Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Waiswa Peter
ID: UNCST-2020-R014921
NEOSEPSIS Project: Reducing neonatal and maternal mortality by rapid detection of sepsis in resource-limited environments
REFNo: HS5058ES

1) Explore and evaluate potential distribution channels and market entry strategies for the NeoSep SAA test. 2) Identify and analyze the barriers that may impede the widespread adoption of the NeoSep SAA test. 3) Determine the cost-effectiveness of implementing the NeoSep SAA test in clinical settings in healthcare resource limited settings and systems. 4) Assess the NeoSep SAA test’s performance as compared to CRP test. 5) Evaluate the applicability of the NeoSep SAA test for the detection of maternal sepsis occurring after the first five days of birth. 6) Assess the NeoSep SAA test’s utility in monitoring response to antibiotic therapy in neonates who have undergone treatment for sepsis.7) Evaluate the diagnostic performance of the optimized NeoSep SAA test for neonatal sepsis by evaluating its sensitivity, specificity, PPV, and NPV.
Uganda 2024-12-02 17:12:10 2027-12-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Katende
ID: UNCST-2023-R006954
ASSESSMENT OF THE CURRENT STATE OF CHILD TRAFFICKING INTO WORST FORMS OF CHILD LABOUR IN NAPAK AND KAMPALA DISTRICT, UGANDA
REFNo: SS2547ES

i. To assess the current nature and dynamics of child trafficking in Napak and Kampala districts.

ii. To indentify the current key factors contributing to child trafficking in Napak district.

iii.To evaluate the community awareness and acceptance levels regarding child trafficking in Napak district.

Uganda 2024-12-02 17:10:31 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patrick Kagurusi Tumusiime
ID: UNCST-2021-R012687
PROJECT MID TERM EVALUATION OF WATER SANITATION AND HYGIENE FOR SEXUAL REPRODUCTIVE HEALTH AND RIGHTS IN AMURU DSITRICT, NORTHERN UGANDA (PIWA Maleng II Project).
REFNo: SS3385ES

1.2 Purpose of the research study/study protocol
To highlight the evaluation process that will be followed during the mid-term evaluation that aims at determining the access and utilization of SRHR services among youths, establishing the barriers and enablers to SRHR services and establish the effect of integration of SRHR and WASH on Menstrual hygiene management among adolescents and youths in communities and schools in Lamogi and Pabbo sub counties in Amuru district.

1.3 Specific objectives of the mid-term evaluation
This mid-term evaluation will aim to achieve the following broad objectives;
i. Determine the level of access and utilization of SRHR services among adolescents and youths in target communities of Pabbo and Lamogi sub counties.
ii. Establish the barriers and enablers of SRHR services uptake among adolescents, youths and women at target communities in Lamogi and Pabbo sub counties.
iii. Establish the effect of integration of SRHR and WASH on Menstrual Hygiene Management among adolescents and youths in target communities and schools of Lamogi and Pabbo sub counties.

Uganda 2024-12-02 17:09:15 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ivan Sserwadda
ID: UNCST-2022-R009568
Respiratory Microbiome: insights into the diagnosis and pathogenesis of Tuberculosis
REFNo: HS4329ES

To understand the role of bacterial, viral and fungal colonization or infection (other than Mycobacterium tuberculosis) in pulmonary TB and in the clinical performance of potential TB triage tests.,To employ the Sanity Respiratory Pathogen Panel (RPP36) for culture and sensitivity testing to identify clinically relevant respiratory pathogens in presumptive tuberculosis patients,To determine the association of the respiratory microbiota and socio-demographic characteristics among presumptive and confirmed tuberculosis patients,To determine the correlation between the clinically significant microbiota and clinical presentation among presumptive and confirmed tuberculosis patients,To determine the clinically significant pathogens co-infecting the presumptive tuberculosis patients ,A systematic review of the respiratory microbiome changes in relation to Tuberculosis,
Uganda 2024-12-02 17:07:10 2027-12-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Betty Akurut Enyipu
ID: UNCST-2021-R013556
Prevalence of Anxiety and Depression Among Students of Uganda Christian University
REFNo: SS3474ES

Development of Innovative Psychotherapy Models: The project will result in the development of group-based psychotherapy models specifically designed to address depression and anxiety among university students. These models will draw upon evidence-based practices while also incorporating culturally relevant elements to ensure effectiveness within the Ugandan context.,
Uganda 2024-12-02 17:06:13 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
JUDITH NASSAAZI
ID: UNCST-2023-R007664
ASSESSING THE KNOWLEDGE AND ATTITUDES OF CAREGIVERS TOWARDS PAEDIATRIC ORTHOPAEDIC SURGERY AT CORSU HOSPITAL
REFNo: HS5217ES

primary objectives;
-To assess the knowledge and attitude of caregivers towards paediatric orthopaedic surgery at CoRSU Hospital

Secondary Objectives
1. To determine the caregivers’ knowledge towards paediatric orthopaedic surgery at CoRSU hospital.
2. To determine the caregivers’ attitude towards pediatric orthopedic surgery at CoRSU hospital 3. To identify factors influencing caregiver decision-making in pediatric orthopaedic surgery
Uganda 2024-12-02 17:05:18 2027-12-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Ssekitoleko
ID: UNCST-2019-R001716
Affordances of makerspaces influencing biomedical undergraduate engineering students' design learning and curriculum localization in Uganda and the USA
REFNo: SIR448ES

Main Objective
To explore and compare how the affordances of the DesignCube makerspaces at Makerere University and Duke University influence biomedical engineering students' design learning and the localization of curriculum by the end of the study period.

Specific Objectives
1.To determine the perceived affordances of the DesignCube makerspaces among undergraduate biomedical engineering students at Makerere University and Duke University within the first four weeks of their engagement in the design coursework.

2.To assess the actual affordances of the DesignCube maker spaces after students’ full engagement with the prototyping and design coursework by the end of the academic term.

3.To identify the factors that foster or limit student engagement with the DesignCube makerspaces at Makerere University and Duke University by the completion of the study.

4.To evaluate how the affordances identified in each context (Makerere and Duke) inform the localization and adaptation of curriculum and pedagogy for design learning in biomedical engineering by the final stage of the study.
Uganda 2024-12-02 17:04:31 2027-12-02 Engineering and Technology Non-Clinical Trial Non-degree Award
Abel Mucunguzi
ID: UNCST-2023-R006397
LEVERAGING THE TEA VALUE ADDITION CHAIN PROJECTS FOR COMMUNITY DEVELOPMENT AND POVERTY REDUCTION: EVALUATING NAADS SUPPORT TO TEA INDUSTRY IN GREATER BUSHENYI, UGANDA
REFNo: SS3382ES

1.4.1 To ascertain the number of transformative community projects /value addition SMEs that have sprung up in the tea producing communities of Greater Bushenyi since the onset of NAADS assistance
1.4.2 To assess the socio-economic impact that has been realized from the transformative community projects /value addition SMEs that strung up in Greater Bushenyi since the onset of NAADS assistance
1.4.3 To establish the challenges/obstacles that have hindered the formation/operation of transformative community projects/value addition SMEs in Greater Bushenyi since the onset of NAADS assistance
1.4.4 To generate alternative approaches by which the government and partners (recipients) of NAADS assistance should have used in order to encourage more transformative community projects /value addition SMEs to spring up and grow in Greater Bushenyi

Uganda 2024-12-02 17:03:29 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jacob  Mutazindwa Kasabunga
ID: UNCST-2024-R015547
Agriculture and Livelihoods in Uganda
REFNo: SS3430ES

Main objective/ purpose
The purpose of the baseline study is to determine baseline values related to the current state of agricultural production, productivity, and the levels of access to commercialization facilities and to affordable and sustainable rural microfinance for value chain development in Uganda.

Specific Objectives
Specifically the baseline study aims: -
i. To assess the feasibility of investments in the coffee, rice, oil seed (sunflower and soybean), simsim (sesame), dairy (milk and milk products), and goats and sheep value chains to improve farmer incomes, and the feasibility of investments in cassava, maize and beans to improve food security as well as the cross-cutting themes of climate change as well as gender.

ii. To obtain qualitative data through conducting stakeholder interviews, facilitating focus group discussions, and obtaining quantitative data through a survey in targeted regions in Uganda.
iii. To assist in other research activities, including assisting the project team in identifying survey subjects that meet project inclusion criteria and respondents that can inform the feasibility study.
iv. To assist in piloting and refinement of data collection instruments and contribute to analysis to inform the Baseline Report and Feasibility Study

Uganda 2024-11-27 15:38:15 2027-11-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Stella Neema
ID: UNCST-2019-R000814
Understanding the processes and acceptability of a child-friendly paediatric formulation of Praziquantel for the treatment of schistosomiasis among preschool-aged children in endemic districts in Uganda
REFNo: SS3420ES

The overall aim of this study is to analyse the factors surrounding the pilot introduction of arPZQ among PSAC in communities in Uganda at the macro, meso and micro levels.

Objectives

1. To evaluate the acceptance, appropriateness and perception of paediatric schistosomiasis treatment and distribution (delivery) among caregivers and other community members

2. To analyse the acceptance and perception of the paediatric praziquantel distribution methods among implementation personnel

3. To evaluate advocacy, social mobilisation and communication strategies and toolkits supporting the delivery of paediatric schistosomiasis treatment

4. To evaluate the pilot implementation of the weight-based dosing protocol


Uganda 2024-11-26 19:48:25 2027-11-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
JOSEPHINE  BAYIGGA
ID: UNCST-2024-R003757
Understanding preferred Tuberculosis Treatment adherence interventions among persons identified with Alcohol use Disorder in Kampala, Uganda: A mixed methods study
REFNo: SS3228ES

The study aims to elicit the preferred tuberculosis treatment adherence interventions among persons with alcohol use disorder in Kampala, Uganda,
Uganda 2024-11-26 19:46:58 2027-11-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Eve  Namisango
ID: UNCST-2021-R014038
Improving end-of-life care for dying patients and their families in Ugandan ICUs
REFNo: HS4832ES

5. Synthesise the findings to produce recommendations for future end-of-life care in ICU practice, research and policy.,To explore clinicians’ experiences of end-of-life care provision in Ugandan ICUs and the use of person-centred outcome measures.,3. To utilise the Integrated Palliative care Outcome Scale (IPOS) staff version as a tool in identifying symptoms and important concerns at the end of life in ICU,2. To assess symptoms and important concerns at end=of-life in ICU using the integrated palliative care outcome scale ,1. To explore ICU clinician’s perspectives of factors influencing the provision of quality end-of-life care through a survey,To explore factors influencing the provision of end-of-life care in Ugandan ICUs test and evaluate the use of person-centred outcome measures in improving end-of-life care in dying patients and their families,
Uganda 2024-11-26 19:41:46 2027-11-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Nalugoda
ID: UNCST-2021-R013343
Improving understanding of Capacity to consent to sensitive biomedical Research among adolescents in Rakai Uganda (ICARE)
REFNo: SS3447ES

Aim 1: Sampling from RCCS-experienced and RCCS-naïve households, and using the MacCAT-CR, examine adolescent capacity to consent to biomedical research and correlates of that capacity.
1.a: Compare capacity to consent among early, middle, and late adolescents and their guardians.
1.b: Assess correlates of capacity, including actionable factors such as health literacy and education and biomedical-related factors such as PrEP eligibility, use, awareness, beliefs, peer norms, and stigma.
Aim 2: Using a systematic qualitative analysis – guided by our conceptual framework for mapping age differences – examine processes of decision-making around biomedical prevention and biomedical research (e.g., stigma, understanding of biomedical prevention and research risks and benefits and constructs like randomization, privacy, safety and autonomy) among guardians and early, middle and late adolescents.
Aim 3: In partnership with US and Uganda researchers, and IRB members, construct a digital toolkit to support decision making regarding key aspects of minor consent in low-resource settings.

Uganda 2024-11-26 19:40:05 2027-11-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jacklyn Arinaitwe Makaaru
ID: UNCST-2024-R015354
Examining the combined effects of a two-generation model involving childcare and financial support interventions to vulnerable businesswomen in urban refugee and host communities in Kampala
REFNo: SS3367ES

i) To understand the status of childcare burden and its attendant constraints on livelihoods for urban refugee women.
ii) To design interventions that alleviate the childcare burden for urban refugee women while at the same time improving their social and economic welfare.
iii) To evaluate the effects of these interventions on reducing the burden of childcare as well as business growth, productivity, profitability, livelihoods, and the wellbeing of urban refugee women/caregivers.

Uganda 2024-11-25 17:30:05 2027-11-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
Viral causes of acute respiratory illness among hospitalized children in Kasese District, Uganda:an observational cohort study.
REFNo: HS5218ES

Primary Objectives

The primary objective of this study is to test the feasibility of implementing rapid molecular diagnostic test and assess the burden and epidemiology of influenza subtypes A and B, SARS- CoV-2, and RSV among pediatric patients hospitalized for ARI in Kasese District, Uganda.

Specific Aims

Determine the feasibility of implementing a rapid molecular diagnostic testing program at peripheral health centers in rural western Uganda. We will measure the number of eligible children consenting to testing, the number of tests performed, the median time from sample collection to result, and the number of invalid test results due to either operator error or equipment issues.

Measure the proportion of pediatric hospitalizations for ARI attributable to SARS-CoV-2, influenza subtype A and B, and RSV in communities with different population densities in Kasese district. We will enroll children admitted with ARI, test a nasopharyngeal swab for influenza, SARS-CoV-
2 and RSV using the Cepheid GeneXpert platform, and document participant demographic information.

Describe the clinical presentation and management for patients admitted with respiratory illness to health facilities in Kasese District. We will record the vaccination history, presenting symptoms, diagnoses, and treatments administered, including antibiotics. We will also follow-up all enrolled participants two weeks after admission to determine illness outcomes. We will compare these variables between those who test positive and those who test negative for SARS-CoV-2, influenza, and RSV.

Uganda 2024-11-25 17:28:46 2027-11-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JULIET BABIRYE ALLEN
ID: UNCST-2023-R005641
PREVALENCE AND ASSOCIATED FACTORS OF DYSLIPIDEMIAS AMONG PLHIV AT GOMBE HOSPITAL, IN RURAL UGANDA
REFNo: HS5050ES

ii. To determine the factors associated with dyslipidemia among PLHIV in rural Uganda.,i. To determine the prevalence of dyslipidemia among PLHIV in rural Uganda,To determine the prevalence of dyslipidemia and the associated factors among PLHIV attending the HIV clinic at Gombe hospital.,
Uganda 2024-11-25 17:25:45 2027-11-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Dorit Stein Talia
ID: UNCST-2022-R010349
Modeling Health and Welfare Impacts of National Health Insurance in Uganda
REFNo: SS2522ES

To advance the use of routinely collected administrative data and simulation modeling for health policy decision-making in Uganda. ,To support evidence-based policy debates around what outcomes a national health insurance program should achieve, for whom, how, and at what cost. ,To quantify the distributional health and financial risk protection benefits that may occur from scaling-up a benefits package of health interventions for the most common chronic diseases in Uganda (i.e., cardiovascular diseases, cancers, diabetes).,This study aims to generate empirical evidence on the potential population health, poverty alleviation, and equity impacts of increasing public expenditure on health in the form of a national health insurance scheme in Uganda.,
USA 2024-11-25 17:24:28 2027-11-25 Social Science and Humanities Non-Clinical Trial Degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
Rapid Research for Diagnostics Development TB Network in children and Assessing Diagnostics at POC for TB in children (R2D2_ADAPT Kids)
REFNo: HS5144ES

1. To validate the diagnostic accuracy of design-locked novel TB tests in children with presumptive intrathoracic TB overall and in key sub-groups to inform policy development.
2. To assess the usability and acceptability of design-locked novel TB tests for children.

Uganda 2024-11-25 17:23:03 2027-11-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rono Josea Josea
ID: UNCST-2024-R002148
Private Sector DMPA-SE Market survey in Uganda
REFNo: SS3402ES

1. To map out the journey of WRA in accessing contraception in urban settings and identify critical touchpoints, pain points, and unmet needs.
2. To segment clients into distinct groups based on demographics, behaviours, motivations, and unmet needs and understand on how each group experiences the contraceptive journey and perceives available options.
3. To explore fit of potential DMPA-SC “concept” offerings to unmet needs from client segments and identify features, benefits, and service components that address specific pain points or desires of the target segments.
4. To explore and develop value propositions associated with each DMPA-SC “concept” offering and explore how the product concept meets the identified needs and motivations of different client segments.
5. To test the appeal, relevance, and potential effectiveness of DMPA-SC concepts. Focus on obtaining detailed feedback on value propositions, potential narratives and identify trade-offs that clients are willing to make when considering different options
6. To develop and refine DMPA-SC messaging strategies that resonate with client segments, addressing their unmet needs and supporting informed choice and self-care.

Uganda 2024-11-25 16:25:42 2027-11-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patience Kinengyere Bemanya
ID: UNCST-2024-R004964
Evaluation of Diabetic Retinopathy Detection Strategies in Urban Kampala, Uganda
REFNo: HS5046ES

To assess WHO DR detection protocols and facilitate the adoption of a customised early DR detection strategy among DM patients in Urban Kampala, Uganda, to enhance management outcomes,
Uganda 2024-11-25 14:19:24 2027-11-25 Medical and Health Sciences Non-Clinical Trial Degree Award
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