Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
William Buwembo
ID: UNCST-2022-R009661
MECHANISMS UNDERLYING DENTAL CARIES AND PERIODONTAL DISEASE IN HIV POSITIVE PERSONS ATTENDING THE MULAGO ISS CLINIC IN UGANDA
REFNo: HS552ES

General Objective
To establish the mechanisms underlying dental caries and periodontal disease in HIV positive adults attending the Mulago ISS clinic in Uganda

Specific Objectives
1. To determine the effect of HIV status on salivary gland function (flow rate, electrolytes, antimicrobial proteins content and DEFB1 single nucleotide polymorphism) in persons with or without dental caries or periodontitis.
2. To determine the abundance and diversity of the oral microbiome in HIV positive individuals with or without dental caries or periodontitis.

Uganda 2020-08-07 2023-08-07 Medical and Health Sciences Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
A mixed-methods observational study to assess the feasibility of conducting COVID-19 vaccine trials among healthcare workers in Uganda
REFNo: HS807ES

I. To assess willingness to participate in COVID-19 vaccine studies and associated factors among healthcare workers in Uganda
II. To estimate the prevalence of underlying health conditions that are associated with poor COVID-19 outcomes among healthcare workers in Uganda
III. To describe the knowledge, attitudes, and practices regarding infection with SARS-CoV-2 and COVID-19 vaccine research among healthcare workers in Uganda

Uganda 2020-08-07 2023-08-07 Medical and Health Sciences Non-degree Award
Mary Ann Etling
ID:
Ethnographic analysis of children with mobility disabilities and their caregivers in Gulu district of post-conflict northern Uganda
REFNo: HS311ES

Identify ongoing needs of children with mobility disabilities and their caregivers in Gulu district.
Characterize physical, economic, social, and environmental barriers that children with mobility disabilities and their caregivers experience in Gulu district.
Investigate changes in the family and how they impact care for children with mobility disabilities in Gulu district.
USA 2020-08-06 2023-08-06 Medical and Health Sciences Non-degree Award
Ronald Moses Galiwango
ID: UNCST-2024-R015239
SARS CoV-2 Infection, Transmission, and Natural History of COVID-2019 Among Persons With and Without HIV and Tuberculosis
REFNo: HS712ES

Primary objective
• Evaluate the impact of HIV infection on presentation and outcomes of COVID-19 disease

Secondary objectives
• Evaluate household transmission of COVID-19 disease among persons with and without HIV infection
• Evaluate the impact of TB infection on presentation and outcomes of COVID-19 disease
• Among persons living with HIV, evaluate the relationship between routine biomarkers (CD4#, viral load) and outcomes of COVID-19
• Among persons living with HIV, evaluate the impact of being on antiretroviral drugs and different ARV regimens on COVID-19 outcomes
• Understand the impact of nutritional and functional status on persons with COVID-19 infection

Uganda 2020-08-06 2023-08-06 Medical and Health Sciences Non-degree Award
Raymond Tweheyo
ID: UNCST-2020-R014507
Exploring the root causes and cultural norms for healthy timing and spacing of pregnancies and assessing access to quality and voluntary family planning in central and western Uganda.
REFNo: HS787ES

Specific objectives:
1)To explore the socio-cultural norms and sexual reproductive health behaviors that influence the youth’s access to FP information and use of FP services.
2)To assess the health system readiness for provision of family planning and youth friendly services in both public and private facilities.
3)To assess the private pharmacy and drug shop readiness for provision of family planning services.
4)To assess community Village Health Team (VHT) capacity and readiness to offer FP services.

UK 2020-08-06 2023-08-06 Medical and Health Sciences Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Assessment of safety and efficacy of COVID-19 Convalescent Plasma for treatment of COVID-19 in adults in Uganda; A randomized controlled trial (CCP TRIAL)
REFNo: HS816ES

General objective
The overall objective of this project is to assess the safety and efficacy of COVID-19 convalescent plasma in the treatment of COVID-19 in Uganda.

Primary objective
1. To determine the efficacy of COVID-19 Convalescent Plasma, as measured by time to RT-PCR negativity of COVID-19 patients treated with COVID-19 Convalescent Plasma.
Secondary objectives
1. To assess the safety of COVID-19 Convalescent Plasma in the treatment of COVID-19 patients in Uganda
2. To document the time to symptom decrease of patients with positive SARS-CoV-2 RT PCR treated with CCP compared to those on standard of care
3. To assess the ability of CCP therapy to stop progression to severe/critical forms of disease

Uganda 2020-08-05 2023-08-05 Medical and Health Sciences Non-degree Award
Jimmy Osuret
ID:
Effectiveness of safe pedestrian crossings for primary school children in Kampala, Uganda: Implications for road safety management
REFNo: HS659ES

The main objective of this study will be to assess the effectiveness of safe pedestrian crossings in reducing child pedestrian road traffic injuries and death around primary school areas so as to persuade policymakers and practitioners to prioritize child pedestrian road safety.
Uganda 2020-08-04 2023-08-04 Medical and Health Sciences Degree Award
Abel Nkolo
ID:
Multimorbidity, Healthcare Processes, versus Mortality among TB/HIV Patients on ART in Uganda
REFNo: HS692ES

1. Determine the association between multimorbidity (non-communicable disease clusters like diabetes, hypertension malnutrition, cancers etc.) and mortality among TB/HIV patients on ART?
2. Analyze the association between demographic factors (sex, age and marital status) and mortality among TB/HIV patients on ART
3. Analyze the association between the phase of TB treatment (Initiation and continuation) and mortality among TB/HIV patients on ART.
4. Determine the association between time of initiation of ART (before the start of TB treatment and after the start of TB treatment) and mortality among TB/HIV patients on ART.
5. Determine the association between the type of TB (pulmonary bacteriologically confirmed, pulmonary clinically diagnosed and extrapulmonary) and mortality among TB/HIV patients on ART.

Uganda 2020-08-04 2023-08-04 Medical and Health Sciences Degree Award
Allen Kabagenyi
ID:
Using Telehealth Services To Support The Continuity Of Family Planning Information, Access, And Utilisation During The Covid-19 Pandemic In Uganda
REFNo: HS799ES

• To conduct a survey among clients on an existing telehealth platform to identify the information gaps and challenges of accessing family planning during the COVID-19 pandemic lockdown.
• To develop an information package for improving access to family planning services
• To assemble a community advisory board (CAB) to review content of the family planning information package
• To pilot the use a telehealth platform for improving continuity and knowledge of family planning services during the COVID-19 lockdown.
• To assess the perceptions towards long-acting reversible family planning methods during the post COVID-19 lockdown. Using the telehealth platform.

Uganda 2020-08-04 2023-08-04 Medical and Health Sciences Non-degree Award
IVAN JJOOGA
ID:
‘Economic analysis of beef cattle fattening systems in Nakaseke District, Central Uganda’
REFNo: A68ES

(i) Overall objective
-To determine the economic performance of beef cattle fattening systems used in Nakaseke District.

(ii) Specific objectives

(a) To assess the profitability of different beef cattle fattening systems in Nakaseke District.
(b) To identify the major challenges hindering the adoption of better beef cattle fattening systems by fatteners.

Uganda 2020-08-03 2023-08-03 Agricultural Sciences Degree Award
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