Samuel Kyobe
ID: UNCST-2019-R000108
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DSpace: Utilizing Data Science to Predict and Improve Health Outcomes in Pediatric HIV
REFNo: HS4003ES
Use explainable machine learning algorithms to integrate multi-omics data with temporal EHRs to improve the diagnosis of active TB in HIV-infected children,Use machine learning to integrate temporal EHRs with genomic data to predict the longitudinal risk of MetS among African children on life-long ART,How can Data Science be utilized to integrate large temporal electronic health records with multiomics data to predict and improve health outcomes of HIV-infected children in Africa.,
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Uganda |
2024-05-31 18:19:52 |
2027-05-31 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Godfrey Siu
ID: UNCST-2021-R005439
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An Evaluation of the Effectiveness of the Parenting for Respectability Programme on Early Childhood Development among Children aged 0-6 years in Uganda
REFNo: HS4168ES
Main Objective
To conduct an effectiveness trial of an adapted (shorter) version of the PfR programme on ECD outcomes nested within wide scale implementation.
Specific Objectives
1.To estimate the effectiveness of the Parenting for Respectability programme on improving ECD specific outcomes (gross motor, fine motor, language and social development) among children aged 0-6 years after 6 months of intervention.
2.To estimate the observed improvement in parental knowledge, practices and parent-child relationships after 6 months of PfR programme interventions.
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Uganda |
2024-05-31 18:18:53 |
2027-05-31 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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JUDITH AKELLO
ID: UNCST-2024-R003967
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Unpacking the Influence of Women's Economic Empowerment Initiatives through Uganda Women’s Entrepreneurship Program on Livelihoods and Cultural Dynamics, Amolatar Sub-Region
REFNo: SS2635ES
Main objective
To explore whether and how economic impact of women's entrepreneurship program initiatives, is influenced by cultural norms and traditions on their engagement in entrepreneurial activities, in Amolatar sub-region.
Specific objectives
1. Analyse the economic impact of women's entrepreneurship programme initiatives in Amolatar sub-region. This involves tracking changes in women's income levels, employment opportunities, and access to financial services as a result of participating in these programs. The study will also evaluate the sustainability of economic improvements over time.
2. Explore the influence of cultural norms and traditions on women's engagement in women entrepreneurship programme activities within Amolatar sub-region. This will involve interviews to understand how cultural beliefs, roles, and expectations shape women's economic opportunities and choices. This study will also examine any shifts in these norms resulting from entrepreneurship program initiatives.
3. Establish the complex interplay between women's entrepreneurship program initiatives and cultural dynamics in Amolatar sub-region. This objective will involve a comparative analysis of the data gathered under the first two objectives to identify areas of alignment and tension between economic empowerment efforts and cultural norms. Additionally, we will investigate the strategies and mechanisms used by empowerment programs to navigate and influence these cultural dynamics.
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Uganda |
2024-05-31 18:05:38 |
2027-05-31 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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ERIC WOBUDEYA
ID: UNCST-2019-R001047
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Shortened RegiMen for Drug-susceptIbLE TB in Children
REFNo: HS4030ES
Primary
1. To determine if an 8-week HPZM regimen in children with presumed drug-susceptible TB disease has non-inferior efficacy to 8-weeks of HRZ(E) plus 8- or 16-weeks of HR(E) for achieving treatment success.
2. To evaluate the safety of the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
Secondary
1. To evaluate the tolerability of the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
2. To determine the weight-banded dosing of rifapentine and moxifloxacin taken as part of the HPZM regimen.
3. To evaluate the palatability and acceptability of the 8-week HPZM regimen in comparison to the 16- or 24-week HRZ(E) regimen among children with and without HIV.
4. To evaluate adherence to the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
5. To evaluate clinical and laboratory characteristics and drug exposures associated with unsuccessful treatment outcomes (treatment failure or death).
6. To evaluate the cost and cost-effectiveness of the 8-week HPZM regimen relative to the 16- or 24-week HRZ(E) standard of care regimen, using a societal approach.
Exploratory
1. To characterize rifapentine and moxifloxacin PK parameters in malnourished children.
2. To evaluate the effect of rifapentine or rifampin, taken as part of the HPZM or HRZ(E) regimen, on the PK of dolutegravir.
3. To evaluate virologic control (less than 200 copies/mL) at 24- and 48-weeks among children with HIV taking a dolutegravir-based ARV treatment regimen co-administered with either HPZM or HRZ(E).
4. To collect and store biospecimens from consented participants for the purpose of future TB research.
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Uganda |
2024-05-31 18:02:19 |
2027-05-31 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Bernard Kikaire
ID:
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Improving identification of new HIV infections and primary drug resistance among adolescents' girls, young women and their sexual partners in Uganda.
REFNo: HS4283ES
To improve identification of HIV infection, describe transmitted drug resistance mutations and HIV transmission network among AGYW and their sexual partners in Uganda.
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Uganda |
2024-05-31 17:57:30 |
2027-05-31 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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