Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
David  Ejalu Livingstone
ID:
ART Adherence among HIV-positive virally unsuppressed adolescents and young people: feasibility, acceptability, and effectiveness of a community-based implementation strategy to optimise compliance with intensive adherence counselling in East-Central Uganda.
REFNo: HS3807ES

1. To determine the level of compliance to IAC and the associated factors among virally unsuppressed Adolescents and Young People living with HIV in East Central Uganda.
2. To explore individual and system-level barriers to and facilitators of compliance to intensive adherence counselling protocol for enhancing ART adherence among unsuppressed Adolescents and Young People living with HIV in East-central Uganda.
3. To design a multifaceted theory-informed community-based IAC Implementation Strategy to optimize adherence for enhancing VLS among unsuppressed AYP in East-central Uganda.
4. To Evaluate the feasibility, acceptability, and effectiveness of a multifaceted theory-informed community-based IAC Implementation Strategy to optimize adherence among unsuppressed AYP in East-central Uganda.

 Uganda 2024-02-09 23:35:00 2027-02-09 Medical and Health Sciences Non-Clinical Trial Degree Award
Peter Elyanu James
ID: UNCST-2021-R013210
 Closing TB Gaps using patient-centered approaches to improve TB Screening, Diagnosis and Prevention among people living with HIV
REFNo: HS3664ES

To assess the performance of novel TB screening algorithms among children,
adolescents, and adults living with HIV and presenting for routine care across a network
of family centered HIV clinics in Uganda and other four sub-Saharan African countries as
compared to the current WHO recommended symptom-based screening strategy.
To compare new diagnostic strategies leveraging the evaluation of multiple specimens
(stool and oral swab Xpert Ultra, early morning urine LF-LAM, point-of-care ultrasound
(POCUS), and a design locked Xpert Host Response Test against a reference standard
(Xpert Ultra on spot and early morning respiratory specimens) to improve diagnostic yield.
To compare the proportion of PLHIV who initiate and complete TPT with 3HP or 6H within
the context of a patient centered differentiated service delivery model allowing selection
of TPT regimen and randomly allocating enhanced adherence support versus the
standard of care for TPT and adherence support.
To evaluate the cost-effectiveness of screening and diagnostic strategies as well as
comparative TPT regimens for the prevention of TB disease among children, adolescents
and adults living with HIV
 Uganda 2024-02-09 23:32:58 2027-02-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Josephine Birungi
ID: UNCST-2023-R005605
 A Family centred approach to enhance lifestyle change and behavioural modification for prevention of cardiovascular diseases among adolescents and their families in Uganda (FaCe-D) study
REFNo: HS3682ES

Main Objective
1. 1. We aim to explore the knowledge on cardiovascular health including CVD risk, perceptions and attitudes of participants, providers and other stakeholders towards the ihealth-T2D family-centered approach (FCA) as an intervention, obtain their input in the modification and design of the intervention to make it appropriate for Ugandan context
Specific Objectives
1. To explore the knowledge on cardiovascular health, perceptions, preferences and recommendations from potential participants on the proposed family-centered approach as an intervention for reducing and controlling common CVD risk factors among adolescents and their families.
2. To identify potential facilitators and barriers to adapting and implementing the FCA intervention in Uganda.
3. To use the data generated to design implementation strategies to promote the delivery, and uptake of the adapted FCA
 Uganda 2024-02-09 23:29:31 2027-02-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nsobya  Samuel
ID: UNCST-2021-R012265
 Characterizing artemisinin resistance in severe malaria (CHARISMA): SMAART sub-study in Uganda
REFNo: HS3161ES

1. To characterize and compare the ex vivo drug susceptibilities of P. falciparum isolates from patients with and without severe malaria.
2. To characterize and compare genomic features of P. falciparum isolates infecting patients with and without severe malaria.
3. To assess whether presence of artemisinin partial resistance is associated with poor clinical outcomes in severe malaria patients.
4. To assess whether prior receipt of antimalarials is associated with artemisinin partial resistance in severe malaria patients

 Uganda 2024-02-09 23:26:22 2027-02-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Assessment of Feasibility, Acceptability and Effectiveness of Training Village Health teams On Household Air Pollution Using Teach BOX
REFNo: HS3723ES

1. To assess the feasibility and acceptability of training Village Health Teams on Household Air Pollution using TeachBox in Jinja district Uganda.
2. To assess the effectiveness of training Village Health Teams on Household Air Pollution using TeachBox in Jinja district Uganda
 Uganda 2024-02-09 23:25:22 2027-02-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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