Musa Sekikubo
ID: UNCST-2021-R014010
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A multi-Centre, randomised, placebo controlled, double-blind, parallel group study to evaluate the safety, tolerability and immunogenicity of two doses of Group B Streptococcus vaccine (GBS-NN/NN2) in women who are pregnant and living with HIV and women who are pregnant and do not have HIV
REFNo: HS1390ES
Objectives
Primary Objectives:
Safety:
To evaluate the safety and tolerability of the GBS-NN/NN2 vaccine in women living with HIV and women without HIV and their newborn babies from vaccination up to delivery/birth.
Immunological:
To compare the transfer rate of vaccine- specific immunoglobulin G (IgG) antibody concentrations from the mother to the baby at birth in women living with HIV with the transfer rate in women without HIV. This endpoint will be used to determine the sample size calculation.
Secondary Objectives
Safety: The safety and tolerability of the GBS-NN/NN2 vaccine in the mother and baby over the first 6 months post-partum, as assessed at 6 months of age.
Immunological: The secondary immunological objectives are:
• To compare IgG antibody responses, specific to the GBS-NN/NN2 vaccine, induced by the first and second vaccine doses over time in pregnant women living with HIV and pregnant women without HIV.
• To evaluate the concentration of IgG antibodies specific for the GBS-NN/NN2 vaccine up to 6 months post-delivery in the mother and baby in women with and without HIV.
• To determine the concentrations of vaccine specific IgG to GBS-NN/NN2 in cord blood at delivery in babies born to women with and without HIV.
Exploratory Objectives
• To compare between groups the isotype composition of the vaccine specific antibodies; in particular IgG and IgA as well as their subclasses, i.e. IgG1-4, IgA1 and IgA2 in maternal and cord blood.
• To compare between groups the vaccine specific IgG antibodies to Rib, Alp1, Alp2 and AlpC, GBS-NN and GBS-NN2 in maternal and cord blood.
• To compare between groups the functional activity of vaccine specific antibodies from cord blood in an opsonophagocytic killing assay (OPkA) and other in vitro assays in selected samples.
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Uganda |
2021-06-08 |
2024-06-08 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
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Using Recency Assays to estimate incident HIV infections among Adolescent Girls and Young Women in Hoima and Mityana/Mubende Districts, Uganda Version 2.0 dated 14 April 2021: Gilead Protocol Number :CO-US-985-6117(eStimating hIv incidEnce amoNg Agyw (SIENA) Study)
REFNo: HS1439ES
Primary Objective
i) To estimate the proportion of incident recent HIV infections among AGYWs aged 16-25 years in Hoima and Mityana/ Mubende districts, Uganda.
Secondary Objective
ii) To compare HIV incidence estimated using the Asanté™ HIV-1 Rapid Recency POC kit with that obtained using the Sedia™ HIV-1 LAg-Avidity EIA and the Abbott ARCHITECT HIV Ag/Ab Combo assays.
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Uganda |
2021-06-08 |
2024-06-08 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Sifiso Lukhele Mbhekeni
ID:
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GENOMIC EVIDENCE OF THE ROLE OF COMMUNICATION SIGNALS IN MEDIATING REPRODUCTIVE ISOLATION AT CONTACT ZONES
REFNo: NS117ES
1. Identify the threshold of variation in communication signals above which species boundaries are maintained.
2. Determine the importance of divergence time and time since secondary contact on levels of interbreeding.
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South Africa |
2021-06-04 |
2024-06-04 |
Natural Sciences |
Non-Clinical Trial |
Degree Award |
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Irene Ayakaka
ID:
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Feasibility of integrating Leprosy systematic contact follow up and Post Exposure Prophylaxis (PEP) into the Routine Leprosy Control Program in Uganda: A case study of Arua and Koboko districts
REFNo: HS1046ES
Objectives
The overall goal of the study will be to contribute to the elimination of leprosy in Uganda and to describe how best to carry out PEP with Single Dose Rifampicin (SDR) in Uganda.
Specific objectives
1. To assess the feasibility of leprosy post exposure prophylaxis in Arua and Koboko; two high burden districts in Uganda
2. To administer single dose rifampicin to eligible contacts of leprosy patients at their homes
3. To assess the factors associated with successful contact investigation for Leprosy in Arua and Koboko districts
4. To describe opportunities and synergies that can be leveraged in the districts to integrate contact investigation with other on-going community-based activities
Secondary Objectives
1. To perform leprosy data verification in Arua and Koboko districts in Uganda.
2. To assess acceptability of leprosy-contact investigation in households and in the community in Arua and Koboko districts.
3. To document the contribution of contact tracing to early leprosy diagnosis and prevention of grade2 disabilities
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Uganda |
2021-06-04 |
2024-06-04 |
Medical and Health Sciences |
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Non-degree Award |
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Danielle Barrington-Francis Jennifer
ID:
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Children and their caregivers’ experiences with incontinence
REFNo: SS806ES
3. Prepare and disseminate results, recommendations and methodologies that can be used in developing more holistic, effective and inclusive humanitarian programming.,2. Collect data on attitudes towards and experiences of incontinence from children (aged five to 11), their caregivers and enabling actors through interviews, focus groups and collaborative story book methodology in Adjumani District; and,1. Develop and assess a collaborative story book methodology to engage children (aged five to 11) in humanitarian contexts in discussions of sensitive topics;,
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Australia |
2021-06-04 |
2024-06-04 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Ceriano Mbiika
ID:
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Systems Approach to ICT/Telecom Network Energy Management for Sustainability in Sub-Saharan Africa.
REFNo: SIR56ES
• To analyze the strategic, policy and regulatory frameworks employed by other countries and borrow ideas to address energy management challenges for Telecom networks in SSA.
• To investigate the weaknesses in the current telecom network energy management approaches across SSA and explore complex emergent properties.
• To investigate the effects and influences of economic-socio-ecological factors on the management of telecom power across Sub-Saharan Africa.
• To investigate and analyze a suitable methodology and technique from the field of systems thinking that can be applied for problem structuring of current telecom network energy management across SSA.
• To formulate a novel framework for guiding the management of sustainable/efficient energy solutions in ICT/Telecom networks across SSA
• To use the proposed framework to contribute innovative solutions and suggestions to the energy complex problems in order to achieve holistic benefits to all the energy system’s stakeholders.
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Uganda |
2021-06-04 |
2024-06-04 |
Engineering and Technology |
Non-Clinical Trial |
Degree Award |
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SABRINA KITAKA BAKEERA
ID: UNCST-2020-R014290
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SEARCH: SMS Electronic Adolescent Reminders for Completion of HPV vaccination in Uganda
REFNo: SS822ES
This protocol is solely for text and voice phone message and intervention development for a subsequent feasibility trial to improve adherence to HPV vaccination schedules in Kampala City., 2: Develop and pre-test HPV vaccine reminders with the target population, 1: Identify desired HPV vaccine text message reminder content (and parallel automated phone reminders) using key informant interviews ,
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Uganda |
2021-06-04 |
2024-06-04 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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WINTERS MUTTAMBA
ID:
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A HEALTH SYSTEMS ANALYSIS AND MODELLING OF METHODS TO MAXIMIZE UPTAKE AND UTILIZATION OF ADVANCED DIAGNOSTICS IN LOW- AND MIDDLE-INCOME COUNTRIES – THE CASE OF COVID-19
REFNo: HS1337ES
1.To quantify the degree of uptake & utilization of COVID-19 diagnostic tests in Uganda, Rwanda, Kenya and UK
2.Map the pathways of uptake and ramping up COVID-19 testing in the study countries.
3.To characterise micro level and macro level factors affecting uptake and utilisation of COVID-19 diagnostic tests in Uganda, Kenya, Rwanda and UK
4.Modelling data obtained in 1) and 2) to identify best models for maximizing uptake of advanced diagnostic tests in health emergencies.
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Uganda |
2021-06-04 |
2024-06-04 |
Medical and Health Sciences |
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Non-degree Award |
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Ivaibi Charles
ID:
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SELECTED CORRELATES OF WORK ENVIRONMENT AND HEALTH SERVICES DELIVERY IN HEALTH CENTRES IN BUSOGA REGION,EASTERN UGANDA
REFNo: SS798ES
(a) To establish the relationship between Support Supervision and Health Services Delivery at Health Centers in Busoga region.
(b) To study the relationship between Physical Work Environment and Health Services Delivery at Health Centers in Busoga region.
(c) To get in-depth information about the relationship between Information Management and Health Services Delivery at Health Centers in Busoga region.
(d) To design a model that will guide effective Health Services Delivery at Health Centers in Busoga region.
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Uganda |
2021-06-04 |
2024-06-04 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Catherine Namuga
ID:
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INVESTIGATING THE POTENTIAL OF BIOACTIVE GAUZE DRESSING IMPREGNATED WITH HERB-LOADED NANOPARTICLES IN FACILITATING WOUND HEALING
REFNo: HS1393ES
The main aim of this work is to functionalise the gauze dressing using herb loaded nanoparticles to enable faster wound healing in excision wound models established in rats.
Specific objectives
1) To determine the antibacterial activity of Bidens pilosa L., Hoslundia opposita Vahl and Ageratum conyzoides L., plant extracts.
2) To determine the effect of the most efficacious antibacterial herbal extract on wound healing rate using excision wound models in rats.
3) To determine the effect of nano encapsulation of the herbal extract using biopolymers, on its antibacterial activity and wound healing rate.
4) To evaluate the effect of incorporating herb loaded nanoparticles into the gauze dressing on its antibacterial activity and wound healing rate.
5) To assess the effect of the herb loaded nanoparticles on the performance characteristic of the gauze dressing.
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Uganda |
2021-06-04 |
2024-06-04 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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