Grace Ndeezi
ID: UNCST-2019-R001802
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A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease
IMR-SCD-301
REFNo: HS1130ES
Primary Objectives
To evaluate the HbF response to IMR-687 versus placebo
To evaluate the safety of IMR-687 versus placebo
Secondary Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
To evaluate the effect of IMR-687 versus placebo on indices of WBC adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of VOCs
To evaluate the effect of IMR-687 versus placebo on quality of life (QoL) measures
Pharmacokinetic Objectives
To evaluate the PK of IMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in RBC characteristics and total Hb
To evaluate the effect of IMR-687 versus placebo on renal function
To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk
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Uganda |
2021-01-21 |
2024-01-21 |
Medical and Health Sciences |
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Non-degree Award |
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FRED SEMITALA COLLINS
ID: UNCST-2020-R014096
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Strengthening Integrated Screening for TB and COVID19 in Kampala, Uganda
REFNo: HS1152ES
The overall goal is to establish the acceptability, feasibility and potential for scaling up the use of COVID19-TB Screening algorithm at Kiruddu National Referral Hospital.
Specific objectives
(1) To explore the perspectives of healthcare providers on the integration of COVID19 and TB screening at Kiruddu National referral Hospital.
(2) To determine the effect of the COVID19-TB algorithm on the proportion of patients screened for TB at Kiruddu National Referral Hospital over a 4-month period.
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Uganda |
2021-01-21 |
2024-01-21 |
Medical and Health Sciences |
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Non-degree Award |
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Kirsten Beyer M
ID: UNCST-2021-R013472
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Assessing Health Professionals’ Knowledge, Perspectives and Practices Regarding HPV and Cervical Cancer Prevention and Control among Women Living with Human Immunodeficiency Virus Infection in Uganda
REFNo: HS782ES
General Objective
The proposed study seeks to examine the role that health professionals play in influencing WHIVs’ perceptions of HPV and cervical cancer and their associated health behaviors in Uganda.
Specific Objective
Interview public health and health care professionals (including clinicians, nurses, counselors, other/public health professionals, and community health workers/village health teams) to examine the following:
1. Knowledge regarding how HPV or cervical cancer impacts WHIV, which populations are impacted most, and frequency of HPV vaccination, screening and treatment.
2. Perspectives regarding barriers/facilitators of cervical cancer and HPV prevention and treatment among WHIV.
3. Practices regarding HIV professionals’ work in cervical cancer and HPV.
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USA |
2021-01-20 |
2024-01-20 |
Medical and Health Sciences |
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Non-degree Award |
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Emmanuel Sendaula
ID: UNCST-2020-R014767
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Clinical profile of HIV-infected patients receiving a holistic approach of care model attending Reach Out Mbuya facilities in Kampala district
REFNo: HS903ES
Main Objective
To describe the clinical profile and the factors associated with viral suppression status among HIV-infected patients receiving a holistic approach of care model in Kampala District.
Specific objectives
1. To describe the clinical profile of HIV-infected patients receiving a holistic model of care in Kampala District.
2. To determine the socio-demographic factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.
3. To determine the clinical factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.
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Uganda |
2021-01-20 |
2024-01-20 |
Medical and Health Sciences |
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Non-degree Award |
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FRANK MULINDWA
ID:
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Glucose metabolism changes in HIV patients starting dolutegravir based antiretroviral treatment in Uganda
REFNo: HS1032ES
1) To determine the incidence and predictors of diabetes at week 48 in Ugandan HIV patients initiating dolutegravir.
2) To describe temporal changes in insulin resistance, pancreatic beta cell function, body mass index and blood glucose in Ugandan HIV patients on dolutegravir for 48 weeks.
3) To determine the effect of DTG on intracellular magnesium levels in Ugandan HIV patients on dolutegravir for 48 weeks.
4) To compare insulin kinetics in patients who develop diabetes while on dolutegravir and those that don’t in Ugandan HIV patients.
5) To determine the difference in DTG pharmacokinetics in HIV positive patients with incident hyperglycemia and those without in Ugandan HIV patients.
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Uganda |
2021-01-20 |
2024-01-20 |
Medical and Health Sciences |
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Non-degree Award |
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Proscovia Nabunya
ID: UNCST-2019-R000970
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SAY NO TO STIGMAâ€: Making Mental Health Visible Among School-Going Children in Rural Uganda
REFNo: SS637ES
The objective of this proposed study is to develop a set of new age-appropriate, culturally relevant signage and messaging around mental health and stigma for this study. The visual solutions will be developed through a set of extensive hands-on creative workshops and focus groups with children as well as school administrators and teachers working in one primary school in the Masaka region of Uganda. After visual and message development, the visuals will be presented to a different group of students within the school to gather feedback on their effectiveness and clarity in portraying mental health and stigma.
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Uganda |
2021-01-20 |
2024-01-20 |
Social Science and Humanities |
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Non-degree Award |
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Polycarp Komakech
ID:
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Incentivizing Action to Reduce Air Pollution and Susceptibility to COVID-19
REFNo: SS667ES
The main objective is to investigate a number of practical and scalable strategies to reduce waste burning through voluntary behavioral change and thereby reduce the exposure of residents to harmful air pollution.
The specific objectives are (a) to investigate whether the provision of information about the link between air pollution and the chances of contracting and dying from COVID-19 can spur action to stop waste burning, (b) to test the efficacy of a novel design where social competition that is not imposed top-down but is organized horizontally can help leaders to organize communities for positive action towards reducing waste burning.
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Uganda |
2021-01-20 |
2024-01-20 |
Social Science and Humanities |
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Non-degree Award |
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SHAFIC MAKUMBI
ID:
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Voluntary Consent to Research on Children: A sub-study of the CHAPAS-4 and ODYSSEY Trial
REFNo: SS677ES
1.2 Overall objective
The aim of this study is to assess parental perception of voluntariness of consent in Paediatric HIV clinical trials and associated factors.
1.4 Specific objectives
1.4.1. To describe the process in which parents and guardians consent for their children to be enrolled in two pediatric HIV Clinical Trials.
1.4.2. To measure the level of perceived voluntariness of consent using the voluntariness ladder
1.4.3. To identify the social demographic, situational and external control factors that influence parental perception of the voluntariness of their consent
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Uganda |
2021-01-20 |
2024-01-20 |
Social Science and Humanities |
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Degree Award |
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Rhoda Wanyenze
ID: UNCST-2021-R013352
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Impact of Masks on Community Spread of COVID-19: Evidence from
Uganda
REFNo: HS1124ES
2.1 General Objective
The aim of this study is to provide policy makers with the first population-based estimate of the extent to which face coverings reduce the spread of SARS-CoV-2. We also intend to provide evidence to the Ministry of Health in Uganda (and public health officials more generally) with evidence about effective communication and education tools for increasing the proper use of masks in the general population.
2.2 Specific Aims
The specific objectives of our study are as follows:
Aim 1: To test whether free mask distribution increases the proper use of masks in intervention communities
Aim 2: To test whether combining free mask distribution with education and communication about masks and COVID-19 increases the proper use of masks in intervention communities Aim 3: To evaluate whether increased mask use affects seroprevalence of SARS-CoV-2
Aim 4: To evaluate potential spillovers, or whether higher mask use in intervention communities affect mask use and probability of infection in neighboring non-intervention communities
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Uganda |
2021-01-20 |
2024-01-20 |
Medical and Health Sciences |
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Non-degree Award |
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Kamya Moses
ID: UNCST-2020-R014203
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COVID-19 sydromic and sero-surveillance using established Uganda malaria surveillance sites.
REFNo: HS1125ES
To establish COVID-19 syndromic surveillance through existing Uganda Malaria Surveillance sites by collecting additional data on COVID-19 specific symptoms.
To perform enhanced surveillance for COVID-19 and assess for serological evidence of past infection with SARS-CoV-2 in patients, in order to estimate disease burden and map the geographic spread of the epidemic.
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Uganda |
2021-01-20 |
2024-01-20 |
Medical and Health Sciences |
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Non-degree Award |
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