Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
David Musoke
ID:
A feasibility study for a randomised controlled trial on integrated malaria prevention in Wakiso district, Uganda
REFNo: HS999ES

1. To explore community willingness to participate in an RCT on integrated malaria prevention.
2. To assess stakeholder perspectives on the RCT on integrated malaria prevention.

Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
David Musoke
ID:
Use of Photovoice to explore community members perspectives on health and healthcare challenges in Mukono District, Uganda
REFNo: HS1058ES

To use photovoice as a community-based participatory research method to explore healthcare delivery including barriers and challenges in Mukono district so as to provide information to inform future research and interventions to improve health of the community.
Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
ALEX NDYABAKIRA
ID:
Durability monitoring of Long Lasting Insecticidal Nets in Uganda, distributed during the 2020 mass campaign
REFNo: HS1109ES

Primary objective
1.To assess the physical durability of 5 different brands of nets over a three-year period, estimate median LLIN survival and identify major determinants of field performance
Secondary objectives
1. To describe major behavioral aspects of net care and repair and their impact on physical durability
2. To assess the insecticidal effectiveness (bio-efficacy) and chemical residue of 5 ITN brands during three years of field use

Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
Clinical manifestations and Outcomes of SARS-CoV-2 Infection in pregnancy in Africa: Novel Insights from the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa and Uganda (AFRE-Mom-CoV-19) protocol
REFNo: HS1164ES

To retrospectively investigate the socio-demographic and clinical characteristics and maternal/infant outcomes of pregnant patients with RT-PCR-confirmed SARS‐CoV‐2 infection in six west, east, central and southern African countries: DRC, Ghana, Kenya, Nigeria, South Africa and Uganda.
Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Amon Nuwahereza
ID: UNCST-2022-R011428
Ride and Arrive Safe (RAS). A Case study of Mbarara Municipality
REFNo: HS577ES

i. To explore the feasibility of the community facilitation and engagement approach in equipping the Boda-boda cyclists with safety riding knowledge and skills.
ii. To develop a Boda-boda safety user check the mobile application for passengers using Boda-boda a means of transport
iii. To evaluate the effect of Boda-boda cyclist training and community engagement in reducing the number of Boda-boda road traffic accident-related admissions at Mbarara Regional Referral Hospital.

Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Denis  Bwayo
ID:
Program Assessment and Implementation Learning for the University Research Co., LLC - Department of Defense HIV Prevention Program – Uganda
REFNo: HS959ES

1.To determine compliance to program set targets for the URC-DHAPP program between October 2018 and September 2021
2.To assess the quality of HIV services delivered at 28 UPDF HIV clinics
3.To determine program outcomes across key program implementation strands in line with 95:95:95 frameworks
4.To share implementation experiences across key program implementation strands including HIV testing, ART services, TB diagnosis and management, PMTCT, OVC and systems strengthening.

Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
ENHANCED ENTOMOLOGICAL SURVEILLANCE(EES) TO INFORM MALARIA CONTROL IN UGANDA
REFNo: HS1059ES

1. To examine the impact of current vector control interventions on malaria vector densities, vector behaviour, and species composition.
2. To monitor the status and intensity of insecticide resistance.
3. To establish the entomological inoculation rates in the selected districts.
4. To build the capacity of districts to conduct routine entomological surveillance

Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
Manifestations and Outcomes of Hospitalized African children and Adolescents with SARS-CoV-2 Infection: Insights from the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa and Uganda (AFRE-Ped-CoV-19) protocol Version November 06 2020. Grant No. 1R25TW011217-01
REFNo: HS1168ES

Study Aims

a) To describe the socio-demographic features; clinical WHO COVID-19 staging at admission, clinical characteristics, laboratory features including inflammatory and
cardiac markers; imaging investigations and associated abnormalities, treatments applied; and comparisons within and across participating African countries.
b) To estimate the prevalence of comorbidities at presentation and recent/current treatment with immunosuppressive drugs and comparisons within and across
participating African countries.
c) To estimate the prevalence of associated tuberculosis (past, current), HIV status (HIV-exposed uninfected or HIV-infected, and type of treatment if HIV-infected), malaria, bacterial infections influenza and other viral infections and comparisons within and
across participating African countries.
d) To assess overall mortality and independent factors associated with mortality and comparisons within and across participating African countries.

Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Grace Ndeezi
ID: UNCST-2019-R001802
A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease IMR-SCD-301
REFNo: HS1130ES

Primary Objectives
To evaluate the HbF response to IMR-687 versus placebo
To evaluate the safety of IMR-687 versus placebo
Secondary Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
To evaluate the effect of IMR-687 versus placebo on indices of WBC adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of VOCs
To evaluate the effect of IMR-687 versus placebo on quality of life (QoL) measures

Pharmacokinetic Objectives
To evaluate the PK of IMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in RBC characteristics and total Hb
To evaluate the effect of IMR-687 versus placebo on renal function
To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk

Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
FRED SEMITALA COLLINS
ID: UNCST-2020-R014096
Strengthening Integrated Screening for TB and COVID19 in Kampala, Uganda
REFNo: HS1152ES

The overall goal is to establish the acceptability, feasibility and potential for scaling up the use of COVID19-TB Screening algorithm at Kiruddu National Referral Hospital.
Specific objectives

(1) To explore the perspectives of healthcare providers on the integration of COVID19 and TB screening at Kiruddu National referral Hospital.
(2) To determine the effect of the COVID19-TB algorithm on the proportion of patients screened for TB at Kiruddu National Referral Hospital over a 4-month period.

Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
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