Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
Search By Approval Date:
Clear Filter Total: 6,552
Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Miriam Nakalembe
ID: UNCST-2021-R014040
NEW APPROACHES FOR THE EARLY DETECTION OF CERVICAL NEOPLASIA
REFNo: HS1161ES

1. Determine acceptability and accuracy of a low-cost smartphone confocal micro-endoscope imaging technique for the diagnosis of CIN 2+. Confocal images will be compared against gold-standard histopathology to obtain preliminary diagnostic performance characteristics.
2. Compare various cervico-vaginal fluid (CVF) biomarkers to gold-standard histopathology for the diagnosis of CIN 2+. Qualitative and quantitative levels of biomarkers will be compared against gold-standard histopathology to obtain diagnostic performance characteristics.


Uganda 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
Susan Tino
ID:
Scale-Up and Capacity Building in Behavioral Science to Improve the Uptake of Family Planning and Reproductive Health Services (SupCap)
REFNo: HS1196ES

1. To test if the BSci Package can lead to an increased uptake of modern contraceptive methods improvements in gender norms, an increase in knowledge of contraceptive methods, birth spacing, and childrearing among postpartum women.

2. To find out how we effectively and efficiently replicate and scale up the BSci Package across Eastern Uganda and elsewhere.

Uganda 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa (SAPPHIRE)
REFNo: HS1239ES

Overall Objective: Our overall objective is to determine to reduce HIV incidence and to improve community health with multi-sector, scalable interventions.

Primary Objective: Reduce HIV incidence using innovative strategies for HIV prevention and treatment to simultaneously reach “persistent driver” populations.

Secondary Objectives:
1. Evaluate and optimize individual intervention component effects, alone (Phase A) and in combination (Phase B), versus control conditions on prevention coverage and HIV viral suppression
2. Assess the effect of the intervention package on other health outcomes (all-cause mortality, tuberculosis, hypertension linkage and control, heavy alcohol use and mother-to-child HIV transmission) in Phase B
3. Evaluate behavioral and other mechanistic pathways for intervention effects on proximal mediators of HIV incidence in Phase B
4. Assess the reach, effectiveness, patient and provider adoption, and fidelity and the maintenance of intervention components in Phase B
5. Use final study data to inform a strategic and sustainable investment model that maximally reduces HIV incidence and improves community health for the combination interventions tested in Phase B

Uganda 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
CARL CHRISTIAN STECKER CHRISTIAN
ID:
Caregiver-Assisted Oral Fluid-based HIV Screening in Children: Estimation of Acceptability, Feasibility and Effectiveness Linked to Index Testing Services in Uganda.
REFNo: HS1258ES

The purpose of this study is to evaluate the acceptability, feasibility and effectiveness of a caregiver-assisted oral fluid based HIV test to screen children for HIV. The results of this study are intended to support expanded access to HIV testing and treatment services for children, and to ensure that all newly diagnosed children are linked to clinical care.

The primary objectives of this study are to:
1. Estimate the acceptability of implementing caregiver-assisted oral fluid-based HIV screening for children as part of index testing services for HIV-positive adults.
2. Estimate the feasibility of implementing caregiver-assisted oral fluid-based HIV screening for children as part of index testing services for HIV-positive adults.
3. Estimate the effectiveness of caregiver-assisted oral fluid-based HIV screening on testing yield, return to clinic, and linkage to ART for newly identified CLHIV.

The secondary objective of the study is to:
Estimate the cost of caregiver-assisted oral fluid-based HIV screening compared to the standard costs of the existing referral to testing program, from the perspective of the health care provider.

USA 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
Leah Pauline
ID:
The Paradox of Being an Adolescent Girl in Uganda During a Global Pandemic
REFNo: SS765ES

My research aims to answer the following
research question and sub-questions:
How do adolescent girls in Uganda navigate the liminal period of COVID-19 when their
educational aspirations of empowerment are put on hold and they face exacerbating
pressures to abide by gender roles/expectations?
Sub-questions:
1- How do high school drop-outs in Uganda differ before and after the onset of the COVID-19 pandemic?
2- What factors influence adolescent girls’ reproductive health and
whether or not they return to school?
3- How do adolescent girls’ future aspirations play a role in their
continuation of schooling?
4- How do adolescent girls interpret peer drop-outs as they navigate their
own decision to continue their education or drop-out?
USA 2021-04-08 2024-04-08 Social Science and Humanities Degree Award
Matthew Cooper
ID: UNCST-2021-R013904
Legacy effects of land-use on tropical soils as constraints on the restoration success and service provision of tropical forests in Uganda
REFNo: NS157ES

The research subject of this project will be the evaluation of soil fertility, soil degradation, C sequestration in both soils and plants, and biodiversity along
tropical secondary forest successions in Western Uganda in three work
packages.
UK 2021-04-06 2024-04-06 Natural Sciences Degree Award
FRANCIS KIBIRIGE
ID:
Do Legislatures Enhance Democracy in Africa, Uganda Chapter
REFNo: SS774ES

DLEDA Project seeks to understand how parliaments in (selected) African countries fulfill the core functions of parliament. This knowledge will enable DLEDA to answer three major questions, including:

Question 1: Which policy decisions are made in the national assembly?

Question 2: Who are the Members of Parliament (i.e. caliber) and how do they interact with each other?

Question 3: How do MPs represent their constituents and what are the existing mechanisms of political accountability?

Uganda 2021-04-06 2024-04-06 Social Science and Humanities Non-degree Award
Allan Lugaajju
ID:
B-CELLS AND HUMORAL FACTORS MEDIATING MALARIA IMMUNITY IN CHILDREN AND ADULTS
REFNo: HS1267ES

1.To quantify reactive Plasmodium falciparum specific B cell subsets against parasite antigens in children and adults.

2.To functionally characterize anti-Plasmodium falciparum B cell subset downstream responses in children and adults

3.To compare the reactivity and proportions of Plasmodium falciparum specific B cell subsets in children and adults

Uganda 2021-04-06 2024-04-06 Medical and Health Sciences Non-degree Award
David Lwanga
ID:
CONFLICTING PRESSURES FOR CHANGE AND INSTITUTIONAL LEGITIMACY IN KAMPALA CAPITAL CITY AUTHORITY, UGANDA.
REFNo: SS780ES

5. To find out the extent to which quantitative results on institution legitimacy of KCCA supports the initial qualitative results.,4. To examine the extent to which the legitimacy of KCCA is a result of harmonizing conflicting pressures for change. ,3. To find out how KCCA dealt with pressures resisting change during the transformation period.,2. To establish the strategic responses that KCCA adopted to attain institutional legitimacy.,1. To establish what institutional pressures influenced the transformation of KCC to KCCA.,To understand how Kampala Capital City Authority attained institutional legitimacy amidst conflicting pressures for change, that is how change initiatives can be positively embraced, hence creating self-reinforcing sequences for institutional legitimacy. ,
Uganda 2021-04-06 2024-04-06 Social Science and Humanities Degree Award
Borja Perez-Viana
ID:
Go for It while You Can: On Time Discounting in High-Risk Environments
REFNo: SS448ES

The poor populations of developing countries are extremely exposed to the vagaries of chance, with agricultural output and livelihoods dependent on highly variable weather patterns. Against this background, it is important to better understand how people in developing countries make decisions involving risk and time trade-offs. Our understanding of these decisions is still hampered by a number of issues. For one, decisions under risk and over time have long been treated separately, whereas in reality, they are closely linked. Investigations in developing countries have often focused on exceedingly simple preference measures that are presented in a theoretical vacuum. Likewise, the identification of causal determinants of preferences remains elusive. We propose to overcome these limitations by combining the modelling of preferences and their determinants with bespoke tools to measure preferences and beliefs. We further propose to combine the model-driven measurements with randomised controlled trials (RCTs) varying theoretically identified determinants of preferences to enable us to draw clear causal inferences. Combining such RCTs with a longitudinal design will further allow us to investigate interactions between the randomly allocated interventions and naturally occurring uncertainty. The study will be carried out in collaboration with the Field Lab, a non-for-profit research organisation, based in Mbale.

We divide our proposal into five work packages:

1. Modelling and measuring future uncertainty: The future is inherently uncertain. It is even more so in developing countries. This uncertainty may indeed drive both high levels of risk taking in the present and extreme time discounting. In this first work package, we aim to model this issue explicitly, and to measure the underlying quantities, with particular attention to future uncertainty.

2. Future probabilities are ambiguous: This work package extends the insights obtained in the first work package to explicitly take the uncertainty surrounding future probability estimates into account. The modelling and experimental measurements are further complemented by a randomised variation of the institution delivering the future payouts.

3. Gain, loss, and mixed inter-temporal prospects: In work package three, we propose to extend the theoretical and measurement apparatus deployed in the first two work packages to a full inter-temporal prospect theory model. This is important to model real decisions, which often involve trading off immediate expenditures against uncertain future outcomes.

4. Background risk and behaviour: Starting from a model of the influence of background risk on decisions under risk and over time, we aim to provide crop insurance to randomly selected subsistence farmers in order to shelter them from background risk. This ought to allow us to draw causal inferences on the effect of background risk on preferences and behaviour.

5. Training, aspirations, and locus of control: Taking risks and investing into the future may be mediated by psychological mechanisms such as aspiration levels or locus of control (beliefs on whether one can control one’s destiny). We aim to augment an existing training intervention by motivational elements aimed directly at shifting these psychological mechanisms, to try and nudge preferences and behaviour in desirable directions.
Spain 2021-03-31 2024-03-31 Social Science and Humanities Non-degree Award
View Sort By:

"A prosperous Science and Technology Led Ugandan Society."