Mary Nanteza Bridget
ID:
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ASSESSING A UGANDAN COMMUNITY FOR ACCEPTABILITY, SHORT- AND LONG-TERM SIDE EFFECTS OF COVID-19 VACCINE UPTAKE AND THE COLLECTION OF RELEVANT BIOLOGICAL SPECIMENS TO SUPPORT IMMUNOLOGICAL, HOST, AND VIROLOGICAL STUDIES ON COVID-19 VACCINE.
REFNo: HS1660ES
STUDY GOAL AND OBJECTIVES
The overall objective of this study is to assess acceptability, document short and long-term side effects, characterize break-through viruses that are linked to COVID-19 vaccination, and collect specimens for studies aimed at understanding host, viral and immunological factors associated with COVID-19 vaccine.
Specific objectives:
1. To assess the community knowledge, attitudes and perceptions (KAP) towards COVID-19 vaccines.
2. To describe the short and long-term side effects of COVID-19 vaccine provided at the UVRI clinic
Blood specimens will be collected for the following immunological and virological studies below:
3. To describe the sensitivity of COV ID-19 breakthrough viruses to prior and co-existing anti-SARS-COV-2 antibody and cellular immune responses after immunization with or without prior history of COVID-19 infection; and to also isolate SARS-CoV-2 Spike-specific human monoclonal antibodies in volunteers with strong neutralization responses.
4. To describe the correlation between pre-COVID-19 vaccination immune status, and outcome of vaccine induced immunity in newly vaccinated persons.
5. To describe COVID 19 immune responses in unvaccinated and already vaccinated persons before and after incident infections
6. To describe break-through viruses following COVID-19 immunization among the vaccinated persons
7. To describe host genetic factors that could be relevant for immune protection and disease outcome
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Uganda |
2021-09-22 |
2024-09-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Eleanor Namusoke Magongo
ID: UNCST-2021-R013199
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Transitioning children to Optimal Regimens of Paediatric Dolutegravir (TORPEDO) in Uganda
REFNo: HS1596ES
the primary objective for the study is to assess patients’/ caregivers’ preference for a paediatric DTG regimen over their previous regimen, when transitioned from another regimen.
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Uganda |
2021-09-22 |
2024-09-22 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Jihane Farhat Ben
ID:
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Evaluation of two strategies part of the Differentiated Services Delivery Models
(DSDM) in Fishermen’s landing sites at Lakes George and Edward, Western
Uganda.
REFNo: HS1574ES
The main objective of the study is to describe acceptability and outcomes (VL suppression and
retention) relevance of MSF Landing site activities for the target populations to reorient
activities and document best practices.
The specific objectives are:
- To measure the proportion of eligible patients who enrol in CCLADs and FTR
- To compare characteristics of patients choosing CCLAD with those choosing FTR
- To measure the retention in care in CCLADS and in FTR at 6 and 12 months
- To measure the viral suppression for patients enrolled in CCLADS and in FTR for at least 1 year
- To describe acceptability and relevance of DSDM, peer zonal leaders, peers at the health facilities, VIP clinic days, OJT/CMEs for health workers and the information points.
|
France |
2021-09-22 |
2024-09-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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IVAN IBANDA
ID:
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Diagnostic and Treatment Delay of Tuberculosis: An In-depth Analysis of the Health-Seeking Behavior of Patients and the Health System Response in Kampala District
REFNo: HS1654ES
To determine the patient and system related factors that contribute to both diagnosis and treatment delays in Kampala District,To determine the proportion of patients that have a treatment delay for tuberculosis in Kampala District.,To determine the proportion of patients with tuberculosis diagnostic delay in Kampala District.,To evaluate the extent of diagnostic and treatment initiation delays of TB patients, identify the major contributors to such delays (patient or system), and study their various determinants.,
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Uganda |
2021-09-22 |
2024-09-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Goylette Chami
ID: UNCST-2023-R006262
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SchistoTrack: Determinants of schistosomiasis infection
and morbidity as part of the Oxford-Uganda Collaboration on Schistosomiasis
REFNo: HS1664ES
Determine whether infection indicators are informative for measuring morbidity risks
associated with schistosomiasis;
2. Prioritize the most common morbidities associated with schistosomiasis, by age, that
require treatment and further research;
3. Understand the relative importance of environmental factors versus current infections for
schistosomiasis- associated morbidities.
4. Assess the feasibility of large-scale tracking of individuals with wearable GPS;
5. Determine whether spatial indicators from wearable devices can better predict individual
infection risk when compared to conventional approaches such as household surveys;
and
6. Develop methods to classify water contact sites based on individual usage and
contamination to understand whether there are focal points for transmission or super
spreaders.
|
USA |
2021-09-22 |
2024-09-22 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Freddy Kitutu Eric
ID: UNCST-2020-R014751
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Development and implementation of a patient-centred peer support intervention to promote the detection, reporting and management of adverse drug reactions among people living with HIV in Uganda
REFNo: HS1206ES
To estimate the effectiveness of the peer support intervention on the rate of ADR-reporting by PLHIV receiving DTG and/or IPT in Uganda,To describe the patterns of ADR-reporting (number, rate, time to reporting, seriousness) by PLHIV receiving DTG and/or IPT in whom the peer support intervention is implemented in Uganda,To determine the barriers and facilitators to implementation of the peer support intervention to promote ADR detection, reporting and management among PLHIV on DTG and/or IPT in Uganda,To develop an innovative peer support intervention for promoting the detection, reporting and management of ADRs in PLHIV receiving DTG and/or IPT in Uganda,
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Uganda |
2021-09-21 |
2024-09-21 |
Medical and Health Sciences |
|
Non-degree Award |
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Maxson Anyolitho Kenneth
ID: UNCST-2021-R013447
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Community Engagement and Schistosomiasis Prevention: A Sociological Analysis of the Citizen Science Model among Selected Communities of Western Uganda
REFNo: SS836ES
Purpose of the study
The purpose of the study is to examine the effectiveness of the Citizen Science model in community engagement to the prevention of schistosomiasis among selected communities of western Uganda. To do this, the study will determine the socio-cultural barriers to the uptake of preventive measures to guide in the development of health education initiatives that can be executed by the Citizen Scientists to help change the behaviour of the community for the prevention of schistosomiasis.
Objectives of the study
This shall be guided by the following research objectives:
1. To determine the level of knowledge, attitude, and practice regarding schistosomiasis among communities of Western Uganda;
2. To explore the health-seeking practices, attitudes, and behaviour associated with schistosomiasis prevention among communities of Western Uganda
3. To understand the lived experiences and perceptions of schistosomiasis by communities of Western Uganda to determine how citizen scientists can be useful in shaping community perspectives
4. To develop and implement contextualized communication strategies for schistosomiasis prevention based on the outcome of the objectives above with help of the citizen scientists
5. To assess the role of the citizen science model of community engagement in the prevention of schistosomiasis among communities of western Uganda
|
Uganda |
2021-09-21 |
2024-09-21 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
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Rheumatic Heart Disease Community Streptococcal Treatment Program “RESETâ€
REFNo: HS1580ES
To improve the algorithm of the Strepic® device for Group A Strep Pharyngitis detection and then to test the performance as compared to microbiological culture (gold standard) and clinical decision rule.,To increase health seeking behavior for sore throat through a multifaceted community awareness campaign.,To improve guideline-based care through frontline healthcare provider education on clinical decision rules and guideline-based care through frontline healthcare provider education on clinical decision rules and guideline-based primary prevention.,To determine the impact of a pragmatic RHD primary prevention program in Uganda,
|
Uganda |
2021-09-21 |
2024-09-21 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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ELIZABETH NALINTYA
ID: UNCST-2021-R012882
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Long title: A community-based Phase III, cluster randomized trial of point-of-care CD4 testing and enhanced screening and prophylaxis in advanced HIV disease
Short title: An enhanced package of care to reduce mortality in advanced HIV disease
REFNo: HS1605ES
Primary Objectives:
1. To assess 24-week survival with retention in care in persons with advanced HIV disease (CD4<200 cells/µL) with point-of-care CD4 testing compared to standard flow cytometry
2. To assess 24-week survival with retention in care with an enhanced diagnostic OI screening and prophylaxis strategy compared to standard WHO package of care in persons with advanced HIV disease
Secondary Objectives:
1. To determine incidence of OIs
2. To measure adverse events with enhanced prophylaxis regimens
3. To assess tolerability and adherence of enhanced prophylaxis regimens
4. To determine incidence and cause of hospitalization for persons with advanced HIV disease
5. To determine cause of death for persons with advanced HIV disease
6. To determine HIV outcomes of viral suppression in persons with advanced HIV disease.
7. Measure cost, cost-effectiveness, and budgetary impact of the CD4 testing strategies, and OI screening and prophylaxis strategies.
|
Uganda |
2021-09-21 |
2024-09-21 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Graham Birch John
ID:
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Title of research project: Oxidative shielding and the inter-generational costs of
reproduction in male wild banded mongooses
REFNo: NS164ES
(1) To understand transgenerational influences on health and reproductive success in
wild mammals.
(2) To investigate the impact of paternal health on the development and reproductive
success of offspring, using banded mongooses as a model system.
|
UK |
2021-09-20 |
2024-09-20 |
Natural Sciences |
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Degree Award |
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