Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
James Katungyi
ID:
The effect of daytime circadian thermal variability on the well-being of building occupants. A case study of office type building occupants in Kampala.
REFNo: SIR41ES

The research objective is to compare short and long-term impacts, of variable indoor thermal conditions (which mimic the outdoor variability) versus static thermal conditions, on the wellbeing of building occupants.
Uganda 2021-04-13 2024-04-13 Engineering and Technology Degree Award
Susannah Mayhew Harding
ID:
Rapid Qualitative Research to support integrated environment, livelihoods and health programming in Uganda (“Supporting Integrated Programming”)
REFNo: HS1137ES

The research objectives are to:
1) Determine the environmental, livelihood and health challenges facing communities living in/near Rushebeya wetland;
2) Identify how, and through what structures and processes, people in these communities make decisions about and respond to identified challenges; and identify whether these responses have changed over time;
3) Examine whether there are differences in responses by age, sex or socio-economic background.
4) Identify messages and intervention activities to address the challenges felt by different groups in these communities.

UK 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Joseph Nkamwesiga
ID:
Epidemiology of Peste des Petits Ruminants (PPR) in Uganda
REFNo: A103ES

General Objective:
To determine national PPR risk profiles [low, medium and high], seroprevalence and incidence of different PPRV lineages, factors that influence PPRV transmission and hence develop a dynamic PPRV transmission model and the best control intervention(s) to limit PPRV transmission in selected livestock production systems in Uganda

The specific objectives of this study are to:
i. stratify Uganda districts into different PPR risk profiles [low, medium and high] by undertaking presence only ecological niche (MaxEnt) modeling of the past PPR outbreaks, small ruminant movements and vaccination coverage data sets
ii. estimate seroprevalence of PPRV and epidemiological factors that influence PPRV transmission within and between different PPR risk profiles and small ruminant production systems
iii. estimate PPR incidence and PPRV lineages involved in different PPR outbreaks across different small ruminant production systems [or agro-ecological zones] in Uganda
iv. develop a PPRV transmission dynamic and eradication model for PPR in selected small ruminant production systems [agro-ecological zones] in Uganda using compartmentalized SEIR mathematical modeling approach

Uganda 2021-04-13 2024-04-13 Agricultural Sciences Degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
Strengthening Antimicrobial Stewardship, Consumption and Use in Uganda (SAMSU)
REFNo: HS1155ES

To conduct Antimicrobial Consumption and Use by ATC/DDD Methodology and the WHO AWaRE classification Antimicrobials intended for use in Humans for the Years 2017, 2018, 2019 and 2020 using Medicine Imports and Local Manufacture Data in Uganda (SCACUS)To examine health facility bottlenecks and determinants of antimicrobial use that affect antibiotic stewardship practices at outpatient departments with the aim of strengthening healthcare professionals’ AMS capability in Eastern Uganda (SAMSEU)
Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Stavia Turyahabwe Stavia
ID: UNCST-2022-R011373
From Directly-Observed Therapy (DOT) to Video Observed Therapy (VOT): A study on the use of evidence based Digital Adherence Technologies (DAT) for improving TB Treatment outcomes
REFNo: HS1183ES

a. Active Case Finding Strategy: To study the impact of increase in case finding of drugs susceptible case in the selected 2 TB units of Kabarole and Mbarara, where the component will be tested.
b. Active Patient Compliance Toolkits: To test the efficacy of patient led adherence using mobile based Video Observed Therapy approach in improving the TB adherence rate and overall improvement in TB treatment outcomes;
c. Active Community-Led Supervision: To test the improvement in TB treatment outcomes like TB Success Rates, Cure rates and Adherence rates in the community let supervision model;
d. Active Ground Building Activities; To assess the change in knowledge, attitude and practice (KAP) level of TB patients; their family members and the community around TB and related issues.

Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
SITUATIONAL ANALYSIS OF EXISTING CAPACITY AND RESOURCES AT MEAKERERE UNIVERSITY TO SUPPORT A RESEARCH TRAINING PROGRAM FOCUSING ON NON-COMMUNICABLE DIEASES AND AGEING AMONG PEOPLE LIVING WITH HIV/AIDS
REFNo: HS1252ES

General Objective
To describe existing research capacity, training and resources within the MakCHS that can be leveraged to design a successful NCD-HIV-Ageing training program at MakCHS
Specific Objectives
To describe existing NCD, HIV and ageing research at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex.
To define the existing NCD, HIV and ageing training activities at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex.
To outline the existing resources to support research and training on NCDs, HIV and ageing at Makerere University and other collaborating institutions within MakCHS and Mulago Hospital complex.
To define a pool of potential trainees that could be recruited for research training on NCDs, HIV and ageing at Makerere University and collaborating institutions within MakCHS and Mulago Hospital complex

Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Barbara Balikuddembe  Ndagire Balikuddembe
ID:
Dental Practitioners’ Knowledge, Attitudes, and Practices Regarding Caries Risk Assessment in the Management of Dental Caries in Uganda: A Cross Sectional Study
REFNo: HS1275ES

i. To determine the knowledge of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan. ii. To determine the attitudes of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan. iii. To determine the practices of dental practitioners regarding caries risk assessment in the management of dental caries in Kampala metropolitan. iv. To explore the training needs of CRA among trainers of dental practitioners in Kampala metropolitan.
Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Degree Award
Victor Musiime
ID: UNCST-2021-R013794
A randomized Trial to investigate strategies to reduce mortality among HIV-infected and HIV-exposed children admitted with severe acute malnutrition in Mulago Hospital, Kampala, Uganda
REFNo: HS1277ES

Primary objective
1. To investigate whether empirical use of an antibiotic with greater antimicrobial sensitivity (ceftriaxone) than standard of care (ampicillin plus gentamicin) will reduce mortality among 300 HIV-infected and HEU children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital in a randomised controlled trial.

Secondary objectives
2. To compare the length of hospitalization, weight-for-height, weight-for-age and height-for-age z-scores between ceftriaxone versus standard of care (ampicillin and gentamicin) treatment arms.
3. To ascertain the frequency of different bloodstream bacterial pathogens and their antimicrobial sensitivities among HIV-infected and HEU children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital participating in the randomised trial.
4. To ascertain the prevalence of, and factors associated with, HIV-infection among children admitted with severe acute malnutrition at Mwanamugimu Nutrition Unit, Mulago Hospital in light of improved PMTCT approaches in a cross-sectional evaluation at admission, among 280 children.
5. To evaluate the pharmacokinetic (PK) parameters of LPV/r among severely malnourished HIV infected children using sparse PK samples. The PK parameter values obtained will then be used in pharmacokinetic-pharmacodynamic (PK-PD) models to determine a possible optimal dose of LPV/r among severely malnourished children, which could then subsequently be evaluated in a clinical trial.

Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
Exploring access to health care and medicines during COVID-19 in Mukono and Luwero districts: critical challenges and feasible policy options for the medicines retail sector
REFNo: HS1302ES

To describe the practical, policy and political barriers to including pharmacies, drug shops and private clinics in the response to COVID-19 and the means to overcome them.,. To describe how national actors and district officials would like to involve the medicines retail sector in their pandemic planning and action for COVID-19. ,To explore how the medicines retail sector in Uganda could be involved in response to COVID-19 and future outbreaks,To document the impact of the COVID-19 pandemic and public health response on the ability of women and the parents of young children in Uganda to access medicines,To document the effect of the government response to COVID-19 on supply of healthcare services/ care provision by drug shops, pharmacies and private clinics in Uganda,To describe how policy can be adapted to ensure continuity of access to essential medicines and support the involvement of the retail sector in COVID-19 activities during this and future outbreaks,To understand how the public health response to COVID-19 is shaping the supply of and access to treatment in the medicines retail sector in Uganda;,
Uganda 2021-04-13 2024-04-13 Medical and Health Sciences Non-degree Award
Irene Mutuku M.
ID:
KNOWLEDGE, ATTITUDES AND PRACTICES TOWARDS COVID-19 PREVENTION MEASURES AMONG COMMUNITIES AT SELECTED GAZETTED INTERNATIONAL ENTRY-POINTS OF KIGEZI SUB-REGION, UGANDA
REFNo: SS660ES

General objective

To assess the knowledge, attitudes and practices towards COVID-19 prevention measures in communities living at gazetted international entry points of the Kigezi sub-region in Uganda.



Specific objectives
i. To establish the knowledge of the community members in selected gazette international entry points in the Kigezi region regarding measures instituted to stop the spread of COVID-19 in Uganda.

ii. To assess the attitudes of the community members in selected gazetted international entry points in the Kigezi region towards measures instituted to stop the spread of COVID- 19 in Uganda.

iii. To investigate the practices of community members in selected gazetted international entry points in the Kigezi region on measures instituted to stop the spread of COVID- 19 in Uganda.

Kenya 2021-04-09 2024-04-09 Social Science and Humanities Non-degree Award
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