Moses Joloba Lutaakome
ID: UNCST-2022-R011558
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A Study to Validate and Improve an Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear Slides: Version 1.0 dated Nov 2020
REFNo: HS1144ES
1. Validate the platform, and assess efficiency improvements from computerized detection approaches.
a. Perform a slide specimen digitization (400 slides, 98 images/slide, 39,200 images).
b. Classify all images as dark/medium/light based on color histogram data.
c. Assess accuracy vs. manual microscopy, and sensitivity/specificity vs. bacterial culture.
d. Develop a new image analysis algorithm by integrating software applications that include Artificial Intelligence (AI) approaches via Convolutional Neural Networks (CNN).
2. Quantify slide staining quality and variability through the use of novel methods which exploit the color spectra of stained slides.
a. Determine factors which led to poor slide preparation.
b. Test a new quality control method (HistoQC) to standardize clinical slide preparations
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Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
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Non-degree Award |
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THOMSON LAKWO LURONI
ID: UNCST-2023-R007843
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Evaluation of the Diagnostic Tests in Areas Hypoendemic for Onchocerciasis –Uganda: a follow-up study.
REFNo: HS1220ES
Objective 1: Evaluate the distribution of anti-OV-16 antibody and other markers of O. volvulus infection in multiple age groups over time in an area of active intervention for onchocerciasis
Objective 2: To determine whether a serologic threshold of 2% that modeling suggested is consistent with interruption of transmission.
Objective 3: Monitor for sero-reversion of OV-16 antibody positivity in a nested cohort of individuals who participated in the previous study.
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Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
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Non-degree Award |
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Moses Joloba Lutaakome
ID: UNCST-2022-R011558
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Predicting the Future: Incipient Tuberculosis (PreFIT)
REFNo: HS1242ES
1.1 Aim:
To validate the clinical performance, cost, and feasibility of a package of ready-to-use new and existing candidate diagnostic assays for the prediction of the development of active TB.
1.2 Objectives:
1. Establish a multi-country diagnostic evaluation cohort of highly exposed TB contacts free of co-prevalent active TB, followed prospectively for active TB development over a 12-months period, and collect and store biological specimens from these contacts at pre-set time-points for laboratory testing; and
2. Validate a package of candidate assays for their predictive accuracy (sensitivity, specificity, positive and negative predictive values) for incident TB, feasibility, and cost. Based on combining results for the different tests, cost-optimised predictive algorithms will be derived.
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Uganda |
2021-03-01 |
2024-03-01 |
Medical and Health Sciences |
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Non-degree Award |
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Miriam Nansunga
ID:
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ASSESSMENT OF THE SAFETY AND EFFICACY OF COMMON MEDICINAL PLANTS OF CENTRAL UGANDA ON IMPAIRED LEARNING AND MEMORY IN RATS
REFNo: HS648ES
1. To identify medicinal plants of Central Uganda used in the management of memory impairment.
2. To determine the effect of the aqueous extracts of the 5 most commonly mentioned plants on escape latency in the Morris Water Maze and step down latency in Passive Avoidance test.
3. To determine the effect of the total crude extracts of the two most effective plants on: acetylcholine, glutamate; muscarinic receptor M1, M3 and M5; glutamate receptors AMPA and NMDA in the hippocampus and orbital frontal cortex
4. To establish the safety and toxicity profile of the two most active plants extracts on memory and learning enhancement.
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Uganda |
2021-02-26 |
2024-02-26 |
Medical and Health Sciences |
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Degree Award |
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Leevan Tibaijuka
ID: UNCST-2021-R012986
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Predictors for preterm neonatal mortality at Mbarara Regional Referral Hospital
REFNo: HS469ES
General objective
To Describe the Predictors for Preterm Neonatal Mortality among preterm babies delivered at Mbarara Regional Referral Hospital (MRRH).
Specific objectives
1. To describe the neonatal mortality of preterm babies at Mbarara Regional Referral Hospital
2. To describe the association of antenatal care attendance, antenatal corticosteroid use and mode of delivery with preterm neonatal death at Mbarara Regional Referral Hospital
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Uganda |
2021-02-25 |
2024-02-25 |
Medical and Health Sciences |
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Degree Award |
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Francis Ekadu
ID:
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Uganda Bribery Index
REFNo: SS392ES
To increase citizens awareness on the prevalence, gravity and impact of corruption in uganda
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Uganda |
2021-02-25 |
2024-02-25 |
Social Science and Humanities |
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Non-degree Award |
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Lucrèce Ahovègbé Yémalin Judith
ID:
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Evaluation of two medicinal plants on key factors causing treatment failure in Hepatitis C infection
REFNo: HS1004ES
1. Evaluate the antiviral and anti-mutagenic effect of A. nilotica and T. ciliata on HCV in presence and absence of DAA
2. Evaluate the effect of A. nilotica and T. ciliata on induced mutation in HCV infection in presence and absence of DAA
3. Determine effect of A. nilotica and T. ciliata on immunologic parameters involved in body response to HCV in presence and absence of DAA
4. Investigate the genotypes of HCV circulating in African region (Uganda, Benin) and their response in vitro to DAAs
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Benin |
2021-02-25 |
2024-02-25 |
Medical and Health Sciences |
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Degree Award |
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PAUL KATO KALYEBARA KALYEBARA
ID:
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INCIDENCES OF RE-MARRIAGE, LIVE CHILDBIRTH AND RECURRENCE OF INCONTINENCE AMONG WOMEN THAT UNDERWENT OBSTETRIC FISTULA REPAIR AT MBARARA REGIONAL REFERRAL HOSPITAL FROM 2010 TO 2019
REFNo: HS1060ES
General objective
To determine the incidences of re-marriage, live childbirth and recurrence of incontinence among women who had successful obstetric fistula repair at Mbarara Regional Referral Hospital from 2009 to 2019.
Specific objectives
1. To determine the incidence of re-marriage among women who had successful fistula repair at Mbarara Regional Referral Hospital from 2010 to 2019.
2. To determine the incidence of live childbirth among women who had successful obstetric fistula repair at Mbarara Regional Referral Hospital from 2010 to 2019.
3. To compare recurrence rates of incontinence after childbirth occurring among women who had successful genitourinary and rectovaginal fistula repair at MRRH from 2010 to 2019.
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Uganda |
2021-02-25 |
2024-02-25 |
Medical and Health Sciences |
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Degree Award |
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FREDDIE SSENGOOBA Peter
ID: UNCST-2021-R011834
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Political Economy Analysis of sub-national health management in Eastern and Southern Africa
REFNo: SS664ES
This study will explore the dynamics taking place at sub-national level (e.g. within counties or districts) as well as between national and sub-national levels along the following objectives:
1. Analyze the environment for decision-making and implementation of health plans at sub-national level, including existing formal and informal processes for decision-making; political, financial, social, and other influences on sub-national prioritization, decision-making and resource allocation, including relevant changes over time (e.g. post-devolution), and how data and evidence play a role.
2. Identify and characterize key stakeholders with a role in sub-national health management and systems—key characteristics will include technical capacity, their use of data and evidence, the relationships and power dynamics between them, and the existing structures for engagements with non-health sector authorities, both formal and informal.
3. Assess existing formal and informal accountability mechanisms for sub-national decision-making for health (both within the health system and for external stakeholders like beneficiary communities, sub-national decision-makers (county/district), and development partners) with a view to identify ways to improve the relative effectiveness of accountability mechanisms in decision processes.
4. Analyze social sector spending trends and beneficiaries, their relation to health sector policies, and how local governance structures influence them, where available.
5. Develop draft plan for piloting strategies to address challenges identified by the PEA, including proposed implementation and monitoring and evaluation approaches, as appropriate.
6. Analyze the policy environment on community health, including key stakeholders, to identify potential approaches for integrating a new community health extension worker program into existing systems, especially at district level
7. Analyze the current digital health innovations governance and accountability structures, (including key stakeholders across sectors and how their responsibilities and priorities overlap,) to identify strategies for strengthening existing structures, enhancing accountability and minimizing duplication
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Uganda |
2021-02-25 |
2024-02-25 |
Social Science and Humanities |
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Non-degree Award |
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Silvia Kahihu Wairimu
ID:
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Improving the Impact of VSLAs on Refugees’ and Host Communities’ Self- reliance, Resilience and Economic Capacity
REFNo: SS658ES
Our main objective is to investigate different facets of the VSLA (structure, benefits, and barriers as well as future opportunities) with the aim of optimizing its design. This is because we hypothesize that optimizing the structure of the VSLA will lead to increased financial inclusion of the group members as well as social capital.
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Kenya |
2021-02-25 |
2024-02-25 |
Social Science and Humanities |
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Non-degree Award |
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