Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Katharine  Brockett
ID:
A study of breast cancer awareness and barriers to accessing breast cancer services amongst adult inpatients and their attendants at Bwindi Community Hospital
REFNo: HS755ES

To find out participants awareness of breast cancer focusing on knowledge of risk factors, signs and symptoms and preventative measures. To ask about participants perceived barriers and identify other issues that may restrict access to breast cancer related care.
UK 2020-08-03 2023-08-03 Medical and Health Sciences Non-degree Award
Doreen Nakimuli
ID: UNCST-2021-R013668
Understanding Self Injection of DMPA-SC: Consumer Insight Research
REFNo: HS767ES

To understand where consumers get their health and family planning information from, where and how they access family planning products, what might motivate them to choose DMPA-SC self-injection, what are the barriers to choosing self-injection, what are consumers’ perceptions and attitudes towards self-injection.
Uganda 2020-08-03 2023-08-03 Medical and Health Sciences Non-degree Award
Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
Evaluation of New Diagnostics and Field evaluation of point-of-care triage tests for Active Tuberculosis.
REFNo: HS688ES

The primary objective of the study is:

1. To finalise a POC-MBT TB triage test suitable for global application and to perform field-testing and validation thereof. The target for each validation process will be the World Health Organisation (WHO) target product profile 90% sensitivity and 70% specificity.

Secondary objectives:
1. To compare the efficacy of the POC-MBT’s TB diagnostic ability between certain sub-classification groups, for example by HIV-status, history of previous TB, extra-pulmonary vs pulmonary TB, and positive vs negative smear/GeneXpert® Ultra/culture.
2. To estimate the efficiency of different TB diagnostic algorithms that include the POC-MBT screening test along with clinical and/or radiological and/or sputa results.
3. To evaluate the POC-MBT as an indicator of treatment response during treatment for active TB.
4. To evaluate a prototype 3-marker gene signature on an Xpert mRNA cartridge using fingerstick blood.
5. To store samples and data to allow the testing or validation of future diagnostic candidates and algorithms, such as automated chest X-ray analysis and transcriptomic bio-signatures.

Uganda 2020-07-30 2023-07-30 Medical and Health Sciences Non-degree Award
Gloria Seruwagi Seruwagi
ID:
Knowledge, adherence and the lived experiences of refugees in COVID-19: A comparative assessment of urban and rural refugee settings in Uganda
REFNo: SS511ES

General objective
We seek to study refugee lived experiences, assess behavioural shifts and determine public compliance and social behaviour in both urban and rural refugee settings

Specific objectives
1. To assess knowledge or awareness of COVID-19 and local perception of risk in urban and rural refugee settings. This will also capture infodemic issues, myths, fears, etc
2. To identify local pre-post COVID attitudes and practices relating to health and social norms. This will include e.g. WASH, healthseeking behaviour, community cohesion practices
3. To explore implementers’ interpretation and enforcement of COVID-19 guidelines.
4. To determine the feasibility of, and adherence to, COVID-19 preventive measures.Will include local interpretations, experiences, innovations, improvisations and explanatory factors
5. To identify community resources, systems and assess their efficacy in the COVID-19 response. E.g. this will cover essential systems and services including health, social care and community leadership
6. To compare urban and rural refugees in line with Objectives 1-5

Uganda 2020-07-30 2023-07-30 Social Science and Humanities Non-degree Award
David Meya Bisagaya
ID: UNCST-2019-R000837
Alternative Meningitis therapies Phase II Trial for Cryptococcal Meningitis (AMPLYX-CM)
REFNo: HS583ES

To determine the safety and efficacy for all drugs for the treatment of cryptococcal meningitis Primary: 1) “Early Fungicidal Activity” (EFA), which is the rate of CSF yeast clearance quantified by the change of log10 Cryptococcus CFU/mL CSF/day as measured by serial quantitative CSF fungal cultures over the first ~2 weeks 2) Incidence of Grade 3-5 laboratory Adverse Events 3) Incidence of Grade 3-5 Clinical Adverse Events or SAEs Secondary: 4) 18-week survival time as time to event analysis a. 2 and 10 week survival time will be presented 5) Among 2-week survivors, 18-week hospital-free survival time 6) Tolerability: all cause drug discontinuation, study withdrawal, or lost-to-follow-up 7) 3-month quantitative neurocognitive performance Z-score 8) Pharmacokinetic studies of APX001A concentrations in blood, CSF, and other bodily fluids/tissues; and with respect to concomitant medicines.
Uganda 2020-07-28 2023-07-28 Medical and Health Sciences Non-degree Award
Gertrude Nakigozi
ID:
Mental Health and Cognition in HIV Infection in Rakai, Uganda
REFNo: HS634ES

Aim 1: Examine separate and interactive effects of HIV and psychosocial determinants on CNS dysfunction in PLWH. Hyp 1. Exposure to sexual/physical trauma or violence will interact with HIV in this population and will be associated with greater impairments/decline in declarative memory, cognitive control, and NVS.

Aim 2: Examine effects of psychosocial determinants on ART adherence in PLWH. Hyp 2. Exposure to sexual/physical trauma or violence will interact with impairments/decline in declarative memory, cognitive control, and NVS will adversely affect ART adherence).

Exploratory Aim 3: Determine biomarkers that relate most strongly and reliably to CNS dysfunction in the context of HIV and/or psychosocial determinants. Hyp 3: Different biomarkers of neuronal damage damage (e.g., neurofilament protein light chain-NFL) and CNS inflammation will relate to patterns of impairment/decline in declarative memory, cognitive control, motor, and NVS in the context of HIV and/or exposure to sexual/physical trauma or violence.

Uganda 2020-07-28 2023-07-28 Medical and Health Sciences Non-degree Award
WILLIAM  MUSAMBA
ID:
Sub-ethnic Identities and Political Conflict in Uganda: The Case of Busoga (1900 to 1967)
REFNo: SS485ES

1)To analyze the influence of British colonial rule on the ethno-political conflicts in Busoga, 2)To assess the position of the Kyabazingaship (Paramount Chieftaincy) in the ethno-political conflicts in Busoga, 3)To examine the nature of political activism of the civic movements in Busoga namely, Young Busoga Association, the Abataka Association and the Abataka Mwoyo Gwa Busoga (Landlords are the Heart of Busoga), 4)To explore the attitude of post-colonial national leadership towards the ethno-political conflicts in Busoga.

Uganda 2020-07-28 2023-07-28 Social Science and Humanities Degree Award
Martha Namusobya Sarah
ID:
Prevalence and factors associated with chronic pulmonary aspergillosis (CPA) among pulmonary tuberculosis (PTB) patients with persisting pulmonary symptoms in Uganda.
REFNo: HS739ES

1. To determine the prevalence of CPA among patients receiving treatment for PTB.
2. To determine factors associated with CPA among patients receiving treatment for PTB.
3. To determine the impact of CPA on health-related quality of life among patients receiving treatment for PTB.


Uganda 2020-07-28 2023-07-28 Medical and Health Sciences Non-degree Award
George Kwizera
ID:
HUMAN CAPITAL AND AGRICULTURAL TRANSFORMATION ON RURAL POVERTY REDUCTION IN UGANDA. A CASE OF KISORO DISTRICT
REFNo: SS442ES

1. To establish how education can ensure rural poverty reduction in Kisoro District
2. To explore the effect of training on rural poverty reduction in Kisoro District.
3. To examine how agricultural transformation can ensure rural poverty reduction in Kisoro District
4. To determine the relationship between agricultural transformation and human capital on rural poverty reduction in Kisoro District.

Uganda 2020-07-27 2023-07-27 Social Science and Humanities Degree Award
Tanner Regan
ID:
Enhancing Voluntary Property Tax Compliance through SMS: A Field Experiment in Kampala, Uganda
REFNo: SS457ES

The overall aim of the research is to identify whether increasing public information on individual’s tax compliance has an effect on tax morale and compliance in the city of Kampala. These findings should help to inform the KCCA in the design of policy changes to increase tax revenues through higher voluntary compliance.

The central question of this research asks, “Does public reporting of tax payments raise compliance?”. We consider two channels of effect through which public reporting can influence compliance. The first is a direct effect; “How does an individual change their compliance behaviour when they know that this will be publicly reported?” and the second considers the effects of such a policy on tax morale; “How do tax payers change their behaviour when they observe others being publicly reported?”.

We address other questions to better answer the central question. In order to gain a further understanding of the underlying mechanisms and optimal policy, we will also ask:

• Whether the type of public reporting matters; “How does public reporting affect compliance behaviour when only compliers are reported, or when only non-compliers are reported?”
• Whether peer group matters for public compliance; “How does public reporting affect compliance behaviour when reporting is done on a village level vs a city level?”.
• Whether taxpayers are more likely to be influenced by knowledge of compliance of high property worth/’influential’ individuals

We are particular keen to understand how the effects of providing public information on compliance compare with other means of improving voluntary compliance in a context of limited trust in government. These additional methods will be identified based on focus group discussions that will be held between April and May 2020.

Canada 2020-07-27 2023-07-27 Social Science and Humanities Non-degree Award
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