Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Moses  Mulumba
ID: UNCST-2021-R013832
An Ethnographic Analysis of the Right to Health Based Monitoring of and Advocacy for the Progressive Realization of Universal Health Coverage in Uganda
REFNo: SS793ES

Study Goal

The goal of the project is to establish the extent to which OPERA plus PAR supports the localization of the right to health

Specific objectives
To build the capacity of civil society and influential academia on the use of the OPERA framework

To explore the current levels of enjoyment of the right to health in Uganda

To assess state commitments and efforts to fulfill the right to health including the use of adequate resources

To examine constraints to the state's compliance to fulfill the right to health.
Uganda 2021-06-14 2024-06-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
Establishing the prevalence of COVID19 infection among patients attending TB clinic, and the effect of COVID19 on TB clinical care in Kampala
REFNo: HS1304ES

Primary objective: 1. To determine the prevalence of COVID-19 infection amongst adult patients attending TB clinics Secondary objectives 1. To determine the prevalence of previous COVID-19 infection amongst adult patients attending TB clinics 2. To explore the experiences of patients attending TB clinic during the COVID-19 pandemic 3. To explore the experiences of healthcare workers in relation to TB care provision during the COVID-19 pandemic
Uganda 2021-06-11 2024-06-11 Medical and Health Sciences Non-degree Award
Arthur Bagonza
ID:
EFFECTIVENESS OF SUPPORT GROUPS ON IMPROVING LIVELIHOOD OF PEOPLE WITH ALBINISM IN UGANDA
REFNo: SS882ES

1. To map and profile all PWA and service providers of PWA in three regions (Northern, Western and Central) Uganda.

2. To construct a model of group support for PWA in three regions of Uganda based on views of PWA.

3. To determine the effectiveness of support groups on increasing access to services and inclusion of People with Albinism in mainstream development processes in Uganda.

4. To explore perceptions of key stakeholders on the use of support groups in increasing access to services and inclusion in mainstream development processes for PWA in Uganda


Uganda 2021-06-11 2024-06-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
Romeo Gichohi wahome
ID:
EFFECTIVENESS OF IMPROVISED CARDBOARD SPLINTS AS AN ALTERNATIVE TO PLASTER OF PARIS IN THE EMERGENCY TREATMENT OF LOWER LIMB FRACTURES
REFNo: HS1357ES

General Objective
1. To determine whether improvised cardboard
splints are a viable effective
alternative to plaster of Paris splints
for lower limb fractures in Mbarara
Regional and Referral
Hospital.
Specific Objectives
1. To compare the clinical effectiveness of immobilization between improvised cardboard
and plaster of Paris splint in lower limb fractures.
2. To compare the time and resource costs between improvised cardboard and plaster of
Paris in splinting of lower limb fractures.
Kenya 2021-06-11 2024-06-11 Medical and Health Sciences Non-Clinical Trial Degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
Accelerating Anti-Tick Vaccine Production Using Computational Approaches and Validation with An In-Vivo Model
REFNo: NS165ES

The specific objectives of this study will be to;
i.Create an open access queryable database of candidate anti-tick vaccine protein from I. scapularis proteome
ii.Identify single and chimeric antigenic anti-tick peptides basing on tick-specific amino acid sequences
iii.Evaluate the immunogenicity of five of the most promising antigenic single and chimeric anti-tick peptides in a laboratory animal [three months New Zealand rabbits] model
Uganda 2021-06-10 2024-06-10 Natural Sciences Non-degree Award
Jerome  Kabakyenga Kahuma
ID: UNCST-2021-R013729
Smart discharges to improve post-discharge health outcomes in children below 6 months old
REFNo: SS855ES

To determine the effectiveness of a Smart Discharge program on post-discharge health seeking behavior and mortality among children under 6 months of age admitted with a proven or suspected infection.
Uganda 2021-06-08 2024-06-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Musa Sekikubo
ID: UNCST-2021-R014010
A multi-Centre, randomised, placebo controlled, double-blind, parallel group study to evaluate the safety, tolerability and immunogenicity of two doses of Group B Streptococcus vaccine (GBS-NN/NN2) in women who are pregnant and living with HIV and women who are pregnant and do not have HIV
REFNo: HS1390ES

Objectives
Primary Objectives:
Safety:
To evaluate the safety and tolerability of the GBS-NN/NN2 vaccine in women living with HIV and women without HIV and their newborn babies from vaccination up to delivery/birth.
Immunological:
To compare the transfer rate of vaccine- specific immunoglobulin G (IgG) antibody concentrations from the mother to the baby at birth in women living with HIV with the transfer rate in women without HIV. This endpoint will be used to determine the sample size calculation.
Secondary Objectives
Safety: The safety and tolerability of the GBS-NN/NN2 vaccine in the mother and baby over the first 6 months post-partum, as assessed at 6 months of age.
Immunological: The secondary immunological objectives are:
• To compare IgG antibody responses, specific to the GBS-NN/NN2 vaccine, induced by the first and second vaccine doses over time in pregnant women living with HIV and pregnant women without HIV.
• To evaluate the concentration of IgG antibodies specific for the GBS-NN/NN2 vaccine up to 6 months post-delivery in the mother and baby in women with and without HIV.
• To determine the concentrations of vaccine specific IgG to GBS-NN/NN2 in cord blood at delivery in babies born to women with and without HIV.
Exploratory Objectives
• To compare between groups the isotype composition of the vaccine specific antibodies; in particular IgG and IgA as well as their subclasses, i.e. IgG1-4, IgA1 and IgA2 in maternal and cord blood.
• To compare between groups the vaccine specific IgG antibodies to Rib, Alp1, Alp2 and AlpC, GBS-NN and GBS-NN2 in maternal and cord blood.
• To compare between groups the functional activity of vaccine specific antibodies from cord blood in an opsonophagocytic killing assay (OPkA) and other in vitro assays in selected samples.

Uganda 2021-06-08 2024-06-08 Medical and Health Sciences Clinical Trial Non-degree Award
Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
Using Recency Assays to estimate incident HIV infections among Adolescent Girls and Young Women in Hoima and Mityana/Mubende Districts, Uganda Version 2.0 dated 14 April 2021: Gilead Protocol Number :CO-US-985-6117(eStimating hIv incidEnce amoNg Agyw (SIENA) Study)
REFNo: HS1439ES

Primary Objective
i) To estimate the proportion of incident recent HIV infections among AGYWs aged 16-25 years in Hoima and Mityana/ Mubende districts, Uganda.
Secondary Objective
ii) To compare HIV incidence estimated using the Asanté™ HIV-1 Rapid Recency POC kit with that obtained using the Sedia™ HIV-1 LAg-Avidity EIA and the Abbott ARCHITECT HIV Ag/Ab Combo assays.
Uganda 2021-06-08 2024-06-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sifiso Lukhele Mbhekeni
ID:
GENOMIC EVIDENCE OF THE ROLE OF COMMUNICATION SIGNALS IN MEDIATING REPRODUCTIVE ISOLATION AT CONTACT ZONES
REFNo: NS117ES

1. Identify the threshold of variation in communication signals above which species boundaries are maintained.
2. Determine the importance of divergence time and time since secondary contact on levels of interbreeding.
South Africa 2021-06-04 2024-06-04 Natural Sciences Non-Clinical Trial Degree Award
Irene Ayakaka
ID:
Feasibility of integrating Leprosy systematic contact follow up and Post Exposure Prophylaxis (PEP) into the Routine Leprosy Control Program in Uganda: A case study of Arua and Koboko districts
REFNo: HS1046ES

Objectives
The overall goal of the study will be to contribute to the elimination of leprosy in Uganda and to describe how best to carry out PEP with Single Dose Rifampicin (SDR) in Uganda.

Specific objectives
1. To assess the feasibility of leprosy post exposure prophylaxis in Arua and Koboko; two high burden districts in Uganda
2. To administer single dose rifampicin to eligible contacts of leprosy patients at their homes
3. To assess the factors associated with successful contact investigation for Leprosy in Arua and Koboko districts
4. To describe opportunities and synergies that can be leveraged in the districts to integrate contact investigation with other on-going community-based activities

Secondary Objectives
1. To perform leprosy data verification in Arua and Koboko districts in Uganda.
2. To assess acceptability of leprosy-contact investigation in households and in the community in Arua and Koboko districts.
3. To document the contribution of contact tracing to early leprosy diagnosis and prevention of grade2 disabilities

Uganda 2021-06-04 2024-06-04 Medical and Health Sciences Non-degree Award
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