Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Elizabeth Kemigisha Kemigisha
ID:
Adolescents’ Perspectives of sexual wellbeing and consent MUST-2021-37
REFNo: HS1438ES

1) To contribute to the understanding about how local and contextual factors such as predominant religion, socially acceptable norms, cultural practices and political sentiment can influence sexual wellbeing of adolescents (10 to 24 year olds) in LMIC’s, 2) To explore adolescents’ understanding of, and perspectives on, sexual wellbeing, capturing different aspects of sexuality development during adolescence, including the evolving capacity to sexual consent,
Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ADOA DENNIS
ID:
Development and Evaluation of a Psychosocial Risk Assessment Tool for Predicting Attrition From HIV Care And Treatment Amongst Adolescents Aged 15-19 Years in Uganda
REFNo: HS1501ES

To assess the feasibility of HCWs administering the psychosocial risk assessment tool to ALHIV aged 15-19 years during routine ART visits to determine risk for attrition ,To evaluate the ability of the tool to predict risk of attrition of ALHIV aged 15-19 years at 3-months, following their enrollment date,Assessment and validation of the risk assessment tool, To develop a psychosocial risk assessment tool,To develop a psychosocial assessment tool for predicting attrition of adolescents aged 15-19 years from HIV care. ,
Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
EVALUATION OF TRUENAT MTB-RIF DX AND TRUENAT MTB ASSAYS IN COMPARISON TO GENEXPERT MTB/RIF ULTRA FOR THE DIAGNOSIS OF PULMONARY TUBERCULOSIS
REFNo: HS1526ES

Primary:
• Assess sensitivity and specificity of Truenat™ MTB-RIF Dx and Truenat™ MTB assays in raw sputum compared to the WHO-endorsed GeneXpert® MTB/RIF Ultra using culture as the gold standard

Secondary:
• Assess the operational feasibility of Truenat™ MTB-RIF Dx and Truenat™ MTB assays
• Determine and compare costs between the Truenat™ MTB-RIF Dx and Truenat™ MTB assays, and Xpert MTB/RIF Ultra
Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Allan Lugaajju
ID:
Community-Based Cardiovascular Disease risk factors assessment in Wakiso and Mpigi districts
REFNo: HS1556ES

1. To determine the prevalence of cardiovascular disease risk factors (hypertension, dyslipidemia, obesity, diabetes, physical inactivity, diet, and age) in Wakiso and Mpigi districts
2. To determine the status of cardiac function of the study participants in Wakiso and Mpigi districts.
3. To explore determinants of life-style factors (physical activity, tobacco and alcohol use) through interviews and focus group discussions
Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Kent Kirya Robert
ID:
Validity and Reliability of Force Inventory in Ugandan Secondary Schools
REFNo: NS275ES

Based on the constructed rationale, this study aims to present the quality of the FCI to the Ugandan context in terms of its validity, reliability, level of difficulty, powers of discrimination, and distractors of items.,The main purpose of the study is to establish the validity and reliability of Force Inventory in Ugandan Secondary Schools. ,
Uganda 2021-08-05 2024-08-05 Natural Sciences Non-Clinical Trial Degree Award
Jolly Magulu
ID: UNCST-2021-R013833
Psychiatric comorbidities of Epilepsy and treatment gaps among children and adolescents attending children\'s outpatient of Butabika National Referral Mental Hospital in Kampala, Uganda
REFNo: HS1465ES

General objective
To determine the prevalence of psychiatric comorbidities of epilepsy and determine the diagnostic deficit and treatment gaps among children and adolescents attending children’s Outpatient at Butabika National Referral mental hospital in Kampala, Uganda.

Specific objectives
1.) To determine the prevalence of psychiatric co-morbidities of epilepsy among children and adolescents attending children’s Outpatient at Butabika National Referral mental hospital.
2.) To determine the proportion of children and adolescents with untreated psychiatric comorbidities of epilepsy attending children’s Outpatient of Butabika National Referral mental hospital.
3.) To establish the patient factors associated with untreated psychiatric comorbidities among children and adolescents with epilepsy attending children’s Outpatient of Butabika National Referral mental hospital.
4.) To find out clinician reflections untreated psychiatric comorbidities among children and adolescents with epilepsy attending children’s Outpatient of Butabika National Referral mental hospital.
Uganda 2021-08-05 2024-08-05 Medical and Health Sciences Non-Clinical Trial Degree Award
Robert Kent Kirya Robert
ID:
Developing a Circular Motion Concept Inventory for evaluating understanding of students of Ugandan Secondary Schools.
REFNo: NS274ES

iii) To evaluate the students’ conceptual change using the circular motion concept inventory's pre-test and post-test scores. ii) Use the circular motion concept inventory to examine the level of conceptual understanding of secondary school students. i) To adapt and validate the statistical indices of circular motion concept inventory.
Uganda 2021-08-05 2024-08-05 Natural Sciences Non-Clinical Trial Degree Award
Susan Kironde Kizito
ID:
THE ROLE, KNOWLEDGE, ATTITUDE AND PRACTICES OF TRADITIONAL HEALERS IN THE MANAGEMENT OF SNAKE BITES: A CASE OF GULU AND KAMULI DISTRICTS, UGANDA
REFNo: HS1434ES

1.Describe the role of traditional healers in the management of snakebites. 2.Assess the knowledge traditional healers have on snakes, snake bite symptoms and signs, and management of snakebite envenoming. 3.Describe the attitude traditional healers have about snakes, and the modes of first aid they use for management of snakebites. 4.Document traditional healers’ practices when providing first aid to snakebite victims. 5.Establish the willingness of traditional healers to contribute towards establishing a community surveillance system for snakebites in Uganda.
Uganda 2021-08-04 2024-08-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
An open label, Phase 2 study to evaluate the safety and immunogenicity of an Ad26.ZEBOV booster dose in Human Immunodeficiency Virus Positive (HIV+) adults previously vaccinated with the Ad26.ZEBOV, MVA-BN-Filo vaccine regimen
REFNo: HS1350ES

• To assess the safety and tolerability of a Ad26.ZEBOV booster dose in HIV positive adults previously vaccinated with the Ad26.ZEBOV, MVA-BN-Filo vaccine regimen.

• To assess humoral responses induced by the booster dose against EBOV glycoprotein (GP), as measured by Filovirus Animal Non-Clinical Group (FANG) Enzyme-Linked Immunosorbent Assay (ELISA) at 7 and 21 days.

Uganda 2021-08-04 2024-08-04 Medical and Health Sciences Clinical Trial Non-degree Award
Sarah Zalwango Karen
ID: UNCST-2021-R005660
Identifying adolescents at high risk of neurocognitive disorder: Development and validation of composite risk index.
REFNo: HS1532ES

a. To develop a CRI by combining intake data on nutrition, immune parameters and HIV status and their interactions and perform internal and external validation of CRI as predictor of ND at 12 months. We hypothesize that the CRI evaluated at intake will successfully predict progressive/incident ND 12 months later.

b. To further internally and externally validate CRI for “out-of-time-window” prediction from 24 to 36 months. We hypothesize that the CRI developed at intake but evaluated at 24 months will successfully predict progressive/incident ND at 36 months.

c. For HEU and HIV-infected children, to refine CRI into CRI-HEU and CRI-HIV, respectively, by including type of maternal ART, viral genome parameters, current cART regimen/adherence (as applicable), and their interactions. We hypothesize that the CRI-HEU and CRI-HIV developed at intake and evaluated at intake and 24 months will successfully predict ND and ND/HAND respectively, 12 months later.

Uganda 2021-08-04 2024-08-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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