Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Achilles Katamba
ID: UNCST-2019-R000540
Understanding the trajectories of individuals in Uganda with trace M. tuberculosis nucleic acid in sputum- The TURN-TB study (Trace Ultra Result iNsight in TB screening)
REFNo: HS1177ES

1.To characterize baseline evidence for current or past TB disease and infection among individuals with Ultra-trace-positive sputum.
2.To longitudinally evaluate the incidence of TB and the dynamics of molecular, imaging, and immunological findings among individuals with trace-positive Ultra but no active TB at study entry.
3.To quantitatively and qualitatively explore the implications of trace-positive results and associated patient trajectories for active TB case finding strategies.

Uganda 2021-03-16 2024-03-16 Medical and Health Sciences Non-degree Award
Stephen  Ojiambo Wandera
ID: UNCST-2021-R012147
Parent-Child Communication on Sexual and Reproductive Health in border districts of Eastern Uganda
REFNo: SS748ES

The aim of the study is to assess parents’ knowledge, attitudes, and practices (KAP) and preferred approaches to PCC on sexual and reproductive health in eastern Uganda. Specific objectives are:
1. To assess parents’ knowledge, attitudes, and practices about parent-child communication about sexual and reproductive health in eastern Uganda.
2. To determine the prevalence and determinants of PCC on SRH in eastern Uganda using survey data.
3. To examine the facilitators and barriers of PCC on SRH using qualitative data among parents in eastern Uganda.
4. To identify parents’ and children’s preferred approaches to PCC on SRH in eastern Uganda.

Uganda 2021-03-16 2024-03-16 Social Science and Humanities Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Strategies for resolving the gap in Adolescent TB care in Uganda: A pilot cluster randomized-controlled trial
REFNo: HS1042ES

1.To develop an adolescent friendly TB screening package in Ugandan health facilities.
2.To evaluate the effectiveness of an adolescent friendly screening package for TB in Ugandan health facilities
3.To ascertain the cost effectiveness of rolling out an adolescent friendly TB screening intervention in Ugandan health facilities

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Immaculate  Nankya Lillian
ID: UNCST-2020-R014784
Validation of an Antigen ELISA based assay for the detection of SARS-CoV-2 RNA: A COVID-19 rapid diagnostic test method
REFNo: HS1103ES

• Demonstrate the ability of the AirJump ESP Platform, a simplified RNA isolation method to extract SARS COV-2 RNA from patient samples
• Evaluate an ELISA based assay to detect RNA converted to cDNA and bound to biotin labeled primers
• Assess accuracy of the ELISA assay in detecting SARS-CoV-2 from paired Nasal Pharyngeal swabs and saliva samples collected from COVID-19 positive and negative participants.
• Determine the Reproducibility of the Antigen ELISA Assay

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
JOSEPH SSUUNA
ID: UNCST-2024-R016102
Epidemiology and impact of HIV, NCD and urbanization syndemic in Africa.
REFNo: HS1188ES

Aim 1: Characterize HIV-related and -unrelated risk factors for cardiopulmonary non-communicable diseases (CP-NCDs) in a novel Rural-to-Urban (R2U) African cohort.

Aim 2: Characterize the impact of air pollution and moderating effects of HIV on cardiopulmonary clinical outcomes among R2U migrants.

Aim 3: Assess HIV and CP-NCDs health services utilization patterns among R2U migrants and design an integrated HIV/CP-NCD intervention.

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
CHRISTOPHER  OPIO KENNETH
ID:
Knowledge, Attitudes and Practice of doctors in Uganda regarding screening, diagnosis and management of colorectal cancer.
REFNo: HS1198ES

To improve early detection, screening and the management of colorectal cancer in Uganda,
Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Amanda Murungi Eunice
ID:
Comparing the two transition feeding approaches in management of severe acute malnutrition among children 6-59 months: a randomized controlled trial (RCT)
REFNo: HS1200ES

To compare the effectiveness and outcomes of two transition phase feeding approaches (RUTF supplemented with F75 and RUTF only) children 6-59 months hospitalized with severe acute malnutrition in Mulago National Referral Hospital
Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Degree Award
Yahaya Gavamukulya
ID: UNCST-2019-R001017
EVALUATION OF THE ANTI-SARS-CoV-2 ACTIVITY OF COMPOUNDS FROM Tephrosia linearis, Zanthoxylum chalybeum and Albizia coriaria AND FORMULATION OF HERBAL PRODUCT(S) FOR MANAGEMENT OF COVID-19
REFNo: HS1222ES

The general objective
To evaluate the antiviral potential of Tephrosia linearis, Zanthoxylum chalybeum and Alibizia coriaria, against SARS-CoV-2 and formulate herbal product(s) for management of COVID -19.

Specific objectives
i. To determine the in vitro anti-SARS‐CoV‐2 activity of the three selected medicinal plants in singular and in combination using SARS‐CoV‐2 infected mammalian cell lines (VeroE6).
ii. To determine the cytotoxicity and acute toxicity of the active medicinal plant(s) on mammalian cell lines (VeroE6) and swiss albino mice respectively.
iii. To determine the effects of the extracts on the immunological profile of cell lines
iv. To formulate and evaluate herbal product (s) from the most active medicinal plants for management of COVID-19.

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Kelly Mannion Ray
ID:
Understanding how variation in food effort and intake correlate with tool use in Bugoma Forest Chimpanzees
REFNo: NS155ES

To understand the potential drivers of tool use and how ecology plays a role
USA 2021-03-15 2024-03-15 Natural Sciences Degree Award
Allen Kabagenyi
ID:
Adolescent Motherhood, Vulnerability Assessment and Newborn care practices, in Eastern Uganda (AMNEP)
REFNo: HS1248ES

The general objective of this study is to develop and test adolescent motherhood vulnerability assessment tool and to examine the knowledge, behavioral practices and perceptions of maternal and new born care among adolescent mothers in Luuka District.
Specific objectives
1. To examine the knowledge levels and awareness of maternal and newborn care among adolescent mothers and the community in Luuka District
2. To develop and test a community based adolescent mothers Vulnerability Assessment Tool
3. To assess the pre and postnatal maternal and newborn care practices and among adolescent mothers and the community in Luuka District
4. To explore the perceptions, vulnerability risk and barriers to unborn and newborn care management among adolescent mothers and the community in Luuka District

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Degree Award
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