Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Radhika Sundararajan Lu
ID:
A pilot study of adherence support delivered by informal health providers to improve entry to and retention in HIV care in rural Uganda
REFNo: HS1747ES

: Pilot test the adapted intervention to evaluate implementation and impact on linkage/retention in HIV and ART adherence among individual PLWH,Adapt an evidence-based layperson adherence support curriculum for delivery by TH.,
USA 2021-10-01 2024-10-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
Evaluation of Clinical Chemistries from Biospecimens Collected with a Painless Capillary Blood Collection TASSO SST Among a Subset of Patients Enrolled in an Observational Study of Sepsis in Uganda
REFNo: HS1751ES

We plan to compare capillary chemistry values collected via the painless Tasso collection device to standard serum chemistry values collected via venipuncture at a single study visit (Day 28 of the main study(HS 2292)) for each consenting participant. We plan to evaluate the correlation between chemistry values from capillary versus venous blood collection and identify any scenarios where the values diverge such as for high or low values or for specific analytes collected in a remote field location. We plan to review the failure rate and causes for failure for the Tasso device
Uganda 2021-10-01 2024-10-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses Ntaro
ID: UNCST-2020-R014133
Effect of student community engagement on sanitation behavior: a case of Community Led Total Sanitation in Kabale District
REFNo: HS1135ES

To evaluate the effect of students community engagement on household level ODF status in Kabale District, Uganda so as to demonstrate the contribution of students in improving CLTS implementation and outcomes
Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Infant extended safety follow-up study – an observational study of brain imaging and child development in infants (DolPHIN-2 PLUS)
REFNo: HS1639ES

1. To determine if there are developmental differences following exposure to DTG or EFV. 2. To examine brain structure and microstructure of HEU children. 3. To determine developmental outcomes. 4. To validate the Hyperfine, low-field MRI system 5. To explore the impact of environmental factors such as antenatal iron-deficient anaemia on brain development in a high-risk birth cohort
Nigeria 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tom  Ngabirano Denis
ID: UNCST-2020-R014491
Effect of Enhanced Neonatal Jaundice Education on Knowledge, Early Detection and Care Seeking by Postnatal Mothers at Jinja Regional Referral Hospital
REFNo: HS1479ES

Objectives General objective To improve mothers’ knowledge of neonatal jaundice for early detection, proper care and prevention of severe neonatal jaundice. Specific objectives 1. To assess the level of mothers’ knowledge about neonatal jaundice at JRRH. 2. To implement an enhanced neonatal jaundice education package for postnatal mothers at JRRH. 3. To assess the effect of an enhanced neonatal jaundice education package on the level of knowledge, early detection and care seeking by postnatal mothers at JRRH.
Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lukia Namaganda Hamid
ID:
Malnutrition as a probable predictor of mortality in cerebral palsy (CP), and the effect of positive deviance and parent facilitator training strategies to malnutrition and caregiving among children and adolescents with CP in the Iganga, Mayuge and Bugweri rural districts of eastern Uganda
REFNo: HS1427ES

Specific Objectives:
1. To assess mortality and whether malnutrition is one of the predictors among a population based sample of children and adolescents with cerebral palsy the Iganga Mayuge-Health and Demographic Surveillance Site (IM-HDSS), Uganda
2. To assess the difference in the change in nutritional status in 2015 and 2019 among children with CP compared to their age and sex matched controls without CP at the IM-HDSS, Uganda.
3. To explore positive and negative nutrition practices among caregivers of well-nourished and under-nourished children with cerebral palsy respectively at the IM-HDSS, Uganda.
4. To determine the difference in the effectiveness of the positive deviance strategy and parent facilitator trainings on CP child and adolescent malnutrition and caregiving within the Iganga, Mayuge and Bugweri districts, Uganda.

Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Clinical Trial Degree Award
Scholastic Ashaba
ID: UNCST-2023-R007613
Self-management among adolescents living with HIV in Uganda
REFNo: HS1697ES

Aim 3: Assess feasibility, acceptability, and preliminary effects of the self-management intervention on HIV outcomes for ALHIV transitioning to adult HIV care,Aim 2: Develop a self-management intervention that will enable ALHIV to successfully transition to adult HIV care,Aim 1: Use qualitative research to elaborate a conceptual model of the barriers faced by ALHIV transitioning to adult HIV care in Uganda,
Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Willy Ssengooba
ID: UNCST-2022-R001801
Evaluation of a new stool-based qPCR for TB diagnosis in children and people living with HIV: a multicentre study in Eswatini, Mozambique and Uganda
REFNo: HS1615ES

To create a biorepository of well characterized pediatric samples at each of the study sites to support the future development and evaluation of novel biomarker research. ,To evaluate the quantitative stool qPCR platform as a tool to monitor treatment response in children and PLHIV,To compare the diagnostic performance of the stool qPCR platform to individual sputum and stool Xpert Ultra, urine LAM, sputum smear, sputum (MGIT) culture results against a clinical diagnosis and bacteriological reference standard,To evaluate the diagnostic accuracy of the stool Mtb qPCR tool compared to a composite reference standard (sputum and stool Xpert Ultra, sputum culture and urine TB-LAM) and clinical diagnosis. ,
Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lillian Wambuzi Ogwang
ID: UNCST-2021-R013189
Seroprevalence of SARS-CoV-2 based on antibody testing among HIV infected mothers and their children in the PROMOTE Cohort at the MU-JHU Research Collaboration: July 2020 through June 2021 SUBSTUDY Version 2.0 Dated 16 Jun 2021
REFNo: HS1658ES

1. To determine the seroprevalence of COVID-19 IgG antibody among PROMOTE women living with HIV on antiretroviral therapy, and their HIV exposed children enrolled in PROMOTE; based on Roche ELISA antibody testing of plasma samples collected July 2020 to Jun 2021• To determine the association of COVID-19 exposure and PROMOTE participant characteristics such as age, CD4 count, BMI, maternal ARV therapy, pregnancy, Breast feeding, maternal Viral load, hospitalization in the past year with SARS-CoV-2 antibody positivity, comorbidity diagnosis (e.g. hypertension, obesity, asthma, TB, pulmonary, cardiac, renal disease, sickle cell disease).

3• To use PROMOTE data to determine maternal and pregnancy outcomes among PROMOTE women who were found to have had COVID-19 infection during pregnancy based on antibody testing during the period July 2020 - June 2021.

Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Evaluation of the performance of the Salmonella Biolineâ„¢ typhi IgG/IgM Fast test in a near-patient testing environment, including evaluation of usability
REFNo: HS1700ES

To evaluate the usability of the Biolineâ„¢ Salmonella typhi IgG/IgM Fast test in the near-patient environment using a questionnaire based survey. ,To establish the performance of the Biolineâ„¢ Salmonella typhi IgG/IgM Fast test in a near-patient setting compared to the performance in a professional lab (i.e. Central Public Health Laboratory) using venous whole blood samples. ,
Uganda 2021-09-29 2024-09-29 Medical and Health Sciences Clinical Trial Non-degree Award
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