Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Munshi Sulaiman
ID:
Applying Behavioural Activation (BA) as a psychological intervention for adolescents in Uganda.
REFNo: HS724ES

The primary objective of the study is to develop a smartphone app to deliver BA and assess whether it is acceptable and feasible for use with 30 adolescents.
As a secondary objective, we aim to validate measures of mental health and wellbeing, cognition, risky behaviours, and socioeconomic indicators for use in this population, and to examine the association between these variables.
If successful, results from this study will be used to inform the developments of a larger pilot RCT in Uganda.

Bangladesh 2020-07-08 2023-07-08 Medical and Health Sciences Non-degree Award
Hiled Mugabe
ID:
Girls Take Lead (GTL) Pilot Project
REFNo: SS492ES

1.Test procedures for recruiting adolescent girls and young women who participate in transactional sex relationships and are at risk of acquiring HIV into the Girls Take Lead intervention.
2.Test whether following the intervention, participants are more aware of the risks associated with transactional sex such as gender based violence, multiple sexual partners, age-disparate sex, non-use of condoms and alcohol use as compared to baseline.
3.Test whether following the intervention, participants are more aware of structural factors in their community that may affect their vulnerability to HIV through transactional sex as compared to baseline.
4.To explore participants’ perceptions of the individual components of the intervention.

Uganda 2020-07-08 2023-07-08 Social Science and Humanities Non-degree Award
Eugene Kinyanda
ID: UNCST-2023-R008028
Integrating the management of depression into routine HIV care in Uganda (the HIV+D trial) –A cluster Randomised Trial
REFNo: HS645ES

To undertake a cluster randomised HIV+D intervention trial to evaluate its effectiveness on depressive disorders, functional outcomes and its cost-effectiveness in routine HIV care in Uganda.
Uganda 2020-07-07 2023-07-07 Medical and Health Sciences Non-degree Award
Esther Nkolo Karungi Karamagi
ID:
Leadership, quality improvement, team functionality, and HIV viral load suppression in Uganda
REFNo: HS686ES

Goal: To understand how to improve viral load suppression for people with HIV
Primary study objective: To understand the relationship between quality improvement team characteristics and viral load suppression for people with HIV
Secondary objective 1: To describe the association between HIV clinic leader’s involvement in the QI team, QI team functionality, and HIV viral load suppression in HIV clinics in Uganda, controlling for patient age and sex.
Secondary objective 2: To understand the association between QI team diversity, QI team functionality, and HIV viral load suppression in HIV clinics in Uganda, controlling for patient age and sex.
Secondary objective 3: To understand the association between QI team skill, QI team functionality, and HIV viral load suppression in HIV clinics in Uganda, controlling for patient age and sex.

Uganda 2020-07-07 2023-07-07 Medical and Health Sciences Degree Award
Ana  Santos
ID:
Applying a Human-Centred Approach to design technology supported Sexual Reproductive Health Interventions in Uganda
REFNo: SS467ES

The purpose of this study is to generate qualitative and quantitative findings and uncover insights regarding familiarity and perceptions of Sexual and Reproductive Health (SRH), including the barriers and drivers of uptake of contraceptive methods among adolescent girls aged 15-19 years from urban and peri-urban areas of Kampala and Arua. Regarding the ITH platform, the study will generate information about adolescent girls’ familiarity with and access to selected technological platforms. The study will also generate information on the landscape of actors involved in the Sexual Reproductive Health arena in Arua and Kampala. These insights will inform subsequent stages of the Human-Centered Design (HCD) of tailored interventions for the selected target populations.
Portugal 2020-07-07 2023-07-07 Social Science and Humanities Non-degree Award
Hellen Nansumba
ID: UNCST-2019-R001368
Health care users’ knowledge, attitudes, and perceptions of broad consent for storage of biological materials and associated data in Uganda
REFNo: HS652ES

Main Objective
To evaluate the HCUs’ knowledge, attitudes, and perceptions of broad consent for storage of biological materials and associated data in a clinical setting in Uganda

Specific objectives
1. To assess HCUs’ understanding of essential elements of the informed consent form
2. To determine HCUs’ attitudes towards informed consent form
3. To determine the acceptability rate for storage of biological materials and associated data
4. To understand the of motivation of HCUs who accept for storage of biological materials and data
5. To assess HCUs’ perception of broad consent for biological materials and data

Uganda 2020-07-01 2023-07-01 Medical and Health Sciences Non-degree Award
John Bosco Ddamulira Mayanja
ID: UNCST-2022-R010819
Burden of Snakebites and Snakebite Envenoming in Uganda: A community survey and Health facility Audit
REFNo: HS566ES

I. Determine the incidence of snakebite envenoming in Uganda
II. Characterize the snakebites and snakebite envenoming in Uganda
III. Describe the snakebite envenoming outcomes
IV. To describe snakes commonly responsible for snake bites in Uganda.
V. Establish the spatial distribution of the common snake species in Uganda
VI. Identify the community practices following snakebite envenoming in Uganda
VII. Assess health facility capacity (human, equipment & supplies) to manage snakebite envenoming

Uganda 2020-06-30 2023-06-30 Medical and Health Sciences Non-degree Award
VICTORIA WALUSANSA ABALIWANO
ID: UNCST-2021-R012155
Exploring the Molecular Spectrum of Colorectal Cancer in Uganda
REFNo: HS667ES

Primary Objective: Estimate the prevalence of BRAF and KRAS mutations, CIMP, and MSI in colorectal tumors in the KCR.
Secondary Objectives:
(1) Describe the demographic and clinical characteristics of colorectal cancer cases in the KCR.
(2) Evaluate associations of demographic and clinical characteristics with the prevalence of BRAF and KRAS mutation, CIMP, and MSI in colorectal cancer cases in the KCR.
(3) Evaluate associations of survival time with tumor molecular phenotypes (BRAF, KRAS, CIMP, MSI) and other participant information.

Uganda 2020-06-30 2023-06-30 Medical and Health Sciences Non-degree Award
Sachin Gathani Gathani
ID:
Effect of Covid-19 lockdown measures on coffee farmers in Central and Western Uganda
REFNo: SS486ES

This study aims to understand the effect of COVID-19 and the consequent lockdown
measures on coffee farming households in the JDE Farm College a program being
implemented by TechnoServe (a non-profit organization). JDE is working in partnership with Technoserve to train coffee farmers on coffee agronomy best practices, helping them improve
the quality and yields of their coffee trees, which in turn will increase their income in the long term. Farmers are enrolled in the training program every 2 years in what is referred to as a
“cohort”. Enrolled farmers come together and form a focal farmer group and a farmer trainer is appointed to run the training sessions. Coffee demo plots are implemented in order to train farmers in real-life conditions. The trainings are conducted every month and attendance is tracked. Laterite is a research, data and advisory firm with offices in Kampala who is partnered with TechnoServe to provide research support for the monitoring and evaluation activities of the TechnoServe Farm College Program.
The main objective of the study is to generate timely data and insights for TechnoServe and coffee industry stakeholders on how coffee farming households that are part of their agronomy training program are affected by COVID-19 crisis and the consequent lockdown measures to address Covid-19. This will be useful for TechnoServe, to inform their programming including targeting interventions to areas that need them most and considering options for redirecting
resources from coffee agronomy to other types of training.
The results from this study will result in monthly briefs (not an academic study) that
demonstrate farmer’ knowledge of COVID-19 and how the lockdown measure may have
affected their farming activities including access to input, farms and markets.
Kenya 2020-06-30 2023-06-30 Social Science and Humanities Non-degree Award
Arthur Kwizera
ID: UNCST-2021-R012928
A multicenter, prospective, randomized, placebo-controlled, open label, stepped wedge clinical trial of respiratory support with continuous positive airway pressure or high-flow oxygen therapy in adults with acute hypoxemic respiratory distress in Uganda.
REFNo: HS523ES

Primary objective
To assess the efficacy of CPAP and HFNC in improving 28-day survival in patients with AHRF.

Secondary objectives
Secondary objectives are to:
- Determine the feasibility, safety, tolerance and comfort of CPAP and HFNC;
- Evaluate the impact of CPAP and HFNC on morbidity, including the need for intubation, ventilator free days, organ dysfunction, and hospital length of stay.


Uganda 2020-06-29 2023-06-29 Medical and Health Sciences Degree Award
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