Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Irene Kahimakazi
ID:
Prevalence and factors associated with gestational diabetes mellitus among women attending antenatal care at Mbarara Regional Referral Hospital
REFNo: SS854ES

1. To determine the prevalence of gestational
diabetes mellitus among women attending antenatal
care clinic at Mbarara Regional Referral
Hospital South Western Uganda
2. To establish the factors associated with
gestational diabetes mellitus among women
attending antenatal care clinic at
Mbarara Regional Referral Hospital, south
western Uganda

 Uganda 2021-05-27 2024-05-27 Social Science and Humanities Non-Clinical Trial Degree Award
Phocas Nyandwi -
ID:
Effect of Firm Financial Strength Factors on Income Retention of General Insurers in East Africa
REFNo: SS829ES

To determine the moderating effect of firm size on the relationship between firm financial distress factors and income retention of General insurers in East Africa,To establish the effect of earnings volatility on income retention of General insurers in East Africa,To assess how liquidity affects income retention of General insurers in East Africa,To investigate the effect of leverage on income retention of General insurers in East Africa,To determine the effect of capital adequacy on income retention of General insurers in East Africa,The general objective of the study is to investigate the effect of firm financial strength factors on income retention of General insurers in East Africa.,
 Burundi 2021-05-27 2024-05-27 Social Science and Humanities Non-Clinical Trial Degree Award
Simon Arunga
ID:
Management of microbial keratitis by private pharmacies in Uganda: a study of knowledge, attitude and practice
REFNo: HS1082ES

1. To determine the Knowledge of private pharmacy workers in Uganda in the management of Microbial Keratitis.
2. To describe the current practice for the management of Microbial Keratitis among private pharmacies in Uganda .
3. To explore ways to engage local pharmacy attendants to improve referral of patients with suspected Microbial Keratitis.

 Uganda 2021-05-25 2024-05-25 Medical and Health Sciences Non-degree Award
Dao Ho
ID:
Palliative Care Needs Assessment in the Emergency Department in Kiruddu Hospital
REFNo: SS796ES

Objective 1: Describe the prevalence of palliative care needs among emergency care patients. In order to assess this objective, we will conduct a palliative care needs survey with patients and health care workers in the Kiruddu Hospital Emergency Department. Objective 2: Explore and illustrate identifiable strengths as well as barriers to delivery of palliative care in the emergency department. In order to assess this objective, we will conduct one-on-one interviews with health care workers in the Emergency Department to further explore this topic.
 USA 2021-05-24 2024-05-24 Social Science and Humanities Non-Clinical Trial Degree Award
Gilbert Sendugwa Sendugwa
ID:
Towards Gender Balance: Understanding the Barriers and Solutions to Include Women-Led Businesses in East Africa
REFNo: SS712ES

This research will document policies and practices that exclude and include women-led businesses in Ethiopia, Kenya, Rwanda, Tanzania, and Uganda. Specifically, it aims to: - Understand the participation of and challenges facing women-led businesses and sole proprietorships in the five countries and regionally. - Identify measures being implemented or tested to improve fairness and inclusion of women in public procurement in the selected countries. - Assess the effectiveness of the measures put in place by specific governments to improve fairness and inclusion. - Recommend actionable changes to improve the current situation, based on the findings of the research and international best practice.
 Uganda 2021-05-21 2024-05-21 Social Science and Humanities Non-degree Award
Joannah Nalwoga
ID: UNCST-2024-R002651
 GROUP B STREPTOCOCCUS GENITAL COLONIZATION PATTERNS AMONG NON- PREGNANT WOMEN OF REPRODUCTIVE AGE AT KAWEMPE NATIONAL REFERRAL HOSPITAL
REFNo: HS728ES

General objective
To determine how colonization with GBS changes over time among non-pregnant women of reproductive age and how the changes correlate with the host immunity
Specific objectives
1. To describe how the GBS colonization status changes over a three months period among non-pregnant women who were uncolonized at baseline
2. To describe how the GBS colonization status changes over a three months period among non-pregnant women who were colonized at baseline

3. To determine whether the concentration of GBS IgG in serum correlates with the concentration of GBS IgG at the vaginal mucosa
4. To determine whether we can predict colonization from GBS IgG concentration in blood
5. To determine whether we can predict colonization from GBS IgG concentration in the vaginal mucosa

Uganda 2021-05-20 2024-05-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Hellen Kinyi Wambui
ID:
“Effect of varying ratios of dietary macronutrients on immune system function of Swiss albino mice”
REFNo: NS159ES

i. To assess the effects of varying macronutrient ratios on the nutrition status of Swiss albino mice
ii. To evaluate the effects of varying macronutrients ratios on leucocyte count, neutrophil adhesion and cytokine production of Swiss albino mice
iii. To determine the effects varying ratios of macronutrients on the production of pro-inflammatory (TNF-α, IFN-γ, IL-6) and anti-inflammatory (IL-10) cytokines in Swiss Albino mice challenged with lipopolysaccharide
iv. To evaluate the effects of varying macronutrients ratios on delayed -type hypersensitivity and antibody titers of Swiss albino mice challenged with cow red blood cells (CRBC)

 Kenya 2021-05-20 2024-05-20 Natural Sciences Degree Award
Enock Matovu
ID:
Development and Evaluation of Recombinant SARS-CoV-2 Spike and Membrane Protein-Based Sub-Unit Vaccines
REFNo: NS146ES

(i) To express recombinant subunits of the RBD region of the spike protein and the M protein
(ii) To characterize the humoral and cell mediated immune response generated by the RBD region and the M protein in mouse models
(iii) To determine the safety of the vaccine candidates in mouse models
(iv) To determine the efficacy of the potential candidate vaccine in mice

 Uganda 2021-05-20 2024-05-20 Natural Sciences Non-degree Award
Lena Mpalampa
ID:
FACTORS ASSOCIATED WITH PROVISION OF PHYSICAL ACTIVITY IN PRIMARY SCHOOLS IN MAKINDYE DIVISION IN KAMPALA
REFNo: SS768ES

5. To establish the school related factors associated with insufficient physical activity offered by the primary schools in Kampala during the school term?,4. To establish the class related factors associated with insufficient physical activity offered by the primary schools in Kampala during the school term?,3. To ascertain the teacher related factors associated with insufficient physical activity offered by the primary schools in Kampala during the school term?,2. To describe the various types of physical activity offered in primary schools in Kampala during the school term,1. To determine the proportion of schools offering sufficient time for PA among primary schools in Kampala during the school term,To analyse the factors associated with insufficient physical activity offered in primary schools in Makindye Division in Kampala during the school term.,
 Uganda 2021-05-20 2024-05-20 Social Science and Humanities Degree Award
Katelin Wilton
ID:
Supporting Families through Community Health Workers during COVID: A feasibility and acceptability study
REFNo: SS752ES

Main objective/ purpose
The main objective of this study is to better understand coping strategies of frontline health workers, feasibility and acceptability indicators of messaging success.
Specific Objectives
The specific objectives of this study are to:
• Understand frontline health workers perspective on their stress and psychosocial wellbeing
• Understand the feasibility and acceptability of behaviorally-informed SEL and MHPSS messaging targeted at adult and child clients delivered through frontline health workers
• Determine whether such messaging targeted at clients may also improve frontline health worker coping strategies

USA 2021-05-20 2024-05-20 Social Science and Humanities Non-degree Award
Paul Atherton
ID:
Girls’ Education Challenge Phase II: Continued Access and Learning during Covid-19 in GEC-II PEAS treatment and control schools in Uganda
REFNo: SS764ES

The final research questions for the proposed study are listed below:

a) How have PEAS sought to provide continued access to learning opportunities during school closures?
b) How are the PEAS supporting girls to return to school, and with what effects on girls’ access to learning opportunities?
c) How are PEAS identifying which girls are most at risk of not returning to school? Can a scorecard approach help projects identify those most at risk within projects in a cost-effective way?
d) How have girls’ learning levels changed during the COVID-19 period?

UK 2021-05-20 2024-05-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
WINNIE NAMBATYA
ID:
Evaluation of the complexity of medicine regimens and drug therapy problems among children with sickle cell anemia in Jinja Regional Referral Hospital: A prescription audit
REFNo: HS1299ES

• To determine the complexity of medication regimens prescribed to the patients with SCA.
• To determine the incidence of DTPs among medications prescribed to children with SCA.

 Uganda 2021-05-20 2024-05-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Waiswa Peter
ID: UNCST-2020-R014921
 ALERT – ACTION LEVERAGING EVIDENCE TO REDUCE PERINATAL MORTALITY AND MORBIDITY IN SUB-SAHARAN AFRICA
REFNo: HS1324ES

To develop and evaluate a multifaceted intervention to i) strengthen the implementation of evidence-based interventions and responsive care and ii) reduce in-facility perinatal mortality and morbidity through a multidisciplinary approach in Benin, Malawi, Tanzania and Uganda.
 Uganda 2021-05-20 2024-05-20 Medical and Health Sciences Non-degree Award
Mark Okwir
ID: UNCST-2021-R013417
 Spectrum, Outcomes, and Factors Associated with the Liver disease in a Tertiary Care Hospital, Northern Uganda: a 5 Year Retrospective Study.
REFNo: HS1333ES

General Objectives
To determine the spectrum, outcome, and factors associated with liver disease in patients admitted at Lira hospital in northern Uganda over the last five years.

Specific Objectives:
1. To describe the spectrum of liver disease among patients admitted to Medical wards in Lira Regional Referral Hospital over the last five years.
2. To determine the factors associated with liver disease among patients admitted with liver disease at Lira Hospital in the last five years.
3. Determine the admission outcomes (mortality and survival) of liver diseases among patients admitted at Lira Reginal Referral Hospital in the last five years.
4. To determine the factors associated with the admission outcomes (mortality and survival) of patients admitted with liver disease at LRRH in the last five years.

Uganda 2021-05-20 2024-05-20 Medical and Health Sciences Non-degree Award
SHAMIM NAMUKASA
ID:
Prevalence of Sickle Cell Trait and Needs Assessment for Up-Take of Sickle Cell Screening Among Secondary School Students in Kampala City
REFNo: SS818ES

To explore the stakeholders' perceptions regarding the uptake of sickle cell screening among secondary school students in Kampala City,To Assess the factors influencing uptake of sickle cell screening services among secondary school students in Central Uganda.,To determine the prevalence of sickle cell trait among secondary school students in Kampala City,Determine the prevalence of sickle cell trait among secondary school students and identify student-related and stakeholders' factors influencing up-take of sickle trait screening,3. To Explore the stakeholders' perspectives regarding the uptake of sickle cell screening services among secondary school students in Central Uganda.,2. To Assess the factors influencing uptake of sickle cell screening services among secondary school students in Central Uganda.,1. To determine the proportion of sickle cell among secondary school students in Central Uganda.,
 Uganda 2021-05-20 2024-05-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Grace Lubega Biyinzika
ID: UNCST-2020-R014149
 Perceptions and adherence to preventive measures for Coronavirus Disease 2019 among rural community households in Wakiso district, Uganda.
REFNo: SS819ES

3. To explore community barriers and facilitators of adherence to COVID-19 preventive measures among rural community households.,2. To assess adherence to COVID-19 preventive measures as issued by the Government of Uganda among rural community households.,1. To assess perceptions towards COVID-19 preventive measures among rural community households. ,To assess community perceptions and adherence to COVID-19 preventive measures in rural community households of Wakiso district, Uganda in order to provide essential information needed by public health officials and other stakeholders to make an informed decision on the most effective strategy for reduced community transmission.,
 Uganda 2021-05-20 2024-05-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
MISAKI WAYENGERA
ID:
Prevalence of Polymorphic genes of Alzheimer disease in Nodding disease Tauopathy.
REFNo: HS726ES

To determine if polymorphisms in the eight common genes associated with Alzheimer Disease (APP, MAPT, PREN-1, PREN-2, BACE-1, BACE-2, IDE, and APOE-ε4) are present in DNA of Nodding Disease patients
 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Degree Award
Obondo Sande James
ID: UNCST-2019-R000241
 Selecting Single Component Adjuvants for Vaccine Formulations
REFNo: HS821ES

1. To determine if adjuvants induce maturation of dendritic cells from healthy donors, LTBI and asymptomatic VL
2. To determine if adjuvants induce antigen-independent proliferation of different lymphocyte populations from healthy donors, LTBI and asymptmatic VL.
3. To measure levels of cytokine production induced by the different adjuvants
4. To determine if adjuvants induce cytotoxicity (as measured by annexin V).

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Neurodevelopmental, Behavioural and Physical Growth Outcomes of Children born to Mothers with Nodding Syndrome in Northern Uganda.
REFNo: HS852ES

Primary Objective
To determine the neurodevelopmental and behavioural outcomes of children born to mothers suffering from nodding syndrome compared to children of healthy mothers.

Secondary Objectives
1.To describe adverse medical conditions children of mothers of nodding syndrome have experienced from birth
2.To determine physical growth outcomes among children born to NS patients.
3.To determine the effect of seizure burden (frequency and duration) during pregnancy on child neurodevelopmental outcomes.
4.To determine the effect of caregiver emotional wellbeing on child neurodevelopmental outcomes.

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-degree Award
Wilson  Tumuhimbise
ID:
A mobile health framework for public private mix in Tuberculosis prevention and care in Uganda
REFNo: HS963ES

1). To explore the barriers and motivators to private hospital engagement in TB care among private healthcare workers with particular focus on understanding the current Public Private Mix frameworks utilized.
2). To develop a mobile phone based framework for enhancing the tracking of TB patients referred from private to public hospitals and assess its initial acceptability and feasibility
3). To assess the preliminary impact of the mobile phone based framework on TB patients’ adherence to referrals for TB diagnosis and treatment in public hospitals.

Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Degree Award
Janet Nakigudde
ID: UNCST-2019-R000444
 Catalyzing Change in Education through a Transformative Learning Collaborative: Scaling-Up of a Social Emotional Learning Curriculum in Uganda A Phase III Randomized Control Trial
REFNo: HS1189ES

Specific Objectives
1. To identify effective strategies to integrate the PD-SEL curriculum into Nakaseke Core Primary Teachers College by applying a learning collaborative approach
2. To carry out additional Professional development adaption of a behavioral management program (PARENT-CORPS) enhancement by integrating teacher/adult SEL training and gender equity. (the PARENT-CORPS program is being adapted at Kibuli CPTC and Bulera CPTC in Hoima but without the SEL component)
3. To evaluate the effectiveness of PD-Enhanced on teachers’ and students’ SEL/SEC when implemented using a task-shifting model with PTC tutors and incorporating a gender-sensitive approach

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-degree Award
Josephine  Ndagire
ID:
Assessment of Justice Delivery for Children Victims of Defilement
REFNo: SS744ES

The main objective of the research is to assess the response of the justice sector in Uganda to the issue of defilement throughout the justice chain in the last decade and the role that the legal framework particularly the law on defilement (as amended in 2007) has played in facilitating or impeding the actions by the sector and ultimately make recommendations on policy and institutional reforms to address the high defilement rates in the face of strong legal guarantees.
Uganda 2021-05-18 2024-05-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Steven Ndugwa Kabwama
ID:
Risk Factors for Non-Communicable Diseases among Adults in a District with a High Prevalence of Schistosomiasis
REFNo: HS1289ES

1. To estimate the prevalence of risk factors for NCDs such as alcohol intake, tobacco use, fruit and vegetable intake, obesity and physical activity among adults in Buyende District.
2. To determine the prevalence of schistosomiasis infection among adults in Buyende District.
3. To assess the factors associated with the risk factors for non-communicable diseases (alcohol use, tobacco use, fruit and vegetable intake, obesity) among persons presenting with or without schistosomiasis infection.

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-degree Award
Johnbosco Turyasingura
ID:
Community participation and sustainability of donar funded potato projects in Kabale district
REFNo: SS758ES

i. To examine effect of project design and implementation of donor funded potato projects in Kabale District.
ii. To determine the effect of project resourcing on sustainability of donor funded potato projects in Kabale District.
iii. To determine the effect of project monitoring and evaluation on the implementation of donor funded potato projects in Kabale District

 Uganda 2021-05-18 2024-05-18 Social Science and Humanities Degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
 Novel and Optimized Diagnostics in Pediatric Tuberculosis in Kampala, Uganda(NOD)
REFNo: HS1341ES

The study has the following objectives:
Objective 1: Evaluate and develop novel assays that diagnose TB by detecting Mycobacterium tuberculosis (MTB) bacterial products in non-sputum body fluids. Objective 2: Evaluate and develop novel assays that diagnose TB by detecting host biomarkers in non-sputum body fluids.
Objective 3: Identify combinations of assays that applied together could be used to diagnose TB among children with unconfirmed.

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edith Wakida K
ID: UNCST-2019-R001225
 Impact and process Evaluation of the Health-Professional Education Partnership Initiative – Transforming Ugandan Institutions Training Against HIV/AIDS
REFNo: HS1351ES

1. To evaluate the acceptability, appropriateness, feasibility, and implementation process of the HIV curriculum
2. To evaluate the acceptability, appropriateness, feasibility, and implementation process of building capacity of primary health care (PHC) providers to provide comprehensive HIV services and strengthen bidirectional linkages between health facilities and communities
3. To evaluate the acceptability, appropriateness, feasibility, and implementation process of the micro-research program

Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
 A phase I study to determine the safety and immunogenicity of the candidate Rift Valley Fever Virus (RVFV) vaccine ChAdOx1 RVF among healthy adult volunteers in Uganda.
REFNo: HS793ES

The primary objective of this study is to assess the safety profile of the candidate vaccine ChAdOx1 RVF in healthy adult volunteers in Uganda. This will be assessed through comparing the frequency of solicited, unsolicited and serious adverse events and changes from the baseline of laboratory safety measures between participants who will receive the active vaccine and those who will receive the placebo.
The Secondary objective is to assess the immunogenicity of the candidate vaccine ChAdOx1 RVF in healthy adult volunteers in Uganda. This will be assessed through quantification of antibodies to the GnGc proteins using ELISA, RVFV neutralising antibody titres and Ex vivo ELISpot and flow cytometry responses to GnGc.
 Uganda 2021-05-17 2024-05-17 Medical and Health Sciences Non-degree Award
Allen Kabagenyi
ID:
Impoverishing and Catastrophic health expenditure on cancer care among persons affected by cancer in Uganda
REFNo: SS851ES

1. To determine the out of pocket expenditure associated with cancer care for persons affected by cancer, by type and stage;
2. To determine the proportion of cancer patients and or their families that experience catastrophic or impoverishing expenditure due to cancer related expenses by cancer type and stage;
3.To characterize the socio-economic interruptions experienced by persons affected by cancer in Uganda.
4.To examine the sociodemographic characteristics associated with cancer care burden in Uganda
5.To assess patients and care givers perceptions and attitudes of cancer care expenditures and health care in Uganda


Uganda 2021-05-17 2024-05-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Julia Dickson-Gomez
ID: UNCST-2019-R000775
 Integration of buprenorphine into a multi-component harm reduction program for people who inject drugs in Kampala, Uganda
REFNo: HS1229ES

To develop a combination HIV prevention intervention for PWID in Kampala Uganda, using the Consolidated Framework for Intervention Research. The combination intervention includes social network HIV/HCV testing, linkage to care for PWID and PrEP for HIV negative PWID. All participants will be offered safe injection equipment, condoms and HIV risk reduction education, and naloxone, buprenorphine, and CBT4CBT for heroin users.
2. To refine the intervention iteratively through implementation cycles using the CFIR framework to identify barriers and find solutions to implementation and scale-up.
3. To assess feasibility, acceptability and initial promise of the intervention with a 6-month pilot test.

 USA 2021-05-10 2024-05-10 Medical and Health Sciences Non-degree Award
Erisa Mwaka Sabakaki
ID: UNCST-2019-R001625
 Engaging Young People in the Development of Digital Mental Health Innovation in Africa
REFNo: SS795ES

To build a network of experts and stakeholders to develop a framework for responsible and relevant digital mental health interventions for young people in African countries
 Uganda 2021-05-10 2024-05-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
William Worodria Ofuti
ID: UNCST-2022-R010915
 Management of Lower Respiratory Tract Infections in Sub-Saharan Africa, a Pragmatic Approach
REFNo: HS1160ES

Primary objective: To define aetiology and resistance patterns of clinically diagnosed CAP among hospitalized individuals using a comprehensive microbiological approach.

Secondary objectives:
1.To determine the level of agreement between molecular and conventional laboratory testing for the diagnosis of CAP.
2.To determine clinical predictors of treatment outcomes (early treatment failure, mortality) in patients hospitalized with CAP.
3.To determine the role of the CURB-65 severity score and biomarkers (CRP and PCT) in predicting treatment outcomes (early treatment failure, mortality) of patients hospitalized with CAP in a high HIV burden setting.

 Uganda 2021-05-07 2024-05-07 Medical and Health Sciences Non-degree Award
Kenneth Mutesasira
ID:
Patient perspectives and reasons for interruption of TB treatment within central Uganda.
REFNo: HS1383ES

-The overall aim of the study is to understand patient reasons for treatment interruption to inform the interventions for improving TB patient retention and final treatment outcomes.
- The second objective is to explore patient's suggestions for improving their adherence throughout the course of treatment.
 Uganda 2021-05-07 2024-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Semitala Fred
ID: UNCST-2020-R014202
 An assessment of current hypertension care (HTN) practices, routines, barriers, and facilitators for people living with HIV at selected health facilities in Kampala and Wakiso Districts in Uganda. A Formative Study
REFNo: SS808ES

Objective 1: To assess for knowledge, attitudes and practices of hypertension management and control.
Objective 2: To document existing guidelines and recommended routines for HTN-HIV integration in HIV clinics.Objective 3: To assess the current practice, routines, barriers and facilitators of HTN-HIV integration in HIV clinics.
Objective 4: To explore key stakeholders’ perspectives on HTN-HIV integration in HIV clinics in Kampala and Wakiso Districts.


Uganda 2021-05-07 2024-05-07 Social Science and Humanities Non-degree Award
James Nyonyintono Mwangwa
ID: UNCST-2023-R005636
 Reporting neonatal demographics, clinical characteristics and outcomes using the deidentified Kiwoko Hospital newborn care unit database
REFNo: SS813ES

Aim 1- Describe demographics, clinical characteristics and outcomes of neonates Aim 2- Describe mortality by birthweight and birth location Aim 3- Evaluate the changes to growth and length of stay after introduction of cue-based feeding in 2019 Aim 4- Evaluate the short-term clinical correlates to a diagnosis of birth asphyxia Aim 5- Determine if frequency of low birthweight admissions correlates to transmission of p. falciparum and decreased use of insecticide treated nets
 Uganda 2021-05-07 2024-05-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Robert Kalyesubula
ID:
Task Shifting Screening and Measurement of Blood Pressure and Blood Sugars by Community Health Workers for Early Detection and Referral of Hypertension and Diabetes in Rural Uganda.
REFNo: SS821ES

1. To train CHWs in detection, referral, and promotion of continuity for diabetes and
hypertension care among community members in Nakaseke district, Uganda.
2. To assess the ability of trained CHWs to detect and refer patients with diabetes and or hypertension in Nakaseke district.
3. To determine compliance to diabetes and hypertension referral care among community
members in Nakaseke district
 Uganda 2021-05-07 2024-05-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
FREDRICK MAKUMBI
ID:
VACCINATION COVERAGE AND ITS DETERMINANTS AMONG CHILDREN AGED 0 TO 59 MONTHS IN KENYA / UGANDA: A HOUSEHOLD SURVEY
REFNo: HS1391ES

STUDY OBJECTIVES

Broad Objective
The main objective of the baseline and endline surveys is to determine the current status and uptake of immunization services in Living Goods’ focus areas in Kenya and Uganda.
Specific Objectives
The specific objectives of the baseline and endline surveys in Kenya and Uganda are to:
1. Determine the percentage of children (aged 0-59 months) fully vaccinated before and after implementation of the program.
2. Determine the equity or lack thereof in immunization coverage.
3. Assess knowledge, skills (CHWs only) and attitudes of CHWs and caregivers of children aged ≤59 months before and after the intervention.
4. Determine health system factors (stock outs, outreaches, micro-plans, etc.) that facilitate or deter vaccine uptake.

 Uganda 2021-05-07 2024-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Josephine Namugumya
ID:
TALENT MANAGEMENT IN UNIVERSITIES IN UGANDA
REFNo: SS681ES

1. To examine the relationship between self-organisation and talent management.

2. To examine the relationship between organisational culture and talent management.
3. To examine the relationship between emotional intelligence and talent management.
4. To examine the relationship between adaptability and talent management

5. To examine the relationship
between self-organisation and Adaptability.
6. To examine the relationship between organisational culture and adaptability.
7. To examine the relationship between emotional intelligence and adaptability.
8. To examine the mediating role of adaptability on the relationship between self -organisation and talent management.

9. To examine the mediating role of adaptability on the relationship between organisational culture and talent management.

10. To examine the mediating role of adaptability on the relationship between emotional intelligence and talent management.
 Uganda 2021-05-05 2024-05-05 Social Science and Humanities Degree Award
Ezekiel Mupere
ID: UNCST-2021-R011972
 Pancreatic Enzymes and Bile Acids: A Non-Antibiotic approach to Treat Intestinal Dysbiosis in Acutely Ill Severely Malnourished Children PB-SAM.
REFNo: HS1193ES

General Objective
• To determine whether treatment with pancreatic enzymes or bile acids reduce mortality in acutely ill hospitalized children with severe malnutrition compared to placebo.

Specific Objectives
To determine:
1. Rate and type of SAEs (including readmissions to hospital)
2. Safety: rate of grade 3 or 4 toxicity events whilst receiving investigational products
3. Intestinal function: number of days with diarrhoea during admission.
4. Use of second and third-line antibiotics during admission and readmission
5. Number of days from enrolment to discharge during admission
6. Growth: (MUAC, weight-for-length, length-for-age) to day 60.

 Uganda 2021-05-05 2024-05-05 Medical and Health Sciences Non-degree Award
Engineer  Bainomugisha
ID: UNCST-2023-R005928
 End-to-end Artificial Intelligence (AI) and data systems for targeted surveillance and management of COVID-19 and future pandemics affecting Uganda (COAST)
REFNo: SIR61ES

1.To strengthen data systems for usable and equitable datasets for AI-driven COVID-19 responses and future pandemics

2.To model and evaluate COVID-19 interventions for targeted government responses.

 Uganda 2021-05-05 2024-05-05 Engineering and Technology Non-Clinical Trial Non-degree Award
Anna Vitali
ID:
Why do firms in Low-Income Countries grow slowly? An Investigation of Demand Side Mechanisms
REFNo: SS711ES

Why do firms in low-income countries grow slowly? My research will provide new evidence on demand-side constraints, that is the challenges that firms face in building a customer base. Specifically, I will study how limited information on product quality restricts the ability of high-quality firms to attract consumers.

Accessing new customers may be especially difficult in developing countries due to high search costs and the lack of institutions that can enforce quality standards. High search costs make it hard for consumers to learn about the existence and the quality offered by different sellers in the market. At the same time, the lack of institutional capacity to enforce quality standards increases the probability of meeting extremely low-quality sellers in the market, thus reducing consumers’ willingness to try out new firms. This type of frictions significantly restricts the ability of high-quality producers to capture customers from lower-quality firm, allowing for the survival of a mass of small, unproductive businesses in the economy.

Customers’ limited ability to observe goods quality can also lead to discrimination against particular groups. For instance, recent studies have shown that individuals tend to underestimate the ability of women relative to men in male-typed domains. If the quality of goods is hard to observe and customers believe that, on average, men have higher ability than women in male-dominated sectors, female entrepreneurs may face significant discrimination from customers when entering male-dominated, high-productivity industries. This could contribute to gender-based employment segregation, one of the leading causes of gender disparity in the labour market.

The findings from my research will shed light on the mechanisms through which policies aimed at improving information on product quality may stimulate firm expansion and employment creation, as well as reduce gender-based employment segregation in low-income economies.

 Italy 2021-04-29 2024-04-29 Social Science and Humanities Degree Award
Tonny Kiyimba
ID:
Dietary pattern and cardio-metabolic profiles of HIV positive Ugandans
REFNo: HS1355ES

3. Assess the association between lifestyle factors (smoking, alcohol consumption and physical activity) and metabolic health of HIV positive Ugandans,2. To assess the association between ART regimen and duration and metabolic health (waist circumference, blood glucose; blood lipid profile – total cholesterol, HDL cholesterol and triglycerides; body composition and blood pressure) of patients with HIV in Uganda,1. To assess the association between dietary intake and metabolic health (waist circumference, blood glucose; blood lipid profile – total cholesterol, HDL cholesterol and triglycerides; body composition and blood pressure) of patients with HIV in Uganda ,To assess the dietary patterns and cardio-metabolic risks of HIV positive Ugandan adults,
 Uganda 2021-04-28 2024-04-28 Medical and Health Sciences Non-Clinical Trial Degree Award
Tumwerinde Emmanuel Aturinde
ID:
Towards a Regendered Military and Women Participation in the AMISOM
REFNo: SS723ES

i. Explore the nature of gender relations in the military institution and its influence on selection, training and deployment of women in peace operations
ii. Analyse the history of women participation in peace operations with reference to the Kenya and Uganda as AMISOM Troop Contributing countries
iii. Examine the roles and experiences of women combatants in peace operations.
iv. Analyse how women participation and experiences in peace operations have contributed to change in gendered military relations in the context anti-antiterrorism Missions.

Uganda 2021-04-27 2024-04-27 Social Science and Humanities Degree Award
Victoria Namuggala Flavia
ID: UNCST-2019-R000991
 The gendered price of precarity. Young women navigating workplace sexual harassment.
REFNo: SS608ES

Principal aim
The principal aim of the project is to contribute to an understanding of the processes of empowerment of young females in response to (vulnerability to) WSH, in order to inform policy directions and civil society efforts aimed at empowering young workers.

Specific objectives are:
1) To contribute to a better understanding of processes of gaining voice and empowerment in response to WSH in different precarious labour settings, by highlighting variation between the formal and informal sector.
2) To contribute to empirical knowledge about WSH in sectors for which limited research exists, and from a youth perspective.
3) To raise awareness among relevant policy actors about the specific conditions that create vulnerability to WSH for young women working in selected formal and informal sectors, and help them design strategies to address this within employment interventions.
4) To contribute to policy development for addressing sexual harassment in the informal sector, in support of implementing Article 8 of ILO Convention 190.
5) To contribute to the development of an ‘everyday language’ in local vernacular in Uganda and Bangladesh, which policy actors, civil society, and young women can comfortably use to articulate WSH.

 Uganda 2021-04-27 2024-04-27 Social Science and Humanities Non-degree Award
Olivia Kituuka
ID:
INFORMED CONSENT PROCESS FOR EMERGENCY SURGERY AT PUBLIC AND PRIVATE HOSPITAL SURGICAL EMERGENCY UNITS IN THE URBAN UGANDAN SETTING
REFNo: HS1208ES

i. To explore and describe patients’ experiences and satisfaction with the informed consent process for emergency surgery, at both public and private not for profit teaching hospitals in Uganda
ii. To explore the roles, perceptions and experiences of the next of kin of patients who have undergone emergency surgery on the informed consent process at both public teaching hospital and private not for profit teaching hospitals in Uganda.
iii. To determine the factors that influence informed consent practices of emergency department staff involved in the informed consent process for emergency surgery in public and private not for profit teaching hospitals in Uganda

 Uganda 2021-04-27 2024-04-27 Medical and Health Sciences Degree Award
Jenna Grzeslo
ID:
Exploring the Feasibility of Empowerment and Livelihood for Adolescents (ELA) in an Afterschool Setting: Formative Research to Inform Programming and Policy in Uganda
REFNo: SS693ES

1. BRAC would like to explore the feasibility of school and government uptake of the programming.

2. Finally, to inform future experimental evaluations, we seek to understand the role of dosage (e.g., the number and frequency of meetings) in designing the updated ELA curriculum.
USA 2021-04-27 2024-04-27 Social Science and Humanities Non-degree Award
Pakoyo Kamba Fadhiru
ID:
A prospective cohort study of oral morphine self-medication by caregivers of paediatric patients at Mulago National Referral Hospital, Kampala
REFNo: HS1331ES

To determine the effect of diversion of patients’ oral morphine by caregivers on their health related quality of life and that of patients in paediatric clinics at Mulago National Referral Hospital,To determine the prevalence and compliance with necessary written internal controls for prescribing, dispensing and administration of oral morphine by paediatrics clinics at Mulago National Referral Hospital,To determine the effect of home-based oral morphine use in palliative care on drug use disorders among caregivers of paediatric patients at Mulago National Referral Hospital. This will be achieved by comparing the prevalence and incidence of self-medication with oral morphine and other controlled drugs between caregivers of paediatric patients with and without prescribed oral morphine.,To determine the factors associated with self-medication with oral morphine among caregivers of paediatric patients on prescribed oral morphine in paediatrics clinics at Mulago National Referral Hospital,To determine the prevalence and incidence of self-medication with oral morphine among caregivers of paediatric patients on prescribed oral morphine in paediatrics clinics at Mulago National Referral Hospital. This will be achieved through a baseline survey of prevalence followed by longitudinal evaluation of incidence of self-medication at endline.,To understand the compliance of paediatric clinics with oral morphine controls and the effect of diversion of patients’ oral morphine by caregivers on the quality of life of paediatric patients and caregivers,4. To determine the effect of diversion of patients’ oral morphine by caregivers on their health related quality of life and that of patients in paediatric clinics at Mulago National Referral Hospital.,3. To determine the prevalence and compliance with necessary written internal controls for prescribing, dispensing and administration of oral morphine by paediatrics clinics at Mulago National Referral Hospital.,2. To determine the effect of home-based oral morphine use in palliative care on drug use disorders among caregivers of paediatric patients at Mulago National Referral Hospital. This will be achieved by comparing the prevalence and incidence of self-medication with oral morphine and other controlled drugs between caregivers of paediatric patients with and without prescribed oral morphine.,1. To determine the prevalence and incidence of self-medication with oral morphine among caregivers of paediatric patients on prescribed oral morphine in paediatrics clinics at Mulago National Referral Hospital. This will be achieved through a baseline survey of prevalence followed by bimonthly longitudinal monitoring of incidence of self-medication.,
 Uganda 2021-04-27 2024-04-27 Medical and Health Sciences Non-degree Award
Sophie Mylan Katherine Hardman
ID:
Epidemics in Refugee Settlements: An ethnographic exploration of ‘Preparedness’ in Palabek Refugee Settlement, Northern Uganda, during times of COVID-19
REFNo: SS745ES

The objective of this study is to understand how epidemic ‘preparedness’ in refugee settlements can pay greater attention to histories, ideas and practices from refugees themselves. Through ethnographic research, including, but not restricted to, fieldwork in Palabek Refugee Settlement, northern Uganda, during times of COVID-19, the connections and disconnections between global policy, biomedical approaches, and ‘preparedness from below’ will be explored as equal objects of study.
 UK 2021-04-27 2024-04-27 Social Science and Humanities Degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
 PRELIMINARY INVESTIGATIONS TO SUPPORT COVID-19 VACCINE ROLL-OUT IN UGANDA [CO-ROLL]
REFNo: SS767ES

The study objectives are
1. To assess uptake of COVID-19 vaccination and associated factors among HCWs and older (>50 years) persons in Uganda
2. To describe the knowledge and attitudes towards COVID-19 vaccines among HCWs and older (>50 years) persons in Uganda
3. To describe the profile of anti-SARS-CoV-2 IgG antibodies before and after vaccination in HCWs and older (>50 years) persons in Uganda.
4. To describe cellular immune responses to SARS-CoV-2 antigens before and after vaccination in HCWs and older (>50 years) persons in Uganda.
5. To describe pre-COVID-19 immunisation innate response profiles, and relate these to the antigen specific vaccine responses in HCWs and older (>50 years) persons in Uganda
6. To determine the social and structural factors that influence uptake of COVID-19 vaccines in HCWs and older (>50 years) persons in Uganda

 Uganda 2021-04-27 2024-04-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ronald Mangeni
ID:
Utility of pooled sputum samples for Tuberculosis screening in a high TB burden setting.
REFNo: HS1329ES

- The overall aim of this study is to determine sensitivity and specificity of pooled sputum samples in the diagnosis of TB in a healthcare setting in Uganda

Secondary objectives
- To determine the effect of varying bacterial loads on the sensitivity and specificity of sputum pooling
- To determine the effect of different pooling ratios on the sensitivity and specificity of sputum pooling
 Uganda 2021-04-27 2024-04-27 Medical and Health Sciences Non-degree Award
FREDRICK MAKUMBI
ID:
Understanding how information on abortion is shared in social networks: a mixed-methods follow up study to refine two social network-based methods for measuring abortion incidence
REFNo: SS814ES

This study aims to understand how information on pregnancy termination is shared within social networks and use this information to assess and improve the use of two social-network based methods for estimating abortion incidence.

Specific objectives
(1) Improve the robustness and accuracy of the estimate of abortion incidence in Uganda
(2) Assess how diffusely information about pregnancy termination is shared within women’s social networks in Uganda
(3) Provide detailed information on the timing and purpose of pregnancy termination disclosure

Uganda 2021-04-27 2024-04-27 Social Science and Humanities Non-degree Award
Martha Mulerwa
ID:
Inter-rater reliability and comparison of the repeatability of four different approaches to setting up goniometers and torsiometers to measure forearm and wrist kinematics.
REFNo: SIR60ES

General objective: Compare the four different approaches to setting up an electro-goniometer and torsiometer listed above in order to determine the most appropriate procedure for wrist kinematics measurements.

Specific Objectives:
To evaluate the repeatability of the four setup procedures
To evaluate inter-rater reliability when setting up the electro-goniometer and torsiometer using the four setup procedures during wrist kinematics
To evaluate intra-rater reliability when setting up the electro-goniometer and torsiometer using the four setup procedures during wrist kinematics

 Uganda 2021-04-27 2024-04-27 Engineering and Technology Non-Clinical Trial Degree Award
Chaning Jang Ahn Wong
ID:
Contextualizing Moral Foundations Theory for Better Messaging in Uganda
REFNo: SS797ES

General Objective:
This study seeks to contextualize the Moral Foundation Theory to the Ugandan context through various instruments to have a better understanding of the social, and personal values of its population.
Specific and Achievable Objectives:
The breakdown of the general objective of this project is as follows:
Adapt the moral foundation research process, as laid out by Knutson and Haidt, to the Ugandan context through exploratory and confirmatory analysis
Diagnose the distribution of moral decision-making across five themes by examining respondents’ classifications of moral violations.
Seeking to understand how the foundations are distributed across the general population.
Use the validated set of moral foundations to inform behavioral change communication/messaging campaigns.

USA 2021-04-27 2024-04-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Enock Matovu
ID:
Development of Indirect Enzyme Linked Immunosorbent Assay [ELISA] for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Surveillance in Uganda
REFNo: HS1382ES

i. To evaluate commercially available formulations of the spike and nucleocapsid antigens derived from E. coli, insect and human cell expression systems to determine the best performer
ii. To determine the diagnostic sensitivity and specificity of the spike and nucleocapsid antigens-based indirect ELISA for diagnosis and community sero-surveillance of SARS-COV2

 Uganda 2021-04-27 2024-04-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Roy Mayega William
ID: UNCST-2022-R010983
 Differences in the formation and development of informal settlements and their effects on residents’ health and safety.
REFNo: SS715ES

General objective
The objective of the proposed research is to conduct formative research in Kampala, Uganda as part of a larger research agenda to compare informal settlements in four countries in East Africa, Uganda, Rwanda, Tanzania and Kenya to determine how history of formation, government strategies to improve settlements and the kinds of improvements that have been made affect the health and well-being of residents.
Specific objectives
Specific objectives of the proposed research include the following.
1. To explore how informal settlements in Kampala, Uganda are formed and how this may cause differences in the settlement’s health hazards.
2. formal To explore strategies that Uganda has taken to improve informal settlements and the health effects of these efforts for the families and children who live in informal settlements.
3. To qualitatively identify the most pressing health needs of families and children in the selected informal settlements within Kampala.

Uganda 2021-04-26 2024-04-26 Social Science and Humanities Non-degree Award
John Storey Douglas
ID:
Understanding factors that influence people's health-seeking behavior to inform a social and behavior change communications campaigns in Uganda
REFNo: SS761ES

The overall objective of this research is to suggest ways of improving the OBULAMU brand and to develop a set of recommendations
to inform a national-level social and behavior change communication strategy for the Ministry of Health in Uganda. In order to achieve this objective, the following smaller objectives will be met:
a)To identify the characteristics and behaviors of different brand users.
b)To understand the barriers and levers to improve past communication efforts.
c)To understand baseline attitudes, perceptions and the socio-ecological context which influences users' health-related decisions.
d)To identify the critical moments in people’s lives across which different health needs become salient
e)To design and test solutions to address the barriers faced by end-users and provide holistic recommendations that can inform the redesigning efforts of the OBULAMU campaign and provide inputs into the national SBC strategy.

 USA 2021-04-26 2024-04-26 Social Science and Humanities Non-degree Award
Gerald Mboowa
ID:
Assessing knowledge, attitudes, perceptions, and skills towards the use of face masks: A community-level perspective
REFNo: SS489ES

i. To assess knowledge, attitudes, and perceptions towards the use of face masks by high- risk groups in Kampala district, Uganda.
ii. To assess skills towards the use of face masks, evaluate the face masks for safety and fitness-for-use, and provide a classification for those commonly circulating on the Ugandan market.
iii. To educate and skill high- risk groups in Kampala district on the rational use and disposal of face masks.

 Uganda 2021-04-22 2024-04-22 Social Science and Humanities Non-degree Award
Lillian Tindyebwa --
ID:
Gender Dynamics - Analysis of Convicts in selected Prisons in Kigezi Region
REFNo: SS521ES

1. To explore gender dynamics of crimes for convicts in major prisons at selected districts in the Kigezi region
2.To identify types of crimes committed by men and women convicts in major prisons in the Kigezi region
3. To establish the gendered patterns formed in committing crimes by convicts in major prisons in the Kigezi region.
4.To explore the underlying motives to commit various crimes by the convicts in major prisons at districts in the Kigezi region.
5.To establish the influence of community that could cause the person to commit a crime.
 Uganda 2021-04-22 2024-04-22 Social Science and Humanities Non-degree Award
Anthony Kadoma
ID:
Understanding stakeholder perceptions on wetland ecosystem services to support conservation and restoration activities
REFNo: SS705ES

To establish past, present, and future wetland conservation and restoration activities in Wakiso district

Identify the stakeholders involved and their roles and motivations

Document and analyze the perceptions stakeholders have on wetland ecosystem services and

To synthesize stakeholders' perceptions and their integration into wetland conservation and restoration activities.
Uganda 2021-04-22 2024-04-22 Social Science and Humanities Degree Award
Moffat  Nyirenda Joha
ID: UNCST-2020-R019333
 Understanding differential effects of lipid lowering agents on lipid isoforms: a multi-center retrospective study in Uganda
REFNo: HS1292ES

a. To determine the patterns of dyslipidaemia among patients who present with dyslipidaemia at primary care and specialist hospitals in Uganda
b. To describe the patient characteristics that are associated with different patterns of dyslipidaemia
c. To determine the commonly used lipid lowering agents
d. To examine the differences in response to lipid lowering therapy
e. To determine the proportion of optimal control among individuals taking lipid-lowering agents
f. To examine the times to optimal LDL-C control among individuals taking lipid-lowering agents

 Malawi 2021-04-22 2024-04-22 Medical and Health Sciences Non-degree Award
Elizabeth Brannon Lynn
ID:
The Role of Former Female Fighters in the National Resistance Movement
REFNo: SS791ES

During conflict, women step into a number of roles that were traditionally reserved for men--with some women joining rebel forces to fight, others taking up peace activism to combat such fighting, and many stepping into roles that were traditionally held by men. A strong literature has emerged detailing women's violent participation in conflict, as well as the motivations, dynamics, and implications of their action. Through their participation, women are able to experience greater equality with men, in addition to building critical skills and networks. However, little is known about how former rebel women build on these experiences post-conflict. Instead, much of the literature suggests that former rebel women experience significant marginalization after conflict, minimizing their future opportunities. Such patterns seem further at odds with patterns of rebel-group-to-political-party transformations. In this project, I have two main objectives. I seek to understand the post-conflict fate of former female fighters and how it relates to former rebel party politics. I ask if and how former female fighters are able to build on their conflict experiences and networks to access positions of political power in the post-conflict environment. Further, I seek to understand broader patterns in which women are elected after conflict. To understand these dynamics, I intend to collect systematic candidate data in Uganda and will complement this will a qualitative analysis based on interviews with former female combatants for the National Resistance Army.
 USA 2021-04-22 2024-04-22 Social Science and Humanities Non-Clinical Trial Degree Award
Anthony Mugeere Buyinza
ID:
PEAK YOUTH, CLIMATE CHANGE AND THE ROLE OF YOUNG PEOPLE IN SEIZING THEIR FUTURE
REFNo: SS670ES

General Objective:

To explore how climate change in Uganda is affecting young lives and youth livelihoods in the regions of Karamoja and Jinja.

Specific objectives:
(i) To document the diverse lives and livelihood strategies of young people
in rural and urban settings;
(ii) To find out how climate change impacts upon young people's lives and livelihoods;

(iii) To identify youth solutions to the challenges they face.
 Uganda 2021-04-21 2024-04-21 Social Science and Humanities Non-degree Award
Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
 An education package to improve health worker communication with women and families after stillbirth or neonatal death: A feasibility study
REFNo: HS1102ES

1. To pilot an education package and associated resources, including train the trainer/training manuals and audio-visual aids to improve health worker communication in Malawi, Uganda, Zambia and Zimbabwe.
2. For feasibility
a. Explore the acceptability and implementation of the package with facility staff receiving training, trainers and service managers across settings.
b. Explore the acceptability and implementation of the package with undergraduate midwifery students receiving training.
c. Assess uptake and attendance/completion of the package.
d. Explore impacts of the research and education package on practice and clinical services.
3. To prepare for a full-scale evaluation:
a. Define the most appropriate primary and secondary outcomes to assess the effect of the educational package on health workers’ communication and parents’ experiences.
b. Assess the acceptability and burden of data collection for participants.
c. Use data to optimise the design and estimate the sample size for a full-scale trial.
d. Exploration of key resources associated with implementing the educational package will be completed to provide an economic understanding of the intervention and its potential impact.
e. To utilise existing and develop additional networks to identify potential sites for a full-scale trial.
4. To combine the feasibility, acceptability and uptake data to develop a full trial protocol by the end of the study.

 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 SARS-CoV-2 seroconversion: a sero prevalence study among cancer patients and health workers at the Uganda Cancer Institute
REFNo: HS1240ES

3. To describe the temporal trends in the anti- SARS-CoV-2 antibody sero-prevalence among cancer patients at the Uganda Cancer Institute,2. To describe the clinical and demographic characteristics associated with history of exposure to SARS-CoV-2 and severity of COVID-19 disease in cancer patients. ,1. To determine SARS-CoV-2 antibody sero-prevalence in cancer patients attending care at the Uganda Cancer Institute,
 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Conrad Muzoora Kihembe
ID: UNCST-2019-R001432
 A randomized clinical TriaL of early empiric Anti-Mycobacterium tuberculosis therapy for Sepsis in sub-Saharan Africa (ATLAS trial)
REFNo: HS1272ES

The primary hypothesis of this clinical trial protocol is that immediate and sepsis specific dose of anti-TB therapy will result in improved 28-day mortality for study participants admitted to hospital with HIV and sepsis in Tanzania and Uganda compared to standard care alone.

The primary objective is:
1) To conduct a randomized 2x2 factorial clinical trial of 1) immediate initiation of empiric anti-TB therapy plus standard care vs diagnosis dependent anti-TB therapy plus standard care alone and 2) sepsis-specific anti-TB therapy plus standard care vs conventional WHO weight-based anti-TB therapy plus standard care for patients presenting with sepsis to two hospitals in Uganda and Tanzania.
1a) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves 28 day mortality compared to diagnosis dependent anti-TB therapy plus standard care.
1b) To determine if sepsis-specific dose anti-TB therapy plus standard care improves 28 day mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.

The secondary objectives include:
1) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves in-hospital mortality compared to diagnosis dependent anti-TB therapy plus standard care
2) To determine if sepsis-specific dose anti-TB therapy plus standard care improves in hospital mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.
3) To determine if empiric immediate initiation of anti-TB therapy plus standard care improves 6 month mortality compared to diagnosis dependent anti-TB therapy plus standard care
4) To determine if sepsis-specific dose anti-TB therapy plus standard care improves 6 month mortality compared to conventional WHO weight-based anti-TB therapy plus standard care.
5) To determine the safety of increased dose anti-TB therapy for patients with sepsis
6) To determine if early achievement of target serum drug concentrations of isoniazid and rifampin, measured at day-2 of TB treatment, associates with more rapid clinical improvement among patients with confirmed TB.

 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
 A Survey Assessing Male Reproduction During or After Treatment Containing Pretomanid
REFNo: HS1340ES

To evaluate the paternity status in male participants who have received a pretomanid containing regimen in one of the following TB Alliance clinical trials: STAND, Nix-TB, SimpliciTB or ZeNix.
 Uganda 2021-04-21 2024-04-21 Medical and Health Sciences Non-degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
 Using community influencer groups to address COVID-19 misinformation and vaccine hesitancy in Buikwe, Uganda
REFNo: HS1140ES

The evaluate the effect of community influencer groups on COVID-19 misinformation and potential COVID-19 vaccine hesitancy.,To form and empower community influencer groups against COVID-19 misinformation and potential COVID-19 vaccine hesitancy ,To explore the effect of COVID-19 misinformation on potential hesitancy towards a future COVID-19 vaccine,To determine the prevalence of potential hesitancy to a future COVID-19 vaccine in Buikwe,To determine the prevalence of COVID-19 misinformation in Buikwe,
 Uganda 2021-04-15 2024-04-15 Medical and Health Sciences Non-degree Award
Noleb Mugisha Mugume
ID:
Integrating cervical cancer screening in HIV clinics and assessing the effect of using a modified referral protocol on access to cancer services among HIV-positive women in Uganda
REFNo: HS1219ES

Major objective: To assess the effect of a modified referral protocol on access to cancer services among HIV-positive women with positive cervical cancer screening findings and describe acceptability of integrating cervical cancer screening services in HIV clinics and referring women with positive screening results using the modified referral protocol.

Specific objectives
1. To assess the effect of using a modified referral protocol on access to cancer services among HIV-positive women with positive cervical cancer screening findings.

2. To describe experiences of HIV-positive women and health care providers with implementation of integrated cervical cancer screening services in HIV clinics and referral using a modified referral protocol

3. To describe acceptability of a program that provides integrated cervical cancer screening services in HIV clinics to women presenting for routine HIV care and links those with positive screening findings to cancer care services using a modified referral protocol among health care providers and mangers in the clinics.

 Uganda 2021-04-15 2024-04-15 Medical and Health Sciences Degree Award
victoria nakibuuka
ID: UNCST-2020-R014741
 Developmental care packages to improve neonatal outcomes – a multidisciplinary approach
REFNo: HS1254ES

To survey current knowledge, practices and attitudes towards developmental care to assess potential barriers and facilitators to implementing and integrating developmental To observe current practice in NICU’s care packages in NICU’s in LMIC

 Uganda 2021-04-15 2024-04-15 Medical and Health Sciences Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
 D3 (PENTA 21) A randomised non-inferiority trial with nested PK to assess DTG/3TC fixed dose formulations for the maintenance of virological suppression in children with HIV infection aged 2 to <15 years old
REFNo: HS1288ES

The overall aim is to evaluate two-drug therapy with DTG/3TC FDC given once daily in comparison with triple-drug ART in HIV-1 infected children and adolescents who are virologically-suppressed on their ART regimen.

PRIMARY OBJECTIVE
To assess whether DTG/3TC is non-inferior to SOC, consisting of an anchor drug (NNRTI, PI or INSTI) and 2 NRTIs, in terms of virological suppression

HYPOTHESIS
Switching to DTG/3TC will provide non-inferior virological suppression to remaining on SOC over 96 weeks.

SECONDARY OBJECTIVES
 To evaluate clinical and laboratory adverse events associated with the trial antiretrovirals
 To evaluate new resistance mutations in participants with virological rebound (confirmed VL≥50 copies/mL)
 To assess low level viraemia and virological reservoirs
 To evaluate adherence, tolerability, acceptability, sleep and health-related quality of life
 To evaluate and model the pharmacokinetics and pharmacodynamics of dispersible and film-coated fixed-dose DTG/3TC formulations in children weighing 6-<40kg using WHO weight band-aligned dosing
 To evaluate cost-effectiveness of treatment maintenance with DTG/3TC FDC if DTG/3TC is shown to be non-inferior to SOC

Uganda 2021-04-15 2024-04-15 Medical and Health Sciences Non-degree Award
Godfrey  Siu
ID: UNCST-2021-R005439
 The impact of COVID-19 on domestic care work in Uganda
REFNo: SS770ES

1. To determine the burden and patterns of domestic care work during the COVID-19 response phase.
2. To determine the barriers and facilitators of domestic work during the lockdown.
3. To examine the effects of COVID-19 on the social, economic and family relations.
 Uganda 2021-04-15 2024-04-15 Social Science and Humanities Non-degree Award
James Katungyi
ID:
The effect of daytime circadian thermal variability on the well-being of building occupants. A case study of office type building occupants in Kampala.
REFNo: SIR41ES

The research objective is to compare short and long-term impacts, of variable indoor thermal conditions (which mimic the outdoor variability) versus static thermal conditions, on the wellbeing of building occupants.
 Uganda 2021-04-13 2024-04-13 Engineering and Technology Degree Award
Susannah Mayhew Harding
ID:
Rapid Qualitative Research to support integrated environment, livelihoods and health programming in Uganda (“Supporting Integrated Programming”)
REFNo: HS1137ES

The research objectives are to:
1) Determine the environmental, livelihood and health challenges facing communities living in/near Rushebeya wetland;
2) Identify how, and through what structures and processes, people in these communities make decisions about and respond to identified challenges; and identify whether these responses have changed over time;
3) Examine whether there are differences in responses by age, sex or socio-economic background.
4) Identify messages and intervention activities to address the challenges felt by different groups in these communities.

 UK 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Joseph Nkamwesiga
ID:
Epidemiology of Peste des Petits Ruminants (PPR) in Uganda
REFNo: A103ES

General Objective:
To determine national PPR risk profiles [low, medium and high], seroprevalence and incidence of different PPRV lineages, factors that influence PPRV transmission and hence develop a dynamic PPRV transmission model and the best control intervention(s) to limit PPRV transmission in selected livestock production systems in Uganda

The specific objectives of this study are to:
i. stratify Uganda districts into different PPR risk profiles [low, medium and high] by undertaking presence only ecological niche (MaxEnt) modeling of the past PPR outbreaks, small ruminant movements and vaccination coverage data sets
ii. estimate seroprevalence of PPRV and epidemiological factors that influence PPRV transmission within and between different PPR risk profiles and small ruminant production systems
iii. estimate PPR incidence and PPRV lineages involved in different PPR outbreaks across different small ruminant production systems [or agro-ecological zones] in Uganda
iv. develop a PPRV transmission dynamic and eradication model for PPR in selected small ruminant production systems [agro-ecological zones] in Uganda using compartmentalized SEIR mathematical modeling approach

 Uganda 2021-04-13 2024-04-13 Agricultural Sciences Degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
 Strengthening Antimicrobial Stewardship, Consumption and Use in Uganda (SAMSU)
REFNo: HS1155ES

To conduct Antimicrobial Consumption and Use by ATC/DDD Methodology and the WHO AWaRE classification Antimicrobials intended for use in Humans for the Years 2017, 2018, 2019 and 2020 using Medicine Imports and Local Manufacture Data in Uganda (SCACUS)To examine health facility bottlenecks and determinants of antimicrobial use that affect antibiotic stewardship practices at outpatient departments with the aim of strengthening healthcare professionals’ AMS capability in Eastern Uganda (SAMSEU)
Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Stavia Turyahabwe Stavia
ID: UNCST-2022-R011373
 From Directly-Observed Therapy (DOT) to Video Observed Therapy (VOT): A study on the use of evidence based Digital Adherence Technologies (DAT) for improving TB Treatment outcomes
REFNo: HS1183ES

a. Active Case Finding Strategy: To study the impact of increase in case finding of drugs susceptible case in the selected 2 TB units of Kabarole and Mbarara, where the component will be tested.
b. Active Patient Compliance Toolkits: To test the efficacy of patient led adherence using mobile based Video Observed Therapy approach in improving the TB adherence rate and overall improvement in TB treatment outcomes;
c. Active Community-Led Supervision: To test the improvement in TB treatment outcomes like TB Success Rates, Cure rates and Adherence rates in the community let supervision model;
d. Active Ground Building Activities; To assess the change in knowledge, attitude and practice (KAP) level of TB patients; their family members and the community around TB and related issues.

Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 SITUATIONAL ANALYSIS OF EXISTING CAPACITY AND RESOURCES AT MEAKERERE UNIVERSITY TO SUPPORT A RESEARCH TRAINING PROGRAM FOCUSING ON NON-COMMUNICABLE DIEASES AND AGEING AMONG PEOPLE LIVING WITH HIV/AIDS
REFNo: HS1252ES

General Objective
To describe existing research capacity, training and resources within the MakCHS that can be leveraged to design a successful NCD-HIV-Ageing training program at MakCHS
Specific Objectives
To describe existing NCD, HIV and ageing research at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex.
To define the existing NCD, HIV and ageing training activities at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex.
To outline the existing resources to support research and training on NCDs, HIV and ageing at Makerere University and other collaborating institutions within MakCHS and Mulago Hospital complex.
To define a pool of potential trainees that could be recruited for research training on NCDs, HIV and ageing at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex

 Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Barbara Balikuddembe  Ndagire Balikuddembe
ID:
Dental Practitioners’ Knowledge, Attitudes, and Practices Regarding Caries Risk Assessment in the Management of Dental Caries in Uganda: A Cross Sectional Study
REFNo: HS1275ES

i. To determine the knowledge of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan. ii. To determine the attitudes of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan. iii. To determine the practices of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan. iv. To explore the training needs of CRA among trainers of dental practitioners in Kampala metropolitan.
Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Degree Award
Victor Musiime
ID: UNCST-2021-R013794
 A randomized Trial to investigate strategies to reduce mortality among HIV-infected and HIV-exposed children admitted with severe acute malnutrition in Mulago Hospital, Kampala, Uganda
REFNo: HS1277ES

Primary objective
1. To investigate whether empirical use of an antibiotic with greater antimicrobial sensitivity (ceftriaxone) than standard of care (ampicillin plus gentamicin) will reduce mortality among 300 HIV-infected and HEU children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital in a randomised controlled trial.

Secondary objectives
2. To compare the length of hospitalization, weight-for-height, weight-for-age and height-for-age z-scores between ceftriaxone versus standard of care (ampicillin and gentamicin) treatment arms.
3. To ascertain the frequency of different bloodstream bacterial pathogens and their antimicrobial sensitivities among HIV-infected and HEU children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital participating in the randomised trial.
4. To ascertain the prevalence of, and factors associated with, HIV-infection among children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital in light of improved PMTCT approaches in a cross-sectional evaluation at admission, among 280 children.
5. To evaluate the pharmacokinetic (PK) parameters of LPV/r among severely malnourished HIV infected children using sparse PK samples. The PK parameter values obtained will then be used in pharmacokinetic-pharmacodynamic (PK-PD) models to determine a possible optimal dose of LPV/r among severely malnourished children, which could then subsequently be evaluated in a clinical trial.

Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
 Exploring access to health care and medicines during COVID-19 in Mukono and Luwero districts: critical challenges and feasible policy options for the medicines retail sector
REFNo: HS1302ES

To describe the practical, policy and political barriers to including pharmacies, drug shops and private clinics in the response to COVID-19 and the means to overcome them.,. To describe how national actors and district officials would like to involve the medicines retail sector in their pandemic planning and action for COVID-19. ,To explore how the medicines retail sector in Uganda could be involved in response to COVID-19 and future outbreaks,To document the impact of the COVID-19 pandemic and public health response on the ability of women and the parents of young children in Uganda to access medicines,To document the effect of the government response to COVID-19 on supply of healthcare services/ care provision by drug shops, pharmacies and private clinics in Uganda,To describe how policy can be adapted to ensure continuity of access to essential medicines and support the involvement of the retail sector in COVID-19 activities during this and future outbreaks,To understand how the public health response to COVID-19 is shaping the supply of and access to treatment in the medicines retail sector in Uganda;,
 Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Irene Mutuku M.
ID:
KNOWLEDGE, ATTITUDES AND PRACTICES TOWARDS COVID-19 PREVENTION MEASURES AMONG COMMUNITIES AT SELECTED GAZETTED INTERNATIONAL ENTRY-POINTS OF KIGEZI SUB-REGION, UGANDA
REFNo: SS660ES

General objective

To assess the knowledge, attitudes and practices towards COVID-19 prevention measures in communities living at gazetted international entry points of the Kigezi sub-region in Uganda.



Specific objectives
i. To establish the knowledge of the community members in selected gazette international entry points in the Kigezi region regarding measures instituted to stop the spread of COVID-19 in Uganda.

ii. To assess the attitudes of the community members in selected gazetted international entry points in the Kigezi region towards measures instituted to stop the spread of COVID- 19 in Uganda.

iii. To investigate the practices of community members in selected gazetted international entry points in the Kigezi region on measures instituted to stop the spread of COVID- 19 in Uganda.

 Kenya 2021-04-09 2024-04-09 Social Science and Humanities Non-degree Award
NEEMA NAKYANJO -
ID:
Fishing and inland communities – understanding transmission linkages and networks
REFNo: SS698ES

a) To understand the socio-structural context of migration of high risk persons/key populations to and from high HIV prevalence Lake Victoria fishing communities and other geographic areas with high HIV-prevalence
b) To use molecular, social and epidemiological data to identify and elucidate the factors/associations of transmission linkages/networks within key and general population cohorts/groups.
c) To increase our understanding of HIV prevention and care utilization of high risk persons/key populations moving to and from places with high rates of HIV infection
 Uganda 2021-04-09 2024-04-09 Social Science and Humanities Non-degree Award
JULIET MWANGA-AMUMPAIRE
ID: UNCST-2022-R009420
 Impact of malnutrition on pharmacokinetic of rifampicin, isoniazid, pyrazinamide and ethambutol in TB-HIV co-infected children
REFNo: HS1217ES

Primary Objective
To assess the effect of Severe Acute Malnutrition (SAM) on plasma concentration of rifampicin, isoniazid, pyrazinamide, and ethambutol in children with TB.

Secondary Objectives
1. To assess the effect of HIV-infection and antiretroviral treatment on plasma concentration of rifampicin, isoniazid, pyrazinamide, and ethambutol in children with TB and Severe Acute Malnutrition (SAM)
2. To assess whether new WHO-based dosages will achieve rifampicin, isoniazid, pyrazinamide, and ethambutol drug concentrations above the target therapeutic concentrations in HIV-TB co-infected children with and without SAM
3. To assess the effect of nutritional parameters, HIV-infection, antiretroviral treatment, and other factors (age, liver enzymes, NAT2 status) on PK parameters of rifampicin, isoniazid, pyrazinamide, and ethambutol in HIV-infected children with TB
4. To build a PK/PD relationship between drug concentrations and TB treatment outcomes
5. To assess rifampicin protein binding in relation with malnutrition and albuminemia
6. To derive an optimal dosing algorithm for rifampicin, isoniazid, pyrazinamide, and ethambutol that will adequately provide optimal exposures to malnourished and HIV infected children

 Uganda 2021-04-09 2024-04-09 Medical and Health Sciences Non-degree Award
Eva  Laker Odongpiny Agnes
ID: UNCST-2024-R004807
 A Toll-Free Call Intervention to Improve Adverse Events Reporting in Patients On Dolutegravir in Three Health Centers in Kampala, Uganda and a Prospective Cohort Study to Describe Adverse Events to Dolutegravir at the Infectious Diseases Institute (DOLUPHARM)
REFNo: HS1263ES

A) Primary objective (Objective 1)
To determine whether a toll-free phone system for reporting of adverse events by clinicians and patients improves adverse event reporting compared to standard reporting methods using paper based or online forms by clinicians in three health centers initiating/switching patients to DTG between November 2020 and October 2021.

B) Secondary objective (Objective 2)
To determine level of uptake and the experiences of clinicians and patients with using a toll-free phone system for reporting adverse events compared to standard reporting methods using paper based or online forms in three health centers initiating/switching patients to DTG between November 2020 and October 2021

Prospective Cohort Study
A) Primary objective (Objective 3)
To describe the incidence and factors associated with occurrence of different adverse events among patients being switched/initiated on a DTG-based regimen at the IDI.

B) Secondary objective (Objective 4)
To determine whether occurrence of adverse events affects adherence to medications among patients being switched/initiated on a DTG-based regimen at the

Uganda 2021-04-09 2024-04-09 Medical and Health Sciences Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
 NEW APPROACHES FOR THE EARLY DETECTION OF CERVICAL NEOPLASIA
REFNo: HS1161ES

1. Determine acceptability and accuracy of a low-cost smartphone confocal micro-endoscope imaging technique for the diagnosis of CIN 2+. Confocal images will be compared against gold-standard histopathology to obtain preliminary diagnostic performance characteristics.
2. Compare various cervico-vaginal fluid (CVF) biomarkers to gold-standard histopathology for the diagnosis of CIN 2+. Qualitative and quantitative levels of biomarkers will be compared against gold-standard histopathology to obtain diagnostic performance characteristics.


Uganda 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
Susan Tino
ID:
Scale-Up and Capacity Building in Behavioral Science to Improve the Uptake of Family Planning and Reproductive Health Services (SupCap)
REFNo: HS1196ES

1. To test if the BSci Package can lead to an increased uptake of modern contraceptive methods improvements in gender norms, an increase in knowledge of contraceptive methods, birth spacing, and childrearing among postpartum women.

2. To find out how we effectively and efficiently replicate and scale up the BSci Package across Eastern Uganda and elsewhere.

 Uganda 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa (SAPPHIRE)
REFNo: HS1239ES

Overall Objective: Our overall objective is to determine to reduce HIV incidence and to improve community health with multi-sector, scalable interventions.

Primary Objective: Reduce HIV incidence using innovative strategies for HIV prevention and treatment to simultaneously reach “persistent driver” populations.

Secondary Objectives:
1. Evaluate and optimize individual intervention component effects, alone (Phase A) and in combination (Phase B), versus control conditions on prevention coverage and HIV viral suppression
2. Assess the effect of the intervention package on other health outcomes (all-cause mortality, tuberculosis, hypertension linkage and control, heavy alcohol use and mother-to-child HIV transmission) in Phase B
3. Evaluate behavioral and other mechanistic pathways for intervention effects on proximal mediators of HIV incidence in Phase B
4. Assess the reach, effectiveness, patient and provider adoption, and fidelity and the maintenance of intervention components in Phase B
5. Use final study data to inform a strategic and sustainable investment model that maximally reduces HIV incidence and improves community health for the combination interventions tested in Phase B

 Uganda 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
CARL CHRISTIAN STECKER CHRISTIAN
ID:
Caregiver-Assisted Oral Fluid-based HIV Screening in Children: Estimation of Acceptability, Feasibility and Effectiveness Linked to Index Testing Services in Uganda.
REFNo: HS1258ES

The purpose of this study is to evaluate the acceptability, feasibility and effectiveness of a caregiver-assisted oral fluid based HIV test to screen children for HIV. The results of this study are intended to support expanded access to HIV testing and treatment services for children, and to ensure that all newly diagnosed children are linked to clinical care.

The primary objectives of this study are to:
1. Estimate the acceptability of implementing caregiver-assisted oral fluid-based HIV screening for children as part of index testing services for HIV-positive adults.
2. Estimate the feasibility of implementing caregiver-assisted oral fluid-based HIV screening for children as part of index testing services for HIV-positive adults.
3. Estimate the effectiveness of caregiver-assisted oral fluid-based HIV screening on testing yield, return to clinic, and linkage to ART for newly identified CLHIV.

The secondary objective of the study is to:
Estimate the cost of caregiver-assisted oral fluid-based HIV screening compared to the standard costs of the existing referral to testing program, from the perspective of the health care provider.

 USA 2021-04-08 2024-04-08 Medical and Health Sciences Non-degree Award
Leah Pauline
ID:
The Paradox of Being an Adolescent Girl in Uganda During a Global Pandemic
REFNo: SS765ES

My research aims to answer the following
research question and sub-questions:
How do adolescent girls in Uganda navigate the liminal period of COVID-19 when their
educational aspirations of empowerment are put on hold and they face exacerbating
pressures to abide by gender roles/expectations?
Sub-questions:
1- How do high school drop-outs in Uganda differ before and after the onset of the COVID-19 pandemic?
2- What factors influence adolescent girls’ reproductive health and
whether or not they return to school?
3- How do adolescent girls’ future aspirations play a role in their
continuation of schooling?
4- How do adolescent girls interpret peer drop-outs as they navigate their
own decision to continue their education or drop-out?
 USA 2021-04-08 2024-04-08 Social Science and Humanities Degree Award
Matthew Cooper
ID: UNCST-2021-R013904
 Legacy effects of land-use on tropical soils as constraints on the restoration success and service provision of tropical forests in Uganda
REFNo: NS157ES

The research subject of this project will be the evaluation of soil fertility, soil degradation, C sequestration in both soils and plants, and biodiversity along
tropical secondary forest successions in Western Uganda in three work
packages.
 UK 2021-04-06 2024-04-06 Natural Sciences Degree Award
FRANCIS KIBIRIGE
ID:
Do Legislatures Enhance Democracy in Africa, Uganda Chapter
REFNo: SS774ES

DLEDA Project seeks to understand how parliaments in (selected) African countries fulfill the core functions of parliament. This knowledge will enable DLEDA to answer three major questions, including:

Question 1: Which policy decisions are made in the national assembly?

Question 2: Who are the Members of Parliament (i.e. caliber) and how do they interact with each other?

Question 3: How do MPs represent their constituents and what are the existing mechanisms of political accountability?

 Uganda 2021-04-06 2024-04-06 Social Science and Humanities Non-degree Award
Allan Lugaajju
ID:
B-CELLS AND HUMORAL FACTORS MEDIATING MALARIA IMMUNITY IN CHILDREN AND ADULTS
REFNo: HS1267ES

1.To quantify reactive Plasmodium falciparum specific B cell subsets against parasite antigens in children and adults.

2.To functionally characterize anti-Plasmodium falciparum B cell subset downstream responses in children and adults

3.To compare the reactivity and proportions of Plasmodium falciparum specific B cell subsets in children and adults

Uganda 2021-04-06 2024-04-06 Medical and Health Sciences Non-degree Award
David Lwanga
ID:
CONFLICTING PRESSURES FOR CHANGE AND INSTITUTIONAL LEGITIMACY IN KAMPALA CAPITAL CITY AUTHORITY, UGANDA.
REFNo: SS780ES

5. To find out the extent to which quantitative results on institution legitimacy of KCCA supports the initial qualitative results.,4. To examine the extent to which the legitimacy of KCCA is a result of harmonizing conflicting pressures for change. ,3. To find out how KCCA dealt with pressures resisting change during the transformation period.,2. To establish the strategic responses that KCCA adopted to attain institutional legitimacy.,1. To establish what institutional pressures influenced the transformation of KCC to KCCA.,To understand how Kampala Capital City Authority attained institutional legitimacy amidst conflicting pressures for change, that is how change initiatives can be positively embraced, hence creating self-reinforcing sequences for institutional legitimacy. ,
 Uganda 2021-04-06 2024-04-06 Social Science and Humanities Degree Award
Borja Perez-Viana
ID:
Go for It while You Can: On Time Discounting in High-Risk Environments
REFNo: SS448ES

The poor populations of developing countries are extremely exposed to the vagaries of chance, with agricultural output and livelihoods dependent on highly variable weather patterns. Against this background, it is important to better understand how people in developing countries make decisions involving risk and time trade-offs. Our understanding of these decisions is still hampered by a number of issues. For one, decisions under risk and over time have long been treated separately, whereas in reality, they are closely linked. Investigations in developing countries have often focused on exceedingly simple preference measures that are presented in a theoretical vacuum. Likewise, the identification of causal determinants of preferences remains elusive. We propose to overcome these limitations by combining the modelling of preferences and their determinants with bespoke tools to measure preferences and beliefs. We further propose to combine the model-driven measurements with randomised controlled trials (RCTs) varying theoretically identified determinants of preferences to enable us to draw clear causal inferences. Combining such RCTs with a longitudinal design will further allow us to investigate interactions between the randomly allocated interventions and naturally occurring uncertainty. The study will be carried out in collaboration with the Field Lab, a non-for-profit research organisation, based in Mbale.

We divide our proposal into five work packages:

1. Modelling and measuring future uncertainty: The future is inherently uncertain. It is even more so in developing countries. This uncertainty may indeed drive both high levels of risk taking in the present and extreme time discounting. In this first work package, we aim to model this issue explicitly, and to measure the underlying quantities, with particular attention to future uncertainty.

2. Future probabilities are ambiguous: This work package extends the insights obtained in the first work package to explicitly take the uncertainty surrounding future probability estimates into account. The modelling and experimental measurements are further complemented by a randomised variation of the institution delivering the future payouts.

3. Gain, loss, and mixed inter-temporal prospects: In work package three, we propose to extend the theoretical and measurement apparatus deployed in the first two work packages to a full inter-temporal prospect theory model. This is important to model real decisions, which often involve trading off immediate expenditures against uncertain future outcomes.

4. Background risk and behaviour: Starting from a model of the influence of background risk on decisions under risk and over time, we aim to provide crop insurance to randomly selected subsistence farmers in order to shelter them from background risk. This ought to allow us to draw causal inferences on the effect of background risk on preferences and behaviour.

5. Training, aspirations, and locus of control: Taking risks and investing into the future may be mediated by psychological mechanisms such as aspiration levels or locus of control (beliefs on whether one can control one’s destiny). We aim to augment an existing training intervention by motivational elements aimed directly at shifting these psychological mechanisms, to try and nudge preferences and behaviour in desirable directions.
 Spain 2021-03-31 2024-03-31 Social Science and Humanities Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Surveillance and Epidemiology of Antimicrobial Resistance Programme (Pilot)
REFNo: HS1268ES

Primary

To evaluate AMR incidence through the establishment of a surveillance platform in LMICs based on Pfizer’s Antimicrobial Leadership Testing and Surveillance (ATLAS) core methodology, while facilitating the expansion of surveillance capacity in participating countries.
Secondary.
To strengthen the quality of identification and antimicrobial susceptibility testing of major bacterial pathogens by the participating laboratories through retesting at a central reference laboratory;
ï‚· To estimate and track the prevalence of resistance phenotypes of major public health importance notably extended spectrum cephalosporin resistance, Carbapenem resistance and MRSA;
ï‚· To generate WGS data that shall be used for epidemiological typing and determining mechanisms of resistance of major resistance phenotypes in participating countries.
 Uganda 2021-03-31 2024-03-31 Medical and Health Sciences Non-degree Award
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
 A Midline Evaluation for a 5 Year Family Planning Implementation Program: The RISE Project in Uganda
REFNo: HS1296ES

1. Describe the socio-demographic characteristics of men and women of reproductive age living in the seven RISE regions at midway of implementation of RISE programme
2. Assess the program progress from baseline to midline on each of the following program intervention areas
a. men and women’s knowledge of FP services and methods in the project areas
b. men and women’s attitudes towards FP in the project areas
c. FP practices amongst men and women of reproductive age in the project areas
d. the intention to use FP services in future among men and women of reproductive age in the project areas
e. Ability and willingness to pay for FP services among men and women of reproductive age group in the project areas
f. level of exposure to SBCC messages on FP amongst men and women of reproductive age in the project areas
g. status of FP user segments for both men and women of reproductive age in the project areas in terms of Knowledge, attitude, practices, intent to use, exposure
3. Assess the effect of COVID-19 on access of family planning services among men and women of reproductive age living in the seven RISE regions at midway of implementation of RISE programme

 Uganda 2021-03-31 2024-03-31 Medical and Health Sciences Non-degree Award
Moses Ocan
ID:
Predictors of local emergence and spread of Artemisinin resistance among Ugandan Plasmodium falciparum parasites
REFNo: HS1169ES

(i) To assess the extent of adherence to national malaria treatment guidelines/policy in malaria treatment in private hospitals, private pharmacies and public hospitals in low and high malaria transmission settings in Uganda
(ii) To determine the prevalence of Pfkelch13 gene mutations among P. falciparum parasites in low and high malaria transmission settings in Uganda
(iii) To determine the prevalence of fd (ferredoxin), arps10 (apicomplast ribosomal protein S10) , mdr-2 (multi-drug resistance protein -2) and crt (chloroquine resistance protein) mutations among Plasmodium falciparum parasites in low and high malaria transmission settings in Uganda

 Uganda 2021-03-26 2024-03-26 Medical and Health Sciences Non-degree Award
Pakoyo Kamba Fadhiru
ID:
Scaling up the Refugees and Host Community’s response towards COVID-19 in Northern Uganda
REFNo: SS755ES

1. To assess the refugee and host communities’ compliance with COVID-19 infection prevention and control measures such as social distancing, hand washing, hand sanitization, use of personal protective equipment, quarantine and notification of cross-border travellers and suspect cases to authorities. 2. To identify community-led initiatives towards COVID-19 infection prevention and control. 3. To build the capacity of refugee settlement and community leaders in COVID-19 infection prevention and control.
Uganda 2021-03-26 2024-03-26 Social Science and Humanities Non-degree Award
Shevin  Jacob Thomas
ID:
EVALUATION OF PHARMACOKINETICS, SAFETY AND FEASIBILITY FOR ADMINISTRATION OF TWO DOSES OF INTRAVENOUS VITAMIN C COMBINED WITH VITAMIN B1 FOR THE MANAGEMENT OF ADULT PATIENTS ADMITTED WITH SEPSIS TO KIRUDDU NATIONAL REFERRAL HOSPITAL Short Title: RANDOMISED EVALUATION OF A VITAMIN C BUNDLE FOR SEPSIS TREATMENT IN AFRICA (REVISTA-DOSE)
REFNo: HS1236ES

General objective: In the future REVISTA-RCT, we intend to evaluate the components of a metabolic bundle comprising vitamin C, vitamin B1, and corticosteroids in order to determine if a combined effect of the bundle has greater efficacy (than bundle components or placebo) in decreasing 28-day mortality due to sepsis in adult patients in SSA. In preparation for the RCT, we intend to utilize the REVISTA-DOSE study to answer key questions about optimal dosing and safety for intravenous vitamin C (in combination with vitamin B1) in patients hospitalized with adult sepsis in two Ugandan referral hospitals. Primary objectives: 1. Describe the dose-plasma concentration response from two different doses of intravenous vitamin C (in combination with vitamin B1) Secondary objectives: 1. Evaluate the safety and tolerability of intravenous vitamin C (in combination with vitamin B1) in adult medical patients with sepsis in Uganda 2. Assess the enrolment rates, adherence to protocol and feasibility of conducting an RCT in patients with sepsis within the ARCS cohort of patients Exploratory objectives: 1. Evaluate association of vitamin C and vitamin B1 levels on clinical parameters/markers, including those for: a. Disease severity: shock; lactate clearance; qSOFA score; ability to stand unaided b. Inflammation, infection: Procalcitonin c. Organ/metabolic function, including: renal function d. Adverse events: hemolysis; oxaluria e. Outcomes: re-hospitalization frequency; length of hospitalization; 6 or 7 and 28d morbidity and mortality
USA 2021-03-26 2024-03-26 Medical and Health Sciences Non-degree Award
Barbara Mukasa
ID:
Evaluating the Glycemic Effects of Dolutegravir (DTG) Among Patients Receiving Dolutegravir Based Regimens at Mildmay Uganda ART sites : A Prospective Cohort Study
REFNo: HS1273ES

1.To determine the incidence of hyperglycaemia among patients receiving DTG based regimen at Mildmay Uganda supported sites. 2.To determine the association between previous NRTI or NRTtI exposure and the incidence of hyperglycemia among patients on TLD.
3.Evaluate predictors of hyperglycaemia among patients on TLD. 4.Describe other adverse events reported by study participants during the study period.
Uganda 2021-03-26 2024-03-26 Medical and Health Sciences Non-degree Award
Agnes Kiragga
ID:
Community Pharmacies for Assessing STI Prevalence using Point of Care diagnostics study (COPHAS)
REFNo: HS1274ES

Aim 1: To estimate the prevalence of curable STIs and HIV among persons accessing health services at community pharmacies in Kampala and Wakiso Districts.

Aim 2: To determine the feasibility and uptake of pharmacy-based specimen collection and POC testing for curable STIs and HIV among persons seeking health care services at community pharmacies in Kampala and Wakiso Districts. Uptake will be measured among the three groups of persons i.e. Persons seeking EC (group 1), clients with STI symptoms (group 2) and persons without STI symptoms (group 3)
Secondary quantitative aims:
Aim 3: To determine treatment completion among persons diagnosed with an STI at the community pharmacies in Kampala and Wakiso Districts.

Aim 4: To determine linkage to care and ART initiation among newly diagnosed HIV positive persons at the community pharmacies in Kampala and Wakiso Districts.

Aim 5: To determine the baseline and 3-month knowledge about STI and STI treatment guidelines, and principles of antimicrobial stewardship of pharmacy staff. In addition, to assess the acceptability of POC STI diagnostics collocated with the pharmacy, to pharmacy owners and staff.

Qualitative aims
Aim 6: To assess the acceptability and client satisfaction of STI and HIV testing at community pharmacies in Kampala and Wakiso Districts.

Partner notification sub-study
Aim 7: To determine the effect of technology-supported partner notification and treatment initiation using Call for LifeTM technology among persons diagnosed with an STI or HIV at community pharmacies.


 Uganda 2021-03-26 2024-03-26 Medical and Health Sciences Non-degree Award
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