Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Kamya Moses
ID: UNCST-2020-R014203
Impact of long-lasting insecticidal nets (LLINs) treated with pyrethroid plus pyriproxyfen vs LLINs treated with pyrethroid plus piperonyl butoxide on malaria incidence in Uganda: a cluster-randomised trial
REFNo: HS1097ES

Primary Objective:
To evaluate the impact of LLINs treated with a pyrethroid insecticide plus pyriproxyfen (PPF LLINs), as compared to LLINs treated with a pyrethroid plus piperonyl butoxide (PBO LLINs), on malaria incidence in Uganda. We will test the hypothesis that malaria incidence will be lower in intervention clusters (randomised to receive PPF LLINs) than in control clusters (randomised to receive PBO LLINs).

Secondary Objectives:
To evaluate the impact of PPF LLINs vs PBO LLINs on parasite prevalence, anaemia, and vector density.
To estimate the cost-effectiveness of delivering PPF LLINs, as compared to PBO LLINs
To assess net durability, survivorship and use of PPF LLINs vs PBO LLINs.

Uganda 2021-01-11 2024-01-11 Medical and Health Sciences Non-degree Award
Robert Opika Opoka
ID: UNCST-2021-R014036
The Influence of Comprehensive Follow-Up in Pediatric Sickle Cell Disease in an African Setting: a retrospective cohort Study
REFNo: HS636ES

General Objectives: To compare a set of sickle cell-related outcomes (mortality, stroke, blood transfusions, and hospitalizations) between children with SCA on a comprehensive follow up schedule under clinical trials setting and that of a cohort of children with SCA receiving routine care at a specialized sickle cell clinic.


Primary Objective: To compare sickle cell-related outcomes in the NOHARM children who were on the placebo arm to those of children of similar age group from the MHSCC who fulfilled the inclusion criteria for the NOHARM study at the time the study was recruiting patients but who were not enrolled.

Secondary Objectives: To assess the added effect of hydroxyurea therapy (in addition to comprehensive follow up schedule) on sickle cell-related outcomes. This shall be done by comparing sickle cell related outcomes in
1) NOHARM children randomized to hydroxyurea arm and that of the cohort of non-study MHSCC children with SCA over the time period of the NOHARM study (calendar years 2015-17).
2) NOHARM children on the MTD dose of hydroxyurea to that of the cohort of non-study MHSCC children with SCA over the time period of the MTD study (calendar years 2018-19).

Uganda 2021-01-08 2024-01-08 Medical and Health Sciences Non-degree Award
JANE  BWIRUKA FRIDA
ID:
Student teachers Narratives on Pedagogical Practices that inform their Competences at Makerere University, Uganda
REFNo: SS518ES

1)Explore the narratives of student teachers on teaching practices that inform their competences at Makerere University.
2)Explore the narratives of student teachers on mentoring practices that inform their competences at Makerere University.
3)Explore the narratives of student teachers on supervision practices that inform their competences at Makerere University.
Uganda 2021-01-08 2024-01-08 Social Science and Humanities Degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
Using new genomic approaches to investigate causes of maternal sepsis among women delivering in sub-Saharan Africa
REFNo: HS969ES

Primary objectives
1)To compare the pathogen profiles using routine microbiology (blood cultures, urinalysis, malaria tests, complete blood count) among women with fever at delivery and those without fever at KNRH
2)To compare the prevalence of Streptococcus agalactiae in placental samples using qPCR among women with fever at delivery and those without fever at KNRH

Secondary objectives
1)To compare the composition and diversity of the nasal and ano-vaginal microbiota among women with fever at delivery and those without fever at KNRH
2)To compare the composition and diversity of the nasal and ano-vaginal microbiota among newborns of women with fever at delivery and the newborns of those without fever at KNRH
3)To compare the single-cell RNA-seq transcriptome of the placentae of women with placental malaria and those without placental malaria at Kawempe National Referral Hospital (KNRH).


Uganda 2021-01-08 2024-01-08 Medical and Health Sciences Non-degree Award
Moreen Kiiza
ID:
The Right to Rehabilitation for the Survivors of Torture: A Case Study of Urban Refugees in Katwe-Kinyolo, Kampala-Uganda
REFNo: SS630ES

1. To assess the adequacy of the legal and policy framework governing rehabilitation for refugee survivors of torture in Uganda.
2. To ascertain the rehabilitation needs of refugee survivors of torture in Uganda.
3. To establish the adequacy of available mechanisms for the rehabilitation of refugee survivors of torture in Uganda.
4. To establish the challenges to the rehabilitation of refugee survivors of torture in Uganda.

Uganda 2021-01-08 2024-01-08 Social Science and Humanities Degree Award
VICTOR BEWAYO
ID: UNCST-2024-R003092
ASSESSMENT OF THE LEVEL OF REPORTING ADVERSE DRUG REACTIONS AND ASSOCIATED FACTORS AMONG HEALTH CARE PROFESSIONALS IN COMMUNITY PHARMACY PRACTICE IN KAMPALA CITY, UGANDA
REFNo: HS956ES

1. To establish the proportion of community pharmacy staff that have reported an ADR in the past one year in Kampala City
2. To identify the factors associated with ADR reporting among community pharmacy staff in Kampala City

Uganda 2021-01-07 2024-01-07 Medical and Health Sciences Degree Award
Erica Harrison
ID:
COVID-19 VACCINE UPTAKE STUDY IN UGANDA
REFNo: SS661ES

Research Questions
What is the public’s knowledge, attitude and perceptions towards COVID-19 vaccine in Africa?
Is there an association between the public perception of COVID-19 vaccine and background vaccine confidence and hesitancy levels.

Specific Objectives
Examine the public’s knowledge of COVID-19 and a future COVID-19 vaccine.
Assess the public’s background vaccine confidence and hesitancy levels.
Assess the public’s perceived risks/benefits of a future COVID-19 vaccine.
Determine the willingness of the public to accept and or recommend a future COVID-19 vaccine.
Examine the influence of the knowledge and perceptions of COVID-19 vaccine on the expected uptake of a potential vaccine.
Examine the public’s handling of COVID-19 related rumors.

UK 2021-01-07 2024-01-07 Social Science and Humanities Non-degree Award
Mariam Namasaba
ID:
A school-based resilience training program for caretakers of children with disabilities in Uganda: a cluster-randomized controlled study
REFNo: HS1027ES

To examine the impact of a resilience training program on the mental well-being and coping strategies of caretakers of CWDs in schools in Uganda.

To assess the impact of a resilience training program on the sense of self-efficacy of school caretakers of CWDs in schools in Uganda.
Uganda 2021-01-06 2024-01-06 Medical and Health Sciences Degree Award
Yvonne Mugerwa Kidza Kitego
ID:
The Kampala Slum Maternal Newborn (MaNe) Project - Innovating for Better Referral Systems: an implementation research protocol
REFNo: HS962ES

• To harness the public and private facility mix to provide quality and affordable maternal and newborn care services to the urban poor.
• To strengthen referral linkages between public and private health facilities for MNH care.
• To educate mothers, caretakers of newborns and spouses about appropriate actions on what MNH services to seek and from where
Uganda 2021-01-06 2024-01-06 Medical and Health Sciences Non-degree Award
NORAH IKINYOM
ID:
THE POTENTIAL OF NUTRI-MEDICINAL PLANTS IN THE MANAGEMENT OF OPPORTUNISTIC INFECTIONS ASSOCIATED WITH HIV/AIDS
REFNo: HS983ES

(a)To determine availability of Nutri-medicinal plant species in Acholi sub region and understand traditional methods and formulations being used in quality assurance of nutri-medicinal plant preparations by Traditional medicine practitioners
(b) to determine chemical composition and nutritional characteristics of nutri-medicinal plants, to be conducted according to good laboratory practices (GLPs)
(c) To evaluate the efficacy of Nutri-medicinal plants in managing the HIV/AIDS Opportunistic infections, to be conducted according to good laboratory practices (GLPs)
Uganda 2021-01-06 2024-01-06 Medical and Health Sciences Degree Award
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