Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
ANTHONY KAYIIRA
ID: UNCST-2020-R014108
Understanding Reproductive Health among Survivors of Paediatric and Young adults (URHSPY) Cancers: a mixed method study
REFNo: HS1652ES

To explore the knowledge, perceptions, and attitude of; parents or caretakers of children with cancer, and health workers on cancer treatment-related reproductive morbidity, at the Uganda Cancer Institute,To describe self-reported reproductive morbidity associated with cancer treatment among childhood and young-adult cancer survivors.,To establish the extent of reproductive morbidity associated with cancer treatment among young cancer survivors in Uganda. In addition, we aim to explore the contextual enablers and barriers to addressing cancer treatment-related reproductive morbidity in Uganda.,
Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda Ndidde
ID: UNCST-2020-R014331
Study Protocol for the Evaluation of Covid 19 Antibody and Antigen Rapid Diagnostic Test (RDT) In the EAC Partner States
REFNo: HS1591ES

Evaluation of ELISA cross-reactivity on stored archived negative samples between East African Partner States. ,Evaluation RDT performance differences between the East African Partner States,- Evaluate the clinical specificity of antibody RDT and ELISA using serum/plasma specimens from COVID-19 negative specimens from pre-COVID-19 (archived stored samples),- Evaluation of COVID19 antibody RDTs and ELISA’s in the East African region, using serum/plasma samples from COVID-19 confirmed based on RT-PCR results (RT-PCR positive test results). ,Evaluation of COVID19 antigen RDTs against gold standard PCR in the East African region,
Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda Ndidde
ID: UNCST-2020-R014331
Evaluation of TUBEX Typhoid TF IgM Antibody test for Early Diagnosis of Typhoid fever Among patients in Uganda
REFNo: HS1548ES

1) To carry out blood culture testing on all samples from patients with signs and symptoms of typhoid fever in the selected facilities of Uganda.
2) To carry out serological testing for Salmonella antibodies using the TUBEX Typhoid TF IgM Antibody test on the serum samples of consented/assented patients whose samples grew Salmonella Typhi.

Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Nalugoda
ID: UNCST-2021-R013343
Exploring the impact of out-migration on remaining partners’ HIV and sexual behavior perceptions and practices in Rakai, Uganda: a qualitative study.
REFNo: SS981ES

The overall aim of this study is to qualitatively explore the impact of out-migration amongst heterosexual couples on non-migrating partners’ HIV and sexual behavior perceptions and practices in Rakai, Uganda.
Uganda 2021-09-09 2024-09-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jafesi Pulle
ID: UNCST-2020-R014213
TRUST IN MEDICAL RESEARCH AMONG PATIENTS AT A REGIONAL REFERRAL HOSPITAL AND COMMUNITY MEMBERS IN LIRA DISTRICT, NORTHERN UGANDA
REFNo: HS1685ES

Explore community perceptions of trust in medical research,2. Determine the other factors associated with trust of medical research,1. Compare level of trust for medical research among community members and persons that are hospitalized.,To compare the level of trust in medical research among people hospitalized at a hospital and the community members, identify associated factors and explore prevailing community perceptions of trust in medical research.,
Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Degree Award
Daniel Mongovin David Thomas
ID:
Dry Rifting in the Albertine-Rhino Graben (DRIAR)
REFNo: NS160ES

To conduct a geological investigation of faulting associated with continental rifting in the magma-poor rift environment in the northernmost Western Branch of the East African Rift System.
USA 2021-09-08 2024-09-08 Natural Sciences Non-Clinical Trial Degree Award
Julian Bagyendera Kobutungi
ID:
Gender, Youth and Social Inclusion Baseline Assessment for the USAID Local Partner Health Services – Ankole (USAID LPS – Ankole)
REFNo: SS1002ES

The main objective is to conduct a mixed method gender and youth social inclusion assessment which includes a literature review; collection of primary quantitative and qualitative data.,
Uganda 2021-09-08 2024-09-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
UNDERSTANDING PATHOGENESIS OF BURKITT LYMPHOMA TO DEVELOP BETTER TREATMENTS FOR AFRICAN ENDEMIC BURKITT LYMPHOMA
REFNo: HS1546ES

4. To establish a BL tumor biorepository at the Uganda Cancer Institute ,3. To generate PDX mouse models of BL to understand the molecular factors that govern response to COM therapy in children with endemic BL at the Uganda Cancer Institute. ,2. To describe the molecular differences between endemic BL and sporadic BL. ,1. To determine the molecular profile of endemic BL tumors at the Uganda Cancer Institute,
Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
PERFORMANCE EVALUATION OF COVID-19 ANTIGEN RAPID DIAGNOSTIC TESTS
REFNo: HS1690ES

To determine the association of positive index test results with disease stage (days since symptom onset, e.g. acute, early, late), symptom severity and symptom severity.,To determine the diagnostic accuracy of SARS-CoV-2 Ag RDTs on a respiratory specimen (NP swab, OP swab, nasal swab, saliva), vs Cobas SARS-CoV-2 assay as performed in patients presenting with influenza-like illness.,
Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
A clinical trial to assess the safety and immunogenicity of LNP-nCOV saRNA-02, a self-amplifying ribonucleic acid (saRNA) vaccine encoding the S glycoprotein of SARS-CoV-2, the causative agent of COVID-19, in SARS-CoV-2 seronegative and seropositive Uganda population
REFNo: HS1641ES

Primary Objective:

• To compare the safety and immune responses for SARS-CoV-2 seronegative and seropositive individuals from two immunisations with LNP-nCOV saRNA-02 administered IM 4 weeks apart at one dose level in 42 participants age 18-45 years.

Exploratory Objectives:
• To characterise the humoral and cellular immune responses to LNP-nCOV saRNA-02 administered at one dose given at 0 weeks and 4 weeks for individuals seronegative and seropositive for SARS-CoV-2 antibodies
• To characterise the profile of class and sub-class of antibody responses
• To characterize infection induced immune responses in participants with naturally acquired infection who are also exposed to the vaccine

Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Clinical Trial Non-degree Award
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