomic impact of TBHs in Amudat and Kaabong districts, Karamoja region
vi.Estimates of the socioeconomic impact of different helminths Species of Veterinary importance in Amudat and Kaabong districts, Karamoja region
Uganda 2021-03-23 2024-03-23 Natural Sciences Non-degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 PrEP Persistence and Risk of HIV and Sexually Transmitted Infections among Transgender Men in Uganda
REFNo: HS990ES

Aim 1: Characterize HIV and STI prevalence and risk among trans men Aim 2: Evaluate PrEP uptake and persistence among HIV-negative trans men Aim 3: Explore sexual health experiences and risk behaviours of trans men in Uganda
Uganda 2021-03-22 2024-03-22 Medical and Health Sciences Non-degree Award
Justin Willis
ID:
Uganda’s past, Uganda futures: debates over government, equality and justice, 1979-80
REFNo: SS473ES

· The building of an interdisciplinary research team that demonstrates the relevance of study of the past through a co-produced programme of research and capacity-building;
· Providing a cohort of early-career Ugandan scholars with mentored experience in the techniques of researching the past through interdisciplinary methods, academic writing, and writing for non-academic audiences;
· Producing a published volume showcasing the work of the team;
· Publishing a project blog presenting key findings of the research to non-academic audienc-es
· Creating media outputs that widen the audience and impact of the research
· Presenting the research to civil society organizations, policy makers and a wider audience through a final mini-conference
· The development of one or more applications for further external funding that will enable the career progression of these researchers and the sustainability of the network

 UK 2021-03-19 2024-03-19 Social Science and Humanities Non-degree Award
Ponsiano Ocama
ID: UNCST-2019-R000440
 Obesogenic Impact of Dolutegravir-based Antiretroviral Therapy among HIV-Infected Ugandans
REFNo: HS1029ES

The primary aim is to rigorously investigate the obesogenic effects of DTG switches including: 1. Body composition changes, using body mass index (BMI) and anthropometrics and whole body DXA to measure lean and fat mass (including whole body, trunk, and limb). 2. Ectopic fat changes, emphasizing hepatic fat as measured noninvasively using the continuous attenuation parameter (CAP) measured in dB/m by FibroScan. 3. Cardiometabolic changes, through measurement of HOMA-IR, hemoglobin (Hb)A1c, and fasting lipid panel. We will also explore a major potential mechanism of INSTIrelated weight gain by measuring orexigenic (ghrelin, adiponectin) and anorexigenic (leptin, PYY) hormones, which have been implicated in the pathogenesis of antipsychotic related weight gain, as well as weight loss related to bariatric surgery
 Uganda 2021-03-18 2024-03-18 Medical and Health Sciences Non-degree Award
Aisa Muhamad
ID:
Rewards Management and Performance of Selected Secondary Schools in the Central Region of Uganda
REFNo: SS713ES

i) To establishthe rewards provided in theselected secondary schools in central region of Uganda.
ii) To examine the relationship between monetary rewards andthe performance of secondary schools in central region of Uganda.
iii) To examine therelationships ofnon-monetary tangible rewardsand the performance of secondary schools in central region of Uganda.
iv) To establish the relationships ofnon-monetary intangible rewards and the performance of secondary schools in central region of Uganda.
v) To examine the level of school performance in the selected secondary schools in central region of Uganda.

Uganda 2021-03-18 2024-03-18 Social Science and Humanities Degree Award
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