Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Paineto Masengere
ID: UNCST-2021-R013195
 Perceptions, barriers, and facilitators of adoption of healthy lifestyles for cardiovascular disease prevention among slum communities in Kampala, Uganda
REFNo: HS1661ES

1. To explore how slum dwellers in Kampala district define a healthy lifestyle in the context of cardiovascular disease prevention.
2. To explore the barriers and facilitators to adopting recommended lifestyles for cardiovascular disease prevention among slum dwellers.
3. To explore the potential roles of community actors in slums in cardiovascular disease prevention.

Uganda 2021-09-10 2024-09-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Felix Oyania
ID: UNCST-2021-R013492
 Feasibility of Primary Repair for Anorectal Malformations in Uganda
REFNo: HS1632ES

To determine the feasibility of primary repair for anorectal malformations in Uganda.,
 Uganda 2021-09-10 2024-09-10 Medical and Health Sciences Non-Clinical Trial Degree Award
FRANK MULINDWA
ID:
Changes in insulin kinetics after withholding dolutegravir in Ugandan HIV patients who develop diabetes while on dolutegravir.
REFNo: HS1493ES

To determine changes in; insulin secretion, insulin sensitivity, insulin clearance and HBA1C at 24 weeks after DTG discontinuation in Ugandan HIV patients who develop diabetes while on DTG.
 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Martha Musyoka Mbenia
ID:
PREDICTORS OF ADVERSE FETO-MATERNAL OUTCOMES AMONG MOTHERS ADMITTED WITH ANTEPARTUM HEMORRHAGE AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1450ES

To describe adverse outcomes and determine predictors of adverse feto-maternal outcomes in mothers with antepartum hemorrhage at Mbarara Regional Referral Hospital
 Kenya 2021-09-09 2024-09-09 Medical and Health Sciences Clinical Trial Degree Award
Jimmyy Opee
ID:
PROPORTION AND FACTORS ASSOCIATED WITH INTRA-PROCEDURAL PAIN AMONG WOMEN UNDERGOING MANUAL VACUUM ASPIRATION FOR INCOMPLETE ABORTION AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1462ES

General objective
To determine the proportion and factors associated with intra-procedural pain among women undergoing Manual Vacuum Aspiration for incomplete abortion at gynecology ward at Mbarara Regional Referral Hospital.

Specific objectives
1. To determine the proportion of women with intra-procedural pain undergoing Manual Vacuum Aspiration for incomplete abortion at gynecology ward at Mbarara Regional Referral Hospital.
2. To determine the factors associated with intra-procedural pain among women undergoing Manual Vacuum Aspiration for incomplete abortion at gynecology ward at Mbarara Regional Referral Hospital.

 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Degree Award
Ronald Mulebeke
ID:
A pilot study to assess the impact of Supportive Supervision and Behavior Change Communication at private health facilities in Uganda
REFNo: HS1588ES

This study will assess the impact of supportive supervision and behaviour change communication to improve the quality of malaria care and data management delivered by clinicians at private health facilities in Uganda.
Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ANTHONY KAYIIRA
ID: UNCST-2020-R014108
 Understanding Reproductive Health among Survivors of Paediatric and Young adults (URHSPY) Cancers: a mixed method study
REFNo: HS1652ES

To explore the knowledge, perceptions, and attitude of; parents or caretakers of children with cancer, and health workers on cancer treatment-related reproductive morbidity, at the Uganda Cancer Institute,To describe self-reported reproductive morbidity associated with cancer treatment among childhood and young-adult cancer survivors.,To establish the extent of reproductive morbidity associated with cancer treatment among young cancer survivors in Uganda. In addition, we aim to explore the contextual enablers and barriers to addressing cancer treatment-related reproductive morbidity in Uganda.,
 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Study Protocol for the Evaluation of Covid 19 Antibody and Antigen Rapid Diagnostic Test (RDT) In the EAC Partner States
REFNo: HS1591ES

Evaluation of ELISA cross-reactivity on stored archived negative samples between East African Partner States. ,Evaluation RDT performance differences between the East African Partner States,- Evaluate the clinical specificity of antibody RDT and ELISA using serum/plasma specimens from COVID-19 negative specimens from pre-COVID-19 (archived stored samples),- Evaluation of COVID19 antibody RDTs and ELISA’s in the East African region, using serum/plasma samples from COVID-19 confirmed based on RT-PCR results (RT-PCR positive test results). ,Evaluation of COVID19 antigen RDTs against gold standard PCR in the East African region,
 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Evaluation of TUBEX Typhoid TF IgM Antibody test for Early Diagnosis of Typhoid fever Among patients in Uganda
REFNo: HS1548ES

1) To carry out blood culture testing on all samples from patients with signs and symptoms of typhoid fever in the selected facilities of Uganda.
2) To carry out serological testing for Salmonella antibodies using the TUBEX Typhoid TF IgM Antibody test on the serum samples of consented/assented patients whose samples grew Salmonella Typhi.

 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Nalugoda
ID: UNCST-2021-R013343
 Exploring the impact of out-migration on remaining partners’ HIV and sexual behavior perceptions and practices in Rakai, Uganda: a qualitative study.
REFNo: SS981ES

The overall aim of this study is to qualitatively explore the impact of out-migration amongst heterosexual couples on non-migrating partners’ HIV and sexual behavior perceptions and practices in Rakai, Uganda.
Uganda 2021-09-09 2024-09-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jafesi Pulle
ID: UNCST-2020-R014213
 TRUST IN MEDICAL RESEARCH AMONG PATIENTS AT A REGIONAL REFERRAL HOSPITAL AND COMMUNITY MEMBERS IN LIRA DISTRICT, NORTHERN UGANDA
REFNo: HS1685ES

Explore community perceptions of trust in medical research,2. Determine the other factors associated with trust of medical research,1. Compare level of trust for medical research among community members and persons that are hospitalized.,To compare the level of trust in medical research among people hospitalized at a hospital and the community members, identify associated factors and explore prevailing community perceptions of trust in medical research.,
 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Degree Award
Daniel Mongovin David Thomas
ID:
Dry Rifting in the Albertine-Rhino Graben (DRIAR)
REFNo: NS160ES

To conduct a geological investigation of faulting associated with continental rifting in the magma-poor rift environment in the northernmost Western Branch of the East African Rift System.
 USA 2021-09-08 2024-09-08 Natural Sciences Non-Clinical Trial Degree Award
Julian Bagyendera Kobutungi
ID:
Gender, Youth and Social Inclusion Baseline Assessment for the USAID Local Partner Health Services – Ankole (USAID LPS – Ankole)
REFNo: SS1002ES

The main objective is to conduct a mixed method gender and youth social inclusion assessment which includes a literature review; collection of primary quantitative and qualitative data.,
 Uganda 2021-09-08 2024-09-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 UNDERSTANDING PATHOGENESIS OF BURKITT LYMPHOMA TO DEVELOP BETTER TREATMENTS FOR AFRICAN ENDEMIC BURKITT LYMPHOMA
REFNo: HS1546ES

4. To establish a BL tumor biorepository at the Uganda Cancer Institute ,3. To generate PDX mouse models of BL to understand the molecular factors that govern response to COM therapy in children with endemic BL at the Uganda Cancer Institute. ,2. To describe the molecular differences between endemic BL and sporadic BL. ,1. To determine the molecular profile of endemic BL tumors at the Uganda Cancer Institute,
 Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 PERFORMANCE EVALUATION OF COVID-19 ANTIGEN RAPID DIAGNOSTIC TESTS
REFNo: HS1690ES

To determine the association of positive index test results with disease stage (days since symptom onset, e.g. acute, early, late), symptom severity and symptom severity.,To determine the diagnostic accuracy of SARS-CoV-2 Ag RDTs on a respiratory specimen (NP swab, OP swab, nasal swab, saliva), vs Cobas SARS-CoV-2 assay as performed in patients presenting with influenza-like illness.,
 Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
 A clinical trial to assess the safety and immunogenicity of LNP-nCOV saRNA-02, a self-amplifying ribonucleic acid (saRNA) vaccine encoding the S glycoprotein of SARS-CoV-2, the causative agent of COVID-19, in SARS-CoV-2 seronegative and seropositive Uganda population
REFNo: HS1641ES

Primary Objective:

• To compare the safety and immune responses for SARS-CoV-2 seronegative and seropositive individuals from two immunisations with LNP-nCOV saRNA-02 administered IM 4 weeks apart at one dose level in 42 participants age 18-45 years.

Exploratory Objectives:
• To characterise the humoral and cellular immune responses to LNP-nCOV saRNA-02 administered at one dose given at 0 weeks and 4 weeks for individuals seronegative and seropositive for SARS-CoV-2 antibodies
• To characterise the profile of class and sub-class of antibody responses
• To characterize infection induced immune responses in participants with naturally acquired infection who are also exposed to the vaccine

 Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Clinical Trial Non-degree Award
David Musoke
ID:
Collaboration between Biomedical and Traditional Mental Health Service Providers in Wakiso District, Uganda
REFNo: HS1581ES

To explore how biomedical service providers and traditional healers can work together to improve access to mental health care in Wakiso district, Uganda.
 Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Janet SEELEY
ID:
Examining ethical issues, stakeholder engagement and acceptability of biobanking in Sub-Sahara Africa
REFNo: HS1645ES

General Objectives:
To explore perceptions, informed opinion and experiences of key stakeholders on approaches and value of community engagement in biobanking in LMIC; and if and how community approval should be obtained.

Specific Objectives:
1. To explore key stakeholders’ perceptions, informed opinions and underlying values around potential benefits of biobanks in SSA and important aspects of operationalising a biobank in LMICs.
2. To describe approaches that could be used to engage communities and stakeholders about biobanking.
3. To examine governance systems and structures that should be in place for a biobank to become operational, and ways in which community voices might be included in those systems
4. To determine initial key elements required to assume a community social license based on outputs of 1-3

UK 2021-09-08 2024-09-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edward  Mukiibi
ID:
RESEARCH DATA MANAGEMENT PRACTICES IN SELECTED HEALTH INSTITUTES IN UGANDA
REFNo: HS1714ES

i) To describe the characteristics of research data created and held in selected Health Institutes in Uganda.

ii) To examine the research data management practices in selected Health Institutes in Uganda.

iii) To evaluate research data management readiness of selected Health Institutes in Uganda.

iv) To explain the challenges affecting adoption and uptake of RDM practices in selected Health Institutes in Uganda.

v) To propose interventions to improve RDM practices in selected Health Institutes in Uganda.

 Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Non-Clinical Trial Degree Award
Zarin Machanda Machanda
ID:
The form and functions of leadership in wild chimpanzees
REFNo: NS288ES

This project will establish chimpanzees (Pan troglodytes) as a new comparative model of human-like leadership by testing how individual variation across a leader’s temperament, behaviour, and physiology shapes collective action in natural social groups. The first aim of the project is to support continuing long-term data collection by the Kibale Chimpanzee Project. We have three additional research aims that are specific to this project: (1) to identify and describe different domains of leadership in wild chimpanzees; (2) identify and describe the characteristics of chimpanzee leaders; and (3) evaluate the success of different pathways to leadership for chimpanzees. This project aims to collect both observational and experimental data that will provide detailed empirical insight into leadership among wild chimpanzees
 USA 2021-09-08 2024-09-08 Natural Sciences Non-Clinical Trial Non-degree Award
Robert Opika Opoka
ID: UNCST-2021-R014036
 An implementation toolkit for the use of hydroxyurea in the treatment of sickle cell anemia in Ugandan children
REFNo: HS1646ES

1) Assess the uptake and proper use of hydroxyurea among SCA patients at Jinja and Atutur Hospitals as a result of the implementation toolkit pilot,
 Uganda 2021-09-03 2024-09-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Walter Ojok
ID: UNCST-2021-R004415
 SYNTHESIS OF NOVEL MESOPOROUS ADSORBENTS FOR FLUORIDE REMOVAL FROM WATER
REFNo: NS158ES

(i) To study the hydrochemical characteristics of Ndali-Kasenda crater lakes used as water sources with focus on the occurrence and spatial distribution of fluoride.
(ii) To explore the possibility of synthesizing biosorbents for fluoride removal using local base materials (Phoenix reclinata seeds, cassava starch and banana extract as soft templates.
(iii) To conduct batch and column experiments on removal of fluoride using synthesized biosorbents to assess their fluoride removal performance.
(iv) To design laboratory scale pilot column filter studies for fluoride removal with high performance synthesized biosorbent for Ndali-Kasenda lake water.

Uganda 2021-09-03 2024-09-03 Natural Sciences Degree Award
Suzan van der Lee
ID:
Dry Rifting In the Albertine- Rhino Graben, Uganda (DRIAR)
REFNo: NS255ES

A geophysical, geochemical, geological, and geodynamic investigation of the Albertine-Rhino Graben in western and northwestern Uganda to improve our understanding of continental rifting in areas where volcanic activity is minimal.
Netherlands 2021-09-03 2024-09-03 Natural Sciences Non-Clinical Trial Non-degree Award
Joweria Nambooze
ID: UNCST-2019-R001118
 FOOD CHOICES AND THE FOOD ENVIRONMENT OF SMALL-HOLDER FARMERS IN MPIGI
REFNo: A146ES

Examine factors influencing maternal food choices and nutrition outcomes and understand how they interact.,Explore the internal and external food environments and how they impact food choice among rural female smallholder farmers,Determine the relationship between agricultural activities on maternal time use and food choices among rural female smallholder farmers,Determine the daily time use patterns of rural female smallholder farmers,Assess the nutritional status of rural female smallholder farmers,To examine the dynamic interactions between women’s time use and food environments and their influence on food choices and nutrition outcomes of rural smallholder female farmers living in Mpigi district,
 Uganda 2021-09-03 2024-09-03 Agricultural Sciences Non-Clinical Trial Non-degree Award
Tu Hoang Phuong
ID:
Forest succession analyses in Kitigo as a basis for close-to-nature reforestation planning
REFNo: NS279ES

To understand the details of termite-fungi relationships in the context of soil nitrogen allocation in Central African derived savanna; to clarify and classify the Nitrogen absorption strategies of various woody species/tree families, in order to develop crucial criteria for tree species selection for Nitrogen limited target sites; to work out if Nitrogen-15 of tree’s living sapwood could be an indicator for soil nitrogen availability.

 Vietnam 2021-09-03 2024-09-03 Natural Sciences Non-Clinical Trial Degree Award
Cristina Clerici
ID:
Yes, women can. The role of information and norms in encouraging women to enter male-dominated sectors in Uganda
REFNo: SS968ES

Gain insights on information available to aspiring female entrepreneurs and the constraints they face when choosing their sector of business.
 Italy 2021-09-03 2024-09-03 Social Science and Humanities Non-Clinical Trial Degree Award
Ziidah Namwaya
ID:
Exploring the use of Active Birthing Techniques for Normal Labour and Birth among Midwives working in the Metropolitan Region, Kampala-Uganda
REFNo: SS976ES

1. To evaluate the status of the environment in the three health facilities Kitebi, Komamboga and Kisugu as regards the use of active birthing techniques
2. To identify the available active birthing techniques at the health facilities
3. To assess current practice as regards the use of active birthing techniques for normal labour and birth among midwives working at the health facilities
4. To determine the level of knowledge as regards the use of active birthing techniques
5. To explore the potential factors that might influence the use of active birthing techniques for normal labour and birth among midwives working at the facilities
6. To describe the acceptability and experience of using upright positions such as hands- and-knees position, squatting, leaning forward, kneeling among pregnant women and midwives in the selected health facilities.

 Uganda 2021-09-03 2024-09-03 Social Science and Humanities Non-Clinical Trial Degree Award
Solomon Wafula Tsebeni
ID: UNCST-2021-R013883
 Assessment of indoor air quality, risk factors and potential health effects among residents in an urban informal settlement in Kampala, Uganda
REFNo: SS996ES

To describe the potential health effects associated with indoor air pollution. ,To assess the factors associated with indoor air pollution among households. ,To determine the levels of indoor PM2.5, and Carbon monoxide (CO) in households., To determine levels of indoor air pollution, its associated risk factors and potential health effects among residents in an informal settlement in Kampala so as to generate information that can be used in design appropriate strategies, policies and practices that promote good air quality in households, hence mitigate health problems associated with indoor air pollution. ,
 Uganda 2021-09-03 2024-09-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Amy  Ritterbusch Elizabeth
ID:
Child Protection Mapping and Honour
REFNo: SS970ES

1.To examine the effect of global narratives of child wellbeing on child protection and rights practices in Uganda
2.To explore prospects for local child protection practices in informing and enriching global child protection policy
3.To explore the concept of honour and examine how it promotes children’s wellbeing and or sustains violence against children in the Ugandan context.

USA 2021-09-03 2024-09-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jesca Nantume
ID: UNCST-2021-R013984
 Knowledge, attitudes and practices towards the tobacco use control measures among teenagers aged (13-19) years; A cross sectional study in the slum areas of Kampala Uganda
REFNo: SS988ES

To evaluate knowledge, attitudes and practices towards tobacco control among teenagers
aged (13-19) years
1. To evaluate existing control measures among teenagers
2. To assess the knowledge, attitudes, and practices of the current tobacco control
measures among teenagers.
3. To evaluate the cause of initiation of tobacco use in slums among teenagers
 Uganda 2021-09-03 2024-09-03 Social Science and Humanities Non-Clinical Trial Degree Award
Danette Cagnet Lee
ID:
Community-led Total Sanitation Programming and the Maintenance of Sanitation Behaviors
REFNo: SS737ES

The purpose of this qualitative, exploratory, case study research is to better understand stakeholder's, including village community members, village leadership, and CLTS practitioner, perceptions of the facilitators and hindrances to the maintenance of sanitation in the maintenance stage of Community-led Total Sanitation programming in Uganda, East Africa. This study seeks the perspective of and participation of village community stakeholders receiving the Community-led Total Sanitation intervention implemented by the non-governmental organization, Kibo Group International.
 USA 2021-09-02 2024-09-02 Social Science and Humanities Non-Clinical Trial Degree Award
Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
 Acute Leukemia Banking and Biology Study for Patients at the Uganda Cancer Institute.
REFNo: HS1590ES

1. To determine the genomic profile of patients with acute leukemia and identify the prevalence of various fusions and mutations in these patients.
2. To collect and store corresponding subjects’ medical information including diagnosis and disease characterization, laboratory and imaging studies, treatment, and outcome.

 Uganda 2021-09-02 2024-09-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
John Baptist Asiimwe
ID: UNCST-2021-R013716
 The Traditional Medicine Practitioner’s Concept of Cancer, its Care, Herbal medicine use and the Patients Perceived benefits (Clinical outcomes) in Selected Districts of Central Uganda.
REFNo: HS1602ES

1. To establish the prevalence and predictors of the use of herbal medicines’ in cancer
2. To explore the concept of cancer and its care in traditional medicine as perceived by traditional medicine practitioners (TMPs) in selected districts of central Uganda
3. To document the herbs used by traditional medicine practitioners (TMPs) to manage cancer in selected districts of central Uganda.
4. To determine the clinical outcomes in patients with cancer treated by traditional medicine practitioners (TMPs).

 Uganda 2021-09-02 2024-09-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Moses Adriko
ID: UNCST-2019-R001787
 Gaining community insights into societal causes of and solutions for schistosomiasis transmission hotspots (InSight-ScHot)
REFNo: HS1616ES

To identify non-mass administration preventative chemotherapeutic control measures for schistosomiasis that members of the community see as implementable
 Uganda 2021-09-02 2024-09-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Enock Matovu
ID:
Identification of the Genetic Markers of Trypanotolerance in Indigenous Cattle of Apach District, Northern Uganda
REFNo: NS247ES

Main Objective
To identify genetic markers of Animal African Trypanosomiasis (AAT) tolerance in indigenous cattle

Specific Objectives

i. To set up a panel of phenotypically characterized indigenous cattle with respect to AAT susceptibility

ii. To develop a data base of reference genomes and transcriptomes of indigenous cattle from an AAT endemic region of mid-northern Uganda
iii. To determine the genotypes associated with trypanotolerance in indigenous cattle

 Uganda 2021-08-31 2024-08-31 Natural Sciences Non-Clinical Trial Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 Assessment of the Implementation Processes and Outcomes of the HIV Assisted Partner Notification Program, Ministry of Health, Uganda
REFNo: HS1671ES

3.2 General Objective
To assess the Implementation processes and outcomes of the HIV Assisted Partner Notification Program in Uganda
3.3 Study Objectives
1. To determine the current level of uptake of APN services and the factors associated with uptake of these services among HIV index clients.
2. To assess the acceptability and uptake of APN services among a sub-sample of partners of APN clients.
3. To assess the extent to which the existing service delivery environment influences the delivery of APN services.
4. To document the perceptions and experiences of users of APN services, challenges faced in utilizing APN services and concerns those users have regarding the way APN services are provided.
5. To determine the positive and negative outcomes of APN services in Uganda, and the support mechanisms available for those who experience negative outcomes.
6. To document the barriers to and facilitators of successful APN implementation and the challenges implementers face during APN implementation.
7. To document the existing opportunities that can inform the future scale-up of the APN program.

 Uganda 2021-08-31 2024-08-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
 A behavioural Science Research to Determine Factors that Facilitate Future Uptake of HIV Prevention Products and Multi-Purpose Prevention Technologies to Prevent HIV and Unwanted Pregnancy in Sub-Saharan Africa Universally Accessible HIV Prevention Technologies for African Girls and Young Women through Knowledge Applied from Behavioural Economics (UPTAKE)
REFNo: HS1540ES

Multi-purpose Prevention Technologies (MPTs) to prevent HIV and unwanted pregnancy in Sub-Saharan Africa

i. To understand facilitators of and barriers to uptake and retention of injectable and implantable long acting pre-exposure prophylaxis (LA-PrEP) and MPT to inform product development, using formative behavioural research methods
ii. To design interventions to impact the uptake of new biomedical HIV prevention products, as part of a suite of self-care and self-screening products for sexual and reproductive health, using quantitative behavioural research methods
iii. To test the effectiveness of the alternate design/interventions and strategies, using marketed LA contraceptive products as proxies for LA HIV prevention products in development
iv. To estimate the cost of retention interventions and the cost effectiveness of products and delivery methods among adolescent girls and young women (AGYW) and female sex workers (FSWs) for prevention of pregnancy and/or HIV, using modelling

 Uganda 2021-08-31 2024-08-31 Medical and Health Sciences Clinical Trial Non-degree Award
Emmy Okello
ID: UNCST-2020-R009792
 “Active Case Detection and Decentralized Dynamic Registry to Improve the Uptake of Rheumatic Heart Disease Secondary Prevention” (ADD-RHD)
REFNo: HS1561ES

Secondary objectives include technical proficiency, acquisition times, global image quality, and user satisfaction and confidence. Each of these parameters will be reported for the entire training group and a sub-group analysis will look for differences between curriculum groups. Acquisition times and image quality will be compared between trainees and expert sonographers.,To determine the impact of a pragmatic RHD primary prevention program in Uganda,
 Uganda 2021-08-30 2024-08-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Comfort Mukasa Hajra
ID:
Real-time access to sanitation information for improved management of sanitation services: A case Study in Kawempe division.
REFNo: HS1458ES

Main Objective:
To test if timely access to sanitation information leads to improved sanitation planning, increased access to safely managed sanitation services and improved multi-sectoral collaboration.

Specific Objectives:
1. To design and test the effectiveness of timely access to sanitation information for planning, coordination and access to improved sanitation services.
2. To validate user needs for sanitation service provision in Uganda.
3. To document scalable best practice mechanisms for improved multi-sectoral planning and coordination on sanitation.
 Uganda 2021-08-30 2024-08-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eric Awich Ochen
ID: UNCST-2021-R013266
 Preventing Gender-based Violence: Video Game Intervention Designed as an Educational Tool to Address Child Marriage in Uganda
REFNo: SS880ES

To assess the effectiveness of the game (Peace) in promoting pro-social attitude/behavior change and empathic capacity among young people to prevent violence.
• Help young people understand what sexual exploitation is and how it is linked to gender inequalities.
• Increase young people’s understanding about how adult power is misused to abuse and silence them.
• Show young people that perpetrators will seek out and exploit young women’s vulnerabilities.
• Help young people understand the impact that sexual coercion has on everyone involved.
• Empower young people in reporting incidents of child sexual abuse and sexual coercion.
• Increase awareness of the role of various agencies/individuals that can help.
• Help young people understand ways in which adults may groom them using various tactics.
• Help young people understand the relationship between sexual coercion and child marriage.
• Give young people the opportunity to develop skills, knowledge, and competencies that can help them make sound decisions for themselves or others in real life situations.
• To support and empower young people in avoiding child marriage


Uganda 2021-08-30 2024-08-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
NAMANDE MUGERWA SARAH
ID:
“EKISAAKAATE” (ROYAL ENCLOSURE) PEDAGOGY AND EARLY CHILDHOOD MORAL LEARNING OUTCOMES IN BUGANDA KINGDOM IN UGANDA
REFNo: SS975ES

To establish the mediating relationship between multiculturalism and early childhood moral learning outcomes.,To examine the relationship between “ekisaakaate” role play instruction pedagogy and early childhood moral learning outcomes.,To determine the relationship between “ekisaakaate” traditional story telling instruction pedagogy and early childhood moral learning outcomes.,To establish the relationship between “ekisaakaate” living values-based contextual instruction pedagogy and early childhood moral learning outcomes.,To find out the relationship between “ekisaakaate” native language instruction pedagogy and early childhood moral learning outcomes. ,
 Uganda 2021-08-30 2024-08-30 Social Science and Humanities Non-Clinical Trial Degree Award
Lazaaro Mujumbusi
ID: UNCST-2023-R007470
 Exploring understandings of and attitudes towards Covid-19 in Mayuge district Uganda
REFNo: SS977ES

1. To explore community members' perceptions of COVID-19 and its transmission, with a focus on ideas about responsibility.
2. To investigate how ideas about responsibility intersect with existing inequalities around occupation, tribe, and gender.
3. To examine whether, and how, understandings of COVID-19 transmission have impacted everyday WaSH practices.
4. To develop insight that may be of value to developing interventions aimed at reducing transmission and/or stigma.

Uganda 2021-08-30 2024-08-30 Social Science and Humanities Non-Clinical Trial Degree Award
Patrick  Vudriko
ID:
Survey to identify priority livestock diseases and diagnostic needs of animal health professionals and farmers in Central and Southwestern Uganda
REFNo: A84ES

Specific objectives
1. To identify the priority livestock and poultry diseases for which diagnostic services and diagnostic kits/aids are needed by various stakeholders (farmers, vets).
2. To assess the perception and attitudes of key stakeholders in the animal industry on the value and quality of existing animal diagnostic services in Uganda

 Uganda 2021-08-27 2024-08-27 Agricultural Sciences Non-degree Award
Suzanne  Kiwanuka N
ID: UNCST-2020-R014671
 Using High Impact Communication Strategies to increase blood donation awareness among secondary school students in Uganda
REFNo: SS802ES

1. To increase knowledge and awareness about blood donation among secondary school students in Uganda using targeted communication strategies.
2. To increase willingness to donate blood among secondary school students in Uganda using targeted communication strategies
3. To increase intention to donate blood among secondary school students in Uganda using targeted communication strategies

 Uganda 2021-08-27 2024-08-27 Social Science and Humanities Non-degree Award
Christine Akello Kalumera Kalumera
ID: UNCST-2021-R013514
 OPTIMISING USER INVOLVEMENT IN USER STORIES COLLECTION, ANALYSIS AND DESIGN TASKS FOR EHIS DEVELOPMENT: APPLYING COLLABORATION ENGINEERING PRINCIPLES TO HUMAN CENTRED DESIGN
REFNo: SIR62ES

The main of objective of this research is to develop a collaborative engineering process to improve user involvement in requirements gathering, analysis and design and stages of the user centred design approach, when developing electronic health information systems
 Uganda 2021-08-27 2024-08-27 Engineering and Technology Non-Clinical Trial Degree Award
Olive Kobusingye Chifefe
ID:
Assessing the impact of COVID-19 on the mobility patterns in Kampala Metropolitan Area
REFNo: HS1636ES

To explore the socio-economic impact of implementing the regulations on transportation.,To describe ways in which transporters coped with the COVID-19 related restrictions on transport. ,To identify ways in which commuters coped with the threat of COVID-19., The overall objective of this study is to examine the impact of the COVID-19 pandemic on mobility patterns in the Kampala Metropolitan area so as to inform planning transportation during the pandemic and in the post-COVID-19 period. ,
 Uganda 2021-08-27 2024-08-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
BRENDA GATI MIREMBE
ID: UNCST-2021-R013390
 A Phase 3, Randomized, Active Controlled, Double-blind Clinical Study to Evaluate the Efficacy and Safety of Oral Islatravir Once Monthly as Pre-Exposure Prophylaxis in Cisgender Women at High Risk for HIV 1 Infection.
REFNo: HS1631ES

Primary Objectives:
1. To evaluate the efficacy of oral ISL QM compared to FTC/TDF QD for the
prevention of HIV-1 infection as assessed by the incidence rate per year of confirmed
HIV-1 infection.

2. To evaluate the safety and tolerability of oral ISL QM compared to oral FTC/TDF QD as assessed by review of the accumulated safety data

Secondary Objective
1. To evaluate the efficacy of oral ISL QM in reducing the incidence per year of HIV-1
infection relative to the background rate.

 Uganda 2021-08-27 2024-08-27 Medical and Health Sciences Clinical Trial Non-degree Award
ROSCO KASUJJA
ID: UNCST-2019-R000504
 Treating Depressive Symptomatology in Congolese Refugees in Uganda and Rwanda: Adapting and Evaluating Community-based Socio-therapy
REFNo: SS263ES

1. Develop implementation guidance for adapting, delivering, supervising and monitoring aCBS for refugees across diverse settings. 2. Build research capacity for evaluating complex interventions in Rwanda and Uganda. 3. Enhancing knowledge about a scalable and inclusive form of intervention aimed at supporting the mental and wellbeing of refugees – a group at high risk of experiencing mental disorders who are markedly underserved in terms of services and support at both the local and global level.
Uganda 2021-08-25 2024-08-25 Social Science and Humanities Non-degree Award
James Bugeza Katamba
ID: UNCST-2021-R013970
 EPIDEMIOLOGY OF BRUCELLOSIS AT THE HUMAN LIVESTOCK INTERFACE IN UGANDA
REFNo: HS1377ES

The general objective is To characterize Brucella infections in ruminants, swine and slaughterhouse workers in Uganda. The specific objectives are 1.To determine the seroprevalence of Brucella antibodies in cattle, shoats, and pigs at selected slaughterhouses in Uganda. 2.To determine the seroprevalence of Brucella antibodies and associated risk factors among slaughterhouse workers in Uganda 3.To determine the Brucella species, biovars circulating in cattle, shoats, swine and slaughterhouse workers and their epidemiological interrelatedness 4.To determine resistance of Brucella to first line antimicrobial agents (Rifampicin and streptomycin)
Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Hakim Sendagire
ID:
Clinical chemistry, hematology and other laboratory profiles of COVID 19 patients, as surrogate markers in management of severe disease
REFNo: HS1339ES

1. To describe the characteristics of peripheral blood cells in patients with varying severity of COVID-19 as compared to those who are negative
2. To describe the characteristics of the clinical chemistry and inflammatory markers in patients with varying severity of COVID-19 as compared to those who are negative
3. To establish the relationship between peripheral blood cells, clinical chemistry and cytokines and the clinical manifestation of COVID 19 and describe the potential markers for disease monitoring.

 Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-degree Award
Stella Muyanja Zawedde
ID: UNCST-2021-R014037
 Prevalence and Outcomes of Mycobacterium bovis infection in Karamoja sub-region, North Eastern Uganda
REFNo: HS1405ES

The primary objective of this study is to determine the prevalence of M. bovis strains among patients diagnosed with TB disease in Karamoja region.,To compare six-month treatment outcomes between patients diagnosed with mycobacterium tuberculosis (M. tb) and those diagnosed with other mycobacterial species including M. bovis. ,To describe the susceptibility patterns of all mycobacterial isolates to first line medicines used in the management of drug susceptible TB. ,To describe the factors associated with having M. bovis among patients diagnosed with TB in the Karamoja region. ,
 Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Janestic Twikirize
ID:
Social Traditional Norms and child Marriage research in Zombo, Nebbi, Packwachi and Adjuman Districts, West Nile
REFNo: SS852ES

What are the roles of (Parents, Clans and relatives, Religious leaders
Cultural leaders, Boys and men in the communities and women and girls in the communities) in a) Promoting Child Marriage b) Preventing child marriage? Elaborate the roles, the specific practices and norms as well as how effective their efforts for and against CEFM are

What is the involvement of the bride-to-be in the decision-making process about her marriage?

What has been and being done to address social norms and practices that promote child early and forced marriages by boys, girls, parents, clan leaders, religious leaders, cultural leaders and community leaders?

Assess the effectiveness of what has been and being done women and girls, men and boys, parents, clan leaders, community and religious leaders to mitigate socio-cultural practices that promote child early and forced marriages

Assess the functionality and effectiveness of Community Child Protection systems from the community, district and national level. Identify strength, weakness and make recommendations to inform project intervention
 Uganda 2021-08-25 2024-08-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Catherine Abaasa N
ID:
Quality, Safety, community perceptions and Practices on Drinking water from selected water sources in Mbarara City , South Western Uganda
REFNo: HS1469ES

i. To assess the physical chemical and microbiological quality of drinking water from selected water sources and establish the water quality index for Mbarara city.
ii. To establish the occurrence of virulence genes associated with Esherichia coli pathotypes isolated from drinking water samples from selected water sources in Mbarara city.
iii. To establish the seasonal variation in safety, quality and water quality index of water from selected water sources in Mbarara city.
iv. To explore the communities’ and water service providers’ perceptions and practices about the quality and safety of drinking water and establish possible mitigation strategies at community level.

 Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Lordrick Alinaitwe
ID:
Transmission and Occurrence of Leptospira infection among humans and livestock in Uganda
REFNo: HS1563ES

To determine the extent, risk factors and potential pathways for Leptospira transmission and infection among potential reservoir animals and human populations in Uganda.,To describe potential pathways and drivers for Leptospira transmission at the animal-human-environmental interface in Uganda, based on statistical modelling,To identify Leptospira species and serogroups that circulate in humans, livestock, and environmental sources in Uganda.,To determine Leptospira seroprevalence and infection among slaughter ruminants and swine in Uganda,To determine Leptospira seroprevalence and associated risk factors among slaughter workers in Uganda,
 Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Mary Goretti Nakabugo Goretti
ID: UNCST-2021-R013051
 Are our Children Learning? Uwezo Basic Assessment of Literacy and Numeracy.
REFNo: SS959ES

Uwezo Uganda intends to undertake the 2021 assessment of basic learning outcomes in literacy and numeracy in order that:
i) Independent evidence on learning levels in literacy and numeracy of children aged 4-16 in Uganda is generated.
ii) The data generated from conducting the learning assessments increases knowledge, awareness and understanding of policy actors, practitioners and the public of children’s learning outcomes and their distribution and that the evidence is used to improve resource allocation and the delivery of education.

 Uganda 2021-08-25 2024-08-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patrick  Vudriko
ID:
Innovations to Address Rampant Vaccine Failures, Shortages and Low Uptake for Sustainable Livestock Disease Control and Productivity in Uganda
REFNo: A136ES

The Proposal is designed to address selected immunizable diseases that affect health and productivity of poultry, small ruminant and cattle in Uganda. The study objectives include;
1. To assess the current animal vaccine supply chain and identify actors, distribution channels, use and constraints that affects animal vaccine utilization in Uganda.
2. To evaluate the level of protective Gumboro & IB virus disease antibodies among vaccinated chicken flocks in commercial farms.
3. To assess the sero-conversion of FMD vaccine and strengthen vaccination efficacy monitoring lab service at Research Center for Tropical Diseases and Vector Control (RTC) Laboratory at COVAB.
4. To assess the current PPR vaccination regimen and the clinical performance of combined PPR- SGP virus vaccine under field situations in small ruminants and develop a vaccination technical framework for effective control of the two diseases in Uganda.

Uganda 2021-08-25 2024-08-25 Agricultural Sciences Non-Clinical Trial Non-degree Award
Mike Kyewalyanga
ID: UNCST-2021-R013531
 Factors associated with virological non-suppression among HIV- Positive children under 5 years on antiretroviral therapy in Mbarara Regional Referral Hospital
REFNo: HS1584ES

1.To determine the proportion of virological non-suppression among HIV positive children under 5 years who have been on ART for at least 6 months, in the ISS clinic of Mbarara Regional Referral Hospital.

2.To determine the factors associated with virological non-suppression among HIV positive children under 5 years who are receiving ART from ISS clinic of Mbarara Regional Referral Hospital.
3.To determine the perceptions of health-care providers and parents/guardians on factors associated with virological non-suppression among HIV positive children under 5 years who are receiving ART from ISS clinic of Mbarara Regional Referral Hospital.

 Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Luz Azlor del Valle
ID:
GAFSP Private Sector Window Uganda Impact Evaluation - Baseline
REFNo: SS943ES

The primary research question is – what is the impacts of an expansion in the fertiliser business on smallholder farmers. The purpose of the evaluation is to account for the interventions and support provided and to derive lessons and recommendations to improve future impact. To meet these objectives the eventual impact evaluation will attempt to answer the following evaluation questions:
1. How does the project affect yields?
2. How does the project affect household income and poverty status of farmers?
3. What is the project’s impact on food security and nutrition?
4. What is the project’s impact on women’s status and empowerment?
 Spain 2021-08-25 2024-08-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jayne Ellis
ID: UNCST-2021-R013987
 “Integrated management of cryptococcal and opportunistic infections to improve outcomes in advanced HIV disease (IMPROVE study)”
REFNo: HS1607ES

1) To generate evidence on the safety (adverse events) and feasibility (adherence and tolerability) of 1HP (one month of isoniazid and rifapentine) for TB preventative therapy (TPT) amongst adults with HIV-associated cryptococcal meningitis.
2) To generate preliminary data on potential secondary benefits (reduced loss to follow-up, reduced active TB disease, reduced mortality due to TB) of early (inpatient initiation) 1HP TPT as compared to standard (outpatient initiation) 1HP TPT amongst adults with HIV-associated cryptococcal meningitis.

UK 2021-08-25 2024-08-25 Medical and Health Sciences Clinical Trial Degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
 Bacterial and Host Determinants in TB Transmission: Immune Phenotypes Associated with Exposure to High and Low Transmission Strains of MTB - Uganda
REFNo: HS1498ES

The goal of this study is to identify the bacterial and host factors that promote transmission of tuberculosis (TB), a necessary first step towards developing drugs and vaccines that prevent the inter-person spread of Mycobacterium tuberculosis (Mtb). This study has five specific aims:

Aim 1: Determine the extent to which household transmission is responsible for co-prevalent and incident TB cases caused by Mtb strains that are genetically distinct from those isolated from the index cases within the same household.

Aim 2: Investigate the in vitro immune phenotype of transmitted versus not-transmitted Mtb strains in households stratifying for HIV status.

Aim 3: Characterize the innate macrophage response to high and low transmission strains and the T-cell response in persons with known household exposure to high and low transmission isolates and the impact of HIV infection.
Aim 4: Identify the component of Mtb genes that aid in bacterial survival in aerosols.
Aim 5: Investigate the bacterial factors underlying divergence in the host response to high and low transmission isolates.


Uganda 2021-08-24 2024-08-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Peter Elyanu James
ID: UNCST-2021-R013210
 CoVPN 3008- UBUNTU Multi-Center, Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern. Version 1.0, dated 16 May 2021. DAIDS Document ID # 38838.
REFNo: HS1642ES

Primary Objectives
The primary objectives of this study are to determine the following:
1. To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent virologically-confirmed symptomatic COVID-19 starting 14 days after dose 2 in adults who are at risk of severe COVID-19
2. To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent severe COVID-19 starting 14 days after dose 2 in adults who are at risk for severe COVID-19
3. To assess safety and tolerability of COVID-19 mRNA vaccine in adults who are at risk of severe COVID-19

Secondary Objectives
The secondary objectives of this study are to evaluate the following:
1. Durability of VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 through the final study visit (Month 12 post-dose 1) in volunteers with no previous COVID-19
2. VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 by neutralization phenotype and Spike sequence features of acquired SARS-CoV-2 viruses (sieve analysis), including VE against the B.1.351/501Y.V2 variant and VE against all other variants combined in volunteers with no previous COVID-19
3. VE of COVID-19 mRNA vaccine against SARS-CoV-2 infection defined by nucleocapsid protein seroconversion regardless of symptomology in volunteers with no previous COVID-19
4. VE of COVID-19 mRNA vaccine against asymptomatic SARS-CoV-2 infection defined by nucleocapsid protein seroconversion without prior occurrence of the symptomatic COVID-19 primary endpoint in volunteers with no previous COVID-19
5. Post -vaccination immune response markers as correlates of risk of COVID-19 and as correlates protection against COVID-19
6. VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 in all participants regardless of baseline SARS-CoV-2 status

Exploratory Objectives
The exploratory objectives of this study are to evaluate the following:
1. VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 by baseline HIV infection status in volunteers with no previous COVID-19 and in all volunteers regardless of previous COVID-19 status
2. VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 by neutralization phenotype and Spike sequence features of acquired SARS-CoV-2 viruses (sieve analysis), including VE against the B.1.351/501Y.V2 variant and VE against all other variants combined in volunteers with no previous COVID-19 and in all volunteers regardless previous COVID-19 status
3. VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 in volunteers with previous COVID-19
4. Relative rate of COVID-19 and severe COVID-19 in placebo recipients with previous COVID-19 compared to vaccine recipients with no previous COVID-19
5. Assess T-cell responses in placebo recipients who develop COVID-19 compared to vaccine recipients who develop symptomatic COVID-19
6. Assess incidence of adverse birth outcomes among pregnant persons enrolled in the trial

 Uganda 2021-08-24 2024-08-24 Medical and Health Sciences Clinical Trial Non-degree Award
Perez Mujuni Perez Mbiire Batwine
ID:
Teachers' welfare, human capital and performance of Government aided primary school in Isingiro District
REFNo: SS964ES

i. To establish the relationship between teachers’ welfare and performance of government aided primary schools in Isingiro District.
ii. To establish the relationship between human capital and performance of government aided primary schools in Isingiro District.
iii. To find out the effect of combining teachers’ welfare and human capital on the performance of government aided primary schools in Isingiro District.
iv. To find out whether monitoring systems mediates teachers’ welfare and the performance of government aided primary schools in Isingiro District.
v. To find out whether monitoring systems mediates human capital and the performance of government aided primary schools in Isingiro District.

 Uganda 2021-08-23 2024-08-23 Social Science and Humanities Non-Clinical Trial Degree Award
Hasifah Namatovu Kasujja
ID:
eHealth Adoption in Uganda. What is the status? eHAU
REFNo: SS945ES

1. To inventory existing eHealth interventions in Uganda to ascertain maturity, failure and successes
2. To study the barriers and facilitators of eHealth adoption in Uganda
3. To develop a framework for successful eHealth adoption
4. To evaluate the framework for utility

 Uganda 2021-08-23 2024-08-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ronald Kiguba
ID: UNCST-2019-R000844
 Two-way risk communication mobile application use versus traditional methods of adverse drug reaction reporting in Uganda: a cluster-randomized controlled trial
REFNo: HS1366ES

This study will: i) assess the feasibility of implementing a mobile app for the reporting of ADRs associated with DTG and IPT at selected ART-sites in Uganda; ii) describe the characteristics (causality, seriousness, completeness, unexpectedness, severity, outcome) of the DTG- and IPT-linked ADR-reports submitted to NPC using the mobile app; and, iii) determine if use of the mobile app versus existing methods of ADR-reporting (paper-form and web-form) increases by 25% the number of reported ADRs linked to DTG and IPT use during 2.5 years of follow-up, iv) determine the cost and cost-effectiveness of using the mobile app versus existing methods of ADR-reporting.
 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Clinical Trial Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
 Multi-Center, Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern.
REFNo: HS1669ES

-To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent
virologically-confirmed symptomatic COVID-19 starting 14 days after dose 2 in
adults who are at risk of severe COVID-19 -2. To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent severe COVID-19 starting 14 days after dose 2 in adults who are at risk for severe COVID-19 -3. To assess safety and tolerability of COVID-19 mRNA vaccine in adults who are at risk of severe COVID-19
Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Clinical Trial Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
 ViiV 205858: Open-label access to dolutegravir for HIV-1 infected children and adolescents completing IMPAACT Studies P1093 and P2019 Version 4.0 dated 10 Dec 2020
REFNo: HS1453ES

Primary
• To provide access to age appropriate formulations of dolutegravir (DTG), either as single entity DTG or as fixed dose combination (FDC) abacavir/dolutegravir/lamivudine (ABC/DTG/3TC), in an open-label protocol to eligible participant s who have completed the P1093 or P2019 parent studies.

Secondary

To assess any serious adverse events (SAEs) and any clinical or laboratory adverse events that lead to the discontinuation of IP (DTG or ABC/DTG/3TC FDC).
 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Clinical Trial Non-degree Award
Baker Lukwago
ID: UNCST-2021-R013259
 Tracking DISC project activities through integrated surveys in Uganda_Version One May 2021
REFNo: HS1481ES

This research protocol includes the DISC research that will happen from 2021 to 2024 in the DISC project’s focus geographies. The methods include several annual rounds of data collection, with 4 research methodologies: provider surveys, client exit interviews (CEIs), Household Surveys (HHS), and two follow up surveys with the individuals who participate in the CEIs.

Research Objectives
1. To understand exposure to information about self-injectable contraceptives in the DISC sentinel areas.
2. To understand knowledge and attitudes about self-injectable contraceptives among women in DISC sentinel areas.
3. To understand sexual and reproductive health empowerment among women of reproductive age and SI users in DISC sentinel areas.
4. To understand users’ experiences with self-injection training
5. To understand providers’ knowledge and attitudes regarding self-injectable contraceptive service provision.
6. To understand initiation and continuation of self-injection following training.
7. To gain lessons regarding client exit survey methodology for future survey implementation among self-inject clients.
8. To gain learnings regarding follow-up methodologies for future survey implementation among self-inject clients, particularly as relates to continuation measurement.

 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Deo Wabwire Ogema
ID: UNCST-2021-R013932
 COVPN 3008: Multi-Center, Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern. Version 1.0 16 May 2021
REFNo: HS1659ES

The primary objectives are:
•To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent virologically-confirmed symptomatic COVID-19 starting 14 days after dose 2 in adults who are at risk of severe COVID-19
•To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent severe COVID-19 starting 14 days after dose 2 in adults who are at risk for severe COVID-19
•To assess safety and tolerability of COVID-19 mRNA vaccine in adults who are at risk of severe COVID-19

Secondary objectives are to evaluate the following:
•Durability of VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 through the final study visit (Month 12 post-dose 1) in volunteers with no previous COVID-19
•VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 by neutralization phenotype and Spike sequence features of acquired SARS-CoV-2 viruses (sieve analysis), including VE against the B.1.351/501Y.V2 variant and VE against all other variants combined in volunteers with no previous COVID-19
•VE of COVID-19 mRNA vaccine against SARS-CoV-2 infection defined by nucleocapsid protein seroconversion regardless of symptomology in volunteers with no previous COVID-19
•VE of COVID-19 mRNA vaccine against asymptomatic SARS-CoV-2 infection defined by nucleocapsid protein seroconversion without prior occurrence of the symptomatic COVID-19 primary endpoint in volunteers with no previous COVID-19
•Post -vaccination immune response markers as correlates of risk of COVID-19 and as correlates protection against COVID-19
•VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 in all participants regardless of baseline SARS-CoV-2 status
gestational age)
The exploratory objectives are to evaluate:
•VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 by baseline HIV infection status in volunteers with no previous COVID-19 and in all volunteers regardless of previous COVID-19 status
•VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 by neutralization phenotype and Spike sequence features of acquired SARS-CoV-2 viruses (sieve analysis), including VE against the B.1.351/501Y.V2 variant and VE against all other variants combined in volunteers with no previous COVID-19 and in all volunteers regardless previous COVID-19 status
•VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 in volunteers with previous COVID-19
•Relative rate of COVID-19 and severe COVID-19 in placebo recipients with previous COVID-19 compared to vaccine recipients with no previous COVID-19
•Assess T-cell responses in placebo recipients who develop COVID-19 compared to vaccine recipients who develop symptomatic COVID-19
•Assess incidence of adverse birth outcomes among pregnant persons enrolled in the trial

 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Clinical Trial Non-degree Award
Edwin Nuwagira
ID: UNCST-2021-R013488
 Improving Pulmonary function after Tuberculosis (IMPACT) at Mbarara Regional Referral Hospital. The incidence, clinical characteristics and factors associated with post-tuberculosis obstructive pulmonary disease at Mbarara Regional Referral Hospital (MRRH)
REFNo: HS1579ES

To determine the incidence, clinical characteristics and factors associated with post-tuberculosis obstructive pulmonary disease at Mbarara Regional Referral Hospital ,
 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Umaru Ssekabira Byansansa
ID:
Assessing COVID-19 sero-prevalence from routine antenatal care visits in Moyo and Adjumani Districts, Uganda, 2021-2022
REFNo: HS1628ES

The aim of this activity is to determine COVID-19 sero-prevalence from women attending antenatal clinics for their first ANC visit in Moyo and Adjumani Districts from April 2021 to September 2022.
The specific objectives of this sero-prevalence assessment shall be to:
•Measure the sero-prevalence of antibodies to COVID-19 in the population of pregnant women attending first ANC by age group, in order to ascertain the cumulative population immunity
•Monitor trends and detect emerging hotspots of COVID-19 in selected geographic areas

 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Doreen Chemutai
ID:
Pathways, Perceptions and Performance: A comparative Analysis of Women on Open and Reserved Seats in Uganda’s 10th Parliament
REFNo: SS971ES

i. To comparatively analyze the motives of women MPs on the reserved and open seats for seeking parliamentary seats in Uganda’s 10th parliament.
ii. To document the experiences of women members of parliament on the reserved and open seats of their journey to parliamentary seats.
iii. To explain voter’s perceptions of performance of women members of parliament on reserved and open seats.
iv. To evaluate the performance differences of women MPs on the reserved and opens seats of representation and legislation

 Uganda 2021-08-20 2024-08-20 Social Science and Humanities Non-Clinical Trial Degree Award
Annet Nanvubya
ID: UNCST-2025-R015525
 Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern version 1.0 16-05-2021.
REFNo: HS1677ES

Primary Objectives
The primary objectives of this study are to determine the following:
• To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent virologically-confirmed symptomatic COVID-19 starting 14 days after dose 2 in adults who are at risk of severe COVID-19
• To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent severe COVID-19 starting 14 days after dose 2 in adults who are at risk for severe COVID-19
• To assess safety and tolerability of COVID-19 mRNA vaccine in adults who are at risk of severe COVID-19

Secondary Objectives

The secondary objectives of this study are to evaluate the following:
• Durability of VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 through the final study visit (Month 12 post-dose 1) in volunteers with no previous COVID-19
• VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 by neutralization phenotype and Spike sequence features of acquired SARS-CoV-2 viruses (sieve analysis), including VE against the B.1.351/501Y.V2 variant and VE against all other variants combined in volunteers with no previous COVID-19
• VE of COVID-19 mRNA vaccine against SARS-CoV-2 infection defined by nucleocapsid protein seroconversion regardless of symptomology in volunteers with no previous COVID-19
• VE of COVID-19 mRNA vaccine against asymptomatic SARS-CoV-2 infection defined by nucleocapsid protein seroconversion without prior occurrence of the symptomatic COVID-19 primary endpoint in volunteers with no previous COVID-19
• Post -vaccination immune response markers as correlates of risk of COVID-19 and as correlates protection against COVID-19
• VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 in all participants regardless of baseline SARS-CoV-2 status
gestational age)

Exploratory Objectives
The exploratory objectives of this study are to:
• VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 by baseline HIV infection status in volunteers with no previous COVID-19 and in all volunteers regardless of previous COVID-19 status
• VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 by neutralization phenotype and Spike sequence features of acquired SARS-CoV-2 viruses (sieve analysis), including VE against the B.1.351/501Y.V2 variant and VE against all other variants combined in volunteers with no previous COVID-19 and in all volunteers regardless previous COVID-19 status
• VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 in volunteers with previous COVID-19
• Relative rate of COVID-19 and severe COVID-19 in placebo recipients with previous COVID-19 compared to vaccine recipients with no previous COVID-19
• Assess T-cell responses in placebo recipients who develop COVID-19 compared to vaccine recipients who develop symptomatic COVID-19
• Assess incidence of adverse birth outcomes among pregnant persons enrolled in the trial


 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Clinical Trial Non-degree Award
Judith Kobusinge
ID:
Effect of selected soil moisture conservation practices on water budgeting in Robusta coffee in Uganda
REFNo: A117ES

1) To predict the effect of soil moisture on Robusta coffee production and productivity in Uganda. 2) To estimate the water use efficiency (WUE) of Robusta coffee at various phenological stages under Albizia coriaria and Open sun 3) To determine the effect of selected soil moisture conservation practices on soil-water relations in Robusta coffee agro-systems.
Uganda 2021-08-19 2024-08-19 Agricultural Sciences Non-Clinical Trial Degree Award
Patrick OJOK
ID:
Teachers’ Perceived Preparedness to Implement the Competency-Based Lower Secondary Curriculum
REFNo: SS810ES

Purpose of the Study The primary purpose of this study is to determine the perceptions of preparedness of lower secondary teachers and explore the factors hindering and/or facilitating the implementation of the new LS curriculum in Uganda. Research Objectives 1) Determine the perceived preparedness of lower secondary school teachers to implement the new lower secondary curriculum. 2) Explore the school and teacher-factors that facilitate/hinder the implementation of the new lower secondary curriculum. 3) Identify the support that lower secondary teachers need to improve their capacity to implement the new LS curriculum.
Uganda 2021-08-19 2024-08-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Christopher Dolan Gerald
ID:
"changing gender norms and gender-responsive humanitarian action in Uganda”
REFNo: SS858ES

 To examine gendered norms, roles and power relations changed during and after forced displacement;
 To explore how existing knowledge on gender issues informed design of the current refugee response; and
 To find out implications for humanitarian agencies of observed changes in gender roles, norms and power relations

 UK 2021-08-17 2024-08-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Elizabeth Najjingo
ID:
Factors that influence false tooth extraction among children below two years in Isingiro, Southwestern Uganda.
REFNo: SS952ES

To explore alternatives that can be used instead of false tooth extraction,To explore outcomes of the practice false tooth extraction,To identify methods used for false tooth extraction in Isingiro district.,To explore factors responsible for false tooth extraction within Isingiro district.,To explore factors responsible for the practice of false tooth extraction and methods used in Isingiro district in South Western Uganda.,
 Uganda 2021-08-17 2024-08-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Munshi Sulaiman
ID:
Mobile money, privacy, security and women’s empowerment: Exploring the impact pathways of digital finance for women’s empowerment
REFNo: SS907ES

This research aims to assess the mechanisms (e.g. security and privacy) through which digital transfers may increase women’s agency and economic empowerment. The study will answer a number of research questions including:
• Are digital transfers more adequate instruments compared to cash transfers for improving women’s economic empowerment?
• Do digital transfers increase women’s privacy over financial information?
• Does privacy of information enhance the women’s enactment of choices?
• Does the secure nature of mobile money transfers significantly impact WEE outcomes?
• Which DFS pathways play a greater role in enhancing women’s agency and enactment of choices; security of money or privacy of information?
Bangladesh 2021-08-17 2024-08-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Laura Sirabella
ID:
Translating sustainable development goals to address poor reproductive health: exploring the role of civil society organisations
REFNo: SS949ES

The objectives of this study are to:
- explore the role of CSOs in translating the SDGs in the context of reproductive health in effective policies;
- explore how CSOs implement such policies;
- investigate how CSOs advocate for the implementation of policies aimed at addressing reproductive health;
- elaborate the role of CSOs in promoting individual and community’s agency to advocate for reproductive justice.
 Italy 2021-08-17 2024-08-17 Social Science and Humanities Non-Clinical Trial Degree Award
Akulia Agnes
ID:
UNDERSTANDING ACCESS TO SCHOOL LEADERSHIP: A CASE OF WOMEN IN PUBLIC PRIMARY SCHOOLS IN KOBOKO DISTRICT, UGANDA
REFNo: SS623ES

The main objective of this study is to establish how women in school leadership been able to navigate their way into leadership positions. Specifically the study will establish factors that motivate women to pursue school leadership positions, the barriers women have to navigate to access positions of school leadership and the strategies women use to enhance them access school leadership positions.
 Uganda 2021-08-16 2024-08-16 Social Science and Humanities Degree Award
Joseph  Olobo Okao Olobo
ID:
A multicentre observational study to assess immune response status in patients before and after treatment for visceral leishmaniasis
REFNo: HS1266ES

Primary Objective To assess systemic and skin immune responses and parasite load in patients before, and at end of treatment for visceral leishmaniasis
Secondary Objectives
1. To identify systemic and local immune correlates of treatment outcome.
2. To evaluate parasite genotype in relation to immune response characteristics
3. To compare immunology and parasitological data across each site and determine possible correlates of progression to PKDL


 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-degree Award
Joseph  Matovu KB
ID: UNCST-2020-R014654
 Formative research to inform the design of a youth-led self-care intervention to increase uptake of voluntary family planning and reproductive health care services among adolescent girls (10-19 years) in Uganda
REFNo: HS1294ES

The overall objective of the study will be to explore adolescent girls perceptions towards provision of self-care FP services and stakeholders’ perceptions towards provision of voluntary FP and RHC information and services to adolescent girls aged 10-19 years by fellow adolescents in order to inform the design of a youth-led self-care intervention to improve uptake of voluntary FP and RHC services to adolescent girls aged 10-19 years in Uganda. Specifically, this study will aim to:
1. Determine differentials in teenage pregnancy rates and contraceptive use by socio-demographic and behavioural characteristics
2. Assess the association between modern contraceptive use and teenage pregnancy rates among adolescents (15-19 years) across the different demographic and health surveys.
3. Explore the FP and RHC information and service needs of the very young adolescent girls (10-14 years) and older adolescents (15-19 years).
4. Explore mechanisms through which adolescent girls (10-19 years) can be involved in the design and delivery of voluntary FP and RHC interventions for fellow adolescents.
5. Explore adolescent girls’ perceptions about self-care FP methods and whether or not self-care FP methods can help to reduce the barriers that adolescents face in accessing and utilizing FP services.
6. Explore key stakeholders’ perceptions towards: a) provision of self-care FP information and services to adolescents; and b) provision of voluntary FP and RHC information and services to adolescent girls aged 10-19 years by fellow adolescents.
7. Explore key stakeholders’ perceptions on the acceptability of an intervention that entails provision of FP and RHC information and services to adolescent girls (10-19 years) by fellow adolescent girls.
8. Explore the barriers to and facilitators of interventions that provide FP and RHC information and services to adolescent girls by adolescent girls in the target districts and how provision of such information and services to adolescent girls by fellow adolescent girls can be improved.
 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-degree Award
Elizeus Rutebemberwa
ID: UNCST-2022-R009070
 Advancing the health of rural communities in Uganda through strong community health programs
REFNo: SS872ES

4.3 General Objective
To evaluate non-monetary incentive packages required for strengthening the community health workforce, which provides critical health services to the rural poor in Masindi District.

Specific objectives
i. To identify the priorities of the national government regarding compensation packages for the VHTs in Masindi District.
ii. To assess how the national government compensation packages align with the priorities of the VHTs in Masindi District.
iii. To identify the structure and group of incentives best suited to motivate VHTs, improve their performance in the delivery of services, and increase their retention in the health workforce in Masindi District.
iv. To identify the behavioural mechanism through which the new incentives may work or fail to work in Masindi District
v. To understand how changes in the national VHT program impact utilization of maternal and child health services, sanitary practices and perception of quality of health services at the community-level



 Uganda 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Manjari Quintanar-Solares
ID:
MICROARRAY PATCH FOR PEDIATRIC ANTIRRETROVIRAL TREATMENT STAKEHOLDER INTERVIEWS IN UGANDA
REFNo: HS1359ES

To define the target product profile (TPP) and preferred user characteristics, identify stakeholder needs, and evaluate potential acceptability of a pediatric ARV MAP
 Mexico 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eun Seok Kim
ID:
Cross-sectional prevalence study of schistosomiasis and soil-transmitted helminthiasis with nested open-label randomised controlled study of evaluating the impact of fatty meal co-administration and double-dosing on albendazole effectiveness against hookworm infection among school-aged children in Mayuge district: Implications for Mayuge NTDs Elimination (MANE) Project
REFNo: HS1411ES

Objective 1: To determine the effect of albendazole administration with a fatty meal such as avocado, versus albendazole administration without a fatty meal, on hookworm cure rate and egg reduction rate.

Objective 2: To determine the effectiveness of dual-dose (400mg/day, two consecutive days) versus single-dose (400mg) albendazole treatment regimens on hookworm cure rate and egg reduction rate.

Objective 3: To identify and evaluate environmental, social and cultural variables affecting hookworm infection, and cure rate and egg reduction rate of albendazole against hookworm.

 South Korea 2021-08-16 2024-08-16 Medical and Health Sciences Clinical Trial Degree Award
Carmen  Logie
ID: UNCST-2021-R013185
 Kuwawezesha Vijana (Empowering Youth): An HIV Self-Testing and Comic Intervention with Refugee Adolescents and Youth in a Refugee Settlement in Northern Uganda
REFNo: SS884ES

The primary study aim is to compare the effectiveness of adding HIV self-testing, education- comics, or both to the standard of care approaches of HIV testing among refugee youth in Bidi Bidi in increasing HIV status knowledge.
The primary outcome is HIV testing uptake (HIV status knowledge, verified through asking HIV serostatus and verifying with voluntary point of care testing).
The secondary outcomes include HIV knowledge, HIV-related stigma, use of SRH services (e.g., condoms, contraception), and linkage to a clinic for confirmatory testing.
 Canada 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Doris Kakuru
ID:
Representation of Young Motherhood: Performing young womanhood, subjectivities and agency in Sexual and Reproductive Health in Uganda
REFNo: SS960ES

To find out the implications of representations of young motherhood on reproductive justice,To establish alternatives of young parenthood which are made available through motherhood performances by young mothers in Uganda (Including their lived experiences, identity formation and agency to adhere, comply or resist dominant subjectivities). ,To examine how dominant notions about young motherhood affect SRHR rights of young mothers in Uganda.,To ascertain how dominant assumptions of young motherhood by different SRHR actors position young mothers in urban poor locales in Uganda. ,
 Uganda 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
 Acceptability and feasibility of mhealth technology for sensitization and contact follow up for high-risk communities for infectious disease outbreaks; Call for Life-COVID (CFL-C) and Call for Life Ebola (CFL-E)
REFNo: SS865ES

1.To document experiences of using an IVR service to support COVID positive patients and for those in COVID quarantine.
2.To evaluate the acceptability of using an IVR service for post COVID-19 mental health screening in Uganda.
3.To assess feasibility of using an IVR service for outbreak response, through documentation of the experience and lessons learned of using CFL-C by health care workers, policy makers, developers and implementing actors
4.To explore barriers and enablers to health seeking behaviour and vaccinations, perceptions/ stigma/ fears/concerns of COVID and other epidemic outbreaks including EVD and mitigation measures (e.g. cancelling funerals – Ebola, school and business closures – COVID, including comparisons of the two) within at risk and hard to reach communities.

UK 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Stella Muyanja Zawedde
ID: UNCST-2021-R014037
 Computer aided detection of Tuberculosis using chest radiography: A clinical validation of the CAD4TB version 7 system.
REFNo: HS1575ES

The primary objective will be to:
a) To determine the sensitivity and specificity of different CAD4TB v7 scores for the detection of bacteriologically confirmed tuberculosis (using Xpert Ultra® as the reference standard) in the Ugandan population.

The secondary objectives will be to
b) To determine the optimal combination of symptoms and chest x-ray features to be used to when triaging patients at the outpatient and HIV clinics.
To determine the most cost-effective algorithm to be used while to screen for TB among patients presenting to the outpatient and HIV clinics in Gulu and Kitgum.

Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
VICTOR TUMUKUNDE SPECTOR
ID:
Assessment of the validity of the measurement of kangaroo mother care duration in a hospital in Uganda: an observational study
REFNo: HS1589ES

o To assess the accuracy of caregiver report on duration of skin-to-skin contact (SSC) in the KMC position among neonates ≤2000g before stabilization.
o To assess the accuracy of healthcare workers’ report on duration of SSC in the KMC position among neonates ≤2000g before stabilization.
o To assess the reproducibility of the two methods of measuring KMC duration.
o To assess the reliability (inter-observer agreement) of gold standard direct observation.

 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Degree Award
Stephen Watya
ID: UNCST-2025-R021507
 UNDERSTANDING PROSTATE CANCER IN MEN OF AFRICAN ANCESTRY.
REFNo: HS1514ES

GENERAL OBJECTIVE
The goal of this project is to understand the genetics and epidemiology of prostate cancer in men of African ancestry.
Specific Objectives (SO):
1. To study common and rare germline variation in association with prostate cancer risk in men of African ancestry, using cutting edge genotyping and sequencing techniques. (UGPCS)
2. To determine non-genetic risk factors associated with prostate cancer among men of African ancestry. (UGPCS)
3. To identify germline and tumor genomic/molecular determinants of aggressive prostate cancer and disease progression in men of African ancestry. (UGPCS)
4. To determine the acceptability and validity of a rapid screening kits for prostate cancer in the Ugandan population. (UGPCS-epi)
5. To assess population level determinants of high PSA (≥4 n/gm) in men of African ancestry (UGPCS-epi).
6. To explore whether circulating tumor cells and circulating tumor DNA can be detected in the blood of men with aggressive prostate cancer and may be used to screen for aggressive disease (UGPCS-screen).
7. To determine disease progression of prostate cancer from the time of presentation among Ugandan men. (UGPCS-screen).

 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Violet Korutaro
ID: UNCST-2019-R000618
 IMPAACT 2017: Phase I/II Study of the Safety, Acceptability, Tolerability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Long-Acting Injectable Rilpivirine in Virologically Suppressed HIV-Infected Children and Adolescents. Short title: ‘MOCHA’ (More Options for Children and Adolescents), DAIDS # 30070, IND # 138,754
REFNo: HS1512ES

To assess the safety of CAB LA + RPV LA through Week 24 in HIV-infected, virologically suppressed adolescents,To confirm the doses for oral CAB followed by injectable CAB LA in HIV-infected, virologically suppressed adolescents by evaluating: Safety and multiple dose PK of oral CAB through Week 4, Safety and multiple dose PK of CAB LA through Week 16, and to confirm doses for injectable RPV LA in HIV-infected, virologically suppressed adolescents by evaluating safety and multiple dose PK of RPV LA through Week 16,To confirm the dose and evaluate the safety, tolerability, acceptability, and pharmacokinetics (PK) of oral cabotegravir (CAB), long-acting injectable cabotegravir (CAB LA), and long-acting injectable rilpivirine (RPV LA) in virologically suppressed HIV‐1 infected children and adolescents aged 12 to <18 years.,
 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Clinical Trial Non-degree Award
Helen Ndagije Byomire
ID: UNCST-2021-R013939
 Skepticism on the Safety and Quality of Generic Medicines from countries with Non-stringent Regulatory Authorities in Uganda.
REFNo: HS1550ES

3. To establish knowledge, attitude and perceptions of health workers and the general population towards generic medicines from countries with the SRAs and those from the N-SRA including Uganda.,2. To compare the quality of selected registered generic medicines on the Ugandan market sourced from countries with SRAs and those from N-SRA including Uganda against the innovator product. ,1. To compare the nature and proportion of adverse drug reactions (ADRs) received by NDA in the period of June 2016 to June 2020 for selected generics from SRAs and those from the N-SRA against the innovator product.,To compare the quality and safety of selected generic medicines on the Ugandan market sourced from countries with Stringent Regulatory Authorities (SRAs) with those from non-stringent regulatory authorities N-SRAs including Uganda. ,
 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jonathan Kayondo
ID: UNCST-2021-R008325
 Multi-Centre, Prospective, Evaluation for Matrix equivalence of capillary whole blood finger-stick and fresh and frozen venous whole blood with the NxTekâ„¢ Malaria Pf Plus Rapid Test Device and NxTekâ„¢ Malaria Pf/Pv Plus Rapid Test Device for the Detection of Plasmodium Infections in Patients with Symptoms Suggestive of Malaria within the Lab and its intended use environment for CE IVDR.
REFNo: HS1587ES

This trial is part of the R&D Verification and Validation studies, to provide clinical matrix equivalence evaluation to support the conformity assessment procedure for the use of fingerstick and venous whole blood samples with Abbott’s NxTek™ Malaria Pf Plus and NxTek™ Malaria Pf/Pv Plus Rapid Test Devices, as performed by professional users, in accordance with WHO PQ TSS-3, WHO PQ Dossier, EU 2017/7461.

Primary Objective: Matrix Equivalence
To assess the matrix equivalence of:
a. Fresh CWBFS and Fresh VWB
b. Frozen VWB and Fresh VWB
when used with the NxTekâ„¢ Malaria Pf/Pv Plus and NxTekâ„¢ Malaria Pf Plus by laboratory professionals (from hereon referred to as Lab operators) in a laboratory environment to support CE IVDR certification.

The test results of the NxTekâ„¢ Malaria Pf Plus and NxTekâ„¢ Malaria Pf/Pv Plus Rapid Test using a VWB sample, will be evaluated against the NxTekâ„¢ Malaria Pf Plus and NxTekâ„¢ Malaria Pf/Pv Plus Rapid Test using CWBFS sample from the same participant. In summary: Fresh CWBFS vs. Fresh VWB*. Likewise, the test results of the NxTekâ„¢ Malaria Pf Plus and NxTekâ„¢ Malaria Pf/Pv Plus Rapid Test using VWB samples that have been exposed to 1x Freeze/Thaw cycle will be evaluated against the NxTekâ„¢ Malaria Pf Plus and NxTekâ„¢ Malaria Pf/Pv Plus Rapid Test using fresh VWB samples from the same participant. In summary: Frozen VWB vs. Fresh VWB*

*indicates: Where Fresh VWB will be the comparator sample type.

The data obtained will be used in the application for CE IVDR certification and WHO PQ. Paired CWBFS and VWB samples will be taken from the same individuals for testing on both NxTekâ„¢ Malaria Pf/Pv Plus and NxTekâ„¢ Malaria Pf Plus RDTs.

Secondary Objective: Intended Users within the Intended Use Environment
Malaria RDTs are used outside of the laboratory for near patient testing (NPT)* by non laboratory healthcare workers with limited training. Thus the secondary objective of this study is to assess the perfromance of the NxTekâ„¢ Malaria Pf/Pv Plus and NxTekâ„¢ Malaria Pf Plus results when used in its intended environment (NPT setting) by intended users (non laboratory healthcare workers with limited training) using CWBFS as the sample type.*see NPT definition Section 4.2-4.3 of protocol (or below sections on trial operator types and trial envitronment types).

 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Clinical Trial Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 PILOT OF A NETWORK-DRIVEN, ADVOCACY INTERVENTION TO PROMOTE CERVICAL CANCER SCREENING IN UGANDA (PHASE 3)
REFNo: HS1633ES

The proposed intervention development study seeks to improve cervical cancer screening in Uganda by engaging and training local public health researchers and program implementers, and empowering women living with cervical cancer risk (WLCCR), defined as women who have ever received CC screening procedures, to advocate for CC screening and early treatment among women in their social networks.
 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Clinical Trial Non-degree Award
Vandana Sharma
ID:
Assessing StrongMinds’ Community-based Therapy Groups with a Gender Lens
REFNo: SS954ES

The overall objective of this research is to better understand gender outcomes of StrongMinds programming, including the experience of women participants of both in-person and remote IPT-G with respect to safety and GBV risks.
 Canada 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
 Validating a Clinical Risk Score for early Management of Tuberculosis in Ugandan Primary Health Clinics - PredicTB study
REFNo: HS1622ES

1. To evaluate the effectiveness of the PredicTB clinical risk score on clinical outcomes. 2. To evaluate the implementation of the PredicTB clinical risk score. 3. To project the long-term impact and cost-effectiveness of PredicTB implementation.
Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Denis Muhangi
ID:
Enhancing Institutional Capacity for Ethical Conduct of Research Involving Animals
REFNo: A141ES

Program objectives
1. To enhance technical capacity of MakSVAR-IACUC to international accreditation level.
2. Establish an Institutional Biosafety committee at the College of Veterinary Medicine, Animal Resources and Biosecurity.
3. To enhance awareness of the national guidelines for the use of animals in research and teaching among researchers and training institutions.

Specific study objectives

1. To determine the status of practices for the ethical conduct for research involving animals in Uganda.
2. To evaluate the available practices for ethical conduct for intervention.

Uganda 2021-08-16 2024-08-16 Agricultural Sciences Non-Clinical Trial Non-degree Award
Kenneth Ssebambulidde Ssebambulidde
ID: UNCST-2021-R013976
 Relationship between maternal or newborn cholesterol levels and neonatal septicaemia: A Ugandan cohort of mother-new-born pairs
REFNo: HS1204ES

Primary objective: To elucidate a relationship between maternal and neonatal cholesterol levels and neonatal septicaemia

Secondary objectives:
1. To determine whether abnormal maternal cholesterol levels are associated with a risk for neonatal septicaemia.
2. To describe the correlation between maternal cholesterol levels and cord blood neonatal cholesterol levels at birth.
3. To determine the association between cord blood cholesterol levels and neonatal septicaemia

Uganda 2021-08-11 2024-08-11 Medical and Health Sciences Non-degree Award
ANTHONY KAYIIRA
ID: UNCST-2020-R014108
 Prognostic value of serum hCG-β level, 12 days after embryo transfer, on predicting live birth among Ugandan women.
REFNo: HS1569ES

4. To determine the sensitivity and specificity of serum hCG-β level cut offs, 12 days after embryo transfer, on predicting pregnancy loss,3. To determine the sensitivity and specificity of serum hCG-β level cut offs, 12 days after embryo transfer, on predicting clinical pregnancy ,2. To determine the sensitivity and specificity of serum hCG-β level cut offs, 12 days after embryo transfer, on predicting biochemical pregnancy ,1. To determine the sensitivity and specificity of serum hCG-β level cut offs, 12 days after embryo transfer, on predicting live birth,To evaluate the prognostic value of serum hCG-β level cut off, 12 days after embryo transfer, on predicting pregnancy outcome among Ugandan women following an IVF-ET cycle.,
 Uganda 2021-08-11 2024-08-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Abel Atukwase
ID:
EXPOSURE ASSESSMENT AND ANALYSIS OF HEALTH RISKS ASSOCIATED WITH CONSUMPTION OF AFLATOXIN CONTAMINATED STAPLES IN UGANDA
REFNo: A132ES

The overall objective of the project is to generate information that will guide the development of evidence-based policies and strategies for management of health risks associated with aflatoxins in Uganda. The specific objectives are to;
1. Determine the levels of aflatoxins in maize, sorghum and groundnuts produced and consumed in Uganda
2. Assess aflatoxin exposure among children (6-59 months) and women of reproductive age (15-49 years)
3. Characterise the health risks associated with consumption of maize, sorghum and groundnuts among children 6-59 months and women of reproductive age (15-49 years)
4. Develop policy briefs aimed at improving awareness amongst policy makers and stimulate formulation of policies and strategies for mitigating aflatoxin associated health risks.
 Uganda 2021-08-11 2024-08-11 Agricultural Sciences Non-Clinical Trial Non-degree Award
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