Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Christine Aanyu
ID:
EQUITABLE MATERNAL CARE FOR WOMEN WITH DISABILITY (EMeralD) STUDY
REFNo: HS722ES

1) Specific Aim 1. Conduct an analysis of disability, pregnancy and birth outcomes, and maternal health care utilization data for pregnant women with disabilities in Uganda.
2) Specific Aim 2. Understand the needs and perceptions of pregnant women with disabilities and identify availability of, and barriers to accessing, maternal health care services.
3) Specific Aim 3. Formulate and develop a model for disability-friendly services for pregnant women.

Uganda 2020-10-07 2023-10-07 Medical and Health Sciences Non-degree Award
David Serwadda -
ID:
Characterizing community exposure to SARS-CoV-2 in Uganda, and assessing biological determinants of virus spread
REFNo: HS878ES

1.Assess the diagnostic sensitivity and specificity of the CoronaChekTM rapid COVID-19 IgM/IgG lateral flow test (CoronaChekTM by Hangzhou Biotest Biotech Co Ltd) for anti- SARS-CoV-2 antibodies detection in Uganda.
2.Conduct enhanced surveillance of COVID19-like symptoms in the context of an existing population cohort and assess the predictive value of prevailing symptoms for COVID-19 exposure based on rapid serological testing in this region.
3.Determine rates of sero-reactivity/positivity among key health care workers at high-volume health centers III and IV and also among PCR-negative contacts of confirmed COVID-19 cases in the region.
4.Explore ‘prior importation of COVID-19 infection in Uganda”/ pre-existing sero-reactivity (may due to ‘related’ coronavirus strains/shared epitopes) in purposively selected archived sera, prioritizing from truck drivers and commercial sex workers that was collected before the lockdown in Uganda / Rakai region.

Uganda 2020-10-06 2023-10-06 Medical and Health Sciences Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Children with Sickle Cell Anaemia in eastern and southern Africa: a double blind randomised trial (the CHEMCHA trial)
REFNo: HS709ES

Primary objective
The general objective is to determine the efficacy and safety of malaria chemoprevention with weekly single day courses of DP compared to monthly single courses of SP in children with SCA in eastern and southern Africa.

Secondary objectives
1. Assess the feasibility and stakeholder perceptions on the uptake (acceptability) and the potential for future roll-out of weekly DP vs monthly SP.
2. Determine the safety of cumulative dosing of DP, especially on cardiac function.
3. Monitor the development of malaria parasite resistance to DP in clinical isolates over time.
Assess patients’ health-related quality of life, cost-effectiveness, equity and economic implications of using weekly courses of DP vs monthly courses of SP as chemoprevention in SCA.
5. Assess acceptability of weekly courses of DP for malaria chemoprevention in SCA vs monthly courses of SP as chemoprevention in SCA.
6. Conduct policy advocacy to engage key stakeholders on policy decisions on using weekly courses of DP or monthly courses of SP for the chemoprevention of malaria in SCA.
 Uganda 2020-10-02 2023-10-02 Medical and Health Sciences Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Hydroxyurea therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda: A single arm open label trial, “BRAIN SAFE II”
REFNo: HS846ES

The primary objective is to determine the impact of daily oral hydroxyurea therapy, 20- 30mg/kg/day, on the frequency and severity of Sickle Cell Vasculopathy(SCV) in a cohort of children treated for three years, as measured by 3 distinct outcomes: abnormal TCD, neurocognitive impairment and primary stroke, compared with baseline.

Secondary objectives
1.Evaluate the impact of Hydroxyurea therapy on structural SCV using MRI and MRA in a randomly selected subset of this cohort.
2.Assess changes to anemia, CRP and malnutrition status during hydroxyurea therapy, over time, compared with baseline levels.


 Uganda 2020-10-02 2023-10-02 Medical and Health Sciences Non-degree Award
Sarah Kiguli
ID: UNCST-2021-R013020
 Nutritional Treatment in Pneumonia Trial. (NuTiP)
REFNo: HS911ES

To establish whether supplementary feeding for 56-days (8 weeks) using Ready to Use Therapeutic Feeds (RUTAFA) in children between 6 months and 12 years with respiratory distress complicated by hypoxia versus usual standard care will improve outcome at 90-days.
 Uganda 2020-10-02 2023-10-02 Medical and Health Sciences Non-degree Award
mariam Namutebi
ID:
TEENAGE FIRST TIME MOTHERS’ PERCEPTIONS ABOUT THEIR HEALTH CARE NEEDS AND THE GAPS IN POSTPARTUM CARE.
REFNo: HS780ES

General objective:
To explore the teenage first time mothers’ perceptions about their postpartum care needs and the gaps in the facility based postpartum care
Specific Objectives:
1. To explore the teenage first time mothers’ perceptions about their postpartum care needs.
2. To identify the current gaps in the facility based postpartum care provided to teenage first time mothers.

 Uganda 2020-10-01 2023-10-01 Medical and Health Sciences Non-degree Award
Joseph Kagaayi
ID: UNCST-2024-R015946
 Impact of COVID-19 Lockdown on HIV and Reproductive, Maternal, Neonatal and Child Health services in Masaka region, Uganda
REFNo: HS865ES

1 Goal
The overall goal of the study is to assess the effect of the COVID-19 lockdown on demand and utilization of RMNCH and HIV services and assess coping mechanisms in order to make evidence-based recommendations for mitigation of the impact during the COVID-19 epidemic and future health emergencies and disasters.

Specific aims
1) To determine the effect of COVID-19 lockdown on discontinuation of Antiretroviral therapy (ART) among patients receiving antiretroviral drugs in 12 districts of the Masaka region.
2) To determine the effect of COVID-19 lockdown on Antenatal care (ANC) attendance, facility deliveries, contraception, immunization, EID, HIV testing among all pregnant women and initiation of option B+ among HIV-positive ANC attendees.
3) To determine the effect of the COVID-19 response on viral load monitoring, intensive adherence counseling and HIV viral suppression among clients in the Masaka region,.
4)To explore clients’, district, and health facility knowledge, attitude and experiences (KAE) and coping mechanisms for sustained ART, and RMNCH services. Qualitative exploration of KAE will provide useful pathways for the effect of lockdown measures on demand and utilization of services.

Uganda 2020-10-01 2023-10-01 Medical and Health Sciences Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
 Validation of SARS-CoV-2 detection by Rapid AirJump RNA Amplification (RARA) COVID Test method
REFNo: HS888ES

We will carry out validation of RARA assay in the laboratory before the field evaluation in testing of SARS-CoV-2.
We intend to understand the inherent characteristics of this assay with regard to accuracy (diagnostic sensitivity, diagnostic specificity), Precision (reproducibility), Limit of detection (LOD), Predictive value (negative and positive), and Assay Efficiency.
Uganda 2020-10-01 2023-10-01 Medical and Health Sciences Non-degree Award
KarenBeth Bohan Heikkinen
ID:
Assessment of Online Modules to Increase Knowledge of Geriatric Care in Health Care Professionals RefNo: MAKSHSREC-2020-6
REFNo: HS727ES

To determine the pharmacists’ satisfaction with pharmacy geriatric online training.,To determine the learning preference in terms of online compared to live educational sessions before and after using the online modules for professional development,To determine the retention of knowledge of geriatric care at three months after completion of all five online educational modules.,To assess the improvement of pharmacy professionals’ knowledge of geriatric care after participating in online educational modules.,
 USA 2020-09-29 2023-09-29 Medical and Health Sciences Non-degree Award
Ignatius Odongo Odongo
ID:
Youth Entrepreneurship in South Africa and Uganda: An Investigation of the Influence of Mental Triggers
REFNo: SS487ES

To contribute to the existing discourse on youth entrepreneurship, by introducing a new applied framework from which youth entrepreneurship can be developed based on the influences of mental triggers. The new framework will include, inter alia, a description of the following:
• the environment that can potentially stimulate youth entrepreneurship;
• the kind of entrepreneurship education that will stimulate and provide requisite skills for the nascent youth entrepreneur; and
• the personal characteristics that can be nurtured for entrepreneurial success.
Armed with this new framework, the stakeholders that areresponsible for youth development, particularly in developing countries, will be able to deal with the psychological and other barriers that impede the youth from venturing and succeeding in entrepreneurship.

 Uganda 2020-09-29 2023-09-29 Social Science and Humanities Degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
 Preventing Infant Malnutrition with Early Supplementation (PRIMES)
REFNo: HS825ES

Aim 1. To describe local experiences and beliefs related to breastfeeding, breast milk expression, non-maternal food sources and infant weight and health.

Aim 2. To determine the range of newborn weight changes, the typical age at which a newborn returns to birth weight, and any association of newborn weight change with early dietary intake, clinical and demographic characteristics, and breastfeeding behaviors.

 Uganda 2020-09-29 2023-09-29 Medical and Health Sciences Non-degree Award
Fred Bulamba
ID: UNCST-2019-R000026
 Mapping perioperative care pathways to support surgical treatment in Low-and-Middle Income Countries
REFNo: HS642ES

The aim of this project is to understand the context of perioperative health systems in Uganda, including the main barriers encountered in the delivery of care.

Objectives:
1. Develop a collaborative approach to perioperative care pathway mapping
2. Carry out a rapid appraisal to map 5 pathways (three “Bellwether procedures and two elective procedures) in Uganda.
3. Refine the process and extend to three low- and middle-income countries

 Uganda 2020-09-28 2023-09-28 Medical and Health Sciences Non-degree Award
marie nanyanzi
ID: UNCST-2019-R001553
 Point Of Entry Sauti Za Wananchi (Voices of the citizens)Extension Survey
REFNo: SS468ES

To understand the COVID-19 effects on the citizens’ experience and key services they receive during this era of COVID-19 especially ▪ Establish citizen access to safe water; ▪ Establish citizen access and usage of health services and knowledge, Attitudes and Practices (KAPs); ▪ Find out level of participation/involvement/interaction in development and public activities /institutions; ▪ Find out access and usage of financial services amongst citizens; ▪ Find out how; what and when citizen access different type of information including government and development information. ▪ Establish the knowledge, Attitudes and Practices (KAPs) of citizens on different guidelines, policies; laws and regulations etc
 Uganda 2020-09-28 2023-09-28 Social Science and Humanities Non-degree Award
mariam Namutebi
ID:
POSTPARTUM CARE: FACILITY READINESS, MIDWIVES’ PERSPECTIVES AND THE EFFECT OF USING INDIVIDUALIZED CARE PLANS ON POSTPARTUM OUTCOMES.
REFNo: HS773ES

General Objective

To assess the facility readiness for the provision of Postpartum care, explore the midwives’ perspectives about postpartum care and evaluate the effect of using individualized care plans on the postpartum outcomes in the greater Mpigi region.
Specific objectives
1. To assess the facility readiness to provide postpartum care in selected facilities in the greater Mpigi region.
2. To explore the midwives’ perspectives towards postpartum care in the greater Mpigi region.
3. To evaluate the effect of using individualized care plans in the immediate and early postpartum period on the monitoring assessments, physical examination and health education of postpartum women in the greater Mpigi region.
4. To describe the postpartum women’s perspectives and midwives’ experiences of postpartum care provided using individualized care plans

 Uganda 2020-09-28 2023-09-28 Medical and Health Sciences Degree Award
Esther Buregyeya
ID: UNCST-2020-R014116
 Using the human-centred design model to inform local adaptation of COVID-19 prevention measures among high-risk populations in Malaba and Mutukula points of entry in Uganda
REFNo: HS848ES

1. To determine knowledge and risk-perceptions on COVID-19 measures among high-risk populations in Malaba and Mutukula points of entry.
2. To assess uptake of recommended COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
3. To explore the facilitators and barriers to uptake of the COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
4. To design, pilot and evaluate localized behavioural interventions to foster uptake of the COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
 Uganda 2020-09-28 2023-09-28 Medical and Health Sciences Non-degree Award
Kirsten Beyer M
ID: UNCST-2021-R013472
 Geospatial Analysis of Kampala Cancer Registry Data
REFNo: HS873ES

Objective 1: Identify spatial and spatiotemporal patterns of cancer in Uganda. a) Use geospatial mapping techniques to estimate cancer burdens across geographic space and through time. b) Create visual representations of cancer patterns (maps, graphs). Objective 2: Examine relationships between social and environmental factors and cancer outcomes in Uganda. a) Use statistical analysis techniques to determine associations between environmental factors and cancer outcomes. Objective 3: Pilot the collection of new KCR variables a) For each new case, we will attempt to acquire marital status, education level, occupation, religion, national Identification number (NIN) (new in Uganda), and precise geographic location information. Objective 4: Determine the true spatial extent of KCR data collection potential. a) Identify the number of cases that are discovered and excluded under current practice, as well as the individual’s parish of residence.
USA 2020-09-28 2023-09-28 Medical and Health Sciences Non-degree Award
Catherine Mwesigwa
ID: UNCST-2019-R000988
 THE DENTAL WORKFORCE IN UGANDA: A SITUATION ANALYSIS
REFNo: HS532ES

1. To take a census of the dental professionals in Uganda
2. To determine the recruitment levels into public/private employment and retention rates of dental surgeons and specialists in Uganda.
3. To determine the factors which influence attraction to, retention within and attrition from the health care system among dental surgeons and specialists
4. To examine the spatial distribution of actively practising dental professionals and public health dental officers relative to urban- rural and public-private characteristics

 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
John Tabuti Robert Stephen
ID: UNCST-2024-R002181
 Development of a Safe and Efficacious Anti-malarial drug from Traditional medicine (DESAT)
REFNo: HS685ES

The aim of this study is to develop an effective anti-malarial phytomedicine. The specific objective are 1) to prioritize malaria treating plants, and to determine 2) efficacy of commonly used herbal medicines, 3) safety of commonly used herbal medicines, and 4) the active compounds in the selected phytomedicines.
 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Thereza Piloya Were
ID: UNCST-2019-R000491
 Effect of the COVID-19 pandemic on access to community health care services for common childhood illnesses among children under five years in Wakiso District, Uganda
REFNo: HS802ES

Primary Objectives 1. To determine the utilisation of Integrated childhood community Management (ICCM) services for children aged under 5 years seeking care at the VHTs in three sub-counties in Wakiso district between January and June 2020
2. To determine the outcomes of the sick children under 5 years seen by the VHTS in three sub-counties in Wakiso district.
Secondary objective
3. To determine the utilisation of health facility level services for sick children aged under 5 years referred from the VHTS in Wakiso district during the period of January to June 2020


Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Eve  Namisango
ID: UNCST-2021-R014038
 Preparedness to face the COVID-19 pandemic in African hospices and palliative care services: A rapid assessment
REFNo: HS806ES

To determine the preparedness and capacity of palliative care service providers in Africa to respond to the COVID-19 pandemic

To explore the potential consequences of the COVID-19 pandemic on palliative care services and service providers in Africa.

 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
FLORENCE NALIMU
ID: UNCST-2024-R002900
 Toxicological Evaluation of Aloe Vera Linn and Aloe Ferox Miller Aqueous Leaf and Green Grind Extracts in Wistar Rats.
REFNo: NS138ES

1. To determine the phytochemical groups in the aqueous leaf and green grind extracts of Aloe ferox and Aloe vera.
2. To determine acute oral toxicity effects of Aloe ferox and Aloe vera aqueous whole leaf and green grind extracts in Wistar rats.
3. To determine sub-acute toxicity effects of Aloe ferox and Aloe vera aqueous leaf and green grind decoctions in Wistar rats.

Uganda 2020-09-23 2023-09-23 Natural Sciences Degree Award
JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
 Pooled screening of SARS-CoV-2 in the surrounding communities of Makerere University as a cost-effective strategy for reopening.
REFNo: HS912ES

General Objective
To assess the prevalence of SARS-CoV-2 and practices towards its prevention in the surrounding communities of Makerere University and the cost-effectiveness of pooled screening testing strategy to inform reopening of Makerere University.

Specific aims
1.To assess Knowledge, attitudes and practices of people living in areas surrounding Makerere University towards SARS CoV-2 prevention

2.Rapid assessment of high-risk populations around Makerere University for SARS CoV 2 by multi sample pool COVID-19 qRT-PCR technique

 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Nelson Kaulukusi Sewankambo
ID:
CRITICAL THINKING ABOUT HEALTH CLAIMS AND CHOICES AMONG SECONDARY SCHOOL STUDENTS IN UGANDA
REFNo: HS916ES

SUB-STUDY 1: Systematic Reviews
General objective:
Our first sub-study addressing main research question 1 above will be a review of existing evidence about strategies for enabling non-professional students to learn to think critically.
Specific objectives:
The primary objective is to provide an overview of what is known from systematic reviews about the effects of strategies to help primary and secondary school students learn to think critically. Secondary objectives are:
i. To map the characteristics of systematic reviews of teaching strategies
ii. To identify needs and priorities for evaluations of teaching strategies based on the findings of the included systematic reviews
iii. To identify needs and priorities for systematic reviews of the effects of teaching strategies for which we are unable to find reliable, up-to-date systematic reviews
iv. To inform the development of a framework for types of teaching strategies
SUB-STUDY 2: Context Analysis
General objective:
The second sub-study will be a context analysis whose main aim will be to establish existing organizational and individual conditions for teaching critical thinking to lower secondary school students in Uganda.
Specific objectives:
i. To explore what demand there is for learning resources for teaching critical thinking about health in secondary schools in Uganda.
ii. To map where teaching critical thinking about health best fits in the national curriculum
iii. To identify and examine relevant resources already in use
iv. To explore conditions for introducing new learning resources
v. To describe what ICT facilities are likely to be accessible in Ugandan secondary schools for teaching and learning purposes, and what, if any, national plans there are for improvements
vi. To identify opportunities and challenges for developing and using digital learning resources to promote critical thinking about treatments

SUB-STUDY 3: Prioritising and sequencing of Informed Health Choices (IHC) Key concepts
The third sub-study will focus on identifying the ideals or key concepts that will be prioritised and ordered for students in lower secondary schools of Uganda for which then learning resources will be developed.
General objective:
To prioritize and sequence the key concepts relevant to recognizing treatment claims and making informed health choices.
Specific objectives:
i. To establish the number of IHC key concepts from a list of 49 to include in learning resources that will be developed for lower secondary school in Uganda.
ii. To determine the order in which the concepts should be learned, and the competencies and dispositions needed to use those key concepts

SUB-STUDY 4: Design and Development of learning resources
General objective:
The fourth sub-study will aim to design learning-resources for teachers and students that they experience positively, that are feasible to use in Uganda, and that lend themselves to translation and adaptation to other contexts.
Specific objectives:
i. To develop learning resources that are relevant, understandable, credible, desirable, well suited in classroom settings and compatible with existing digital resources for improving critical thinking about treatments.

SUB-STUDY 5: Develop, Test and validate of the outcome evaluation tools
General objective:
To develop and test a flexible bank with multiple-choice questions for use as the claim evaluation tools as well as assess the test-taker’s ability to identify claims.
Specific objectives:
i. To develop and test a flexible bank of multiple-choice questions (MCQs) that will constitute the claim evaluation tools.
ii. To assess the validity, reliability and responsiveness of several items addressing prioritised key concepts using Rasch analysis.

SUB-STUDY 6: Evaluation of the learning materials
General objective:
We will seek to evaluate the short-term effects of the learning-resources on lower secondary students’ and teachers’ ability to make individual and policy health choices.
Specific objectives:
i. To evaluate learning-resources designed to teach lower secondary school students and teachers to assess claims about effects of treatments and their ability to make individual and policy health choices.


SUB-STUDY 7: Process Evaluation during the trials
General objective:
To assess the factors that influence the impact of the developed learning resources and how the use of the learning-resources if found to be effective can be scaled up, adapted and translated for use in other contexts.

Specific objectives:
i. To determine the extent to which the intervention was delivered as intended
ii. To document the barriers and facilitators that might influence the implementation and impact of the intervention
iii. To establish factors that might influence its scaling up
iv. To document any additional adverse or beneficial effects as observed.
v. To establish how the use of the learning-resources if found to be effective can be scaled up, adapted and translated for use in other contexts

SUB-STUDY 8: One-year follow -up
General objective:
The seventh sub-study question will seek to evaluate the long-term effects of the learning-resources on lower secondary students’ and teachers’ ability to make individual and policy health choices.
Specific objectives:
i. To evaluate learning-resources one year post the short-term evaluation in the RCT designed to teach lower secondary school students and teachers to assess claims about effects of treatments and their ability to make individual and policy health choices.

 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Martin Chebet
ID: UNCST-2021-R013909
 A cluster randomised trial to evaluate the effectiveness of household alcohol-based handrub for the prevention of sepsis, diarrhoea and pneumonia in Ugandan infants
REFNo: HS919ES

Primary objectives
The principal objective of this study is to determine whether the provision of
alcohol-based hand rub (ABHR) to pregnant women for postnatal household use
is effective for the prevention of severe illness or death during the first 3 months
of life.
Secondaryobjectives
• To determine the impact of ABHR use by the carer on clinical omphalitis.
• To determine the cost and cost-effectiveness of providing ABHR to pregnant
women in rural Eastern Uganda as a way of preventing early childhood severe
illness and death in the first 3 months of life.
• To assess health inequities in participants by comparing the study outcomes in
each wealth quintile.
• To explore current hand hygiene practices and options of improving practice in
rural Ugandan villages
• To explore the mechanisms of action (mediators and moderators) of
caregiver ABHR training on prevention of severe illness or death during the
first 3 months of life.
• To explore the mechanisms of action (mediators and moderators) of caregiver
ABHR training on depression and ABHR use.

 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Bjorn Van Campenhout -
ID: UNCST-2020-R014080
 Demand and supply factors constraining the emergence and sustainability of an efficient seed system in Uganda.
REFNo: SS603ES

The proposed study aims to provide innovative, evidence-based insights on the: i. Mechanisms that encourage more efficient marketing and distribution of seed and traits at various levels of commercialization and across heterogeneous populations and agro-ecologies (“improving seed supply”), and; ii. Mechanisms that nudge farmers—youth, women, and smallholders—into using improved varieties and quality seed, including varieties and seed for climate-smart and nutrient-dense crops and traits (“enhancing seed demand”).
 Belgium 2020-09-23 2023-09-23 Social Science and Humanities Non-degree Award
Charles Drago Kato Drago
ID: UNCST-2021-R012897
 Clinical evaluation of novel plasma biomarkers for stage diagnosis among sleeping sickness patients in Uganda
REFNo: HS520ES

1. To identify plasma biomarkers associated with either early or late stage T. b. gambiense disease using proteomics methods and compare with those previously identified for T. b. rhodesiense.
2. To determine the potential of plasma biomarkers identified using proteomics methods in discriminating between early and late stage patients for both T. b. rhodesiense and T. b. gambiense sleeping sickness.
3. To initiate the setup of a biomarker research team and laboratory at Makerere University.

Uganda 2020-09-18 2023-09-18 Medical and Health Sciences Non-degree Award
Sarah Nanzigu
ID:
Effects of Co-administration of HAART and Antiepileptic drugs on pharmacokinetics, seizure control and ART outcomes among Ugandans aged 0-24 years. Short title: Study of Co-medication with HAART and antiEpileptic Drugs Acronym: Co-HED
REFNo: HS546ES


General Study Objective: To evaluate the pharmacokinetics and clinical effects of HIV and antiepileptic co-medication among Ugandan patients aged 0-24 years.

SUB-STUDY I
This will be a cross-sectional, evaluating short and long-term effects of HAART-AED co-medication on the pharmacokinetics and treatment outcomes of HAART among Ugandans aged 0-24 years.

Specific objectives for sub-study 1
The specific objectives to be addressed during this sub-study will include the following:
1. To determine the effect of combined treatment with HAART and antiepileptic agents on virological control among HIV infected Ugandans aged 0-24 years, attending Baylor HIV clinic.
2. To determine the effect of combined treatment with HAART and antiepileptic agents on the immunological outcomes of HIV infected Ugandans aged 0-24 years, attending Baylor HIV clinic.
3. To determine the effect of combined treatment with HAART and antiepileptic agents on the safety of Ugandans aged 0-24 years, attending Baylor HIV clinic.

The study shall as well address secondary objectives that include the following:
1. To determine the effect of combined treatment with HAART and antiepileptic agents on efavirenz plasma concentrations, among HIV infected Ugandans aged 0-24 years attending Baylor HIV clinic.
2. To determine the effect of combined treatment with HAART and antiepileptic agents on lopinavir plasma concentrations, among Ugandans aged 0-24 years attending Baylor HIV clinic.

SUB-STUDY II
The main objective of this sub-study will be to evaluate the effect of HAART on the pharmacokinetics and clinical outcomes of carbamazepine and sodium valproate among Ugandans aged 0-24 years during 6 months of combined treatments for HIV and epileptic conditions.

Specific Objectives for sub-study II
1. To determine the effect of HAART on the pharmacokinetics of carbamazepine among Ugandans aged 0-24 years, during 6 months of combined treatment for HIV and epilepsy
2. To determine the effect of HAART on the pharmacokinetics of sodium valproate among Ugandans aged 0-24 years, during 6 months of combined treatment for HIV and epilepsy
3. To determine the effect of HAART on seizure control among Ugandans aged 0-24 years, during 6 months of combined treatment for HIV and epilepsy
4. To determine the effect of HAART on the safety of antiepileptic agents among Ugandans aged 0-24 years, during 6 months of co-medication with HAART and either carbamazepine or sodium valproate
Secondarily, we shall determine concentrations of the respective antiretroviral agents (efavirenz or lopinavir). The concentrations of the antiretroviral drugs estimated from study 11, will be compared to those obtained in study 1 in an attempt to establish a direct link of the effect of AEDs on the pharmacokinetics of antiretroviral agents. In addition, we shall attempt to evaluate the likelihood of a concentration-dependent effect of efavirenz on the pharmacokinetics and treatment outcomes of antiretroviral agents.





 Uganda 2020-09-18 2023-09-18 Medical and Health Sciences Non-degree Award
Lucas Ampaire
ID:
Microbial contamination of locally prepared beverages vended in Kisenyi parish, Kampala: Prevalence, associated factors and utility of rapid diagnostic tests
REFNo: HS586ES

1. To determine the prevalence and factors associated with microbial contamination of locally prepared beverages vended in Kisenyi Parish, Kampala, Uganda.
2. To determine the common contaminating microbial agents in the locally prepared beverages and their antibiotic sensitivity patterns.
3. To assess the performance of MaxSignal® E. coli O157 Strip Test Kit and MaxSignal® Salmonella Strip Test Kit on food-borne pathogens in locally prepared beverages vended in Kisenyi Parish, Kampala , Uganda
4. To develop and evaluate the performance of a local multiplexed strip/cassette for rapid detection of common food contaminants

 Uganda 2020-09-18 2023-09-18 Medical and Health Sciences Degree Award
Jane Achan Edwin
ID: UNCST-2023-R005498
 Malaria among patients admitted with COVID-19: a case series
REFNo: HS666ES

General Objective: To understand the burden and clinical consequences of malaria among COVID-19 patients Specific objectives 1. To determine the prevalence of malaria among patients with COVID-19 and to evaluate the risk of malaria following hospital discharge. 2. To determine the magnitude of previous exposure to malaria among patients with COVID-19 3. To document the impact of malaria on clinical outcomes of patients with COVID-19 4. To assess the potential impact of currently used antimalarial drugs (artemether-lumefantrine and dihydroartemisinin-piperaquine) on clinical outcomes among COVID-19 patients prescribed these drugs as per current clinical indications 5. To document the clinical spectrum of malaria among patients with COVID-19 6. To evaluate the potential interactions between COVID-19 and other infectious diseases including HIV/AIDS and TB 7. To describe health worker perspectives on the management of malaria in COVID-19 patients
Uganda 2020-09-16 2023-09-16 Medical and Health Sciences Non-degree Award
Nathan Fiala
ID: UNCST-2022-R009060
 The Long-term Impacts of a cash-based Employment Program in Northern Uganda
REFNo: SS501ES

1.To evaluate the long-term effectiveness of a cash-based youth employment program using a randomized controlled trial.
2. To understand the effect of COVID-19 and restrictions on youth employment
 USA 2020-09-16 2023-09-16 Social Science and Humanities Non-degree Award
JANE  AMUGE
ID:
Upholding Cooperative Identity as a crucial determinant of Cooperative Resilience: A case study of cooperatives in Uganda
REFNo: SS544ES

1. To identify how cooperatives have optimised their unique character enshrined in their definition, principles and values to cope, remain stable, adapt to situations, innovate and remain resilient in the face of adversity.
2. To establish how adherence or non-adherence to the definition, principles and values of cooperatives have increased their risks, vulnerabilities and contributed to their instability, limited adaptation and innovation thus their lack of resilience.
3. To find out the influence of other factors apart from cooperative identity, on cooperative resilience or the lack of it.

 Uganda 2020-09-16 2023-09-16 Social Science and Humanities Non-degree Award
Gladys Nakalema
ID:
DECISIONAL CAPACITY AND COERCION AMONG PATIENTS ENROLLED IN RESEARCH AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: SS479ES

i. To assess the decisional capacity of research participants at Mbarara Regional Referral Hospital (MRRH) ii. To assess the level of coercion to consent to study participation among research participants at MRRH iii. To determine the association between decisional capacity and level of coercion to consent to study participation among research participants at MRRH
Uganda 2020-09-15 2023-09-15 Social Science and Humanities Degree Award
Annet Nakaganda
ID:
Developing a Standardized tool for cancer risk factors Surveillance: A case study of the prevalence of cancer risk factors in Eastern Uganda (CARIFAS)
REFNo: HS754ES

1. Developing a standardized tool for assessing cancer risk factors in Uganda.
2. Estimating the prevalence of cancer risk factors in Mayuge district (Eastern Uganda

 Uganda 2020-09-15 2023-09-15 Medical and Health Sciences Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
 EVALUATION OF THE SAFETY AND EFFICACY OF VECTOCLORÃ’-PLUS EMULSIFIABLE CONCENTRATE [E.C.]: A RANDOMISED SINGLE-BLINDED POSITIVE CONTROLLED MULTI-SITE ACARICIDE FIELD TRIAL
REFNo: NS129ES

General objectives
To determine the efficacy and safety of Vectoclor®-Plus E.C. (Ceva Santé Animale, Libourne) hereinafter called Vectoclor®-Plus when used on cattle for tick control.

Specific objectives
-To determine the efficacy of Vectoclor®-Plus when used on cattle for tick control
-To determine the safety of Vectoclor®-Plus when used on cattle for tick control
 Uganda 2020-09-15 2023-09-15 Natural Sciences Non-degree Award
George Lugalambi William
ID:
UNICEF Handwashing with Soap
REFNo: SS551ES

What factors constrain and prevent individuals and households from washing their hands with soap?

What knowledge, attitudes and practices are prevalent regarding handwashing with soap?

What needs to be done to scale up handwashing with soap initiatives?

Establish barriers to change and how the strategy can efficiently and effectively address them.
 Uganda 2020-09-15 2023-09-15 Social Science and Humanities Non-degree Award
Numa Memisevic
ID:
Breaking stereotypes and remodeling the concept of sexual violence prevention by building resiliency and defense skills among vulnerable women
REFNo: SS542ES

The aim of the foregoing proposal is to test a novel empowerment-based sexual assault prevention
training initiative targeting women at high risk for sexual violence in Uganda. This intervention
focuses on both non-physical and physical measures.
 Yugoslavia 2020-09-10 2023-09-10 Social Science and Humanities Degree Award
Hesbon  Owilla Hansen
ID:
QUANTITATIVE AND QUALITATIVE STUDY ON INNOVATION FOR MEDIA VIABILITY IN EAST AFRICA
REFNo: SS417ES

1. To bolster the viability of media outlets
2. To galvanize media innovation in East Africa, with a focus not just on creative content but on new and sustainable business models for the future.
Kenya 2020-09-08 2023-09-08 Social Science and Humanities Non-degree Award
Fatuma  Namusoke University
ID:
Barriers, knowledge and antimalarial antibodies in relation to Intermittent Preventive Treatment in pregnancy use in Kawempe National Referral Hospital
REFNo: HS620ES

1. Explore the barriers of IPTp implementation in Kawempe National Referral Hospital
2. To describe the knowledge and perceptions of IPTp among mothers Kawempe National Referral Hospital
3. To determine the association between quantity and quality of antimalarial antibodies in puerperium and use of IPTp during pregnancy

 Uganda 2020-09-04 2023-09-04 Medical and Health Sciences Non-degree Award
Mark Jordans
ID: UNCST-2020-R014861
 Increasing the efficiency of an education programme to facilitate rapid adoption and sustainable scale-up.
REFNo: SS451ES

Aim: To increase the efficiency and scalability of the Can’t Wait to Learn (CWTL) programme, through increasing access, attendance, retention and facilitating programme adoption.

The specific objectives of the present research studies are:
1) To develop and test a caregiver engagement intervention to increase children’s equitable access to, attendance of and retention in CWTL;
2) To assess and optimise the CWTL implementation team model to facilitate rapid adoption and scale up of the programme;
3) To evaluate the value for money of CWTL and identify drivers and drainers of value for money.
 Netherlands 2020-09-04 2023-09-04 Social Science and Humanities Non-degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Optimizing malaria treatment for HIV-malaria co-infected individuals by addressing drug interactions between Artemether-Lumefantrine and Efavirenz.; a randomized trial
REFNo: HS820ES

General Objective: To utilize innovative interventions to overcome drug interactions between artemether-lumefantrine and efavirenz to guide malaria treatment for individuals co-infected with HIV and malaria.
Specific objectives:
1. To determine the safety and Pharmacokinetics of the double dose artemether-lumefantrine when administered with efavirenz based ART among healthy volunteers (malaria negative and HIV negative individuals).
2. To determine the safety and Pharmacokinetics of the 5-day course of artemether-lumefantrine when administered with efavirenz based ART among healthy volunteers (malaria negative and HIV negative individuals).
3. To determine the safety, pharmacokinetics and malaria treatment outcome of a standard dose of artemether-lumefantrine compared to double of the standard dose for weight and a 5-day course of artemether-lumefantrine for treatment of uncomplicated malaria among HIV-Malaria co-infected individuals receiving efavirenz-based ART.
4. To determine the safety and Pharmacokinetics of artemether-lumefantrine when administered with Dolutegravir based ART among HIV-malaria co-infected individuals

 Uganda 2020-09-04 2023-09-04 Medical and Health Sciences Non-degree Award
Grace Kagoro
ID: UNCST-2021-R013951
 Digital citizen science for community-based resilient environmental management
REFNo: NS126ES

1. Enhance a network of hazard reporters and participating communities across the targeted districts.
2. Strengthen the academic capacities (PhD & MSc) of the two partner institutions hence development of
evidence based research on disaster risk reduction and sustainable rural livelihood strategies.
3. Generate knowledge factors controlling the spatial- temporal distribution of environmental risks and land
degradation.
4. Contribute to the establishment of a platform for multi-actor dialogue of environmental resilience.
5. Contribute towards the interpretation and policy recommendations to the policy makers basing on the
collected data about environmental natural hazards, resilience and mitigation measures.
6. Increase community awareness about effect of human activities on accelerating environmental natural
hazards, their resilience and mitigation measures.
7. Develop and test new methods to initiate multi-lateral interactions between rural communities, district
authorities and scientists and favor the implementation of resilient livelihood practices.
8. Enhance the knowledge and skills of the Geo-observers as environmental facilitators to be able to serve as
interface between the communities and the scientists.

 Uganda 2020-09-04 2023-09-04 Natural Sciences Degree Award
Laban Musinguzi Kashaija
ID: UNCST-2020-R014407
 Baseline Survey on HIV Prevention Programme among Key Populations in Uganda
REFNo: SS508ES

The baseline study shall establish knowledge on:
• KPs ability to protect themselves against HIV
• The level of access to KP friendly health services
• The level of structural barriers to HIV treatment and prevention for KPs
• The level of organizational capacity of programme partners & cross-country programme interventions.

 Uganda 2020-09-04 2023-09-04 Social Science and Humanities Non-degree Award
Edgar Tusingwire Bagarukayo Bagarukayo
ID:
Analysis of Capacity development and Participation of Local companies in the Oil and gas industry: A case of Ugandan Companies
REFNo: SS515ES

-To examine the approaches and mechanisms used by Ugandan Companies’ for capacity development;
- To examine the roles of various capacity building actors and how they facilitate or inhibit capacity development;
- To analyze how Ugandan Companies’ have deployed the capacity acquired to participate in the oil and gas industry in Uganda.

Uganda 2020-09-04 2023-09-04 Social Science and Humanities Degree Award
PAUL ISABIRYE
ID:
Determinants of Family Planning Services uptake among first time parents in Uganda
REFNo: HS868ES

1. To determine the level of uptake of family planning services among first time parents.
2. To identify the individual factors that determine family planning services uptake among the first time parents.
3. To assess the contextual drivers of family planning services uptake among the first time parents.
4. To assess family planning services uptake challenges among first time parents.

 Uganda 2020-09-02 2023-09-02 Medical and Health Sciences Non-degree Award
PAUL ISABIRYE
ID:
An Analysis of the drivers of Antenatal Care leaks along the ANC cascade in Uganda: A case study of RHITES Implementing Mechanisms
REFNo: HS876ES

a. To identify the causes of dropout of mothers from antenatal care service delivery in Uganda.
i. To identify the individual factors that drive drop out of mothers from ANC services.
ii. To identify socio-cultural factors that influence mothers to drop out of antenatal care along the ANC cascade.
iii. To examine the institutional factors that drive loss of clients in ANC care across the ANC cascade.
b. To determine the level of completion of four ANC visits and more than four ANC visits among mothers attending antenatal care
c. To identify the approaches used by the different health institutions to minimize loss of mothers from antenatal care across the ANC cascade.

 Uganda 2020-09-02 2023-09-02 Medical and Health Sciences Non-degree Award
Rita Nakalega
ID: UNCST-2019-R000599
 PEER-DELIVERED HIV SELF-TESTING AND PrEP FOR YOUNG WOMEN IN UGANDA
REFNo: HS845ES

1. To assess the feasibility and acceptability of using peer-delivered HIVST and oral PrEP to young women in Uganda.
2. To explore how peer-delivery of HIVST and PrEP influences PrEP persistence among young wome
 Uganda 2020-08-28 2023-08-28 Medical and Health Sciences Degree Award
Diana Nabbumba Erinah
ID:
Exploring the systemic nature of social care provision and expectations for older people in rural Uganda: A transformative qualitative study
REFNo: HS322ES

This study aims to investigate the current state of social care for older people in rural areas of Uganda. It will establish who is responsible for aged care in rural Uganda, the challenges and gaps in the current social care system and provide recommendations to address these gaps and challenges. The study is significant because it will contribute to the body of knowledge of social care in rural areas of developing countries. More specifically, this research will increase awareness of the plight of older people in seeking social care, and allow for recommendations to be made to key relevant stakeholders
 Uganda 2020-08-26 2023-08-26 Medical and Health Sciences Degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 Project Evaluation Protocol for the ACE-FORT Project: Entitled; “Accelerating Epidemic Control in Fort Portal Region in the Republic of Uganda under the President’s Emergency Plan for AIDS Relief (PEPFAR)”
REFNo: HS740ES

i) To determine the extent to which the project; a) Increases the proportion of PLHIV with known HIV status by 2020, b) Increases the proportion of people diagnosed with HIV accessing ART by 2020, c) Increases proportion of people receiving ART who are virally suppressed by 2020, d) Achieves coverage of high impact combination prevention interventions in scale-up districts by 2020, e) Provides Healthy, Safe, Stable, Schooled, and case management services along the Continuum of Response to eligible OVC and their families and graduate families out of Vulnerability by 2023, f) Strengthens regional and district governance and systems for sustained epidemic control by 2023.
ii) To Assess the relevance of; a) Prevention services in reducing the incidence of HIV in Fort portal region, b)Treatment and care services in reducing HIV related morbidity and mortality, c) OVC services in reducing the vulnerability of families with HIV.
iii) To assess the potential for sustainability of project components, results achieved and other efforts aimed at achieving HIV epidemic control in Fort Portal region.
iv) To assess the cost of; a) identifying new HIV positive children and adults, b) retaining HIV positive clients in care, c) graduating OVC’s from vulnerability.

 Uganda 2020-08-26 2023-08-26 Medical and Health Sciences Non-degree Award
ELIZABETH EKIRAPA-KIRACHO
ID: UNCST-2021-R013443
 Activity-Based Costing and Management of HIV Services at the Facility Level in Uganda
REFNo: HS796ES

The main objective of this study is to obtain routine and accurate cost information on the provision of HIV and health services at the facility level and to use this information to effectively allocate resources, improve monitoring efforts, and increase efficiency. Specifically to;
1. To collect primary data on expenditure, utilization and service delivery of core HIV services from health facility providers and clients.

2. To collect secondary data on service delivery and HIV expenditures for core HIV services from health facilities.


Uganda 2020-08-26 2023-08-26 Medical and Health Sciences Non-degree Award
molly naisanga
ID: UNCST-2023-R005602
 THE IMPACT OF KNOWLEDGE, PERCEPTIONS AND BELIEFS OF PATIENTS’ ABOUT ANTICOAGULATION AND THEIR ASSOCIATION WITH INTERNATIONAL NORMALIZED RATIO CONTROL IN UGANDA AND SOUTH AFRICA MIXED METHODS STUDY
REFNo: HS609ES

1. To describe the relationship between patients’ beliefs about warfarin and INR control.
2. To explore patients’ knowledge, perceptions and beliefs about warfarin treatment in Ugandan and South African patients receiving anticaogulation.
3. To explore the knowledge, perceptions and practices of Ugandan and South African health care providers about provision of warfarin.

 Uganda 2020-08-24 2023-08-24 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 An open-label, randomized, single intravenous dosing study to investigate the effect of fixed dose combinations of tenofovir/lamivudine or atazanavir/ritonavir on the pharmacokinetics of remdesivir in Ugandan healthy volunteers
REFNo: HS654ES

Primary objectives
1. To assess the safety and tolerability of single intravenous doses of remdesivir in adult healthy volunteers
2. To evaluate the intracellular pharmacokinetics of single dose intravenous remdesivir with or without co-administration of oral fixed-dose combination tenofovir/lamivudine with patients serving as their own controls

Secondary objectives
1. To evaluate the difference in plasma and intracellular pharmacokinetics of intravenous remdesivir among healthy volunteers receiving tenofovir/lamivudine versus healthy volunteers receiving tenofovir/lamivudine plus atazanavir/ritonavir tablets.
2. To generate a population pharmacokinetic model to describe inter-individual variability in intracellular pharmacokinetics of remdesivir

 Nigeria 2020-08-24 2023-08-24 Medical and Health Sciences Non-degree Award
DEUS KAMYA
ID:
In-vitro activity of mycobacteriophages against Mycobacterium tuberculosis biofilms
REFNo: HS774ES

1. To characterize the lytic activity of mycobacteriophages using Mycobacterium smegmatis mc2155 as host bacterium
2. To determine mycobacteriophage host range on a panel of 50 clinical isolates of Mycobacterium tuberculosis
3. To determine the inhibitory and disruptive effect(s) of mycobacteriophages on Mycobacterium tuberculosis-biofilms
Uganda 2020-08-24 2023-08-24 Medical and Health Sciences Degree Award
CATHERINA NAZZIWA
ID:
Perspectives on Genetic Research and Curative Therapies for Sickle Cell Disease
REFNo: SS520ES

The main objective of this study is to assess perspectives of diverse sickle cell disease stakeholders in Uganda regarding participation in genetics research and curative therapies for sickle cell disease, and to identify the related key ethical, social and cultural issues.
Uganda 2020-08-24 2023-08-24 Social Science and Humanities Degree Award
CATHERINE ABBO
ID:
Incorporating mental health and psychosocial support in the Ugandan Police Child and Family Protection Department toll free line to address sexual and gender-based violence (SGBV) complaints.
REFNo: HS791ES

1. To explore the understanding of TFLOs regarding MHPSS needs of complainants of SGBV. 2. To develop and implement a mental health and psychosocial support training for 20 TFLOs working in Kampala and Wakiso Districts. 3. To conduct an evaluation of the training programme among the TFLOs.
Uganda 2020-08-24 2023-08-24 Medical and Health Sciences Degree Award
Gilbert Habaasa
ID:
Death registration completeness, gendered Social norms and Behavioural practices affecting death registration in Uganda
REFNo: SS539ES

i. To establish the prevalence of death registration in HDSS sites of Uganda (absolute number of deaths registered).
ii. To find out the level of data quality for death registration in HDSS sites of Uganda
(death registration completeness, timeliness of death registration).
iii. To generate gendered vital statistics using existing death data in HDSS sites of Uganda (Age Specific Mortality Rates, Life expectancy at birth and cause of death by age and gender)
iv. To find out the gendered social norms and behavioral practices that lead to under-registration of deaths in Uganda.

Uganda 2020-08-24 2023-08-24 Social Science and Humanities Non-degree Award
Faith Sebuliba Rosemary Kasumba
ID:
To explore Nursing Students Readiness to Learn in a Technology Enhanced Environment in Degree Completion Programs in Institutions of Higher Education in Uganda
REFNo: HS716ES

i.Describe nursing student self-efficacy of technical competencies that promote, their readiness to learn in technology enhanced environments.
ii.Describe personal attributes associated with nursing students’ readiness to learn in technology enhanced environments.
iii.Determine institutional support that promote nursing students readiness to learn in technology enhanced environments.
iv.Determine nursing students’ perspectives regarding their readiness to learn in a technology enhanced environment.

Uganda 2020-08-21 2023-08-21 Medical and Health Sciences Degree Award
Noah Kiwanuka
ID: UNCST-2021-R010125
 Bio ethical Issues in the Use of Mobile Phone Data for Public Health Research in Uganda
REFNo: HS717ES

1. To perform a systematic review of the literature to document the current state-of-evidence on the ethics related to the use of mobile phone CDRs and data from other mobile devices for public health research in Africa. We will search published and unpublished literature to identify what is known and gaps in knowledge about ethics of CDRs.
2. To assess perception, attitudes and concerns of key stakeholders in relation to the utilization of CDRs for public health research in Uganda. We will conduct a mixed- methods study using key informant interviews and focus group discussions and quantitative surveys to gather information about ethical concerns, opinions, and suggestions from a range of selected stakeholders. The stakeholders will include patients, community members, health workers, health researchers, government officials, telecommunication companies, Institutional Review Boards/Ethics Committees, academic faculty, research organizations, ICT regulatory boards among others.


 Uganda 2020-08-21 2023-08-21 Medical and Health Sciences Non-degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 Same-Day PrEP Initiation and Sexual Health for Transgender Women
REFNo: HS772ES

1) Evaluate the feasibility and acceptability of same-day F/TAF PrEP initiation among African trans women

2) Characterize F/TAF persistence and test the impact of drug level feedback among African trans women taking PrEP

3) Explore how self-care interventions for sexual health influence HIV/STI prevention choices among African trans women and their sexual partners
 Uganda 2020-08-21 2023-08-21 Medical and Health Sciences Non-degree Award
Simon Peter Katongole
ID:
Strengthening health systems for quality health care: case study of misdiagnosis among hospitalized patients in general hospitals in Uganda
REFNo: HS826ES

To examine health system factors associated with misdiagnosis for improving health care quality in general hospitals in Uganda.
Specific objectives
a) To determine the prevalence of misdiagnosis for patients admitted to general hospitals in Uganda.
b) To examine association between health system and individual-related predictors with misdiagnosis in general hospitals in Uganda.
c) To explore health workers’ perspectives of the predictors of misdiagnosis among admitted patients in general hospitals in Uganda.
d) To assess the financial cost of misdiagnosis among inpatients in hospitals in Uganda.

 Uganda 2020-08-21 2023-08-21 Medical and Health Sciences Degree Award
Richard Muhindo
ID:
Fighting COVID-19: Assessment of Health Systems Support for Psychosocial Preparedness and Needs of Health Workers Providing Essential Patient Care in Uganda
REFNo: HS715ES

3. To develop and propose a model for psychosocial and emotional support for healthcare professionals working in contexts of contagious disease outbreaks ,2. To examine health systems institutional capacity to provide psychosocial and emotional support to health professionals providing essential care to people with COVID-19.,1. To describe the psychosocial preparedness and of healthcare professionals providing essential care to people with COVID-19,To assess the health systems’ support for psychosocial preparedness and needs of healthcare professionals providing essential care for people with COVID-19 in Uganda,
 Uganda 2020-08-20 2023-08-20 Medical and Health Sciences Non-degree Award
Japheth Kwiringira Nkiriyehe
ID: UNCST-2019-R000408
 GEO-SOCIO, CAPACITY INTERSECTIONS ON HEALTH CARE OUTCOMES IN KALANGALA ISLANDS, UGANDA
REFNo: SS506ES

Main Objective
To explore how intersections of social, geographical and health provider capacity influence access to health care and outcomes.
Specific Objectives
1. Investigate the relationship between geo-social factors, health care providers’ capacity and health care access (supply and demand factors) produce health outcomes.

2. Investigate the relationship between geo-social factors, health care providers’ capacity and utilisation of health care services.

Uganda 2020-08-20 2023-08-20 Social Science and Humanities Non-degree Award
Hawa  Nalwoga
ID:
Improving access to prompt and adequate cancer care: Liquid biopsy biobank to promote early cancer diagnosis, screening and monitoring (Makerere University Liquid Biopsy Biobank Project (MakLBBP)
REFNo: HS808ES

1. To create a liquid biopsy biobank of blood samples obtained from Ugandan patients with any of the five cancers: cervical cancer, breast cancers, prostate, colorectal and oesophageal cancers and from normal control participants
2. To assess awareness, knowledge and opinion of cancer patients and health volunteers regarding causes of cancer, cancer diagnosis and management of cancer
Secondary specific objectives
3. To explore likely acceptability and perceptions of cancer patients and caregivers towards biospecimen donation for biobanking to use in cancer research at Hoima, and Jinja Regional Referral hospitals and Uganda Cancer Institute

Uganda 2020-08-20 2023-08-20 Medical and Health Sciences Non-degree Award
Matt Baillie Smith
ID:
Skills acquisition and employability through volunteering by displaced youth in Uganda
REFNo: SS447ES

Research Objectives 1.To conceptualize the relationship between different forms of volunteering and the acquisition of skills by Ugandan refugee youth. 2. To map and explain where and how young refugees in Uganda are engaged in volunteering. 3. To identify and understand the factors that shape participation in volunteering by refugee youth in Uganda. 4. To assess the impact of volunteering by refugee youth in Uganda on employability and achieving meaningful work. Research Questions 1. How is volunteering understood by young refugees in Uganda and how does this vary between settings (e.g. urban or rural settlement), and by factors such as gender, age, sexuality, nationality and ethnicity? 2. Where and how do young refugees in Uganda engage in volunteering? 3. What factors shape young refugees’ participation in volunteering in Uganda? 4. How have volunteering experiences shaped the employment trajectories of refugees who have found meaningful work in Uganda and how does the impact of volunteering on employability vary by setting, and by factors such as gender, age, sexuality, ethnicity and nationality?
UK 2020-08-19 2023-08-19 Social Science and Humanities Non-degree Award
Terence Odoch Amoki
ID:
Understanding Campylobacteriosis transmission dynamics using "One Health", computational and systems dynamics modeling approaches
REFNo: HS663ES

The specific objectives are:
i. Determine fecal occurrence of Campylobacter in children poultry and pigs
ii. Characterize Campylobacter from children pigs and poultry
iii. Describe relatedness of the Campylobacter isolates
iv. Develop transmission models for Campylobacter
v. Characterize phenotypic and genotypic antimicrobial resistance in Campylobacter organisms isolated from human’s poultry and pigs in Uganda

 Uganda 2020-08-19 2023-08-19 Medical and Health Sciences Non-degree Award
Alex Paul Wacoo
ID:
Probiotic approach for prevention of aflatoxins induced liver cancer
REFNo: HS707ES

To determine aflatoxin levels in blood and urine samples and the gut microbial profiles in faecal matter of patients with and without liver cancer as well as determine the binding and degradation potential of the isolated gut bacteria.
Uganda 2020-08-19 2023-08-19 Medical and Health Sciences Non-degree Award
Phillis Babirye
ID:
Perception of Biobanking among sample collectors, sample transporters, laboratory staff and biobank staff at Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit
REFNo: SS469ES

1. To explore the level of knowledge of biobanking among sample collectors, sample transporters, laboratory staff and biobank staff at MRC/UVRI & LSHTM Uganda Research Unit 2. To explore the perceptions towards biobanking among sample collectors, sample transporters, laboratory staff and biobank staff at MRC/UVRI & LSHTM Uganda Research Unit
Uganda 2020-08-18 2023-08-18 Social Science and Humanities Degree Award
Verena Wiedemann Christina
ID:
Tracking price dynamics during a pandemic
REFNo: SS495ES

Publication of academic study in peer-reviewed journal,Information of policy makers Please note that the districts listed below do not reflect the sample at large. This is because we struggled to add details on a national sample. We strive to include volunteers from all across Uganda.
 Germany 2020-08-18 2023-08-18 Social Science and Humanities Degree Award
Dorothy Nakiyaga
ID:
STAKEHOLDERS’ PARTICIPATION IN SCHOOL MANAGEMENT TO ENHANCE LEARNERS’ACADEMIC ACHIEVEMENT IN SELECTED SECONDARY SCHOOLS IN UGANDA
REFNo: SS483ES

(i) Examine stakeholder participation in school improvement planning to enhance the learners’ academic achievement of government-aided secondary schools in Kampala district.
(ii) Evaluate stakeholder participation in the budgeting process to enhance the learners’ academic achievement of government-aided secondary schools in Kampala district.
(iii) Analyze the relationship between stakeholder participation in coordinating the academic activities and the enhancement of learners’ academic achievement of selected secondary schools in Kampala district.
(iv) Explore the stakeholder’s perceptions about their participation in school management to enhance the learners’ academic activities in government-aided secondary schools in Kampala district.
(v) Develop a theoretical model that will explain the role of stakeholders’ participation in the enhancement of learners’ academic achievement in government-aided secondary schools.

 Uganda 2020-08-18 2023-08-18 Social Science and Humanities Degree Award
Rosalind Parkes-Ratanshi Parkes-Ratanshi
ID:
Use of unmanned air vehicles (medical drones) to overcome geographical barriers to delivery Antiretroviral therapy: The Bufumira pilot.
REFNo: HS725ES

In this study, we shall evaluate the use unmanned air vehicles (Medical Drones) to deliver ART to adult patients eligible/enrolled in community DSD models in Bufumira Islands, Kalangala district. The geography of the islands is ideal for this project because of the flat landscape and water coverage. We hypothesize that the use of drones would be acceptable to patients and stakeholders, reduce facility drug stock outs, increase retention in care by 10% in intervention (at 12 months) as compared to the control health centres and be cost neutral (to the patients and health sector perspectives)


 UK 2020-08-18 2023-08-18 Medical and Health Sciences Non-degree Award
DANIEL OKELLO AYEN
ID:
Measuring PLHIV Perceptions of Quality of Care to Identify Barriers to Accessing and Utilizing HIV Services in 15 Fast-Track Cities
REFNo: HS756ES

The primary objective of the study is to explore clinical, structural, and social factors influencing perceptions on quality of care of PLHIV in urban healthcare settings. The secondary objectives include:
1) to evaluate differences in QoC perspectives and burden between PLHIV subpopulations, defined by socio-demographic characteristics; and
2) to evaluate differences in QoC perspectives and burden between various PLHIV subpopulations, according to their biomedical / clinical status.
 Uganda 2020-08-18 2023-08-18 Medical and Health Sciences Non-degree Award
Emma Durden Louise
ID:
NEW HORIZONS COLLABORATIVE INITIATIVE IMPACT EVALUATION
REFNo: SS510ES

The proposed study is an evaluation of the New Horizons Collaborative programme which combines elements of process evaluation, impact assessment and outcome evaluation (Rossi et al, 2004).

The purpose of the study is to evaluate the effectiveness, relevance, efficiency and sustainability of the programme, in order to assess its value to the programme beneficiaries and other stakeholders.

Please note that for the purposes of this study, we use the Organisation for Economic Co-operation and Development (OECD)’s criteria for evaluation, and their definitions as follows:

The concept of effectiveness refers to how effective the programme was in meeting its objectives and bringing about change.

Relevance refers to the extent to which the programme objectives and design have responded to the needs of the beneficiaries, partners, priorities and countries where it has been implemented.

Efficiency refers to the extent to which the programme delivers, or is able to deliver, results in an economic and timely way.

Sustainability refers to the extent to which the net benefits of the intervention continue, or are likely to continue.

The evaluation will focus on descriptive and normative questions, including looking at what the programme achieved (effectiveness), exploring to what extent it addressed an identified need and how it aligns with government priorities (relevance) how it was perceived and valued (relevance and sustainability), whether the programme objectives are being met (efficiency and effectiveness), what unintended outcomes were produced (relevance and effectiveness), how efficient the programme was in terms of representing value for money (efficiency and sustainability) and what specific features of the programme and context made a difference (sustainability).

The specific objectives for the evaluation are as follows:

1. To ascertain the reach of the programme in the three selected countries (effectiveness)
2. To measure the impact of NHC on patient’s lives (schooling, social interaction) (effectiveness and relevance)
3. To measure the overall indirect benefit to caregivers (such as reduction in morbidity and hospitalization of their children) (effectiveness and relevance)
4. To measure the impact of NHC as a catalyst for health systems strengthening (relevance and sustainability)
5. To evaluate how efficient the programme was (efficiency and sustainability)

 South Africa 2020-08-18 2023-08-18 Social Science and Humanities Non-degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Needs assessment for the curriculum development and training on new study design for the Research Ethics Committee members at Makerere University and Mulago hospital complex
REFNo: HS542ES

General Objective
To determine the training needs on new study designs amongst REC members so as to generate information necessary for designing a curriculum geared towards building capacity and expertise in review of complex study designs.
Specific Objectives
1. To determine the training needs on new study design amongst the REC members
2. To determine the regulatory guideline gaps that impede the research approval process amongst the REC members

 Uganda 2020-08-17 2023-08-17 Medical and Health Sciences Non-degree Award
Kenneth Mulungu
ID:
Intrapreneurship and Technological Innovation in Optimizing Qualitative Research as Evidenced at Infectious Diseases Institute, Uganda
REFNo: SIR38ES

1.To describe lived experiences associated with the use of Jiegnote software among transcribers at Infectious Diseases Institute.
2.To determine the acceptability of the Jiegnote software among transcribers at Infectious Diseases Institute.
3.To compare and contrast data outcomes achieved with the Jiegnote software to that from the use of traditional transcription methods at Infectious Diseases Institute

 Uganda 2020-08-17 2023-08-17 Engineering and Technology Degree Award
Geofrey Musinguzi
ID:
The Crane Survey – bio-behavioral HIV-related surveillance for key and priority populations in Uganda
REFNo: HS737ES

Primary Objective 1. To estimate HIV prevalence and VL suppression among those living with HIV Secondary 1.To inform population level prevention and treatment cascades 2.To estimate the prevalence of select STI 3.To estimate HIV incidence for certain target populations 4.To estimate population sizes of certain key populations 5.To collect mapping information related to key populations 6.To build local capacity to conduct quality HIV surveys and surveillance among KP and other populations at risk for HIV.
Uganda 2020-08-17 2023-08-17 Medical and Health Sciences Non-degree Award
FRANCIS KIBIRIGE
ID:
Urbanization, public goods provision and quality of democracy in Uganda
REFNo: SS494ES

To carry out a nationally representative survey of the views of Ugandan citizens, aged 18 and over, regarding urbanization, delivery of public goods and quality of democracy in Uganda.

This survey intends to inform FES-Uganda’s long-term policy and advocacy programming, as well as efforts of her partners and stakeholders. With 3 similar surveys being conducted in Uganda, Kenya and Tanzania, the results of this survey will be shared internally within FES country offices in the 3 participating country for a joint plan of action. Lastly, in each of the 3 countries, the survey findings will be shared with stakeholders including government, civil society and the media in order to increase their knowledge of the views and priorities of the Ugandan people
 Uganda 2020-08-17 2023-08-17 Social Science and Humanities Non-degree Award
MARY ANYANGO OYO-NYEKO
ID:
Performance Management and Quality of Lecturers' Services in Makerere University.
REFNo: SS477ES

The study will be guided by the following objectives;
i) To establish the relationship between goals setting of the university and quality of lecturers’ services in Makerere University.
ii) To establish the relationship between staff appraisal of academic staff and quality of lecturers’ services in Makerere University.
iii) To investigate the relationship between career development of academic staff and quality of lecturers’ services in Makerere University.
iv) To examine the relationship between effective rewards of staff and quality of lecturers’ services in Makerere University.

Uganda 2020-08-13 2023-08-13 Social Science and Humanities Degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 The Efficacy and Safety of Hydroxychloroquine for The Treatment of Non-Severe Covid-19
REFNo: HS839ES

To compare the viral clearance among adults with non-severe COVID-19 randomized to receive hydroxychloroquine plus standard of care vs. standard of care.
2. To evaluate the safety and tolerability of Hydroxychloroquine among COVID-19 patients in Uganda
 Uganda 2020-08-13 2023-08-13 Medical and Health Sciences Non-degree Award
Violet Kayom Okaba
ID:
Assessment of the Process of Delivery of the Essential Newborn Care Practices in the Antenatal Care Clinic in Kawempe National Referral Hospital in Uganda
REFNo: HS752ES

Primary objectives
1. To evaluate the mothers’ knowledge on essential newborn care practices following antenatal care attendance in Kawempe National Referral hospital.
2. To determine the facilitators and barriers to delivery of the ENC practices in the ANC clinic in Kawempe National Referral hospital.

Secondary objective
1. To evaluate the uptake of the essential newborn care practices in the ANC clinic of Kawempe National Referral hospital using the RE-AIM framework.

 Uganda 2020-08-12 2023-08-12 Medical and Health Sciences Non-degree Award
Mary Nabakooza
ID:
SCHOOL-BASED MENTORSHIP AND TEACHING COMPETENCIES. A COMPARATIVE STUDY OF PUBLIC AND INTERNATIONAL SCHOOLS IN WAKISO DISTRICT
REFNo: SS422ES

to examine the relation ship between school -based mentorship on lesson preparation in public schools and international schools in wakiso district.
To establish the relationship between the school -based mentorship on lesson presentation in public schools and international schools in wakiso district.
To determine the relationship between the school -based mentorship on assessing of learners'performance in public schools and international schools in wakiso district.

 Uganda 2020-08-11 2023-08-11 Social Science and Humanities Degree Award
Laban Musinguzi Kashaija
ID: UNCST-2020-R014407
 THE EFFECT OF COVID-19 ON THE WELL BEING OF CHILDREN IN UGANDA
REFNo: SS540ES


1. To document the nature and perpetrators of the cases of violence against children (VAC) in the wake of COVID-19 pandemic in Uganda.
2. To assess the effect of COVID-19 pandemic on children’s access to violence against children preventive and response services in Uganda.
3. To assess the effect of COVID-19 pandemic on children’s utilization of violence against children preventive and response services in Uganda.
4. To inform the child protection policy and programming process during and after this pandemic and similar future pandemics.
Uganda 2020-08-11 2023-08-11 Social Science and Humanities Non-degree Award
Muhmood Kiryowa Haruna
ID:
Periodontal disease in diabetic patients attending kiruddu referral hospital
REFNo: HS610ES

To determine the prevalence and factors associated with periodontal disease in diabetic patients attending kiruddu referral hospital
 Uganda 2020-08-10 2023-08-10 Medical and Health Sciences Degree Award
Ruth Kaziga
ID:
SOCIOCULTURAL CONSTRUCTION OF BODY IMAGE AND ITS EFFECT ON SELF-ESTEEM OF OLDER BANYAKOLE ADOLESCENT GIRLS IN THE ANKOLE REGION, SOUTH WESTERN UGANDA
REFNo: SS466ES

1. To describe the self-perception of adolescent girls' construction of body image within the Ankole society
2. To explore the contradictory societal expectations of body image where the older adolescents live
3. To identify facilitators and barriers to body image and self-esteem

 Uganda 2020-08-10 2023-08-10 Social Science and Humanities Degree Award
Matthew Bird Aileen
ID:
Consumer Protection Survey
REFNo: SS523ES

In this study, we aim to generate insights on consumer protection topics related to mobile telecommunications and digital finance in Uganda. Areas to be explored through this nation-wide phone survey include consumer usage and preferences regarding service providers, levels of trust, pricing awareness, challenges, fraud, dispute resolution, and the impact of COVID-19 on these topics. This project is being conducted in partnership with the Uganda Communications Commissions (UCC).
USA 2020-08-10 2023-08-10 Social Science and Humanities Non-degree Award
William Buwembo
ID: UNCST-2022-R009661
 MECHANISMS UNDERLYING DENTAL CARIES AND PERIODONTAL DISEASE IN HIV POSITIVE PERSONS ATTENDING THE MULAGO ISS CLINIC IN UGANDA
REFNo: HS552ES

General Objective
To establish the mechanisms underlying dental caries and periodontal disease in HIV positive adults attending the Mulago ISS clinic in Uganda

Specific Objectives
1. To determine the effect of HIV status on salivary gland function (flow rate, electrolytes, antimicrobial proteins content and DEFB1 single nucleotide polymorphism) in persons with or without dental caries or periodontitis.
2. To determine the abundance and diversity of the oral microbiome in HIV positive individuals with or without dental caries or periodontitis.

Uganda 2020-08-07 2023-08-07 Medical and Health Sciences Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
 A mixed-methods observational study to assess the feasibility of conducting COVID-19 vaccine trials among healthcare workers in Uganda
REFNo: HS807ES

I. To assess willingness to participate in COVID-19 vaccine studies and associated factors among healthcare workers in Uganda
II. To estimate the prevalence of underlying health conditions that are associated with poor COVID-19 outcomes among healthcare workers in Uganda
III. To describe the knowledge, attitudes, and practices regarding infection with SARS-CoV-2 and COVID-19 vaccine research among healthcare workers in Uganda

 Uganda 2020-08-07 2023-08-07 Medical and Health Sciences Non-degree Award
Mary Ann Etling
ID:
Ethnographic analysis of children with mobility disabilities and their caregivers in Gulu district of post-conflict northern Uganda
REFNo: HS311ES

Identify ongoing needs of children with mobility disabilities and their caregivers in Gulu district.
Characterize physical, economic, social, and environmental barriers that children with mobility disabilities and their caregivers experience in Gulu district.
Investigate changes in the family and how they impact care for children with mobility disabilities in Gulu district.
 USA 2020-08-06 2023-08-06 Medical and Health Sciences Non-degree Award
Ronald Moses Galiwango
ID: UNCST-2024-R015239
 SARS CoV-2 Infection, Transmission, and Natural History of COVID-2019 Among Persons With and Without HIV and Tuberculosis
REFNo: HS712ES

Primary objective
• Evaluate the impact of HIV infection on presentation and outcomes of COVID-19 disease

Secondary objectives
• Evaluate household transmission of COVID-19 disease among persons with and without HIV infection
• Evaluate the impact of TB infection on presentation and outcomes of COVID-19 disease
• Among persons living with HIV, evaluate the relationship between routine biomarkers (CD4#, viral load) and outcomes of COVID-19
• Among persons living with HIV, evaluate the impact of being on antiretroviral drugs and different ARV regimens on COVID-19 outcomes
• Understand the impact of nutritional and functional status on persons with COVID-19 infection

 Uganda 2020-08-06 2023-08-06 Medical and Health Sciences Non-degree Award
Raymond Tweheyo
ID: UNCST-2020-R014507
 Exploring the root causes and cultural norms for healthy timing and spacing of pregnancies and assessing access to quality and voluntary family planning in central and western Uganda.
REFNo: HS787ES

Specific objectives:
1)To explore the socio-cultural norms and sexual reproductive health behaviors that influence the youth’s access to FP information and use of FP services.
2)To assess the health system readiness for provision of family planning and youth friendly services in both public and private facilities.
3)To assess the private pharmacy and drug shop readiness for provision of family planning services.
4)To assess community Village Health Team (VHT) capacity and readiness to offer FP services.

 UK 2020-08-06 2023-08-06 Medical and Health Sciences Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Assessment of safety and efficacy of COVID-19 Convalescent Plasma for treatment of COVID-19 in adults in Uganda; A randomized controlled trial (CCP TRIAL)
REFNo: HS816ES

General objective
The overall objective of this project is to assess the safety and efficacy of COVID-19 convalescent plasma in the treatment of COVID-19 in Uganda.

Primary objective
1. To determine the efficacy of COVID-19 Convalescent Plasma, as measured by time to RT-PCR negativity of COVID-19 patients treated with COVID-19 Convalescent Plasma.
Secondary objectives
1. To assess the safety of COVID-19 Convalescent Plasma in the treatment of COVID-19 patients in Uganda
2. To document the time to symptom decrease of patients with positive SARS-CoV-2 RT PCR treated with CCP compared to those on standard of care
3. To assess the ability of CCP therapy to stop progression to severe/critical forms of disease

 Uganda 2020-08-05 2023-08-05 Medical and Health Sciences Non-degree Award
Jimmy Osuret
ID:
Effectiveness of safe pedestrian crossings for primary school children in Kampala, Uganda: Implications for road safety management
REFNo: HS659ES

The main objective of this study will be to assess the effectiveness of safe pedestrian crossings in reducing child pedestrian road traffic injuries and death around primary school areas so as to persuade policymakers and practitioners to prioritize child pedestrian road safety.
 Uganda 2020-08-04 2023-08-04 Medical and Health Sciences Degree Award
Abel Nkolo
ID:
Multimorbidity, Healthcare Processes, versus Mortality among TB/HIV Patients on ART in Uganda
REFNo: HS692ES

1. Determine the association between multimorbidity (non-communicable disease clusters like diabetes, hypertension malnutrition, cancers etc.) and mortality among TB/HIV patients on ART?
2. Analyze the association between demographic factors (sex, age and marital status) and mortality among TB/HIV patients on ART
3. Analyze the association between the phase of TB treatment (Initiation and continuation) and mortality among TB/HIV patients on ART.
4. Determine the association between time of initiation of ART (before the start of TB treatment and after the start of TB treatment) and mortality among TB/HIV patients on ART.
5. Determine the association between the type of TB (pulmonary bacteriologically confirmed, pulmonary clinically diagnosed and extrapulmonary) and mortality among TB/HIV patients on ART.

 Uganda 2020-08-04 2023-08-04 Medical and Health Sciences Degree Award
Allen Kabagenyi
ID:
Using Telehealth Services To Support The Continuity Of Family Planning Information, Access, And Utilisation During The Covid-19 Pandemic In Uganda
REFNo: HS799ES

• To conduct a survey among clients on an existing telehealth platform to identify the information gaps and challenges of accessing family planning during the COVID-19 pandemic lockdown.
• To develop an information package for improving access to family planning services
• To assemble a community advisory board (CAB) to review content of the family planning information package
• To pilot the use a telehealth platform for improving continuity and knowledge of family planning services during the COVID-19 lockdown.
• To assess the perceptions towards long-acting reversible family planning methods during the post COVID-19 lockdown. Using the telehealth platform.

Uganda 2020-08-04 2023-08-04 Medical and Health Sciences Non-degree Award
IVAN JJOOGA
ID:
‘Economic analysis of beef cattle fattening systems in Nakaseke District, Central Uganda’
REFNo: A68ES

(i) Overall objective
-To determine the economic performance of beef cattle fattening systems used in Nakaseke District.

(ii) Specific objectives

(a) To assess the profitability of different beef cattle fattening systems in Nakaseke District.
(b) To identify the major challenges hindering the adoption of better beef cattle fattening systems by fatteners.

Uganda 2020-08-03 2023-08-03 Agricultural Sciences Degree Award
Katharine  Brockett
ID:
A study of breast cancer awareness and barriers to accessing breast cancer services amongst adult inpatients and their attendants at Bwindi Community Hospital
REFNo: HS755ES

To find out participants awareness of breast cancer focusing on knowledge of risk factors, signs and symptoms and preventative measures. To ask about participants perceived barriers and identify other issues that may restrict access to breast cancer related care.
 UK 2020-08-03 2023-08-03 Medical and Health Sciences Non-degree Award
Doreen Nakimuli
ID: UNCST-2021-R013668
 Understanding Self Injection of DMPA-SC: Consumer Insight Research
REFNo: HS767ES

To understand where consumers get their health and family planning information from, where and how they access family planning products, what might motivate them to choose DMPA-SC self-injection, what are the barriers to choosing self-injection, what are consumers’ perceptions and attitudes towards self-injection.
Uganda 2020-08-03 2023-08-03 Medical and Health Sciences Non-degree Award
Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
 Evaluation of New Diagnostics and Field evaluation of point-of-care triage tests for Active Tuberculosis.
REFNo: HS688ES

The primary objective of the study is:

1. To finalise a POC-MBT TB triage test suitable for global application and to perform field-testing and validation thereof. The target for each validation process will be the World Health Organisation (WHO) target product profile 90% sensitivity and 70% specificity.

Secondary objectives:
1. To compare the efficacy of the POC-MBT’s TB diagnostic ability between certain sub-classification groups, for example by HIV-status, history of previous TB, extra-pulmonary vs pulmonary TB, and positive vs negative smear/GeneXpert® Ultra/culture.
2. To estimate the efficiency of different TB diagnostic algorithms that include the POC-MBT screening test along with clinical and/or radiological and/or sputa results.
3. To evaluate the POC-MBT as an indicator of treatment response during treatment for active TB.
4. To evaluate a prototype 3-marker gene signature on an Xpert mRNA cartridge using fingerstick blood.
5. To store samples and data to allow the testing or validation of future diagnostic candidates and algorithms, such as automated chest X-ray analysis and transcriptomic bio-signatures.

 Uganda 2020-07-30 2023-07-30 Medical and Health Sciences Non-degree Award
Gloria Seruwagi Seruwagi
ID:
Knowledge, adherence and the lived experiences of refugees in COVID-19: A comparative assessment of urban and rural refugee settings in Uganda
REFNo: SS511ES

General objective
We seek to study refugee lived experiences, assess behavioural shifts and determine public compliance and social behaviour in both urban and rural refugee settings

Specific objectives
1. To assess knowledge or awareness of COVID-19 and local perception of risk in urban and rural refugee settings. This will also capture infodemic issues, myths, fears, etc
2. To identify local pre-post COVID attitudes and practices relating to health and social norms. This will include e.g. WASH, healthseeking behaviour, community cohesion practices
3. To explore implementers’ interpretation and enforcement of COVID-19 guidelines.
4. To determine the feasibility of, and adherence to, COVID-19 preventive measures.Will include local interpretations, experiences, innovations, improvisations and explanatory factors
5. To identify community resources, systems and assess their efficacy in the COVID-19 response. E.g. this will cover essential systems and services including health, social care and community leadership
6. To compare urban and rural refugees in line with Objectives 1-5

Uganda 2020-07-30 2023-07-30 Social Science and Humanities Non-degree Award
David Meya Bisagaya
ID: UNCST-2019-R000837
 Alternative Meningitis therapies Phase II Trial for Cryptococcal Meningitis (AMPLYX-CM)
REFNo: HS583ES

To determine the safety and efficacy for all drugs for the treatment of cryptococcal meningitis Primary: 1) “Early Fungicidal Activity” (EFA), which is the rate of CSF yeast clearance quantified by the change of log10 Cryptococcus CFU/mL CSF/day as measured by serial quantitative CSF fungal cultures over the first ~2 weeks 2) Incidence of Grade 3-5 laboratory Adverse Events 3) Incidence of Grade 3-5 Clinical Adverse Events or SAEs Secondary: 4) 18-week survival time as time to event analysis a. 2 and 10 week survival time will be presented 5) Among 2-week survivors, 18-week hospital-free survival time 6) Tolerability: all cause drug discontinuation, study withdrawal, or lost-to-follow-up 7) 3-month quantitative neurocognitive performance Z-score 8) Pharmacokinetic studies of APX001A concentrations in blood, CSF, and other bodily fluids/tissues; and with respect to concomitant medicines.
Uganda 2020-07-28 2023-07-28 Medical and Health Sciences Non-degree Award
Gertrude Nakigozi
ID:
Mental Health and Cognition in HIV Infection in Rakai, Uganda
REFNo: HS634ES

Aim 1: Examine separate and interactive effects of HIV and psychosocial determinants on CNS dysfunction in PLWH. Hyp 1. Exposure to sexual/physical trauma or violence will interact with HIV in this population and will be associated with greater impairments/decline in declarative memory, cognitive control, and NVS.

Aim 2: Examine effects of psychosocial determinants on ART adherence in PLWH. Hyp 2. Exposure to sexual/physical trauma or violence will interact with impairments/decline in declarative memory, cognitive control, and NVS will adversely affect ART adherence).

Exploratory Aim 3: Determine biomarkers that relate most strongly and reliably to CNS dysfunction in the context of HIV and/or psychosocial determinants. Hyp 3: Different biomarkers of neuronal damage damage (e.g., neurofilament protein light chain-NFL) and CNS inflammation will relate to patterns of impairment/decline in declarative memory, cognitive control, motor, and NVS in the context of HIV and/or exposure to sexual/physical trauma or violence.

Uganda 2020-07-28 2023-07-28 Medical and Health Sciences Non-degree Award
WILLIAM  MUSAMBA
ID:
Sub-ethnic Identities and Political Conflict in Uganda: The Case of Busoga (1900 to 1967)
REFNo: SS485ES

1)To analyze the influence of British colonial rule on the ethno-political conflicts in Busoga, 2)To assess the position of the Kyabazingaship (Paramount Chieftaincy) in the ethno-political conflicts in Busoga, 3)To examine the nature of political activism of the civic movements in Busoga namely, Young Busoga Association, the Abataka Association and the Abataka Mwoyo Gwa Busoga (Landlords are the Heart of Busoga), 4)To explore the attitude of post-colonial national leadership towards the ethno-political conflicts in Busoga.

Uganda 2020-07-28 2023-07-28 Social Science and Humanities Degree Award
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