Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Bruce Kirenga J
ID: UNCST-2019-R001460
Strategies for resolving the gap in Adolescent TB care in Uganda: A pilot cluster randomized-controlled trial
REFNo: HS1042ES

1.To develop an adolescent friendly TB screening package in Ugandan health facilities.
2.To evaluate the effectiveness of an adolescent friendly screening package for TB in Ugandan health facilities
3.To ascertain the cost effectiveness of rolling out an adolescent friendly TB screening intervention in Ugandan health facilities

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Immaculate  Nankya Lillian
ID: UNCST-2020-R014784
Validation of an Antigen ELISA based assay for the detection of SARS-CoV-2 RNA: A COVID-19 rapid diagnostic test method
REFNo: HS1103ES

• Demonstrate the ability of the AirJump ESP Platform, a simplified RNA isolation method to extract SARS COV-2 RNA from patient samples
• Evaluate an ELISA based assay to detect RNA converted to cDNA and bound to biotin labeled primers
• Assess accuracy of the ELISA assay in detecting SARS-CoV-2 from paired Nasal Pharyngeal swabs and saliva samples collected from COVID-19 positive and negative participants.
• Determine the Reproducibility of the Antigen ELISA Assay

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
JOSEPH SSUUNA
ID: UNCST-2024-R016102
Epidemiology and impact of HIV, NCD and urbanization syndemic in Africa.
REFNo: HS1188ES

Aim 1: Characterize HIV-related and -unrelated risk factors for cardiopulmonary non-communicable diseases (CP-NCDs) in a novel Rural-to-Urban (R2U) African cohort.

Aim 2: Characterize the impact of air pollution and moderating effects of HIV on cardiopulmonary clinical outcomes among R2U migrants.

Aim 3: Assess HIV and CP-NCDs health services utilization patterns among R2U migrants and design an integrated HIV/CP-NCD intervention.

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
CHRISTOPHER  OPIO KENNETH
ID:
Knowledge, Attitudes and Practice of doctors in Uganda regarding screening, diagnosis and management of colorectal cancer.
REFNo: HS1198ES

To improve early detection, screening and the management of colorectal cancer in Uganda,
Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Amanda Murungi Eunice
ID:
Comparing the two transition feeding approaches in management of severe acute malnutrition among children 6-59 months: a randomized controlled trial (RCT)
REFNo: HS1200ES

To compare the effectiveness and outcomes of two transition phase feeding approaches (RUTF supplemented with F75 and RUTF only) children 6-59 months hospitalized with severe acute malnutrition in Mulago National Referral Hospital
Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Degree Award
Yahaya Gavamukulya
ID: UNCST-2019-R001017
EVALUATION OF THE ANTI-SARS-CoV-2 ACTIVITY OF COMPOUNDS FROM Tephrosia linearis, Zanthoxylum chalybeum and Albizia coriaria AND FORMULATION OF HERBAL PRODUCT(S) FOR MANAGEMENT OF COVID-19
REFNo: HS1222ES

The general objective
To evaluate the antiviral potential of Tephrosia linearis, Zanthoxylum chalybeum and Alibizia coriaria, against SARS-CoV-2 and formulate herbal product(s) for management of COVID -19.

Specific objectives
i. To determine the in vitro anti-SARS‐CoV‐2 activity of the three selected medicinal plants in singular and in combination using SARS‐CoV‐2 infected mammalian cell lines (VeroE6).
ii. To determine the cytotoxicity and acute toxicity of the active medicinal plant(s) on mammalian cell lines (VeroE6) and swiss albino mice respectively.
iii. To determine the effects of the extracts on the immunological profile of cell lines
iv. To formulate and evaluate herbal product (s) from the most active medicinal plants for management of COVID-19.

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Kelly Mannion Ray
ID:
Understanding how variation in food effort and intake correlate with tool use in Bugoma Forest Chimpanzees
REFNo: NS155ES

To understand the potential drivers of tool use and how ecology plays a role
USA 2021-03-15 2024-03-15 Natural Sciences Degree Award
Allen Kabagenyi
ID:
Adolescent Motherhood, Vulnerability Assessment and Newborn care practices, in Eastern Uganda (AMNEP)
REFNo: HS1248ES

The general objective of this study is to develop and test adolescent motherhood vulnerability assessment tool and to examine the knowledge, behavioral practices and perceptions of maternal and new born care among adolescent mothers in Luuka District.
Specific objectives
1. To examine the knowledge levels and awareness of maternal and newborn care among adolescent mothers and the community in Luuka District
2. To develop and test a community based adolescent mothers Vulnerability Assessment Tool
3. To assess the pre and postnatal maternal and newborn care practices and among adolescent mothers and the community in Luuka District
4. To explore the perceptions, vulnerability risk and barriers to unborn and newborn care management among adolescent mothers and the community in Luuka District

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Degree Award
Sebastian Linnemayr
ID: UNCST-2021-R012696
INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)
REFNo: HS1286ES

We propose to test INMIND in a pilot, 3-arm randomized controlled trial (RCT) in Uganda with two intervention groups. All participants (including in the control group) will receive information about the importance of behavioral routines, as is part of the standard adherence counseling for treatment initiators, and create personalized ART adherence anchoring strategies. In the first intervention group, participants will additionally receive text messages to keep adherence and their anchoring strategy salient. In the second group, we add small incentives awarded conditionally on taking ART pills within a time window that corresponds to participants’ personalized anchoring strategy to increase the immediate rewards of adherence.

The Specific Aims
1.Develop the intervention using the ADAPT-ITT framework and evaluate the feasibility and acceptability of INMIND.
2: Test the preliminary effectiveness of the intervention, including the relative effectiveness of two different implementation approaches
3. Collect data in preparation for a subsequent R01 application
USA 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Dickens Akena Howard
ID: UNCST-2019-R000179
The effect of psycho-education on clinical outcomes among patients with a first episode psychosis in central Uganda - A pilot randomized control trial
REFNo: HS1026ES

The study objectives are to (a) Conduct formative work and develop a manual for delivering psycho-education messages by Village Health Team (VHTs) members to individuals with first episode psychosis (FEP) and their families in central Uganda. (b) Examine the efficacy of psycho-education on symptom severity, stigma and retention in care. (c) Document feasibility and acceptability of implementing this intervention as well as barriers to its implementation
Uganda 2021-03-12 2024-03-12 Medical and Health Sciences Non-degree Award
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