Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Julian Natukunda
ID:
Long-term retention and associated positive practices among Community Client Led ART Distribution groups (CCLADs) in Uganda
REFNo: SS895ES

3. To investigate the association between uncommon practices and long-term retention in CCLADs to confirm uncommon practices are PD behaviors,2. To identify uncommon practices (group and individual) among high retention groups, using the positive deviance approach,1. To assess retention and time for time to withdrawal from CCLAD groups since enrolment in the program ,
Uganda 2021-07-05 2024-07-05 Social Science and Humanities Non-Clinical Trial Degree Award
Elodie Freymann Marion
ID:
Intergenerational Transmission of Self-Medicative Knowledge in Chimpanzees? Examining Putative Modes and Mechanisms of Information Transmission Between Chimpanzees
REFNo: NS257ES

Homo sapiens are not the only species to self-medicate. Over the last few decades, self-medication has been observed in a variety of primate and non-primate species and throughout a wide range of localities (Janzen, 1978; Huffman, 2016). Non-human self-medication takes many forms and involves a variety of medicinal resources. These include self-medicative resources (SMRs) known to be used in medicinal behaviors like leaf swallowing (Wrangham & Nishida, 1983) and bitter-pith chewing (Huffman & Seifu, 1989), putative therapeutic resources (PTRs) which are irregular dietary items with known bioactive properties, ingested when an individual is ill, and medicinal foods (MFs) which are foods eaten at low frequencies in the absence of symptoms, at certain times of year when their associated medicinal properties are likely most beneficial for preventing future infection or illness (Huffman, 1997). While bioactive and limitedly nutritious botanical species remain the best studied medicinal resources, clay, termite soil, and cambium beneath peeled tree bark are also widely acknowledged as possessing medicinal properties (Pebsworth et al., 2019). In recent literature, many other resource types have been proposed as candidates for further study, including driver ants, honey, ash, and mushrooms, although no studies thus far have empirically established the intentional use of these resources by sick chimpanzees.

Although chimpanzees have been shown to transmit medicinal information to their peers in experimental settings (Huffman & Hirata, 2004; Huffman et al., 2010), the modes, mechanisms, and social learning processes through which chimpanzees transmit medicinal knowledge and behaviors remain untested in free-ranging chimpanzees. This project, titled ‘Intergenerational Transmission of Self-Medicative Knowledge in Chimpanzees? Examining Putative Modes and Mechanisms of Information Transmission Between Chimpanzees’ will consist of three studies, all of which aim to test hypotheses related to intergenerational self-medicative knowledge transmission: the modes and mechanisms facilitating this transmission, and how this knowledge disperses across communities in wild populations. This research will be carried out as part of the completion of Ms Freymann’s DPhil at the University of Oxford.

The first study, titled ‘Gestural Communication During Chimpanzee Self-Medication Events? An analysis of multi-modal signaling between self-medicating models and observers’ will examine whether or not model individuals use specific multi-modal signals and/or increased signaling frequencies to communicate medicinal information to offspring or non-kin observers. The second study, titled ‘Mapping the Self-Medicative Landscape: Do wild chimpanzees revisit medicinal resource sites when seeking treatment?’ will evaluate the presence or absence of habitually utilized SMR sites, to determine whether or not preferred locational ‘hotspots’ exist for chimpanzees within their habitat, and may function as contextual clues to alert chimpanzee observers to the potential onset of a self-medicative event. The third study, titled ‘Evaluating Inter-Community and Intra-Community Variation in Resource Selection and Self-Medicative Behaviors' will evaluate whether or not medicating individuals demonstrate inter-group and/or intra-group variation in their employment of self-medicative behaviors and medicinal resource selection, as well as whether or not social and demographic variables can predict the presence of these variants.

There are two neighboring habituated chimpanzee communities in Budongo forest, the Sonso community, with has ~65 individuals, and the more recently habituated Waibira community which has ~120 individuals. While this research will begin with the Sonso community, if this group becomes unavailable for study due to other scheduled projects, Ms Freymann will flexibly move her data collection to the Waibira community to make the study a cross-community comparison.

Research Questions
1. Gestural Communication During Chimpanzee Self-Medication Events?
• Are gestural signals used at higher frequencies during medicinal events than during normal feeding events?
• Do models use signals at higher frequencies in the presence of an observer during medicinal ingestion events than during medicinal events in which the medicating individual is alone?
• Do medicators increase signaling frequencies during medicinal events based on relatedness to observers?
• Is the proportion of ‘successful’ begging outcomes higher during medicinal events than the proportion of ‘successful’ begging outcomes during normal feeding events?
• Do signaling frequencies between individuals during medicinal events vary based on demographic characteristics or health state?
• Are there specific signals that are used during medicinal events which are not commonly used during normal feeding events?
• Do signal types between models and observers exhibited during medicinal events vary based on social relationships, demographic characteristics, resource type, or behavioral type?

2. Mapping the Self-Medicative Landscape
• Are locations where SMR or PTR ingestion events took place spatially clustered into hot spots?
• Do individuals re-use the same SMR resource hotspots when they are sick?
• Do sick individuals utilize sites with high resource abundance scores over sites where the resource is scarce?
• Do any demographic variables (age, sex and reproductive status) predict which individuals visit which medicinal hotspots?
• When sick individuals travel away from the group to self-medicate, do they choose the most efficient route, foregoing nutritious resources and normal feeding sites to get to the closest available resource, or do they ignore closer sites and return to habitually used sites?

2. Evaluating Inter-Community and Intra-Community Variation in Resource Selection and Self-Medicative Behaviors
• Across all individuals in the community, are specific sickness behaviors correlated with an increase in ingestion of any specific resource type or species?
• Does there appear to be behavioral variation during medicinal events?
• If variation does exist, can horizontal or vertical transmission predict the diffusion pathways of the behavioral variants?
• Does variation in self-medicative behavioral techniques or resource selection appear to be cultural?

USA 2021-07-05 2024-07-05 Natural Sciences Non-Clinical Trial Degree Award
Mary Grace  Nakate Nakate
ID:
The psychological experience and the Perceived Support of Nurses who Underwent Mandatory Quarantine or Self Isolation During Covid-19 Pandemic in Uganda and Kenya
REFNo: SS877ES

Major Objective
To explore the psychological experience and perceived support of nurses who underwent mandatory quarantine or self-isolation in Uganda and Kenya during the COVID-19 pandemic.

Specific Objectives
1.Describe the experiences of depression among the nurses who underwent mandatory quarantine or self-isolation in Uganda and Kenya during the COVID-19 pandemic.
2.Examine the anxiety experienced by the nurses who underwent mandatory quarantine or self-isolation in Uganda and Kenya during the COVID-19 pandemic.
3.Describe the stressful experiences of nurses who underwent mandatory quarantine or self-isolation in Uganda and Kenya during the COVID-19 pandemic.
4.Describe the perceived psychological support of the nurses who underwent mandatory quarantine or self – isolation during the COVID-19 pandemic. in Uganda and Kenya

Uganda 2021-07-05 2024-07-05 Social Science and Humanities Non-Clinical Trial Non-degree Award
ASIIMIRE  DONATH
ID: UNCST-2021-R013270
Women's Economic Empowerment and Changing Family Patterns in Ankole Sub-region
REFNo: SS873ES

Women's eduction and changing family patterns in A nkole.
Earning of Income by women and changing family patterns in Ankole Sub-region.
Women's access and control over productive assets and changing family patterns in Ankole
Uganda 2021-07-05 2024-07-05 Social Science and Humanities Non-Clinical Trial Degree Award
marie nanyanzi
ID: UNCST-2019-R001553
Sauti Za Wananchi (Voices of citizens) Baseline Survey Panel II
REFNo: SS887ES

o Gather opinions from the citizens on the key services they receive especially
ï‚§ Establish citizen access to safe water;
ï‚§ Establish citizen access and usage of health services;
ï‚§ Establish the citizens attitudes and practices on issues related to COVID-19
ï‚§ Find out level of participation/involvement/interaction in development and public activities /institutions;
ï‚§ Find out access and usage of financial services amongst citizens;
ï‚§ Find out how; what and when citizen access different type of information including government and development information.
ï‚§ Establish the knowledge, Attitudes and Practices (KAPs) of citizens on different policies; laws and regulations etc

Uganda 2021-07-05 2024-07-05 Social Science and Humanities Non-Clinical Trial Non-degree Award
Amos Kijjambu
ID:
EVALUATION OF THE BARRIERS, OPPORTUNITIES, AND VACCINE HESITANCY FOR CHILDHOOD IMMUNISATIONS IN URBAN AREAS; A CASE STUDY OF NANSANA MUNICIPALITY, UGANDA.
REFNo: HS1507ES

General Objective
• To assess the barriers, opportunities, and vaccines hesitancy for childhood immunizations in urban areas to design relevant interventions to improve immunization coverage and improve the health outcomes of children.
Specific Objectives
• To establish the immunization coverage rates in Nansana municipality for children aged under two years.

• To identify factors (parents/guardians-child, health system factors) associated with uptake of immunization for preventable childhood illnesses in Nansana Municipality, Uganda.

• To establish the prevalence of vaccine hesitancy among parents/guardians of children aged <24 months in Nansana Municipality.
• To identify the determinants of vaccine hesitancy among the parents/guardians of children aged < 24 months in Nansana Municipality.

Uganda 2021-07-05 2024-07-05 Medical and Health Sciences Non-Clinical Trial Degree Award
Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
Exploring Understanding and Acceptability for Participation in Randomized Placebo-Controlled Trials and Delayed Consent Involving Sepsis Patients in Uganda (REVISTA-QUAL)
REFNo: SS913ES

General objective
The overarching goal of this study is to explore patients’, clinical providers’ and caregivers’ understanding of placebo controls, delayed consent and overall acceptability of participation in RCTs involving sepsis patients in a representative Ugandan RRH.
4.3 Specific objectives
1. To describe the patients’, clinical providers’ and caregivers’ understanding of RCTs and the informed consent processes in a representative Ugandan RRH
2. To explore the patients’, clinical providers’ and caregivers’ acceptability of participation in RCTs, including being randomized to a placebo arm and alternative approaches to the consenting process (e.g., delayed consent) for critically ill patients hospitalized in a representative Ugandan RRH.

Uganda 2021-07-05 2024-07-05 Social Science and Humanities Non-Clinical Trial Non-degree Award
Francis Anyanzu
ID:
The role of social networks in destination selection among urban refugees in Uganda
REFNo: SS519ES

Main objective
To investigate the role of social networks in destination selection among the urban refugees in Uganda
Specific objectives
a) To investigate the socio-demographic characteristics of the urban refugees in Uganda
b) To map the movement histories and social networks of the urban refugees in Uganda.
c) To examine the influences of social networks in the selection of city of destination.

Uganda 2021-07-02 2024-07-02 Social Science and Humanities Degree Award
Laban Musinguzi Kashaija
ID: UNCST-2020-R014407
Knowledge, Attitudes and Practices (KAP) Study on Children with Disabilities (CWD) living in families and institutions in Uganda
REFNo: SS585ES

The study seeks to achieve two primary aims/objectives:
1. To evaluate the current Knowledge, Attitudes and Practices (KAP) regarding the (i) attributes and conceptualization of CWD (ii) the use of institutional care for CWD and (iii) the barriers/enablers of the full and meaningful integration of CWD into community life.
2. To explore possible interplay between the identified Knowledge/Attitudes and Practices. This includes investigating the relations between the conceptualization/attributes of CWD, the use of institutional care for CWD and the integration of CWD into community life.
Uganda 2021-07-02 2024-07-02 Social Science and Humanities Non-degree Award
MICHAEL KAWOOYA GRACE
ID: UNCST-2020-R014672
A Retrospective review of new interventional and selected imaging procedures at ECUREI-Mengo Hospital from 2008-2018
REFNo: HS1053ES

Main Objective
1. To identify diagnostic and interventional radiology procedures at ECUREI radiology department, Mengo Hospital.

Specific Objectives
1. To identify and determine image-guided interventional radiology procedures and related outcomes at ECUREI radiology department, Mengo Hospital from 2008 to 2018
2. To identify and determine diagnostic radiology procedures and related outcomes at ECUREI radiology department, Mengo Hospital from 2008 to 2018.
Uganda 2021-07-02 2024-07-02 Medical and Health Sciences Non-degree Award
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