Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Isaac Ebiju
ID: UNCST-2024-R003903
 Assessing the Impact of Summary Clinical Guidelines (charts and wheels) on Rational Antibiotic Use and Compliance with Uganda Clinical Guidelines Among Outpatient Prescribers: A case study of Health Centres III & IV in Kampala, Uganda.
REFNo: HS4926ES

To assess the impact and sustainability of summary clinical guidelines for improving compliance of prescription patterns with treatment guidelines on antibiotic use among prescribers at health Centers III and IV in Kampala, Uganda.,To analyze factors affecting guideline utilization among prescribers at health Centers III and IV in Kampala, Uganda.,To assess the compliance and prescription patterns of the Uganda Clinical Guidelines by prescribers at health Centers III and IV in Kampala, Uganda. ,To determine if the use of summary clinical guidelines improves the rational use of antibiotics and adherence to Uganda clinical guidelines among prescribers in outpatient departments of Health Centre IIIs and IVs in Kampala, Uganda.,
 Uganda 2024-10-14 8:08:10 2027-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Thereza Piloya Were
ID: UNCST-2019-R000491
 Effects of Social Determinants of Health on Type 1 Diabetes (T1D) Care in Sub Saharan Africa; Perspectives from Uganda.
REFNo: HS5008ES

Primary
i. To describe the SDOH among the children and youths in Uganda.
ii. To determine the impact of SDoH on glycemic control of children and youths aged 6 months- 25 years in Uganda.
iii. To determine the effect of the SDoH on the physical growth of children and youths in Uganda.
Secondary
i. To set up a database of SDoH for children with T1D in Uganda.
ii. To determine the effect of the SDoH on the complications (DKA, severe hypoglycemia and hypertension) of children and youths in Uganda.

 Uganda 2024-10-14 8:06:50 2027-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
 Impact of Non-B HIV-1 Subtype on second-line Protease Inhibitor Regimens in Africa (INSPIRE)
REFNo: HS5035ES

To evaluate the effect of replicative fitness on susceptibility to PIs in patients with repeated failure in presence of known and novel Gag and Env PI-associated mutations.,To assess HIV-1 drug resistance in PI-resistant viruses using phenotypic drug susceptibility assay and recombinant viruses based on gag, pol, and env genes derived from patients failing 2L.,To determine the basis for second line (2L) treatment failures on ATV/r- and LPV/r-containing regimens in the absence and presence of protease-associated drug resistance.,To determine the effect of Non-B HIV-1 Subtype on second-line Protease Inhibitor Regimens in Africa.,
 Uganda 2024-10-14 8:03:22 2027-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Benjamin Eyre
ID: UNCST-2024-R002750
 Enumerating development: how interdisciplinary perspectives on the treatment of research officers can improve data for social transformation
REFNo: SS3327ES

To generate new knowledge on FOs perspectives in relation to their work practices and conditions with a particular focus on how they see this affecting the quality of the data they produce. ,To explore challenges FOs negotiate, including low salaries, precarious employment contracts, pressure to perform quickly, working in dangerous environments, and negotiating knowledge hierarchies.,To document the lived experience of FOs working in the behavioural economics research sector in Uganda. Their work involves conducting surveys, experiments, and RCTs in informal urban settlements, peri-urban, and rural areas. ,
 UK 2024-10-14 8:02:17 2027-10-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
 Providing Rapid HIV viral Diagnostics at Point of Care (The PROmPT) study.
REFNo: HS4881ES

Primary:
To evaluate quantitative performance of the HIV self-testing platform in a resource-limited setting (Uganda) compared to a laboratory-based, gold-standard FDA-approved HIV VL test (Roche Cobas Quantitative HIV-1 RNA, or Abbott Real Time HIV-1 assay, or similar) in PLHIV who have both viral suppression and non-suppression.

Secondary:
To evaluate patient acceptability of the HIV self-testing platform compared to gold standard VL assay
To compare the Turnaround Time (TaT) of the HIV VL self-testing assay and lab-based VL assay
To compare the assay performance of the HIV self-testing platform to lab-based testing by sex, age group, HIV viral load, HIV clade, and HIV risk group

 UK 2024-10-08 18:13:17 2027-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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