Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
JACOB BIBOHERE
ID: UNCST-2025-R021298
Assessment of CDC Data Triangulation Activities to Enhance Immunization and Vaccine-Preventable Disease Surveillance Programs in Selected African Countries
REFNo: HS6596ES

1.To assess the extent to which data triangulation has been integrated into the existing immunization and/or VPD surveillance staff workload, program processes, and practices at national and sub- national levels. 2.To identify programmatic successes, challenges, enabling factors, and innovations reported by immunization and/or VPD program staff through the application of triangulation analytic tools. 3.To examine the immunization programmatic decisions, actions, and outcomes that have been informed by the use of data triangulation concepts. 4.To explore and identify sustainability strategies and recommendations for ensuring that data triangulation and existing tools remain integrated into routine program activities.
Uganda 2025-10-29 12:42:52 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shivan Kamugisha Kaitesi
ID: UNCST-2025-R019815
Socio-Ecological Systems Assessment of Factors Influencing the Lion population in the Greater Virunga Landscape
REFNo: NS989ES

1. Develop a population dynamics model for lions in the Greater Virunga Landscape 2. Assess the functionality of lion movement corridors within GVL 3. Examine the impacts of land use and climate change on the suitable habitat for lions 4. Evaluate factors of human-lion conflict and develop strategies for conflict mitigation and coexistence.
Uganda 2025-10-29 12:41:40 2028-10-29 Natural Sciences Non-Clinical Trial Degree Award
Michael Harvey
ID: UNCST-2025-R022115
HERPETOFAUNAL DIVERSITY AND BASELINE ECOLOGICAL ASSESSMENT IN SELECT SITES OF NORTHERN AND WESTERN UGANDA
REFNo: NS1049ES

• Generate a list of reptiles and amphibians inhabiting Mount Kadam and surrounding areas
• Compare the distributions of reptiles and amphibians across different habitats within the boundaries of the research site.
• Establish a reference collection of vouchered specimens from the reserve in a local international research collection/museum.
• Tabulate baseline ecological data for each species (see data collection for details)
• Involve local community, students, and other stakeholders in survey methods and data recording
• Publish results of survey in peer-reviewed scientific journals

USA 2025-10-24 17:36:31 2028-10-24 Natural Sciences Non-Clinical Trial Non-degree Award
DENISH  ONGOL OGWANG
ID: UNCST-2025-R022077
THE IMPLEMENTATION OF THE PRISONERS’ RIGHT TO VOTE IN UGANDA. A CASE STUDY OF LUZIRA PRISONS, 1995-2021
REFNo: SS4502ES

1. To assess the adequacy of the legal framework for the implementation of prisoners’ right to vote in Uganda.
2. To identify the challenges that Luzira Prisons face in the implementation of the prisoners’ right to vote
3. To develop a framework for the implementation of the prisoners’ right to vote in Uganda.

Uganda 2025-10-24 17:35:10 2028-10-24 Social Science and Humanities Non-Clinical Trial Degree Award
Mudarshiru Bbuye
ID: UNCST-2025-R019080
EXPLORING THE ASSOCIATION BETWEEN AIR QUALITY AND THE BURDEN OF RESPIRATORY TRACT INFECTIONS IN KAMPALA, UGANDA
REFNo: HS6603ES

General objective To explore the impact of ambient air pollution on the incidence, prevalence, and severity of respiratory tract infections, and the extent of enforcement of air quality control policies and regulations in Kampala, Uganda, a low-resourced urban setting Specific Objectives 1.To conduct a systematic review and meta-analysis to quantify the association between ambient air pollution and respiratory tract infections in low- and middle-income countries (LMICs). 2. To characterise the spatial variation in ambient PM2.5 exposure and its correlation with respiratory tract infection health effect among sub-populations in Kampala, Uganda 3.To determine the effect of air quality policies and regulations on the long-term ambient PM2.5 levels and the respiratory tract infections health effects in Kampala, Uganda. 4. To explore the limitations of adaptation and enforcement of air pollution control policies and regulations to reduce the ambient air pollution health effects in Kampala, Uganda.
Uganda 2025-10-24 17:34:12 2028-10-24 Medical and Health Sciences Non-Clinical Trial Degree Award
Dr. James Wasike Mangeni Byanasaye
ID: UNCST-2020-R008019
DENTAL ANTIMICROBIAL STEWARDSHIP IN UGANDA - DEVELOPING AN EVIDENCE BASED INTERVENTION
REFNo: HS6561ES

Aim: To develop evidence-based, behaviour science informed antimicrobial stewardship intervention aimed at reducing antibiotic prescribing to adult patients for dental issues.
Objectives:
1. To understand the factors that influence antibiotic prescribing by health care practitioners to adult patients for dental issues.
2. To explore the perspectives of patients seeking dental care on the use of antibiotics for dental issues.
3. To explore community stakeholders' perspectives on the use of antibiotics for dental issues
4. To co-produce an evidence-based, behaviour science informed dental antibiotic stewardship intervention for Uganda.


Uganda 2025-10-24 17:32:56 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Deogratius Ssemwanga
ID: UNCST-2025-R021563
Performance Evaluation for Diagnostic Tests
REFNo: HS6649ES

Primary Objective

The overall objectives of this performance evaluation are:

• To verify the performance characteristics of new on-the-market NAATs and antigen RDTs.
• To establish well-characterized viral pathogen sera/plasma reference panels to support evaluation efforts and quality assurance.

• To evaluate the performance characteristics of new, on-the-market, EIAs and RDTs (IgA, IgG and IgM).
• To train laboratory and POC staff in biosecurity and the required technical skills to perform diagnostic testing.

Specific Objectives:

• To confirm whether or not a new NAAT complies with the manufacturer’s specifications,
• To determine the performance equivalence of new on-the-market NAATs, including POC devices, using available gold standards (or any other comparatively/equally as good WHO/FDA approved NAAT),
• To determine the performance equivalence of new on-the-market antigen tests against the gold-standard NAAT,
• To determine the sensitivity and specificity of new on-the-market diagnostic EIAs and RDTs against a gold-standard method,
• To evaluate the operational characteristics of new on-the-market immunoassays. Operational utility characteristics that may be considered include;
o ease of performance
o specimen type utility
o inter-reader variability
o reaction endpoint stability
o suitability for use in facilities with limited infrastructure (no/limited electricity, no/limited clean water)
• To document SOPs and train laboratory staff in performing testing using recommended diagnostic tests,
• To establish a repository of well-characterized natural infection and vaccination sera/plasma as well as swabs/extracted RNA to support future evaluation and verification of immunoassays.
• To establish a cohort of natural infection and vaccinated cases in the country whose samples and demographic characteristics will be used to help understand the dynamics of human immunity development to viral infection in order to inform the clinical interpretation of the various diagnostic assays.

Uganda 2025-10-24 17:31:36 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Grace Muzanyi
ID: UNCST-2021-R013731
Exploration Of the Correlation Between Active TB Immunological Markers and Sputum Culture: A Cytokine TB (CYTO-TB) Study
REFNo: HS6426ES

Main Objective
1. To explore the correlation of TB immunological markers (IL-2, IL-2Ra, I-P10, MIP-β, MCP-1) and TB sputum cultures at five-time points: before the start of treatment (Month 0), then Months 1, 2, 5, and 6.
Specific Objectives
1. 1. To assess the level of each or a combination of cytokines at the time points of active TB diagnosis, months 1, 2, 5, and 6, and how they relate to sputum culture on liquid (days to positivity) and solid (quantitative colony counts) media
2. 2. 2. To assess the baseline level of each cytokine or a combination and how it correlates with (a) the clinical response to TB treatment at months 1, 2, 5, and 6; (b) the clinical severity, and radiographic extent (severity) of TB disease at diagnosis and end of treatment.
3. 3. To evaluate the differences in the TB cytokine levels between active and latent TB during treatment with ERHZ (for active TB), and 6H (for latent TB), stratified by HIV status
4. 4. To evaluate the TB cytokine levels across three populations of active TB, Latent TB, and TB-exposed healthy volunteers who are TST/IGRA negative
5. 5. To compare the cost-effectiveness of TB immunological markers against sputum culture (standard of care).
Uganda 2025-10-24 17:30:54 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Wilber Sabiiti
ID: UNCST-2024-R016293
UNDERSTANDING INFECTIOUS AND NON-INFECTIOUS DISEASE TRENDS IN KANUNGU DISTRICT TO INFORM PUBLIC HEALTH PLANNING AND INTERVENTIONS
REFNo: HS6462ES

1. Determine types and trends of diseases in Kanungu from 2015–2025.
2. Compare quality and quantity of HCF records with MoH’s DHSI data.

Uganda 2025-10-24 17:28:54 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Agatha Nakibuule Martha
ID: UNCST-2024-R016574
EXPLORING HIV SELF-TESTING: PERCEPTIONS AND EXPERIENCES OF SEX WORKERS AND MALE CLIENTS ON KOOME ISLAND, UGANDA
REFNo: HS6306ES

1.3 Objectives
1.3.1 General objective
The overall objective of this study is to increase the adoption and use of HIVST kits among sex workers and their clients on Koome Island, by qualitatively exploring their perceptions, preferences and experiences of using HIVST kits for HIV prevention, and assessing how HIVST may influence status disclosure, behaviour change and linkage to care.
1.3.2 Specific objectives
1. To explore the perceptions, preferences and experiences of HIV self-testing among sex workers on Koome Island.
2. To explore the perceptions, preferences and experiences of HIV self-testing among male clients of sex workers on Koome Island.
3. To assess perceptions, practices, and norms of sex worker peers and healthcare providers that may influence HIVST scale-up and implementation for sex workers and their clients in island fishing communities.


Uganda 2025-10-24 17:27:53 2028-10-24 Medical and Health Sciences Non-Clinical Trial Degree Award
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