Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Harriet Akello
ID: UNCST-2021-R013785
Relationship between mental health and health work functioning during the covid-19 pandemic in Uganda
REFNo: HS1407ES

To identify connection between depression, anxiety and stress with health functioning during COVID-19 pandemic ,To determine prevalence of depression, anxiety and stress among healthcare workers during COVID-19 pandemic ,To determine relationship between mental health and health work functioning during covid-19 pandemic in Uganda,
Uganda 2021-06-24 2024-06-24 Medical and Health Sciences Non-Clinical Trial Degree Award
Jackson Amone
ID:
A usability study on the knowledge and practice of a novel Medium Pressure Reservoir oxygen prototype in Uganda
REFNo: HS1497ES

Phase 2: The primary objective of the usability study is to gather clinical and BMET feedback on the use of the MPR with patients of diverse characteristics and its ability to function through power interruptions &/or in situations where there is high patient volume,Phase 1: The primary objective of the simulated use summative evaluation is to gather evidence of safe and effective use of the device to support regulatory filing.,
Uganda 2021-06-24 2024-06-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JUDITH NASSAAZI
ID: UNCST-2023-R007664
LONG TERM EFFECTS OF ORTHOPAEDIC INJURY ON PATIENTS IN UGANDA
REFNo: HS1047ES

General Objective
To determine long-term effects of orthopaedic injury on patients in Uganda 8years following the injury.
Specific Objectives
• To determine the long-term economic impact of tibia and femur fractures on patients and their families
• To determine the health related quality of life of the patients who sustained tibia and femur fractures 8years following their injuries.

Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-degree Award
Kaijuka Benson
ID:
CORPORATE SOCIAL RESPONSIBILITY AND FINANCIAL PERFORMANCE OF SAVINGS AND CREDIT COOPERATIVE SOCIETIES IN UGANDA. A CASE STUDY OF MITOOMA DISTRICT, WESTERN UGANDA
REFNo: SS668ES

The research will specifically tackle the following research objectives; to establish the level of investment made in philanthropic involvement activities on the financial performance of SACCOs in Mitooma district, Western Uganda, to examine the role of investment made in ethical involvement activities on the financial performance of SACCOs in Mitooma district, Western Uganda and to find out how of investment made in economic involvement activities on the financial performance of SACCOs in Mitooma district, Western Uganda.
Uganda 2021-06-23 2024-06-23 Social Science and Humanities Degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
Characterizing STIs and antimicrobial resistance in men with urethral discharge syndrome in Uganda
REFNo: HS1338ES

Primary:
• To assess and compare the prevalence of pharyngeal STIs (gonorrhea, chlamydia) in relation to urogenital STIs, characterize the antimicrobial resistance (AMR) profile of pharyngeal and urogenital gonorrhea, and identify demographic and behavioral risk factors associated with STIs at different anatomical sites. STIs and AMR profiles will be determined using a combination of traditional laboratory methods (cultures) and molecular approaches, including, but not limited to nucleic acid amplification tests (NAATs).

Secondary:
• To assess acceptability of self-collected tests in men with UDS and pharyngeal testing for STIs in Uganda.
• To estimate the prevalence of 4 STIs in a population of men with UDS caused by the following pathogens: Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), Trichomonas vaginalis (TV), and Mycoplasma genitalium (MG) using NAATs.
• To estimate the proportion of STIs (CT/NG/MG) at multiple anatomical sites (penis and pharynx (throat))
• To assess the prevalence of HIV and syphilis, and compare HIV result to self-reported HIV status.
• To explore socio-demographic, behavioural and clinical factors associated with positive STI diagnosis and antimicrobial-resistant infections.
• To compare the antimicrobial susceptibility profiles of pharyngeal and urogenital NG isolates recovered the same participant(s).
• To compare the distribution of AMR markers in pharyngeal and urogenital NG.
• To determine the effectiveness of treatment for urogenital NG infections on pharyngeal infections.
• To explore the feasibility of detecting NG and AMR markers using a single-cell molecular approach directly from pharyngeal samples.
• To collect pharyngeal samples for future metagenomics analysis to explore the role of microbiome on pharyngeal NG infections and AMR.
• To explore the role of commensal Neisseria species on the development of AMR in NG.
To provide samples to be added to the Johns Hopkins International STI biorepository at Johns Hopkins School of Medicine, Baltimore, MD USA.


UK 2021-06-23 2024-06-23 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Drug Interactions between Dolutegravir (DTG) and escalating-doses of Rifampicin (RIF) Study
REFNo: HS1376ES

The secondary objectives of the trial are to determine the safety and tolerability of the DTG/RIF combination, the PK of RIF, induction of PgP and CYP3A4 and effect of DTG on appetite,Primary Objective The primary objective of the study is to determine changes to the PK parameters of DTG when administered with standard, medium and high doses of RIF in HIV-negative, TB-monoinfected participants coming to the end of continuation TB therapy with standard doses of RIF and INH over a 10 week period,
Nigeria 2021-06-23 2024-06-23 Medical and Health Sciences Clinical Trial Non-degree Award
Mark Okwir
ID: UNCST-2021-R013417
Meningitis: Burden, Causes, Pathogenesis and Prevention in Rural Northern Uganda
REFNo: HS1420ES

Aim 1: To prospectively collect data on all patients with meningitis and meningitis symptoms who were admitted to LRRH to assess etiologies and pathogenesis of meningitis using modern diagnostic testing not previously available and evaluate the causes, burden of disease, and outcomes of meningitis. Aim 2: To perform CrAg screening of 10,000 HIV-positive patients to determine the prevalence of cryptococcal antigenemia and conduct a case control study to compare outcomes among CrAg-positive patients and CD4-matched CrAg-negative controls.
Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Olivia Kituuka
ID:
HLA TYPING OF 5 MAJOR ETHNIC GROUPS IN UGANDA AND KNOWLEDGE AND ATTITUDES ABOUT ORGAN DONATION AND TRANSPLANTATION AMONG HEALTH CARE WORKERS, HEALTH POLICY MAKERS AND THE URBAN POPULATION IN UGANDA.
REFNo: HS1447ES

To determine the prevalence of Human Leucocyte Antigen (HLA) sub-types among individuals from five largest ethnic groups in Uganda. ,To assess Knowledge Attitudes and perceptions among urban populations and key stakeholders in Kampala city on organ transplantation in Uganda,
Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Perspectives of stakeholders in research on post-trial access to investigative products: The Post Trial Access (PTA) Study
REFNo: HS1449ES

General Objective
To explore the understanding and perspectives of key research stakeholders about the provision of post-trial access in clinical trials conducted in Uganda.
Specific Objectives
1.To explore research stakeholders’ knowledge of post-trial access in Uganda

2.To explore research stakeholders’ perspectives about post-trial access in clinical trials conducted in Uganda.

3.To describe the post-trial access practices and or experiences among key research stakeholders in Uganda

Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shelley Jones
ID:
Women to Women Research for Economic Empowerment in Uganda: A Participatory Action Research Project
REFNo: SS710ES

The goal of this project is to engage women in Uganda in conducting research that investigates successful community-based, women-led entrepreneurial initiatives in order to inventory, analyze, and report on best practices and lessons learned that will contribute to knowledge that can be accessed by other women who are interested in entrepreneurship. The objectives are to support the participants to 1) develop research skills that will enable them to gain information, knowledge, and insights into how to develop thriving, sustainable initiatives that provide sufficient income to attain and sustain a reasonable standard of living; 2) create and disseminate knowledge around issues directly concerned with women’s empowerment through entrepreneurship
Canada 2021-06-21 2024-06-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
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